Corrigendum: Effect of soil temperature on nutrient allocation and mycorrhizas in Scots pine seedlings

(Plant and Soil 239: 173–185, 2002.)An inadvertent omission of figure captions occurred in the article by Domisch et al. Please find the correct captions below: Figure 1. Relationship between the numbers of root tips identified by the WinRHIZO programme and counted manually under a dissecting microscope (n = 128). Figure 2. (A) N, (B) P and (C) Ca content and allocation within different parts of the seedlings at 3, 6 and 9 weeks and at soil temperatures of 5, 9, 13 and 17°C. The P and Ca content of the new roots in all harvests at 5 °C and in the first harvest at 9 °C is estimated (see text for details) (n = 14). Standard errors are indicated. Figure 3. (A) Al and (B) Fe content and allocation within different parts of the seedlings at 3, 6 and 9 weeks and at soil temperatures of 5, 9, 13 and 17 °C. The Al and Fe content of the new roots in all harvests at 5 °C and in the first harvest at 9 °C soil temperature is estimated (see text for details) (n=14). Standard errors are indicated. Figure 4. (A) Total numbers of tips of new roots and (B) their relative distributions within the groups at 3, 6 and 9 weeks and at soil temperatures of 5, 9, 13 and 17 °C (n = 14; ± standard errors) Figure 5. (A) Total numbers of mycorrhiza of new roots and (B) their relative distributions within the groups at 3, 6 and 9 weeks and at soil temperatures of 5, 9, 13 and 17 °C (n = 14; ± standard errors).     

Tension receptors on the apodemes of muscles in the walking legs of the crab,Cancer magister †

1. Mechanoreceptors monitoring tension in working muscles are described in the Decapoda Crustacea.

2. The receptors are associated with apodemes of muscles in the walking leg and are well‐developed in the extensor and flexor of the meropodite (Figures 1, 2).

3. The unbranched dendrites of the receptor neurones innervate the tissues surrounding the insertions of the muscle fibres (Figures 3, 4, 5(A)).

4. The receptors show spontaneous activity with the M‐C joint at resting position and this activity increases when the muscle is stretched by holding the joint at a different position (Figure 7).

5. Isometric tension increase in the muscle recruits sensory units (Figures 8, 10(A)) and increases the activity of units firing (Figure 9).

6. Apodeme receptors may be an entirely distinct input channel from chordotonal organs (Figure 10(B,C)). Joint movements produced by a standard muscle stimulus against increasing loads reveal very different responses (Figure 11).

7. Attempts to determine whether chordotonal organs (CP1, Figures 5(B), 6) monitor isometric muscle tension (Figure 12) suggest possible complexities in their dynamic responses.

8. Abbreviations used in this paper are FASN flexor apodeme sensory nerve, EASN extensor apodeme sensory nerve, BASN bender apodeme sensory nerve, and OASN opener apodeme sensory nerve.     

A Simple and Efficient Method to Isolate Macrophages from Mixed Primary Cultures of Adult Liver Cells

Kupffer cells are liver-specific resident macrophages and play an important role in the physiological and pathological functions of the liver^1-3. Although the isolation methods of liver macrophages have been well-described^4-6, most of these methods require sophisticated equipment, such as a centrifugal elutriator and technical skills. Here, we provide a novel method to obtain liver macrophages in sufficient number and purity from mixed primary cultures of adult rat liver cells, as schematically illustrated in Figure 1.After dissociation of the liver cells by two-step perfusion method^7,8,a fraction mostly composed of parenchymal hepatocytes is prepared and seeded into T75 tissue culture flasks with culture medium composed of DMEM and 10% FCS.Parenchymal hepatocytes lose the epithelial cell morphology within a few days in culture, degenerate or transform into fibroblast-like cells (Figure 2). As the culture proceeds, around day 6, phase contrast-bright, round macrophage-like cells start to proliferate on the fibroblastic cell sheet (Figure 2). The growth of the macrophage-like cells continue and reach to maximum levels around day 12, covering the cell sheet on the flask surface. By shaking of the culture flasks, macrophages are readily suspended into the culture medium. Subsequent transfer and short incubation in plastic dishes result in selective adhesion of macrophages(Figure 3), where as other contaminating cells remain suspended. After several rinses with PBS, attached macrophages are harvested. More than 10⁶ cells can be harvested repeatedly from the same T75 tissue culture flask at two to three day intervals for more than two weeks(Figure 3).The purities of the isolated macrophages were 95 to 99%, as evaluated by flow cytometry or immunocytochemistry with rat macrophage-specific antibodies (Figure 4).The isolated cells show active phagocytosis of polystylene beads (Figure 5), proliferative response to recombinant GM-CSF, secretion of inflammatory/anti-inflammatory cytokines upon stimulation with LPS, and formation of multinucleated giant cells⁹.In conclusion, we provide a simple and efficient method to obtain liver macrophages in sufficient number and purity without complex equipment and skills.This method might be applicable to other mammalian species.     

