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1.
Čedomila Milin Robert Domitrović Marin Tota Jasminka Giacometti Mira Ćuk Biserka Radošević-Stašić Zlatko Ciganj 《Biological trace element research》2001,82(1-3):201-210
The mineral content (zinc, iron, magnesium, and calcium) in the liver, spleen, and thymus of male Balb/C mice was analyzed.
Animals were fed, over 21 d, diets enriched with corn oil (FCO diet) or olive oil (FOO diet) (5% addition to standard pellet,
w/w). Olive oil with predominant oleic acid (C18:1, n-9) had a quite different composition than corn oil, in which linoleic
acid (C18:2, n-6) prevails. The zinc and magnesium tissue concentrations were not changed in either group. The calcium concentration
in liver as well as the calcium concentration in spleen increased in mice fed both the FCO and FOO diets. Furthermore, mice
fed both the FOO and FCO diets had increased spleen iron concentration. Mice fed the FCO diet had increased thymus calcium
concentration compared to controls. The results show the effect of diets with unsaturated, particularly polyunsaturated fatty
acids, on the calcium and iron concentration in some organs. 相似文献
2.
T. Atinmo I. O. Adeyefa E. A. Fadero J. F. Olorunleke 《Biological trace element research》1985,8(2):93-104
Mineral balance was studied by metabolic balance techniques in 13 healthy college females aged 21–23 yr. They were fed diet containing 1780 kcal, 2580 kcal, and 25 g protein in a 20-d experiment period. Both diets contained approximately 5.28 mg zinc, 216.85 mg calcium, and 364.3 mg magnesium. The diet consisted of habitually consumed foods. Blood, urine and fecal samples were collected for mineral analysis using atomic absorption spectrophotometry. Plasma mineral levels were not affected by the change in dietary energy intake. Fecal calcium and magnesium were significantly higher when subjects were fed the low calorie (1780 kcal) diet, whereas there was no significant difference in fecal zinc for the two levels of dietary energy. Urinary calcium and magnesium were also significantly higher when the diet provided 1780 kcal though, on the other hand, urinary zinc was significantly higher when the diet provided 2680 kcal (P<0.05). Urinary calcium and magnesium correlated negatively, whereas urinary zinc correlated positively, with the dietary energy intake (P o<0.05). Dietary energy intake has a significant effect on the mineral balance of the subjects. 相似文献
3.
We investigated the effect of magnesium supplementation on zinc distribution in rats given excess calcium as carbonate. Rats
were given a control diet (5 g/kg calcium and 0.5 g/kg magnesium), a high calcium diet (HC, 25 g/kg calcium and 0.5 g/kg magnesium)
or the high calcium diet supplied with magnesium (HCM, 25 g/kg calcium and 2.5 g/kg magnesium) for 4 weeks. Calcium carbonate
and magnesium oxide were used for increasing these mineral concentrations in diets. Although feed intake did not differ among
the groups, the excess calcium suppressed feed efficiency, irrespective of dietary magnesium concentration. Femoral magnesium
concentration was lower in the HC group than in the control and the HCM groups. Femoral zinc concentration was higher in the
HC group and the HCM group than in the control group. The zinc concentration in the kidney was lower in the HC group and the
HCM group than in the control group. The excess calcium did not affect zinc concentration in plasma and other tissues such
as the liver, testis, and spleen, irrespective of dietary magnesium. These results suggest that the increasing bone zinc and
the decreasing renal zinc do not result from magnesium insufficiency in rats given excess calcium as carbonate. 相似文献
4.
Calcium, magnesium, and zinc balances were determined in eleven young adult college females (mean age, 24.9±2.35) during a 39-d metabolic study when the subjects were fed an adequate calorie and protein diet based on habitually consumed foods. Analysis showed that the dietary contribution of calcium, magnesium, and zinc to the RDA were 53.6, 26.4, and 57.9%, respectively. Mean fecal losses of calcium and magnesium were low, while fecal zinc losses were higher than the daily intake. Mean urinary excretion of calcium was within the normal range, but was low for magnesium whereas urinary zinc was higher than normal. Mean daily apparent retentions of calcium and magnesium were positive, whereas positive apparent retention for zinc were observed in four of the subjects. Plasma calcium and magnesium remained normal, but mean plasma zinc declined at the end of the study. Significant correlations were observed between the fecal losses of calcium and magnesium and calcium and zinc. Urinary calcium also correlated significantly (P<0.05) with urinary magnesium, but not with zinc. It appears that adequate protein and calorie intake in the presence of low dietary intake of calcium, magnesium, and zinc has no significant effect on calcium and magnesium status whereas a lowering effect on plasma zinc and apparent zinc retention was observed in the subjects studied. 相似文献
5.
