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1.
Yuanyuan Liu Min Ke Ming Yan Shuren Guo Mane Emily Mothobi Qiang Chen Fang Zheng 《Molecular biology reports》2011,38(2):1301-1307
GJA8 plays an important role in lens growth and transparency. Therefore, we hypothesized that two single nucleotide polymorphisms
(SNPs) in GJA8 might be associated with age-related cataract. We investigated the SNPs rs1495960 and rs9437983 using polymerase chain reaction-restriction
fragment length polymorphism (PCR-RFLP) and DNA sequencing, in 96 age-related cataract patients, and 208 gender- and age-matched
healthy controls. No significant differences between cases and controls were seen in genotype or allele distributions of rs1495960
(P > 0.05). The allele distribution of rs9437983 was different between cases and controls, but no difference was detected in
its genotype distribution. Cataract patients had a significantly lower G–G haplotype frequency (4.9% vs. 15.5%, P = 0.0001), and a significantly higher G–A haplotype frequency (45.6% vs. 36.4%, P = 0.030) than controls. Limiting to nuclear cataract cases significantly increased the differences between cases and controls
for G–G and G–A haplotypes. These results support that the GJA8 gene may be a novel susceptibility gene for age-related cataracts. 相似文献
2.
Recently, a study reported that magnesium played a part in the attack of chronic diseases, such as arteriosclerosis, diabetes,
metabolic syndrome, and hypertension. However, there are not even enough studies to evaluate magnesium intakes. Therefore,
in this study, we evaluated the magnesium intakes of 500 healthy adults. In addition, by selecting 50 targets, we examined
the correlation between magnesium intake and antioxidant capacity biomarkers. In the age group of 19–29, the daily magnesium
intake was 276.3 mg for males and 232.1 mg for females. In the age group of 30–49, it was 305.1 mg and 246.5 mg, respectively.
In the age group of 50–64, the magnesium intake was 294.4 mg for males and 245.7 mg for females. As for the age group of 19–29,
the magnesium intake per 4,187 kJ of energy intake was 129.8 mg, which was significantly lower than the 164.6 mg by the age
group of 30–49 and 172.4 mg by the age group of 50–64. The ratio of magnesium intake to the recommended intake was 82.1% for
those in the age group of 19–29, 87.7% for those in 30–49, and 86.1% for those in 50–64. The rate of the subjects with magnesium
intakes lower than the estimated average requirement was 55.3% in the age group of 19–29, 52.4% in 30–49, and 54.2% in 50–64.
The magnesium intake from food groups were in the descending order of vegetables, cereals, and fish for the subjects in the
age group of 19–29, and vegetables, cereals, and beverages for the subjects in the age groups of 30–49 and 50–64. The source
food items of magnesium intake were in the descending order of Kimchi, tofu, rice, and coffee in the age group of 19–29, coffee,
Kimchi, tofu, and rice in 30–49, and coffee, Kimchi, rice, and tofu in 50–64. From the 50 targets aged 19–29, significant
correlation was not indicated among magnesium intake, serum magnesium, and antioxidant capacity biomarkers. In conclusion,
the magnesium intake status of some Korean adults is unsatisfactory. And it is suggested that this low intake of magnesium
has no correlation with antioxidant capacity. 相似文献
3.
Effects of long-term selenium yeast supplementation on selenium status studied in the rat 总被引:1,自引:0,他引:1
Dietrich Behne Dorothea Alber Antonios Kyriakopoulos 《Journal of trace elements in medicine and biology》2009,23(4):258-264
To investigate the selenium status during long-term dietary supply of selenium yeast, 30-day-old male rats were fed for 379 days a methionine-adequate low-selenium diet supplemented with 0.2 mg Se/kg (selenium-adequate diet) or 1.5 mg Se/kg (high-selenium diet) in the form of selenium yeast that contained 60% of the element as l-selenomethionine. Their selenium load was determined at several intervals by neutron activation analysis of the selenium concentrations in the main selenium body pools, skeletal muscle and liver. After 64 days the tissue selenium concentrations plateaued in both groups and then stayed at that level. Compared with the selenium-adequate group, elevated tissue selenium concentrations were found in the high-selenium group, but the increase by a factor of 3.5 in the muscle and by a factor of 2.3 in the liver was smaller than the 7.5-fold increase in the selenium intake. In the selenium-adequate group about 50% of the muscle selenium and 30% of the liver selenium and in the high-selenium group about 85% of the muscle selenium and 70% of the liver selenium were estimated to be present in non-selenoprotein forms. During selenium depletion the liver glutathione peroxidase activity in the high-selenium group remained unaffected for 4 weeks and then decreased more slowly than that in the selenium-adequate group. From these results it can be concluded that selenium incorporated from the selenium yeast diet into non-selenoprotein forms can serve as an endogenous selenium source to maintain selenoprotein levels in periods of insufficient selenium supply. 相似文献
4.
