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A methodology for obtaining maximum likelihood estimates of life table regression coefficients from complex survey data is presented. Certain of the issues of writing a likelihood for survey data are presented and discussed. The proposed methodology includes consideration of the sampling design in any inference by using design based variance estimates for the parameters. An example is given using data from the 1973 United States National Survey of Family Growth.  相似文献   

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The fit of the logit and probit models for quantal response data can be improved by embedding these classical models within a richer parametric family indexed by one or two shape parameters. In this paper, a symmetric extended logistic model indexed by a shape parameter λ is discussed with application to dose response curves. The usual maximum likelihood method is employed to estimate the parameters of the model. The need to include the shape parameter λ is illustrated by analyzing a set of real experimental data and comparing the fit of the extended logistic model to those obtained by the standard logit and probit models.  相似文献   

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可交换条件下多维结构回归模型总体平均处理效应的估计   总被引:2,自引:5,他引:2  
在可交换条件下,当响应变量为多维时,利用结构回归模型研究总体平均处理效应的估计。  相似文献   

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The consequences of the misspecification of a regression model are considered. For small effects of covariates a proportional consistency theorem is derived. The consistent estimation of the covariance matrix of the estimates is discussed.  相似文献   

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This paper deals with the analysis of ordinal data by means of a threshold model. Maximum likelihood estimation is discussed and two examples are used to illustrate the methods.  相似文献   

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生长曲线参数估计的一种新方法-优化回归组合法   总被引:3,自引:0,他引:3  
在现有文献研究的基础上,对生长曲线参数估计问题又作了进一步研究,给出了生长曲线参数估计的一种新方法优化回归组合法,该方法创造性地将最优化方法与回归方法结合在一起,利用最优化理论中的区间搜索和一维搜索,可以得到一系列c^*值,利用回归方法可求得与其相对应的一系列a和b的值.当c取最优值c时,a和b便得到最优值a^*和b^*经示例计算表明,这种参数估计法具有较高的精度,  相似文献   

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This paper presents an extended threshold model for analyzing ordered categorical data. The model admits interactions between the position of the thresholds and the levels of the effective factors. These interactions are described according to the approach of Milliken and Graybill (1970). Especially important for practical application is the special assumption that there is a linear relation between interactions and thresholds, and that the slopes of the concerning regression lines may be different for samples. This means that the latent variables are distributed according to the same type of distributions, but may have different expectations and variances. Underlying this submodel, the estimation of parameters and the testing of hypotheses according to the maximum likelihood method is described. The procedure is illustrated by a numerical example, and an outline is given about a cluster analysis using model parameters.  相似文献   

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Quantitative research especially in the social, but also in the biological sciences has been limited by the availability and applicability of analytic techniques that elaborate interactions among behaviours, treatment effects, and mediating variables. This gap has been filled by a newly developed statistical technique, known as graphical interaction modelling. The merit of graphical models for analyzing highly structured data is explored in this paper by an empirical study on coping with a chronic condition as a function of interrelationships between three sets of factors. These include background factors, illness context factors, and four self‐care practices. Based on a graphical chain model, the direct and indirect dependencies are revealed and discussed in comparison to the results obtained from a simple logistic regression model ignoring possible interaction effects. Both techniques are introduced from a more tutorial point of view instead of going far into technical details.  相似文献   

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We consider longitudinal studies in which the outcome observed over time is binary and the covariates of interest are categorical. With no missing responses or covariates, one specifies a multinomial model for the responses given the covariates and uses maximum likelihood to estimate the parameters. Unfortunately, incomplete data in the responses and covariates are a common occurrence in longitudinal studies. Here we assume the missing data are missing at random (Rubin, 1976, Biometrika 63, 581-592). Since all of the missing data (responses and covariates) are categorical, a useful technique for obtaining maximum likelihood parameter estimates is the EM algorithm by the method of weights proposed in Ibrahim (1990, Journal of the American Statistical Association 85, 765-769). In using the EM algorithm with missing responses and covariates, one specifies the joint distribution of the responses and covariates. Here we consider the parameters of the covariate distribution as a nuisance. In data sets where the percentage of missing data is high, the estimates of the nuisance parameters can lead to highly unstable estimates of the parameters of interest. We propose a conditional model for the covariate distribution that has several modeling advantages for the EM algorithm and provides a reduction in the number of nuisance parameters, thus providing more stable estimates in finite samples.  相似文献   

