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1.
Aim: To compare the efficacy of 14‐day and 5‐day amoxicillin treatment on the eradication rate during tetracycline containing sequential H. pylori therapy, and also to compare the eradication rate of this regimen with those used in similar studies performed in Turkey. Method: This study included 112 patients infected with H. pylori that were randomized into 2 groups. In group A, patients (n = 56) received pantoprazole (40 mg BID) and amoxicillin (1 g BID) for 5 days, followed by pantoprazole (40 mg BID), tetracycline (500 mg QID), and metronidazole (500 mg TID) for the remaining 9 days. In group B, patients (n = 56) received pantoprazole (40 mg BID) and amoxicillin (1 g BID) for 5 days, followed by pantoprazole (40 mg BID), tetracycline (500 mg QID), metronidazole (500 mg TID), and amoxicillin (1 g BID) for the remaining 9 days. Eradication rates were calculated using both intention‐to‐treat (ITT) and per‐protocol (PP) analyses. Results: In all, 112 patients were subjected to ITT analysis and 109 patients completed the study. In group A, H. pylori eradication was achieved in 46 (82.1%) of the 56 patients included in the ITT analysis and in 46 (83.6%) of the 55 patients included in the PP analysis. In group B, H. pylori eradication was achieved in 44 (78.57%) of the 56 patients included in the ITT analysis and in 44 (81.48%) of the 54 patients included in the PP analysis ( Table 2 ). The eradication rates were not statistically significant between the 2 groups ( p > .005). Table 2. Eradication rates in the two study groups | Group A | Group B | p | n | ITT/PP | n | ITT/PP | Eradication | Female | 21 | 70%/72.4% | 34 | 79.06%/82.9% | NS | Male | 25 | 6.1%/96.1% | 10 | 76.9%/76.9% | NS | Total | 46 | 82.1%/83.6% | 44 | 78.57%/81.48% | NS | - NS, not significant; PP, per‐protocol; ITT, intention‐to‐treat.
Conclusion: Extended duration of amoxicillin treatment during the entire tetracycline containing sequential therapy period did not improve the H. pylori eradication rate. As a consequence, sequential therapy using 5‐day amoxicillin is an acceptable first‐line therapy option for the eradication of H. pylori in Turkey. 相似文献
2.
Recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. The exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity‐related pathologies. The objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ROS) production during the adipogenesis in 3T3‐L1 adipocytes, and to investigate their total phenol contents and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activities. Our results show that high total phenol contents were observed in the extracts of Ecklonia cava (see Table 1 for taxonomic authors) (681.1 ± 16.0 μg gallic acid equivalents [GAE] · g ?1), Dictyopteris undulata (641.3 ± 70.7 μg GAE · g ?1), and Laurencia intermedia (560.9 ± 48.1 μg GAE · g ?1). In addition, DPPH radical scavenging activities were markedly higher in Sargassum macrocarpum (60.2%), Polysiphonia morrowii (55.0%), and Ishige okamurae (52.9%) than those of other seaweed extracts ( P < 0.05). Moreover, treatment with several seaweed extracts including D. undulata, Sargassum micracanthum, Chondrus ocellatus, Gelidium amansii, Gracilaria verrucosa, and Grateloupia lanceolata significantly