Background Studies have shown that pets are very important sensitizing agents in patients with asthma. Respiratory disorders and allergic
diseases are common in the State of Qatar.
Objective The aim of the present study was to determine whether exposure to pets and domestic animals plays a significant role in the
development of asthma and allergic rhinitis among Qatari school children aged 6–14 years.
Design A cross-sectional prospective study.
Setting Public schools for boys and girls in urban and semi-urban areas.
Subjects A total of 3,500 Qatari school boys and girls aged 6–14 years were approached. After exclusion of those who did not give consent
for the study and incomplete questionnaires, 3,283 (98.3%) participants were included in the data analysis.
Methods A multistage sampling technique was used and different schools from urban and semi-urban areas were selected. A standard questionnaire
was distributed to parents of randomly selected school children aged 6–14 years between February 2003 and February 2004.
Results The overall prevalence of asthma was 19.8% and the mean age of the children was 9.0 ± 2.0 years. The male and female percentages
were 52.3% and 47.7% respectively. Nine hundred and ninety-six families out of 3,283 (30.3%) owned pets. It was found that
among children with no family history of asthma, the relative risk (RR) of asthma with pets at home was 1.19 and the 95% confidence
interval (CI) was 1.0–1.4 (P = 0.025). The RR of having allergic rhinitis was 1.60 (95% CI = 1.4–1.8; P < 0.001) and risk of having eczema was also significantly higher in participants with pets at home (RR = 1.28; 95% CI = 1.1–1.5;
P < 0.001).
Conclusion In the present study, the prevalence of asthma, allergic rhinitis, and eczema was significantly more common in families with
domestic animals than in those without. 相似文献
5.
Noriyuki Shiraishi Tetsuya Taguchi Hideo Kinebuchi 《Biological trace element research》1993,39(2-3):129-137
It was determined if the sensitivity inmacular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6–8-d-old or 3–4-wk-oldmacular mutant mouse to copper-induced toxicity was not affected by sex. However, 8–9-wk-old mutant females were more sensitive to
copper-induced toxicity than mutant males. Furthermore, 6–8-d-old or 3–4-wk-old mutant males were more sensitive to copper-induced
toxicity than 8–9-wk-old mutant males. However, age-related differences in sensitivity to copper-induced toxicity did not
occur significantly in mutant females. On the other hand, in the case of normal mice, the sensitivity in 6–8-d-old or 3–4-wk-old
mice to copper-induced toxicity was not also affected by sex. In contrast to mutant, however, 8–9-wk-old normal males were
more sensitive to copper-induced toxicity than 8–9-wk-old normal females. Adult males were also more sensitive to copper-induced
toxicity than 6–8-d-old or 3–4-wk-old males. However, age-related differences in sensitivity to copper-induced toxicity did
not occur significantly in normal females. These results indicate that sex- and age-related differences in the copper-induced
toxicity exist inmacular mutant mice. 相似文献
6.
From January to September, 2005, we collected fecal samples from 60 chimpanzees at Gombe National Park, Tanzania and examined
them for parasites. We compared current parasite prevalence data with previous studies to obtain a pattern of parasitism over
time. There were considerable similarities in the parasite species composition and prevalence, although we noted some variations.