Erratum to: Central European Journal of Biology, Volume 6, Issue 5

Paper by Péli et al. “Ecophysiological responses of desiccation-tolerant cryptobiotic crusts” in Volume 6, Issue 5, 838–849 / October 2011; DOI: 10.2478/s11535-011-0049-1 contains incorrect graphic file inserted as Figure 6. The correct Figure 6, together with its caption is presented below.     

Erratum to: “Nano-characterization of Jagged-1-educated dendritic cells”

Paper by Xing et al. “Nano-characterization of Jagged-1-educated dendritic cells” in Volume 6, Issue 6, 981-989 / December 2011; DOI: 10.2478/s11535-011-0063-3 contains an error in the graphic file inserted as Figure 1 and also an incorrect figure caption. The corrected Figure 1, together with its caption is presented below.     

Activation of command fibres to the stomatogastric ganglion by input from a gastric mill proprioceptor in the crab,Cancer pagurus †

In semi‐intact preparations of the crab Cancer pagurus the normal output from the stomatogastric ganglion (StG) was a regular pyloric cycle (Figure 4). Repeated stimulation of the posterior stomach nerve (psn) of the posterior gastric mill proprioceptor (PSR) often induced series of spontaneous gastric cycles. We were therefore able to describe the normal gastric cycle as recorded in the output nerves from StG and to identify most of the relevant motor neurones by reference to the muscles that they innervate (Figure 10). The gastric cycle output was variable (Figures 5, 6), although in many preparations one complex type of output predominated (Figure 7). The basic feature of the gastric cycle was an alternation of activity between the single cardio‐pyloric neurone (CP) and a complex variable burst in the lateral cardiac (LC), the gastro‐pyloric (GP), the gastric (GM), and other associated neurones. During this normally occurring complex gastric burst significant changes occurred in the pyloric cycle, notably an increase in activity of the pacemaker pyloric dilator (PD) group and an inhibition of the lateral pyloric (LP), inferior cardiac (IC) and ventricular dilator (VD) neurones (Figures 6, 7, 8, 9). These changes are probably associated with an opening of the cardio‐pyloric valve and food passage into the pyloric filter. The gastric output was related to the normally observed movements of the dorsal ossicles of the gastric mill and thus to the operation of the teeth of the mill (Figure 11). Increased input from the PSR is associated with the grinding action of the teeth which is caused by the complex gastric burst (Figure 12).

Stimulation of the psn during an ongoing regular pyloric output caused changes in the cycle which mimicked those occurring during the spontaneous gastric cycle (Figure 13; Table 1). Stimulation of the psn during ongoing gastric activity also affected the gastric units (Figure 14). The input pathway from the PSR is shown to be through the stomatogastric nerve (sgn), the connection between the commissural ganglia and the stomatogastric ganglion (Figure 15). The commissural ganglia are known to receive most of the sensory input from the foregut and PSR input is probably processed there. Recordings from the sgn show that psn stimulation activates a small number of centrally originating units, and that the activity of these units coincides with the pyloric output changes (Figures 15, 16). We therefore label the units command interneurones. Their effects could be mediated by direct connections to only the PD pacemaker neurones of the pyloric cycle. Control experiments showed that PSR input is not necessary for the pyloric output changes to occur during gastric output but that similar output changes can be evoked by input resulting from induced gastric movements (Figure 15(E)). We think that the pyloric cycle output changes are normally controlled by a number of mechanisms at different levels (Figure 17). We cannot easily explain the effects of PSR input on the gastric cycle neurones.

These findings are important because they allow us to study a specific input to the StG without disrupting its normal input‐output pathways to the central nervous system. Further experiments on the system designed to test the assumption that the sgn units are in fact responsible for the pyloric output changes, and to investigate the processing of the PSR input are outlined.     