Katsuhiko Yokoi Mieko Kimura Yoshinori Itokawa 《Biological trace element research》1991,29(3):257-265
To clarify the influence of iron deficiency on mineral status, the following two synthetic diets were fed to male Wistar rats: a control diet containing 128 micrograms iron/g, and an iron-deficient diet containing 5.9 micrograms iron/g. The rats fed the iron-deficient diet showed pale red conjunctiva and less reactiveness than the rats fed the control diet. The hemoglobin concentration and hematocrit of the rats fed the iron-deficient diet were markedly less than the rats fed the control diet. The changes of mineral concentrations observed in tissues of the rats fed the iron-deficient diet, as compared with the rats fed the control diet, are summarized as follows: . Iron concentrations in blood, brain, lung, heart, liver, spleen, kidney, testis, femoral muscle, and tibia decreased; . Calcium concentrations in blood and liver increased; calcium concentration in lung decreased; . Magnesium concentration in blood increased; . Copper concentrations in blood, liver, spleen and tibia increased; copper concentration in femoral muscle decreased; . Zinc concentration in blood decreased; . Manganese concentrations in brain, heart, kidney, testis, femoral muscle and tibia increased. These results suggest that iron deficiency affects mineral status (iron, calcium, magnesium, copper, zinc, and manganese) in rats. 相似文献
6.
Ahmed S. Rahman Mieko Kimura Katsuhiko Yokoi Tanvir-E Naher Yoshinori Itokawa 《Biological trace element research》1996,53(1-3):57-64
Three groups of rats were fed two types of synthetic diets for 52 d. The—A group was allowed free access to a vitamin A-deficient
diet and showed classical signs of vitamin A deficiency. The brain was the only organ in our experiment where no significant
weight difference was present among the three groups. In the brain, calcium concentration was significantly higher in the—A
group when compared with the PF (Pair-fed; allowed restricted amount of control diet) and +A groups (allowed free access to
control diet). In the tibia, calcium and magnesium concentrations were significantly lower in the—A group when compared with
other two groups. Excessive accumulation of calcium in brain and apparently similar unbalance in bone, mineral concentration
were observed in central nervous system (CNS) degenerative diseases. Our results suggest that abnormal metabolism of calcium
and magnesium in some tissues and excessive accumulation of calcium in brain may be responsible for the development of neurological
disorders in vitamin A-deficient rats. 相似文献
7.
The effect of dietary calcium on the metabolism of iron, zinc, copper, and manganese in male and female rats was investigated. For 3 or 6 weeks the rats were fed three diets containing: (1) 0.26, (2) 0.52, or (3) 2.08% Ca. The apparent absorption of iron was depressed by the high calcium diet, and manganese absorption was highest in the low calcium groups. Generally there was a decrease in the absorption of minerals from 3 to 6 weeks. With an increase in the dietary calcium the absorption of Ca and P decreased. The liver iron concentration in the females fed diet 3 decreased from about 600 to 200 microg/g dry weight. The high calcium intake also caused a slight increase in the heart calcium levels in both sexes. However, diet 3 prevented kidney calcification in the female rats at 6 weeks and this was attributed to a dramatic decrease in the urinary phosphorus, although the calcium had increased about 40 times. In males, on the other hand, the high calcium diet caused some kidney calcification. 相似文献
8.
Forrest H. Nielsen 《Biological trace element research》2009,128(3):220-231
An experiment with rats was conducted to determine whether magnesium retention is increased and calcium utilization is altered
by a marginal zinc deficiency and whether increased oxidative stress induced by a marginal copper deficiency exacerbated responses
to a marginal zinc deficiency. Weanling rats were assigned to six groups of ten with dietary treatment variables of low zinc
(5 mg/kg for 2 weeks and 8 mg/kg for 7 weeks), low copper (1.5 mg/kg), adequate zinc (15 mg/kg), and adequate copper (6 mg/kg).