Generally, parasite prevalence decreased over time, with the present prevalence being lower than in previous surveys. We identified
8 types of parasites, all of which had previously been documented in the chimpanzees of Gombe. Three nematodes — Oesophagostomum sp., Strongyloides fulleborni, and Abbreviata caucassica— occurred at higher prevalence (41.2–45.5%) but relatively lower than previous findings of 50–91%. We also diagnosed unidentified
strongyles at a moderate prevalence (33%), lower than a previous record of 41%. Probstmayria gombensis occurred at relatively low prevalence (16.4%) vs. past observations (23–59%), while the prevalence of Trichuris sp. (7.3%) was closely similar to previous records of 5–9%. We also observed unidentified ciliate at 9% within the same range
as in previous studies (5–28%). The prevalence of Troglodytella abrassarti was 78%, closely similar to previous findings of 75%. There was no significant variation in parasite prevalence between chimpanzees
of the Kasekela community and those of the Mitumba community, although the former tended to have higher prevalence of helminths
than the latter. The causes of the similarities and variations in parasite prevalence over time are discussed. The study provides
baseline data for monitoring of chimpanzee health at Gombe. 相似文献
7.
Andreas König Thomas Romig Christof Janko Ralph Hildenbrand Ernst Holzhofer York Kotulski Christian Ludt Michael Merli Stefanie Eggenhofer Dorothea Thoma Johanna Vilsmeier Dorothea Zannantonio 《European Journal of Wildlife Research》2008,54(3):439-447
This paper describes the design and the preliminary evaluation of an integrated approach to the control of Echinococcus multilocularis in foxes using praziquantel bait. Air distribution of bait in agricultural and recreational areas was combined with distribution
of bait by hand in towns and villages to cover the entire fox population in the 213-km2 baiting area. Bait distribution density was 50/km2, and bait was distributed once every 4 weeks. Pre-baiting prevalence was 35% (22–50% CI 95%). During a 1-year period following
the first 4 months of bait distribution, only one positive fox was found (prevalence 1%; 0–4% CI 95%). No significant change
had occurred in the unbaited control area. This prevalence decline is far more pronounced than in previous fox-baiting studies,
which is likely to be due to the increased bait distribution density and baiting frequency, and the inclusion of the ‘urban’
fox population. 相似文献
8.
Young-Hoon Park Jeong Ah Shin Kyungdo Han Hyeon Woo Yim Won-Chul Lee Yong-Moon Park 《PloS one》2014,9(1)
Purpose
To explore the relationship of the metabolic syndrome (MetS) and its components with age-related cataract in a representative Korean population.Methods
We analyzed the data from the Korea National Health and Nutrition Examination Surveys (2008–2010). A total of 11,076 adults (4,811 men and 6,265 women) aged 40 and over who completed ophthalmologic examination were evaluated. Cataract was defined as the presence of cortical, nuclear, anterior (sub)capsular or posterior subcapsular cataract, from slit-lamp examination or previous cataract surgery. MetS was defined according to the Joint Interim Statement proposed in 2009 from the International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute.Results
The prevalence of cataract and MetS in this population was 39.4% (37.1% for men and 41.6% for women) and 38.5% (37.6% for men and 39.4% for women), respectively. Cataract prevalence tended to increase with the number of MetS components in both genders (both P< 0.001). After being controlled for confounders, however, MetS was significantly associated with cataract only in women (adjusted odds ratio (aOR), 1.24; 95% confidence interval (CI), 1.02–1.50]. Reduced HDL cholesterol, elevated fasting glucose, and elevated triglycerides were also significantly associated with cataract in women (aOR, 95% CI; 1.27 (1.07–1.50), 1.23 (1.01–1.50), and 1.26 (1.04–1.52), respectively). In the subgroup analysis for cataract subtype, MetS and reduced HDL cholesterol were significantly associated with nuclear cataract in women (aOR, 95% CI; 1.25 (1.07–1.55) and 1.25 (1.03–1.52), respectively). However, such associations were not found in men.Conclusions
Our results suggest that MetS and its components appear to be associated with age-related cataract only among Korean women, especially in nuclear cataract. 相似文献9.