Erratum: High speed sCMOS‐based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes

In the article by M.B. Sikkel et al. (doi: 10.1002/jbio.201500193), published in J. Biophotonics 9 , 311–323 (2016), an error occurred in the computer code that was used to generate Figure 3. This erratum is published to correct Figure 3, the calculated value of t_geom and the experimentally determined value of t_optics in the text of the article.     

Erratum to: Singh R.K. and Gunjan A. Histone tyrosine phosphorylation comes of age. Epigenetics 2011; 6:153-60.

We recently noticed that there is a major error in Figure 1 of our review published in Epignetics 2010, Volume 6, Issue 2. During the preparation of the figure, the human and yeast H2B tyrosines were numbered the same, making the human numbering incorrect. The correct Figure 1 with proper numbering of human tyrosines is below.

Erratum to:

Singh R.K. and Gunjan A. Histone tyrosine phosphorylation comes of age.Epigenetics 2011; 6:153-60.     

Expression of Concern

“MiRNA‐218 regulates osteoclast differentiation and inflammation response in periodontitis rats through MMP9”, Cell. Microbiol. 2019;21:e12979, by Jie Guo, Xuemin Zeng, Jie Miao, Chunpeng Liu, Fulan Wei, Dongxu Liu, Zhong Zheng, Kang Ting, Chunling Wang, and Yi Liu. The Editors of Cellular Microbiology and the publisher John Wiley & Sons agree to publish an Expression of Concern regarding the above article, published online in Cellular Microbiology on November 16, 2018, in Wiley Online Library ( https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12979 ). In September 2019, the journal was contacted regarding concerns about the data presented in Figures 6 and 7 because of high level of similarities in the graphs presented in these figures. The different bars in the graphs show identical height. The standard deviation bars are also of identical length. Although one graph expresses the number of TRAP‐positive cells (Figure 6b) and the other graphs express the relative mRNA expression of different osteoclast‐related genes (Figure 6c‐g), all graphs are identical. The bars in the graphs in Figure 7 that represent 5 different osteoclast genes show the same height. Figures 6 and 7 show identical mRNA expression for a series of different genes: V‐ATPase, NFATc1, CTSK, DC‐STAMP and TRAP. In December 2019, the journal requested the authors to provide the raw data of the experiments presented in the article and for explanations of the similarities. The authors responded that the similarities were due to unintentional errors and provided Excel spread sheets containing processed data in March 2020. The data provided in the Excel sheets that were sent by the authors were analyzed and it was concluded that the calculations as shown in the Excel sheets are correct. However, the concerns raised regarding similarities in the heights of bars representing different parameters and narrow range of standard deviations presented in Figures 6–7 remained. The authors disagree with the concerns raised. In addition, the editors were concerned by manipulations of western blot images to represent single bands instead of doublets for COL1 in Figures 5 and 8 and for MMP9 in Figures 3A and C, 4C, 5A and D, and 8A. The first issue concerning COL1 bands has been addressed and corrected during the peer‐review process. The latter has been clarified after publication and following a request from the editors for the raw data of all figures in the article. In the published article, western blots of MMP‐9 in Figures 3A and C, 4C, 5A and D, and 8A show active‐MMP‐9 only and do not include pro‐MMP‐9 bands that were present in the original western blot experiments. The authors explained that on the original blots that were provided during the peer‐review process, MMP‐9 show doublets that represent pro‐MMP‐9 and active‐MMP‐9. As no significant difference was found for pro‐MMP‐9, the authors only presented single bands for active‐MMP‐9 in the publication version. The authors’ institution, Shandong University, did not respond to a request from the Publisher and the Editor‐in‐Chief to investigate whether the data arose from the originally reported experiments, are unmodified, and are suitable for publication. As a result, the journal is issuing this expression of concern to readers.     