Two groups of rats were fed the adequate-zinc diet with low or adequate copper and pair-fed with corresponding rats fed the
low-zinc diet. When compared to the pair-fed rats, marginal zinc deficiency significantly decreased the urinary excretion
of magnesium and calcium, increased the concentrations of magnesium and calcium in the tibia, increased the concentration
of magnesium in the kidney, and increased the urinary excretion of helical peptide (bone breakdown product). Marginal copper
deficiency decreased extracellular superoxide dismutase and glutathione, which suggests increased oxidative stress. None of
the variables responding to the marginal zinc deficiency were significantly altered by the marginal copper deficiency. The
findings in the present experiment suggest that increased magnesium retention and impaired calcium utilization are indicators
of marginal zinc deficiency.
Mention of a trademark or proprietary product does not constitute a guarantee or warranty by the U.S. Department of Agriculture
and does not imply its approval to the exclusion of other products that also might be suitable. The U.S. Department of Agriculture,
Agricultural Research Service, Northern Plains Area is an equal opportunity/affirmative action employer, and all agency services
are available without discrimination. 相似文献
9.
Katsuhiko Yokoi Mieko Kimura Yoshinori Itokawa 《Biological trace element research》1990,24(2-3):223-231
To clarify the influence of dietary tin deficiency on growth and mineral status, the following two different synthetic diets were fed to male Wistar rats: group 1—a diet containing 1.99 μg tin/g; group 2—a diet containing 17 ng tin/g. The rats in group 2 showed poor growth, lowered response to sound, and alopecia, with decreased food efficiency compared with rats in group 1. The changes of mineral concentrations in tissues observed in group 2, compared with group 1, are summarized as follows: calcium concentration in lung increased; magnesium concentration in lung decreased; iron concentrations in spleen and kidney increased; iron concentration in femoral muscle decreased; zinc concentration in heart decreased; copper concentrations in heart and tibia decreased; manganese concentrations in femoral muscle and tibia decreased. These results suggest that tin may be essential for rat growth. 相似文献
10.
Katsuhiko Yokoi Mieko Kimura Yoshinori Itokawa 《Biological trace element research》1996,51(2):199-208
The effects of low dietary rubidium on plasma biochemical parameters and mineral levels in tissues in rats were studied. Eighteen male Wistar rats, weighing about 40 g, were divided into two groups and fed the diets with or without supplemental rubidium (0.54 vs 8.12 mg/kg diet) for 11 wk. Compared to the rats fed the diet with supplemental rubidium, the animals fed the diet without rubidium supplementation had higher urea nitrogen in plasma; lower rubidium concentration in tissues; lower sodium in muscle; higher potassium in plasma, kidney and tibia, and lower potassium in testis; lower phosphorus in heart and spleen; lower calcium in spleen; higher magnesium in muscle and tibia; higher iron in muscle; lower zinc in plasma and testis; and lower copper in heart, liver, and spleen, and higher copper in kidney. These results suggest that rubidium concentration in tissues reflects rubidium intake, and that rubidium depletion affects mineral (sodium, potassium, phosphorus, calcium, magnesium, iron, zinc, and copper) status. 相似文献
11.
To clarify the influence of dietary tin deficiency on growth and mineral status, the following two different synthetic diets were fed to male Wistar rats: group 1--a diet containing 1.99 micrograms tin/g; group 2--a diet containing 17 ng tin/g. The rats in group 2 showed poor growth, lowered response to sound, and alopecia, with decreased food efficiency compared with rats in group 1. The changes of mineral concentrations in tissues observed in group 2, compared with group 1, are summarized as follows: calcium concentration in lung increased; magnesium concentration in lung decreased; iron concentrations in spleen and kidney increased; iron concentration in femoral muscle decreased; zinc concentration in heart decreased; copper concentrations in heart and tibia decreased; manganese concentrations in femoral muscle and tibia decreased. These results suggest that tin may be essential for rat growth. 相似文献
12.