Purpose
To study the relationship between outdoor activity and risk of age-related cataract (ARC) in a rural population of Taizhou Eye Study (phrase 1 report).Method
A population-based, cross-sectional study of 2006 eligible rural adults (≥45 years old) from Taizhou Eye Study was conducted from Jul. to Sep. 2012. Participants underwent detailed ophthalmologic examinations including uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), intraocular pressure (IOP), slit lamp and fundus examinations as well as questionnaires about previous outdoor activity and sunlight protection methods. ARC was recorded by LOCSⅢ classification system. The prevalence of cortical, nuclear and posterior subcapsular cataract were assessed separately for the risk factors and its association with outdoor activity.Results
Of all 2006 eligible participants, 883 (44.0%) adults were diagnosed with ARC. The prevalence rates of cortical, nuclear and posterior subcapsular cataract per person were 41.4%, 30.4% and 1.5%, respectively. Women had a higher tendency of nuclear and cortical cataract than men (OR = 1.559, 95% CI 1.204–2.019 and OR = 1.862, 95% CI 1.456–2.380, respectively). Adults with high myopia had a higher prevalence of nuclear cataract than adults without that (OR = 2.528, 95% CI 1.055–6.062). Multivariable logistic regression revealed that age was risk factor of nuclear (OR = 1.190, 95% CI 1.167–1.213) and cortical (OR = 1.203, 95% CI 1.181–1.226) cataract; eyes with fundus diseases was risk factor of posterior subcapsular cataract (OR = 6.529, 95% CI 2.512–16.970). Outdoor activity was an independent risk factor of cortical cataract (OR = 1.043, 95% CI 1.004–1.083). The risk of cortical cataract increased 4.3% (95% CI 0.4%-8.3%) when outdoor activity time increased every one hour. Furthermore, the risk of cortical cataract increased 1.1% (95% CI 0.1%-2.0%) when cumulative UV-B exposure time increased every one year.Conclusion
Outdoor activity was an independent risk factor for cortical cataract, but was not risk factor for nuclear and posterior subcapsular cataract. The risk of cortical cataract increased 4.3% when outdoor activity time increased every one hour. In addition, the risk of cortical cataract increased 1.1% (95% CI 0.1%-2.0%) when cumulative UV-B exposure time increased every one year. 相似文献10.
C. Köppel L. Knopf M.-P. Ryser R. Miserez B. Thür K. D. C. Stärk 《European Journal of Wildlife Research》2007,53(3):212-220
The large abundance of free-ranging wild boars (Sus scrofa) and a trend towards animal friendly outdoor management of domestic pigs lead to an increasing probability of disease transmission
between those animal populations. In 2001, an active monitoring was started for classical swine fever (CSF), Aujeszky’s disease
(AD) and porcine brucellosis (PB) in wild boars in Switzerland. The objective of this programme was to document the serological
status of wild boars regarding the selected pathogens. To continue this serosurveillance, 1,060 wild boar samples were collected
during two regular hunting seasons in 2004–2005. Furthermore, in a pilot study, 61 outdoor pigs from 14 farms located in areas
with high wild boar densities were sampled in 2004 and serologically tested for AD and PB. All wild boar samples were negative
for CSF. Seroprevalence for AD was 2.83% (95% CI 1.91–4.02%). Seroprevalence for PB was 13.5% (95% CI 10.7–16.7%) for the
Rose Bengal test and 11.05% (95% CI 8.82–13.61%) for the indirect ELISA. There was no serological evidence for AD in domestic
pigs. All tested animals from 13 piggeries were seronegative for PB, but three pigs from the same farm showed doubtful results.
Further investigations on the farm did not indicate the presence of PB in the herd. These findings urge the need for better
diagnostic tools to obtain reliable results concerning PB prevalence. Since contact and following transmission of infectious
agents between infected wild boars and outdoor pigs might occur in the future, it is advisable to include outdoor pigs in
areas at risk in routine surveillance programmes. 相似文献
11.
A total of 4,287 primary school children, comprising 1,740 males and 2,547 females in Arochukwu local government area of Abia
state Nigeria were examined for clinical signs of dermatophytoses. About 873 (20.4%), consisting of 505 males and 368 females
had lesions consistent with dermatophytoses. The disease was more prevalent in males (29%) than females (14.4%) in a ratio
of approximately 2:1 (P < 0.05). The infection rate increased from 16.8% in the 4–6 year age group to a peak of 28.1% in the 10–12 year age bracket
and dropped sharply to 5.6% in the 16–18 year group. The highest prevalence (39%) was observed among males aged 10–12 years
while females 16–18 years had the lowest prevalence (2.5%). Tinea capitis was the predominant clinical type of dermatophytoses,
and occurred in 13.7% of the total population studied and 67% of lesion positive cases. Trichophyton soudanense and Trichophyton tonsurans the predominant aetiological agents of dermatophytoses with a prevalence of 26.2% and 21.6%, respectively. Others include
Trichophyton mentagrophytes (18.8%), Epidermophyton floccosum (8.3%), Microsporum audouinii (6.4%), Microsporum gypseum (6.0%), Trichophyton rubrum (5.5%) and Microsporum ferrugineum (7.3%), which was isolated for the first time in Nigeria. 相似文献
12.
