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Biological differences among metazoans and between cell types in a given organism arise in large part due to differences in gene expression patterns. Gene-distal enhancers are key contributors to these expression patterns, exhibiting both sequence diversity and cell type specificity. Studies of long-range interactions indicate that enhancers are often important determinants of nuclear organization, contributing to a general model for enhancer function that involves direct enhancer-promoter contact. However, mechanisms for enhancer function are emerging that do not fit solely within such a model, suggesting that enhancers as a class of DNA regulatory element may be functionally and mechanistically diverse. 相似文献
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Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay 总被引:1,自引:0,他引:1
Melnikov A Murugan A Zhang X Tesileanu T Wang L Rogov P Feizi S Gnirke A Callan CG Kinney JB Kellis M Lander ES Mikkelsen TS 《Nature biotechnology》2012,30(3):271-277
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Summerbell D Ashby PR Coutelle O Cox D Yee S Rigby PW 《Development (Cambridge, England)》2000,127(17):3745-3757