Takahisa Takeda Mieko Kimura Katsuhiko Yokoi Yoshinori Itokawa 《Biological trace element research》1996,54(1):55-74
Mineral (phosphorus, sulfur, potassium, calcium, magnesium, iron, zinc, copper, and manganese) concentrations were measured in plasma, and several tissues from female Wistar rats (young: 3-wk-old; mature: 6-mo-old) were fed on a dietary regimen designed to study the combined or singular effects of age and dietary protein on mineral status. Three diets, respectively, contained 5, 15, and 20% of bovine milk casein. Nephrocalcinosis chemically diagnosed by increased calcium and phosphorus in kidney was prevented in rats fed a 5% protein diet. Renal calcium and phosphorus were more accumulated in young rats than mature rats. A 5% protein diet decreased hemoglobin and blood iron. The hepatic and splenic iron was increased by a 5% protein diet in mature rats but was not altered in young rats. Mature rats had higher iron in brain, lung, heart, liver, spleen, kidney, muscle, and tibia than young rats. A 5% protein diet decreased zinc in plasma and liver. Zinc in tibia was increased with dietary protein level in young rats but was not changed in mature rats. A 5% protein diet decreased copper concentration in plasma of young rats but not in mature rats. Mature rats had higher copper in plasma, blood, brain, lung, heart, liver, spleen, and kidney than young rats. With age, manganese concentration was increased in brain but decreased in lung, heart, liver, kidney, and muscle. These results suggest that the response to dietary protein regarding mineral status varies with age. 相似文献
13.
《Archives of animal nutrition》2013,67(4):320-328
This study was performed to compare the bioavailability of two organic zinc compounds, a zinc glycinate complex and a zinc amino acid chelate with that of zinc sulphate in growing pigs fed a basal diet composed mainly of wheat, barley and soybean meal. The experiment included 96 pigs with an average body weight of 8 kg, allotted to ten groups of nine to ten pigs each. The first group received the basal diet, containing 42 mg of native zinc per kg, without zinc supplementation over a period of five weeks. The other nine groups received the basal diet supplemented with 15, 30 or 50 mg of zinc/kg as zinc sulphate, zinc glycinate or the zinc amino acid chelate. Pigs fed the unsupplemented diet had a lower growth performance (body weight gain, feed conversion ratio) than the other nine groups. Supplementation of 15 mg zinc/kg diet (irrespective of zinc form) was sufficient to yield optimum growth performance. Plasma zinc concentration and activity of alkaline phosphatase were rising with increasing zinc supplementation levels up toa maximum reached at a supplementary level of 30 or 50 mg/kg diet for activity of alkaline phosphatase and plasma zinc concentration, respectively. The response of those parameters to zinc supplementation did, however, not differ between thethree zinc compounds considered. The apparent digestibility of zinc from the diet was also not different for the three zinc compounds. In conclusion, these findings show that the bioavailability of the two organic zinc compounds did not differ from that of zinc sulphate in growing pigs fed a diet with wheat, barley and soybean meal as major components. 相似文献
14.
This study was performed to compare the bioavailability of two organic zinc compounds, a zinc glycinate complex and a zinc amino acid chelate with that of zinc sulphate in growing pigs fed a basal diet composed mainly of wheat, barley and soybean meal. The experiment included 96 pigs with an average body weight of 8 kg, allotted to ten groups of nine to ten pigs each. The first group received the basal diet, containing 42 mg of native zinc per kg, without zinc supplementation over a period of five weeks. The other nine groups received the basal diet supplemented with 15, 30 or 50 mg of zinc/kg as zinc sulphate, zinc glycinate or the zinc amino acid chelate. Pigs fed the unsupplemented diet had a lower growth performance (body weight gain, feed conversion ratio) than the other nine groups. Supplementation of 15 mg zinc/kg diet (irrespective of zinc form) was sufficient to yield optimum growth performance. Plasma zinc concentration and activity of alkaline phosphatase were rising with increasing zinc supplementation levels up to a maximum reached at a supplementary level of 30 or 50 mg/kg diet for activity of alkaline phosphatase and plasma zinc concentration, respectively. The response of those parameters to zinc supplementation did, however, not differ between the three zinc compounds considered. The apparent digestibility of zinc from the diet was also not different for the three zinc compounds. In conclusion, these findings show that the bioavailability of the two organic zinc compounds did not differ from that of zinc sulphate in growing pigs fed a diet with wheat, barley and soybean meal as major components. 相似文献
15.