Shiow-Ing Wang Long-Teng Lee Ming-Lun Zou Chen-Wei Fan Chin-Liang Yaung 《Radiation and environmental biophysics》2010,49(1):57-65
The purpose of the study was to investigate whether proximity to nuclear power plants may increase the risk of abnormal pregnant
outcomes among the resident women. In this ecological study, data were used from the Health Services Birth Reports Database
established by the Bureau of Health Promotion, National Department of Health, Taiwan, in 2001–2004. Chi-square-tests were
carried out to investigate the “Plant-vicinity” and “Non plant-vicinity” group in terms of pregnancy outcome. Additionally,
logistic regression was performed to investigate whether residence in the vicinity of a nuclear power plant was related to
any abnormal pregnancy results. Based on data from 5,679 included subjects, no difference was observed between pregnancy outcomes
of the “Plant-vicinity” and “Non plant-vicinity” groups. After accounting for possible confounders, the adjusted odds ratios
were 1.20 (95% CI = 0.56–2.56) for stillbirth, 1.21 (95% CI = 0.95–1.53) for premature birth, 1.04 (95% CI = 0.79–1.37) for
low birth weight, and 1.58 (95% CI = 0.85–2.93) for congenital deficiencies, respectively, when comparing the “Plant-vicinity”
with the “Non plant-vicinity” group. The results of the study indicate that residence in the vicinity of a nuclear power plant
is not a significant factor which will cause abnormal health situations during pregnancy. 相似文献
13.
Benjamin Krause Heike Culmsee Karsten Wesche Erwin Bergmeier Christoph Leuschner 《Biodiversity and Conservation》2011,20(11):2347-2364
Floodplain meadows are severely threatened by land use change and intensification in Central Europe. This study investigates
quantitative and qualitative changes in the vegetation of wet and species-rich mesic meadows in the floodplains of north Germany
since the 1950s, considering their spatial extent, fragmentation, and replacement by other land use types. Historical high-resolution
vegetation maps were compared with recent vegetation surveys in seven study regions (six unprotected areas, one protected
reference area) in former West and East Germany. The unprotected sites showed alarming losses in wet and species-rich mesic
meadows in the past 50 years (>80%). Wet meadows were substituted by species-poor, intensively managed grasslands (26–60%
of the former area), arable fields (0–47%) or set-asides (2–33%). Species-rich mesic meadows were transformed to arable fields
(42–72%) or species-poor, intensively managed meadows (14–72%). Decreases in effective mesh size and patch size indicated
increasing fragmentation of wet meadows, whilst changes in landscape structure were less consistent in mesic meadows. Only
slight changes in the protected floodplain study area indicate that landscape change is mostly caused by local effects such
as fertilisation and drainage, but not by general trends such as atmospheric N deposition or climate warming. Despite the
contrasting political systems in West and East Germany with different agroeconomic frames, all unprotected study areas showed
similar losses and increasing fragmentation of floodplain meadows, which may negatively influence the natural dynamics of,
and the gene flow between, meadow plant populations. We conclude that floodplain meadows in north Germany urgently call for
high-priority conservation measures. 相似文献
14.
A total of 100 maize and 50 poultry feed samples collected in 1998 at random from nine and eight districts of Haryana, respectively,
were analysed for fumonisin B1. The samples were collected from poultry farms, feed manufacturers and markets. Ninety one (91%) maize samples and forty
two (84%) poultry feed samples were found to contain fumonisin B1. Fumonisin B1 contamination in the maize samples ranged from 0.1–87.0 ppm. Whereas the poultry feed samples contained fumonisin B1 in the range of 0.02–28.0 ppm. It indicated widespread prevalence of fumonisin B1 in maize and poultry feeds in different areas of Haryana.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
15.