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For analyzing longitudinal binary data with nonignorable and nonmonotone missing responses, a full likelihood method is complicated algebraically, and often requires intensive computation, especially when there are many follow-up times. As an alternative, a pseudolikelihood approach has been proposed in the literature under minimal parametric assumptions. This formulation only requires specification of the marginal distributions of the responses and missing data mechanism, and uses an independence working assumption. However, this estimator can be inefficient for estimating both time-varying and time-stationary effects under moderate to strong within-subject associations among repeated responses. In this article, we propose an alternative estimator, based on a bivariate pseudolikelihood, and demonstrate in simulations that the proposed method can be much more efficient than the previous pseudolikelihood obtained under the assumption of independence. We illustrate the method using longitudinal data on CD4 counts from two clinical trials of HIV-infected patients.  相似文献   

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  总被引:1,自引:0,他引:1  
The purpose of this study was to evaluate the evolution of HIV infected patients and to bring out some significant factors associated with this pathology. The main criteria revealing the State of illness is viral load measurement (VL). However the CD4 lymphocytes also represent an important marker as these reflect the State of the immune reservoir. Many studies have been carried out in this field and different models have been proposed with a view to a better understanding of this disease. Multi State Markov models defined in terms of CD4 counts, or in terms of viral load, have proved to be very useful tools for modelling HIV disease progression. The model we have developed in this study is based on both the CD4 lymphocytes counts and VL. Markov models are characterized by transition intensities. In this paper we explored several structures in succession. First, we used a homogeneous continuous time Markov process with four states defined by crossed values of CD4 and VL in a given patient at a given time. Then, the effect of certain covariates on the infection process was introduced into the model via the transition intensity functions, as with a Cox regression model. Since the hypothesis of homogeneity may be unrealistic in certain cases, we also considered piecewise homogeneous Markov models. Finally, the effects of covariates and time were combined in a piecewise homogeneous model with a covariate. We applied these methods to data from 1313 HIV-infected patients included in the NADIS cohort.  相似文献   

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This paper describes mathematical and computational methodology for estimating the parameters of the Burr Type XII distribution by the method of maximum likelihood. Expressions for the asymptotic variances and covariances of the parameter estimates are given, and the modality of the log-likelihood and conditional log-likelihood functions is analyzed. As a result of this analysis for various a priori known and unknown parameter combinations, conditions are given which guarantee that the parameter estimates obtained will, indeed, be maximum likelihood estimates. An efficient numerical method for maximizing the conditional log-likelihood function is described, and mathematical expressions are given for the various numerical approximations needed to evaluate the expressions given for the asymptotic variances and covariances of the parameter estimates. The methodology discussed is applied in a numerical example to life test data arising in a clinical setting.  相似文献   

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AZZALINI  A. 《Biometrika》1994,81(4):767-775
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The Poisson regression model for the analysis of life table and follow-up data with covariates is presented. An example is presented to show how this technique can be used to construct a parsimonious model which describes a set of survival data. All parameters in the model, the hazard and survival functions are estimated by maximum likelihood.  相似文献   

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On occasion, generalized linear models for counts based on Poisson or overdispersed count distributions may encounter lack of fit due to disproportionately large frequencies of zeros. Three alternative types of regression models that utilize all the information and explicitly account for excess zeros are examined and given general formulations. A simple mechanism for added zeros is assumed that directly motivates one type of model, here called the added-zero type, particular forms of which have been proposed independently by D. LAMBERT (1992) and in unpublished work by the author. An original regression formulation (the zero-altered model) is presented as a reduced form of the two-part model for count data, which is also discussed. It is suggested that two-part models be used to aid in development of an added-zero model when the latter is thought to be appropriate.  相似文献   

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