巨胞饮的机制及功能的研究进展

巨胞饮（macropinocytosis）是内吞的一种形式,指在某些因素刺激下,细胞膜皱褶形成大且不规则的原始内吞小泡,它们被称为巨胞饮体。巨胞饮体的直径一般为0．5～2μm,有时可达5μm。与其它内吞形式的小泡相比,巨胞饮体直径较大,为非选择性地内吞细胞外营养物质和液相大分子提供了一条有效途径。最近的研究表明,巨胞饮具有清除凋亡细胞、参与免疫反应、介导某些病原菌侵袭细胞、更新细胞膜等功能。     

A brief review

This article serves as a brief history and review of EBM—how EBM developed, its strengths and limitations, and the need for constant improvements. Hopefully, this review will have enhanced your understanding of EBM and its importance and stimulated you to apply EBM to your own practice. As more data and therapies become available, and as clinical guidelines continue to evolve based on EBM, we should expect patient outcomes to improve.     

Cellular calcium and atherosclerosis: A brief review

Evidence for and against the theory that cell calcium is causally involved in the pathogenesis of atherosclerosis is presented and evaluated. In particular, it is argued that: (1) arterial calcium is increased in atherosclerosis; (2) this increase in tissue calcium content is largely intracellular; (3) this increased intracellular calcium content is caused by increased plasma membrane calcium permeability; (4) the increased calcium content is causally related to atherogenesis; (5) many of the cell physiological, cell biological, biochemical, and molecular biological processes, known to function abnormally in atherosclerosis, are also known to be calcium regulated; and (6) these processes are activated or inactivated in atherosclerosis in a manner consistent with increased cell calcium. It is concluded that the calcium-atherogenesis hypothesis has the potential to unify macroscopic clinical risk factors in terms of intracellular mechanisms that are controlled by cell calcium, and that this hypothesis deserves further experimental tests.     

Recovery from training: a brief review: brief review

Athletes spend a much greater proportion of their time recovering than they do in training. Yet, much attention has been given to training with very little investigation of recovery. The purpose of this review is to stimulate further research into this vital area of training. Recovery can be categorized in three terms: i) immediate recovery between exertions; ii) short-term recovery between repeats (e.g., between resistance sets or interval bouts); and iii) training recovery between workouts. The focus of this review is training recovery. Full training recovery is essential to optimal performance and improvement. This review includes an examination of extant research on recovery and a very brief review of some potential modalities and techniques for hastening recovery and the time course of recovery and responses to some treatments. Measures of recovery and practical considerations are discussed briefly. Much research is needed in this area, but there are obstacles to high quality research. Attention must be given to key issues in research on recovery, especially the individual response to recovery treatments.     

Congenital malformations and season of birth: A brief review

Abstract

Evidence for congenital malformations related to season of birth and to sex of infant is discussed for malformation of the central nervous system, the cardiovascular system, and the musculoskeletal system.     

Studies of the basicranial axis: A brief review

Growth and development of the cranial base have interested students of anatomical disciplines for more than a century. Flexure of the basal region has been of particular interest and is among the most assiduously studied characteristics of the skull. Reports may be found in journals serving such a diversity of professional interests that a summary of facts and the more interesting speculations on unsettled aspects of this subject should be of value. This paper is a review of the literature from Virchow's and Schaeffer's writings in the latter half of the last century to those of the most recent investigators. It includes the works of anatomists, anthropologists, embryologists and orthodontists, among others.     

A brief review of holopelagic annelids

Annelids are one of the most successful major animal lineagesin terms of number of species and of habitats occupied. Despiteannelids being common in terrestrial, aquatic, and marine environments,only a limited number of lineages have evolved a holopelagicexistence. Most of these holopelagic lineages belong to Phyllodocida(nereidids, syllids, scale worms, and jawed worms) and moreparticularly often within the family Phyllodocidae. These wormsgenerally appear to retain many characteristics of adult annelids.Moreover, we provide molecular evidence showing that the well-knownalciopids are derived from within Phyllodocidae. In contrast,at least two lineages, Poeobius meseres/Flota flabelligera andprobably Chaetopterus pugaporcinus, are derived through paedomorphicprocesses acting on larvae from lineages that have sedentaryadult forms. Herein, we will briefly review the known diversityof holopelagic annelids with discussion of their evolutionaryorigins.     

A brief review of Chinese synapsids

In this short note are reviewed all the synapsid discoveries made in China between 1935 and 1980; their stratigraphical and geological distributions are discussed. A few systematic corrections are included.     