A. S. Litvinova P. O. Ratmanova E. I. Evina R. R. Bogdanov A. N. Kunitsyna D. A. Napalkov 《Human physiology》2011,37(2):161-167
The age-related changes in saccadic eye movements (the latency, the duration of single saccades and the percentage of multistep
saccades) were compared in healthy subjects and patients with Parkinson’s disease. Healthy volunteers without neurological
symptoms were divided into six age groups: (17–20, 21–30, 31–40, 41–50, 51–60, and 61–75 years of age); and parkinsonian patients,
into three groups (41–50, 51–60, and 61–75 years of age). According to the data obtained, the saccade characteristics depend
on the age in both the subjects without neurological symptoms and parkinsonian patients. In healthy volunteers, the percentage
of multistep saccades and the mean saccade latency increase significantly after the age of 60 years. These parameters in patients
with Parkinson’s disease significantly exceed the values in healthy subjects from the age-matched groups. The “disease” factor
has a greater influence on the saccade latency and the percentage of multistep saccades than the “age” factor. The duration
of single saccades depends on age to a lesser degree and does not change in patients with Parkinson’s disease. The peculiarities
of the development of neurodegenerative processes in cases of normal aging and in idiopathic parkinsonism are discussed. 相似文献
16.
Suresh K. Gupta Vivekananthan Kalaiselvan Sushma Srivastava Rohit Saxena Shyam S. Agrawal 《Biological trace element research》2010,136(3):258-268
Cataract is the opacification in eye lens and leads to 50% of blindness worldwide. The present study was undertaken to evaluate
the anticataract potential of Trigonella foenum-graecum Linn seeds (fenugreek) in selenite-induced in vitro and in vivo cataract. In vitro enucleated rat lenses were maintained
in organ culture containing Dulbecco’s modified Eagles medium (DMEM) alone or in addition with 100 μM selenite and served
as the normal and control groups, respectively. For the test group, the medium was supplemented with selenite and T. foenum-graecum aqueous extract. The lenses were incubated for 24 h at 37°C. After incubation, the lenses were processed for the estimation
of reduced glutathione (GSH), lipid peroxidation product (malondialdehyde), and the antioxidant enzymes. In vivo selenite
cataract was induced in 9-day-old rats by subcutaneous injection of sodium selenite (25 μmol/kg body weight). Animals in the
test group were injected with different doses of aqueous extract of T. foenum-graecum 4 h before the selenite challenge. A fall in GSH and a rise in malondialdehyde levels were observed in control as compared
to normal lenses. T. foenum-graecum significantly (P < 0.01) restored glutathione and decreased malondialdehyde levels. A significant restoration in the activities of antioxidant
enzymes such as superoxide dismutase (P < 0.01), catalase, (P < 0.01), glutathione peroxidase (P < 0.01), and glutathione-S-transferase (P < 0.01) was observed in the T. foenum-graecum supplemented group as compared to control. In vivo, none of the eyes was found with nuclear cataract in treated group as
opposed to 72.5% in the control group. T. foenum-graecum protects against experimental cataract by virtue of its antioxidant properties. Further studies are warranted to explore
its role in human cataract. 相似文献
17.
I. P. Butkevich V. A. Mikhailenko E. A. Vershinina P. O. Semenov 《Journal of Evolutionary Biochemistry and Physiology》2009,45(5):596-603
In the 7–8- and the 10–11-day old male rat pups born to dams exposed to an immobilization stress for the last week of pregnancy
and to the dams exposed to no stress (control), behavioral parameters were studied: the level of depression in the test of
forced swimming (the Porsolt’s test) and 24 h after a long pain response during inflammation (the formalin test—a subcutaneous
injection of 2.5% formalin into the hind leg plantar pad). In control pups, significant age-related changes in the forced
swimming were revealed: the immobility time was longer in animals of the older age group, whereas no age differences were
found in parameters of the persistent inflammatory pain and in flexing + shaking behavior. The prenatal stress produced an
increase in the immobility time and the flexing + shaking behavior in the 7–8-day old, but not in the 10–11-day old rat pups.