Psyllium husk, a highly viscous fiber, has beneficial effects for health, but has been reported to inhibit absorption of calcium. The present study found the effects of fiber viscosity on calcium, magnesium, and zinc absorption with partially degraded psyllium preparations to be one fifth viscosity (LD-HP) and one seventieth viscosity (HD-HP) using normal and ovariectomized rats. Magnesium absorption was reduced with ingestion of intact psyllium (50 g/kg diet) for 4 weeks but this reduced absorption was increased with lower viscous psyllium preparations. Moreover, the absorption in the HD-HP group was higher than in the control group (100 g cellulose/kg diet) in ovariectomized rats. Changes in calcium and zinc absorption were similar to those in magnesium absorption. Cecal pH was reduced only in rats fed HD-HP in both normal and ovariectomized rats. These results indicate that reduction of psyllium viscosity tends to counter inhibitory effects on mineral absorption. 相似文献
16.
Joanna Suliburska Paweł Bogdański Monika Szulińska 《Biological trace element research》2013,151(2):263-268
The aim of this study was to assess the metabolic and physiological changes in rats fed a diet high in fat, fructose, and salt, and with excess iron level. Mineral status was also estimated. Wistar rats were assigned to groups fed either a standard control diet (C) or a diet high in fat, fructose, and salt. The noncontrol diets contained either normal (M) or high level (MFe) of iron. After 6 weeks, the length and weight of the rats were measured, and the animals were euthanized. The kidneys and gonads were collected, and blood samples were taken. Serum levels of insulin, nitric oxide, and iron were measured. The iron, zinc, copper, and calcium concentrations of tissues were determined. It was found that the M diet led to a significant increase in the relative kidney mass of the rats compared with the control group. Among the rats fed the M diet, markedly higher serum level of iron and lower levels of zinc and copper were observed in tissues, while significantly higher calcium levels were found in the gonads. The MFe diet resulted in decreased obesity index, insulin level, and nitric oxide serum concentration in the rats, when compared with both the M and C diets. The high iron level in the modified diet increased the relative mass of the gonads. The excess iron level in the diet disturbed the zinc, copper, and calcium status of tissues. The decrease in insulin and nitric oxide in rats fed the diet high in iron, fat, fructose, and salt was associated with disorders of zinc, copper, and calcium status, as well as with an increase in the relative mass of the gonads. 相似文献
17.
The relationship between 6-mercaptopurine-induced alterations in mineral metabolism and the teratogenic effects of the drug were investigated. Pregnant Sprague-Dawley rats were fed diets containing 4.5, 100, or 1,000 micrograms Zn per 1 g diet. On day 11 of gestation, dams were given intraperitoneal injections of 6-mercaptopurine (27.5 mg/kg). At term, dams fed the 1,000-micrograms Zn per 1 g diet showed fewer drug-induced deleterious effects on reproduction and embryogenesis than did those fed lower levels of zinc. Mineral analysis of maternal and fetal tissues revealed pronounced effects of 6-mercaptopurine on metabolism of zinc, copper, iron, calcium, and magnesium. The results of this study indicate that 6-mercaptopurine teratogenesis may be due in part to drug-induced changes in mineral metabolism. 相似文献
18.
Both arginine and silicon affect collagen formation and bone mineralization. Thus, an experiment was designed to determine
if dietary arginine would alter the effect of dietary silicon on bone mineralization and vice versa. Male weanling Sprague-Dawley
rats were assigned to groups of 12 in a 2×2 factorially arranged experiment. Supplemented to a ground corn/casein basal diet
containing 2.3 μg Si/g and adequate arginine were silicon as sodium metasilicate at 0 or 35 μg/g diet and arginine at 0 or
5 mg/g diet. The rats were fed ad libitum deionized water and their respective diets for 8 wk. Body weight, liver weight/body
weight ratio, and plasma silicon were decreased, and plasma alkaline phosphatase activity was increased by silicon deprivation.