Interaction Energies and Dynamics of Alkali and Alkaline-Earth Cations in Quadruplex-DNA-Structures

We have investigated the nonbonded interaction energies and dynamical properties of different types of cations in quadruplex DNA structures using the GROMOS force field [1]. Quadruplex structures consist of planar guanine-quartets stacking together and causing the formation of a channel, large enought to enclose several cations (Figure 1). In recent years many experimental studies have indicated a prefered formation of this unusually stabel complexes with K⁺-ions. However, the high selectivity of this cation has not yet been understood [2].To determine the most stable coordination sites and the mobility of cations, we have calculated the pair potential energy of alkali and alkaline-earth cations along the helical axis of a model quadruplex structure (Figure 2). Our force field calculations indicate that small ions like Li⁺, Na⁺, Mg²⁺ and Ca²⁺ are free to move throught the channel. In contrast, for K⁺ and larger ions a high potential barrier appears, located in the plane of the tetramer unit. These findings are in agreement with data from X-ray crystallography, indicating that K⁺ cations are located between two planes while Na⁺ ions also can occupy coordination sites in the G-quartet plane.Considering solvent atoms in our calculations leads to the observation that a cation at the end of the quadruplex strongly interacts with one water molecule located near the entrance of the cage. Snapshots taken at different times of the MD simulation provide configurations which differ mainly in the position of this complexing water molecule. Moving away from the entrance of the cage causes a significant decrease of the potential barrier for K⁺ and smaller cage cations (Figure 3). For the larger ions the potential barrier is much higher than the thermal energy (not shown), preventing the cations from leaving and entering the cage.This conclusion is in agreement with results from our MD simulations. We followed the dynamics of different cations. While K⁺ is able to leave as well as to re-migrate into the channel (movie I), this was not observed for other types of cations. Figure 4 shows the time history of the positional fluctuations of potassium along the helical axis, and in Figure 5 we have monitored the distance between the O6-oxygen atoms of the outer G-quartet. It becomes clearly evident that the cation movement through the planes is correlated with the dynamic behaviour of the tetrameric planes. When the K⁺-ion penetrates the tetrameric unit to enter the quadruplex, the O6-O6-distance - a measure of size of the hole of the plane - increases. After a while the cation has reached the cage position and the G-quartet contracts to the initial value. That means the tetrameric planes perform a kind of breathing motion.For lithium ions we find a much higher mobility of the cation within the quadruplex channel. Two of three ions are leaving the cage instantaniously (not shown).Another indication of the experimentally observed much weaker complexation tendency of quadruplexes with lithium is the change in the distances of planes (a measure for the cage size) with time. While in the case of potassium the distance of planes is nearly the same for all three cages, for lithium the central occupied cage is much smaller than the cage in the starting structure, indicating that the DNA structure has to adjust its conformation to the cation size. On the other side the outer unoccupied cages are much greater and less stable. Due to this cation induced quadruplex deformation we observe an unwinding of the DNA-structure in the presens of lithium ions at longer simulation periods (400 ps).     

An ab initio study of di- and trifluorobenzene–benzene complexes as relevant to carbonic anhydrase II–drug interactions

Ab initio calculations at the MP2/6-31G* level have shown that variously substituted di- and trifluorobenzenes form non-covalent complexes with benzene that adopt either aromatic–aromatic or H---F binding, the choice being determined by the pattern of fluorination. The binding energies of these structures are from 3.4 to 4.5 kcal mol^–1. This range is large enough to account for observed variations in the binding affinity of a library of fluoroaromatic inhibitors of carbonic anhydrase. This enzyme has an aromatic amino acid at a central position in the active site. The diverse modes of binding of the dimers also suggest that aggregates of fluorobenzenes might adopt specified 3-dimensional shapes in the solid state. Figure Observed structure for 1,2-difluorobenzene     

Evaluation of the 2‐(1‐Hexyloxyethyl)‐2‐devinyl pyropheophorbide (HPPH) mediated photodynamic therapy by macroscopic singlet oxygen modeling [J. Biophotonics 9, No. 11–12, 1344–1354 (2016)]

In the article by R. Penjweini, M. M. Kim et al. (doi: 10.1002/jbio.201600121 ), published in J. Biophotonics 9, 1344–1354 (2016), the constants C₀₁, C₀₂, b₁, and b₂ determined from fitting the fluorescence single value decomposition (SVD) for phantoms with different optical properties and the corresponding Figure 2(a) are not correct. This erratum is published to correct the Section 2.3 and Figure 2(a).     

Erratum to Beicheng Sun et al. Cell Cycle Volume 7, Issue 7; pp. 934-939

In the paper, “The level of oncogene H-Ras correlates with tumorigenicity” by Beicheng Sun, Yun Gao, Lei Deng, Guoqiang Li, Feng Cheng and Xuehao Wang (Cell Cycle 2008; 7:934-9), the authors found that Figure 2D is incorrect. The original data found in the report is correct, and the correct figure is included here.     

Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection

Hearing loss and balance disturbances are often caused by death of mechanosensory hair cells, which are the receptor cells of the inner ear. Since there is no cell line that satisfactorily represents mammalian hair cells, research on hair cells relies on primary organ cultures. The best-characterized in vitro model system of mature mammalian hair cells utilizes organ cultures of utricles from adult mice (Figure 1) ^1-6. The utricle is a vestibular organ, and the hair cells of the utricle are similar in both structure and function to the hair cells in the auditory organ, the organ of Corti. The adult mouse utricle preparation represents a mature sensory epithelium for studies of the molecular signals that regulate the survival, homeostasis, and death of these cells.Mammalian cochlear hair cells are terminally differentiated and are not regenerated when they are lost. In non-mammalian vertebrates, auditory or vestibular hair cell death is followed by robust regeneration which restores hearing and balance functions ^{7, 8}. Hair cell regeneration is mediated by glia-like supporting cells, which contact the basolateral surfaces of hair cells in the sensory epithelium ^{9, 10}. Supporting cells are also important mediators of hair cell survival and death ¹¹. We have recently developed a technique for infection of supporting cells in cultured utricles using adenovirus. Using adenovirus type 5 (dE1/E3) to deliver a transgene containing GFP under the control of the CMV promoter, we find that adenovirus specifically and efficiently infects supporting cells. Supporting cell infection efficiency is approximately 25-50%, and hair cells are not infected (Figure 2). Importantly, we find that adenoviral infection of supporting cells does not result in toxicity to hair cells or supporting cells, as cell counts in Ad-GFP infected utricles are equivalent to those in non-infected utricles (Figure 3). Thus adenovirus-mediated gene expression in supporting cells of cultured utricles provides a powerful tool to study the roles of supporting cells as mediators of hair cell survival, death, and regeneration.     

α-Galactose based neoglycopeptides. Inhibition of verotoxin binding to globotriosylceramide

Solution and solid phase strategies for the synthesis of α-galactose based neoglycopeptide derivatives Figure 2, Figure 3, Figure 3, Scheme 3 and Scheme 4 were developed. Neoglycopeptides generated were tested for the inhibition of verotoxin binding to globotriosylceramide (Gb3) using ELISA. Among all of the compounds tested, only the lipid derivatives of neoglycopeptides, Figure 3 and Scheme 4 and Figure 3 and Scheme 4 were found to be inhibitors, IC₅₀=2.0 mM (Figure 3 and Scheme 4) and 0.2 mM (Figure 3 and Scheme 4). All of the inhibitors ( Figure 3 and Scheme 4) have a similar branching of the two α-galactosyl units at the N-terminal glycine residue of a short peptide and a lipid moiety attached at the C-terminal site. Both of these factors seem to be crucial for the inhibition. It is interesting to note that the inhibitors have only a portion of the natural trisaccharide ligand. The secondary groups either may contribute in sub-site oriented interactions with the protein receptors or may mimic the internal sugar units of the cell-surface ligand, Gb3.     

Single-drug multiligand conjugates: synthesis and preliminary cytotoxicity evaluation of a paclitaxel-dipeptide "scorpion" molecule

To improve the targeting properties of receptor-directed drug-peptide conjugates, a multiligand approach was proposed and a model "scorpion" conjugate (6, Figure 1), consisting of two peptide "claws" and a paclitaxel (PTX) "tail", was synthesized. The cell surface receptor-directed peptide used in this single-drug multiligand (SDML) model was a segment of the amphibian peptide bombesin (BBN) which had the Y6Q7W8A9V10G11H12L13M14-NH2 sequence, designated here as BBN[6-14] (2, Figure 2). Due to the lipophilic nature of both PTX and BBN[6-14], compound 6 had a low water solubility. To enhance the solubility, PEG derivatives of this conjugate were prepared with the polymer inserted either in the claws or in the tail regions. In a preliminary random screening, conjugate 6 showed superior cytotoxic activity in several GRPR-positive human cancer cell lines as compared to free PTX and two single-drug single-ligand (SDSL) conjugates. In a receptor blocking experiment, addition of excess unconjugated BBN[6-14] ligand reduced the cytotoxicity of conjugate 6, indicating the receptor-mediated mechanism of drug delivery. The PEG-derived conjugates showed activities which were intermediate between SDSL and the SDML congeners. Also, an increase in the number of the PEG segments lowered cytotoxicity, possibly due to steric hindrance against ligand-receptor binding. Taken together, these results demonstrate the potential of the multiligand approach in the design of receptor-targeting conjugates for tumor-specific drug delivery.     