This resulted in elimination of the age differences in the immobility time in the prenatally stressed animals. Thus, use of
different methodic approaches has allowed revealing peculiarities in the parameters of the degree of depression and duration
of the pain response at inflammation in the 7–8- and 10–11-day old rat pups, which indicates heterogeneity of the infantile
development stage that, according to literature data, includes in rats the period from the 5th to the 10th postnatal days. 相似文献
18.
A. X. Bigard D. Merino F. Lienhard B. Serrurier C. Y. Guezennec 《European journal of applied physiology and occupational physiology》1997,75(5):380-387
The aim of this study was to quantify the degenerative and regenerative changes in rat soleus muscle resulting from 3-week
hindlimb suspension at 45° tilt (HS group, n = 8) and 4-week normal cage recovery (HS-R group, n = 7). Degenerative changes were quantified by microscope examination of muscle cross sections, and the myosin heavy chain
(MHC) composition of soleus muscles was studied by sodium dodecyl sulphate polyacrylamide gel electrophoresis. At the end
of 3-week hindlimb suspension, histological signs of muscle degenerative changes were detected in soleus muscles. There was
a significant variability in the percentage of fibres referred to as degenerating (%dg) in individual animals in the HS group
[%dg = 8.41 (SEM 0.5)%, range 4.66%–14.08%]. Moreover, %dg varied significantly along the length of the soleus muscle. The
percentage of fibres with internal nuclei was less than %dg in HS-soleus muscles [4.12 (SEM 0.3)%, range 1.24%–8.86%]. In
4-week recovery rats, the greater part of the fibres that were not referred to as normal, retained central nuclei [15.8 (SEM
2.2)%, range 6.2%–21.1%]. A significant increase in the slow isoform of MHC was recorded in the HS-R rats, compared to muscles
from age-matched rats (P < 0.01). These results would suggest that a cycle of myofibre degeneration-regeneration occurred during HS and passive recovery,
and that the increased accumulation of slow MHC observed in soleus muscles after recovery from HS could be related to the
prevalence of newly formed fibres.
Accepted: 14 October 1996 相似文献
19.
Purpose
Changes in lens may reflect the status of systemic health of human beings but the supporting evidences are not well summarized yet. We aimed to determine the relationship of age-related cataract, cataract surgery and long-term mortality by pooling the results of published population-based studies.Methods
We searched PubMed and Embase from their inception till March, 2014 for population-based studies reporting the associations of any subtypes of age-related cataract, cataract surgery with all-cause mortality. We pooled the effect estimates (hazards ratios [HRs]) under a random effects model.Results
Totally, we identified 10 unique population-based studies including 39,659 individuals at baseline reporting the associations of any subtypes of cataract with all-cause mortality from 6 countries. The presence of any cataract including cataract surgery was significantly associated with a higher risk of death (pooled HR: 1.43, 95% CI, 1.21, 2.02; P<0.001; I2 = 64.2%). In the meta-analysis of 9 study findings, adults with nuclear cataract were at higher risks of mortality (pooled HR: 1.55, 95% CI, 1.17, 2.05; P = 0.002; I2 = 89.2%). In the meta-analysis of 8 study findings, cortical cataract was associated with higher risks of mortality (pooled HR: 1.26, 95% CI, 1.12, 1.42; P<0.001, I2 = 29.7%). In the meta-analysis of 6 study findings, PSC cataract was associated with higher risks of mortality (pooled HR: 1.37, 95% CI, 1.04, 1.80; P = 0.03; I2 = 67.3%). The association between cataract surgery and mortality was marginally non-significant by pooling 8 study findings (pooled HR: 1.27, 95% CI, 0.97, 1.66; P = 0.08; I2 = 76.6%).Conclusions
All subtypes of age-related cataract were associated with an increased mortality with nuclear cataract having the strongest association among the 3 cataract subtypes. However, cataract surgery was not significantly related to mortality. These findings indicated that changes in lens may serve as markers for ageing and systemic health in general population. 相似文献20.
Saichin Isipradit Maytinee Sirimaharaj Puwat Charukamnoetkanok Oraorn Thonginnetra Warapat Wongsawad Busaba Sathornsumetee Sudawadee Somboonthanakij Piriya Soomsawasdi Umapond Jitawatanarat Wongsiri Taweebanjongsin Eakkachai Arayangkoon Punyawee Arame Chinsuchee Kobkoonthon Pannet Pangputhipong 《PloS one》2014,9(12)