Silicon deprivation also decreased femoral calcium, copper, potassium, and zinc concentrations, but increased the femoral
manganese concentration. Arginine supplementation decreased femoral molybdenum concentration but increased the femoral manganese
concentration. Vertebral concentrations of phosphorus, sodium, potassium, copper, manganese, and zinc were decreased by silicon
deprivation. Arginine supplementation increased vertebral concentrations of sodium, potassium, manganese, zinc, and iron.
The arginine effects were more marked in the silicon-deprived animals, especially in the vertebra. Germanium concentrations
of the femur and vertebra were affected by an interaction between silicon and arginine; the concentrations were decreased
by silicon deprivation in those animals not fed supplemental arginine. The change in germanium is consistent with a previous
finding by us suggesting that this element may be physiologically important, especially as related to bone DNA concentrations.
The femoral and vertebral mineral findings support the contention that silicon has a physiological role in bone formation
and that arginine intake can affect that role.
The U.S. Department of Agriculture, Agricultural Research Service, Northern Plains Area is an equal opportunity/affirmative
action employer, and all agency services are available without discrimination.
Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the U.S. Department
of Agriculture and does not imply its approval to the exclusion of other products that may be suitable. 相似文献
19.
Massive, toxic doses of vitamin D have been shown to cause nephrocalcinosis in rats, but the effect of this vitamin within its range of fluctuation in commercial rat diets was unknown. Therefore, in two experiments with young female rats, the effect on nephrocalcinosis of a moderately increased level of vitamin D in the diet was studied, that is 5000 IU/kg versus the recommended concentration of 1000 IU/kg. This was done using purified diets with 0.5% (w/w) calcium and 0.04% magnesium containing either 0.2 or 0.6% phosphorus (P). Rats fed the diets containing 0.6% P showed severe kidney calcification compared to those fed the 0.2%-P diets. The level of vitamin D in the 0.2 and 0.6%-P diets did not affect kidney calcification. Bone density was increased after feeding diets containing 5000 instead of 1000 IU of vitamin D/kg. This study suggests that, within 28 days, a moderate increase of the amount of vitamin D in the diet has no influence on the development of kidney calcification. This in turn suggests that the variation in nephrocalcinosis severity and incidence seen in practice in rats fed different commercial diets is unlikely to be related to the different vitamin D concentrations in these diets. However, in rats fed such diets bone metabolism may be influenced differently. 相似文献
20.
On the basis of the evidence of the enhanced susceptibility to kainate-induced seizures in young rats fed a zinc-deficient
diet for 4 weeks, the relationship between zinc release from hippocampal neuron terminals and seizure susceptibility was studied
in young rats fed the zinc-deficient diet for 2 weeks. Timm’s stain, with which histochemically reactive zinc in the presynaptic
vesicle is detected, was not attenuated in mossy fibers and other areas in the hippocampus after 2-week zinc deprivation,
whereas the attenuation was observed after 4-week zinc deprivation. Extracellular zinc concentration was not also decreased
after 2-week zinc deprivation, unlike the case after 4-week zinc deprivation. To check the capacity for zinc release from
neuron terminals after 2-week zinc deprivation, the hippocampus was excessively stimulated with 100 mM KCl. The increase in
extracellular zinc concentration of zinc-deficient group was significantly more than that of control group. These results
suggest that zinc release from hippocampal neuron terminals is not affected by 2-week zinc deprivation. On the other hand,
the latency in myoclonic jerks of zinc-deficient group was significantly shorter than in the control group after treatment
with kainate, while the latency in clonic convulsions was not different between the two groups. Intracellular fura-2 signal,
a calcium indicator, was significantly higher in the hippocampal CA3 areas of zinc-deficient group 4 s after delivery of kainate
to dentate granule cells. These results suggest that susceptibility to kainate-induced seizures is altered prior to the decrease
in extracellular zinc concentration and zinc release from neuron terminals in zinc-deficient young rats. The alteration of
calcium signaling seems to be involved in the susceptibility in zinc deficiency. 相似文献