土壤动物学研究的回顾与展望

简明介绍了土壤动物学的研究进展及我国的研究概况,提出了今后的研究重点和保护自然资源的建议。     

Insulin structure and function

Throughout much of the last century insulin served a central role in the advancement of peptide chemistry, pharmacology, cell signaling and structural biology. These discoveries have provided a steadily improved quantity and quality of life for those afflicted with diabetes. The collective work serves as a foundation for the development of insulin analogs and mimetics capable of providing more tailored therapy. Advancements in patient care have been paced by breakthroughs in core technologies, such as semisynthesis, high performance chromatography, rDNA-biosynthesis and formulation sciences. How the structural and conformational dynamics of this endocrine hormone elicit its biological response remains a vigorous area of study. Numerous insulin analogs have served to coordinate structural biology and biochemical signaling to provide a first level understanding of insulin action. The introduction of broad chemical diversity to the study of insulin has been limited by the inefficiency in total chemical synthesis, and the inherent limitations in rDNA-biosynthesis and semisynthetic approaches. The goals of continued investigation remain the delivery of insulin therapy where glycemic control is more precise and hypoglycemic liability is minimized. Additional objectives for medicinal chemists are the identification of superagonists and insulins more suitable for non-injectable delivery. The historical advancements in the synthesis of insulin analogs by multiple methods is reviewed with the specific structural elements of critical importance being highlighted. The functional refinement of this hormone as directed to improved patient care with insulin analogs of more precise pharmacology is reported.     

A brief review of concurrent activation potentiation: theoretical and practical constructs

Enhancing the acute quality of the resistance training stimulus is the goal of many research and applied professionals. To that end, many methods have been proposed and a variety of training strategies and ergogenic supplements have been investigated. Postactivation potentiation is one phenomenon that has been frequently examined, offering some promise in this regard. Though never previously applied in the strength and conditioning profession, dental research on jaw clenching, studies examining the Jendrassik maneuver and remote voluntary contractions and research on motor overflow together make a compelling case for the existence of a concurrent activation potentiation phenomenon and the acute ergogenic advantage associated with the simultaneous activation of muscles other than the prime mover or synergists. Evidence demonstrates that this advantage is accrued via activation of the H reflex and through cortical overflow. Ultimately, through research and practical application, athletes may be taught to optimize the type, timing, and magnitude of remote muscle actions in order to gain an ergogenic advantage and increase the acute response of the prime movers. This strategy may be especially useful during the most difficult portion of a resistance training repetition and during the most difficult repetitions of a resistance training set.     

Electrophoresis in nanochannels: brief review and speculation

The relevant physical phenomena that dominate electrophoretic transport of ions and macromolecules within long, thin nanochannels are reviewed, and a few papers relevant to the discussion are cited. Sample ion transport through nanochannels is largely a function of their interaction with electric double layer. For small ions, this coupling includes the net effect of the external applied field, the internal field of the double layer, and the non-uniform velocity of the liquid. Adsorption/desorption kinetics and the effects of surface roughness may also be important in nanochannel electrophoresis. For macromolecules, the resulting motion is more complex as there is further coupling via steric interactions and perhaps polarization effects. These complex interactions and coupled physics represent a valuable opportunity for novel electrophoretic and chromatographic separations.     

Hidrocystomas--a brief review

Hidrocystomas, eccrine and apocrine, are rare cystic lesions that form benign tumors of the sweat glands. In this clinical review, we present a "classic" case of hidrocystoma and review the main epidemiologic, histologic, and clinical features. We also review the effectiveness of experimental treatment methods and present information about associated syndromes and differential diagnosis, focusing especially on hidrocystomas' resemblance to basal cell carcinoma.     

A brief review of DNA and RNA chemical synthesis

Current methodologies used to synthesize DNA and RNA are reviewed. These focus on using controlled pore glass and microarrays on glass slides.     

Insulin resistance,lipotoxicity and endothelial dysfunction

The number of people with the insulin-resistant conditions of type 2 diabetes mellitus (T2DM) and obesity has reached epidemic proportions worldwide. Eighty percent of people with T2DM will die from the complications of cardiovascular atherosclerosis. Insulin resistance is characterised by endothelial dysfunction, which is a pivotal step in the initiation/progression of atherosclerosis. A hallmark of endothelial dysfunction is an unfavourable imbalance between the bioavailability of the antiatherosclerotic signalling molecule nitric oxide (NO) and proatherosclerotic reactive oxygen species. In this review we discuss the mechanisms linking insulin resistance to endothelial dysfunction, with a particular emphasis on a potential role for a toxic effect of free fatty acids on endothelial cell homeostasis.