Cellular organization of the brain renin-angiotensin system

A model of intracellular Ang II formation (Figure 1) implies that angiotensinogen neurons exist and that CNS Ang II acts both as a neurotransmitter as well as a neurohormone. Such a mechanism is consistent with the immunocytochemical localization of a fraction of brain Ang II in neurosecretory vesicles. To date, several dozen peptide neurotransmitters and neurohormones have been studied. Those assigned to peptidergic systems follow the generalized pathway of biosynthesis shown in Figure 1. In peptidergic systems, a prohormone and all of its processing enzymes are synthesized in the rough endoplasmic reticulum of a cell and move into the Golgi apparatus (Figure 1: #1-3). In the Golgi the prohormone and processing enzymes are packaged into the same vesicle (#3). These secretory vesicles then migrate toward the plasma membrane, frequently via axonal or dendritic projections to terminals. Within these cytoplasmic vesicles and prior to release, the processing enzymes are activated (#4) and the prohormone enzymatically processed, yielding the active peptide (#5-6). Only then do the vesicles fuse with the plasma membrane (in a calcium-dependent process), releasing their contents (#7-8). Once released, the active peptide migrates across the extracellular space and interacts with specific cell surface receptors to initiate a response (#9). Finally, receptor-bound peptide degradation is initiated by receptor-mediated endocytosis (#10-11). For angiotensin peptides to be produced intracellularly, the cell must present only one secretory pathway for Golgi packaging of renin and angiotensinogen; otherwise current theories of protein sorting would predict that these two proteins would be segregated even if synthesized within the same cell. Small quantities of co-packaged renin and angiotensinogen occurring via "spill-over" between compartments seems an unsatisfactory process for a regulated hormone system. Figure 2, depicting an extracellular mechanism for producing Ang II in the brain, has also been proposed. The mechanism of extracellular angiotensin formation is consistent with the molecular information encoded within the component proteins, known mechanisms of protein secretio, well-defined systemic renin-angiotensin enzymatic cascades, and demonstration of all the components of the renin-angiotensin system in the extracellular compartments of the brain. This model (Figure 2) allows independently coordinated gene expression and synthesis of renin (#1R), angiotensinogen (#1A), and angiotensin-converting enzyme (# 1C) in the same or different cells.(ABSTRACT TRUNCATED AT 400 WORDS)     

Letting Go is Never Easy： Abscission and Receptor- Like Protein Kinases

Abscission is the process by which plants discard organs in response to environmental cues/stressors, or as part of their normal development. Abscission has been studied throughout the history of the plant sciences and in numerous species. Although long studied at the anatomical and physiological levels, abscission has only been elucidated at the molecular and genetic levels within the last two decades, primarily with the use of the model plant Arabidopsis thaliana. This has led to the discovery of numerous genes involved at all steps of abscission, including key pathways involving receptor-like protein kinases （RLKs）. This review covers the current knowledge of abscission research, highlighting the role of RLKs.     

Deconstructing PML‐induced premature senescence

The authors contacted the journal after being alerted to errors in Fig 6C. The authors provided the source data, which show that the panel had been assembled and presented incorrectly. Fig 6C is herewith corrected. The authors note that the corrected panel shows similar results, although less pronounced for the induction of p53 acetylation by PMLIV, consistent with what had been reported previously in PML+/+ MEFs (Fig 3C in Pearson et al, 2000). PMLIV‐induced increase in p53 acetylation is also shown in human fibroblasts (Fig 5B). The authors state that this correction does not affect the message of Fig 6, nor does it impact the overall conclusions of the article.The authors apologize for this oversight and any confusion it may have caused. The source data are available with this notice together with the corrected figure. Figure 6C. Original. Figure 6C. Corrected.. Source data are available online for this figure      

Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem 69:377–391.

Srebrow A, Friedmann Y, Ravanpay A, Daniel CW, Bissell MJ (1998): Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells. J Cell Biochem 69:377–391. In Figure 3 on pages 384 and Figure 4 on page 385, two labels were misprinted. The top label on the right side of Figure 3B should have been Hoxb-7 instead of Hoxb-1, and the center label of Figure 4B should have been Hoxb-7 instead of Hoxa-7. The corrected figures are reprinted on the following pages. The Publisher apologizes for the error.