inhibited adipocyte differentiation and ROS production during differentiation of 3T3‐L1 preadipocytes. Furthermore, the production of ROS was positively correlated with lipid accumulation ( R2 = 0.8149). According to these preliminary results, some of the seaweed extracts can inhibit ROS generation, which may protect against oxidative stress that is linked to obesity. Further studies are required to determine the molecular mechanism between the verified seaweeds and ROS, and the resulting effects on obesity. Table 1. List of Korean seaweed extracts of 49 species evaluated in this experiment. Type | No. | Scientific name | Collection time | TP1 (μg GAE · g?1) | Brown macroalgae | SE‐1 | Chondracanthus tenellus (Harv.) Hommers. | April 27, 2006 | 112.8 ± 15.1lm | SE‐2 | Colpomenia sinusa (F. C. Mertens ex Roth) Derbes et Solier in Castagne | May 11, 2006 | 44.0 ± 4.1opqrs | SE‐3 | Dictyopteris divaricata (Okamura) Okamura | April 6, 2006 | 41.5 ± 5.6pqrs | SE‐4 | Dictyopteris pacifica (Yendo) I. K. Hwang, H.‐S. Kim et W. J. Lee | April 27, 2006 | 80.9 ± 8.3mno | SE‐5 | Dictyopteris prolifera (Okamura) Okamura | November 26, 2007 | 48.4 ± 3.0nopqrs | SE‐6 | Dictyopteris undulata Holmes | July 28, 2007 | 641.3 ± 70.7b | SE‐7 | Dictyota asiatica I. K. Hwang | April 6, 2006 | 52.9 ± 7.6nonopqr | SE‐8 | Ecklonia cava Kjellm. | October 22, 2006 | 681.1 ± 16.0a | SE‐9 | Ecklonia stolonifera Okamura | November 26, 2007 | 36.5 ± 3.4pqrs | SE‐10 | Endarachne binghamiae J. Agardh | March 10, 2006 | 50.4 ± 2.6nopqrs | SE‐11 | Hizikia fusiformis (Harv.) Okamura | July 23, 2006 | 16.4 ± 1.2rs | SE‐12 | Hydroclathrus clathratus (C. Agardh) M. Howe | May 11, 2006 | 18.1 ± 0.9rs | SE‐13 | Ishige okamurae Yendo | May 26, 2006 | 237.4 ± 1.6h | SE‐14 | Lethesia difformis (L.) Aresch. | May 11, 2006 | 11.2 ± 1.9s | SE‐15 | Myelophycus simplex (Harv.) Papenf. | April 27, 2006 | 39.5 ± 3.2pqrs | SE‐16 | Padina arborescens Holmes | July 29, 2007 | 172.9 ± 23.1ij | SE‐17 | Sargassum fulvellum (Turner) C. Agardh | April 27, 2006 | 119.1 ± 5.6kl | SE‐18 | Sargassum micracanthum (Kütz.) Endl. | December 21, 2006 | 468.0 ± 22.7e | SE‐19 | Sargassum patens C. Agardh | January 21, 2007 | 41.5 ± 5.7pqrs | SE‐20 | Sargassum confusum C. Agardh f. validum Yendo | March 8, 2008 | 110.9 ± 3.5lm | SE‐21 | Sargassum horneri (Turner) C. Agardh | March 1, 2006 | 84.8 ± 9.4lmn | SE‐22 | Sargassum macrocarpum C. Agardh | January 21, 2007 | 353.9 ± 59.1g | SE‐23 | Sargassum muticum (Yendo) Fensolt | January 21, 2007 | 72.1 ± 14.9nop | SE‐24 | Sargassum nipponium Yendo | April 6, 2006 | 54.0 ± 3.5nopqr | SE‐25 | Sargassum sagamianum Yendo | March 8, 2008 | 41.0 ± 6.7pqrs | SE‐26 | Sargassum thunbergii (Mertens ex Roth) Kuntze | July 23, 2006 | 27.7 ± 0.8qrs | SE‐27 | Scytosiphon gracilis Kogame | May 26, 2006 | 30.2 ± 5.6qrs | SE‐28 | Scytosiphon lomentaria (Lyngb.) Link | May 11, 2006 | 66.5 ± 8.9nopq | Red macroalgae | SE‐29 | Bonnemaisonia hamifera Har. | April 27, 2006 | 44.1 ± 2.3opqrs | SE‐30 | Callophyllis crispata Okamura | May 11, 2006 | 37.6 ± 12.6pqrs | SE‐31 | Chondria crassicaulis Harv. | May 11, 2006 | 45.4 ± 4.4opqrs | SE‐32 | Chondrus crispus Stackh. | May 26, 2006 | 40.7 ± 8.0pqrs | SE‐33 | Chondrus ocellatus Holmes | May 11, 2006 | 47.2 ± 1.7nopqrs | SE‐34 | Gelidium amansii (J. V. Lamour.) J. V. Lamour. | April 27, 2006 | 525.3 ± 35.9d | SE‐35 | Gloioperltis furcata (Postels et Rupr.) J. Agardh | May 26, 2006 | 147.7 ± 6.4jk | SE‐36 | Gloioperltis complanta (Harv.) Yamada | May 26, 2006 | 58.2 ± 6.4nopq | SE‐37 | Gracilaria verrucosa (Hudson) Papenf. | March 6, 2008 | 55.1 ± 7.5nopqr | SE‐38 | Grateloupia elliptica Holmes | May 26, 2006 | 154.4 ± 12.9j | SE‐39 | Grateloupia filicina (J. V. Lamour.) C. Agardh | May 11, 2006 | 38.2 ± 2.2pqrs | SE‐40 | Grateloupia lanceolata (Okamura) Kawag. | July 23, 2006 | 32.7 ± 3.0pqrs | SE‐41 | Laurencia intermedia J. V. Lamour. | May 11, 2006 | 560.9 ± 48.1c | SE‐42 | Laurencia intricata J. V. Lamour. | April 27, 2006 | 35.4 ± 4.0pqrs | SE‐43 | Laurencia okamurae Yamada | May 11, 2006 | 193.2 ± 41.9i | SE‐44 | Lomentaria hakodatensis Yendo | April 27, 2006 | 165.2 ± 15.1ij | SE‐45 | Polyopes affinis (Harv.) Kawag. et H.‐W. Wang | May 26, 2006 | 42.9 ± 2.3opqrs | SE‐46 | Polysiphonia morrowii Harv. | May 11, 2006 | 392.4 ± 40.3f | SE‐47 | Prionitis cornea (Okamura) E. Y. Dawson | October 22, 2006 | 47.9 ± 3.6nopqrs | Green macroalgae | SE‐48 | Enteromorpha prolifera (O. F. Müll.) J. Agardh | March 26, 2006 | 42.0 ± 5.3pqrs | SE‐49 | Ulva pertusa Kjellm. | April 27, 2006 | 48.3 ± 3.8nopqrs | - GAE, gallic acid equivalents; SE, seaweed extracts.
- 1TP, total phenol content is micrograms of total phenol contents per gram of seaweed extract based on gallic acid as standard. The values are means ± SD from three replications.
- a–sMeans in the same column not sharing a common letter are significantly different (P < 0.05) by Duncan’s multiple test.
Citing Literature Number of times cited according to CrossRef: 21 - Kas?m Cemal Güven, Burak Coban, Osman Özdemir, Pharmacology of Marine Macroalgae, Encyclopedia of Marine Biotechnology, 10.1002/9781119143802, (585-615), (2020). Wiley Online Library
- Giovanna Bermano, Teodora Stoyanova, Franck Hennequart, Cherry L. Wainwright, Seaweed-derived bioactives as potential energy regulators in obesity and type 2 diabetes, , 10.1016/bs.apha.2019.10.002, (2019). Crossref
- Ana Rocío Múzquiz de la Garza, Mireya Tapia-Salazar, Maribel Maldonado-Muñiz, Julián de la Rosa-Millán, Janet Alejandra Gutiérrez-Uribe, Liliana Santos-Zea, Bertha Alicia Barba-Dávila, Denis Ricque-Marie, Lucía Elizabeth Cruz-Suárez, Nutraceutical Potential of Five Mexican Brown Seaweeds, BioMed Research International, 10.1155/2019/3795160, 2019 , (1-15), (2019). Crossref
- M. Lynn Cornish, Alan T. Critchley, Ole G. Mouritsen, A role for dietary macroalgae in the amelioration of certain risk factors associated with cardiovascular disease, Phycologia, 10.2216/15-77.1, 54 , 6, (649-666), (2019). Crossref
- Carolina Gonçalves-Fernández, Jorge Sineiro, Ramón Moreira, Oreste Gualillo, Extraction and characterization of phlorotannin-enriched fractions from the Atlantic seaweed Bifurcaria bifurcata and evaluation of their cytotoxic activity in murine cell line, Journal of Applied Phycology, 10.1007/s10811-018-1729-2, (2019). Crossref
- Noelia Flórez‐Fernández, María P Casas, María Jesús González‐Muñoz, Herminia Domínguez, Microwave hydrogravity pretreatment of Sargassum muticum before solvent extraction of antioxidant and antiobesity compounds, Journal of Chemical Technology & Biotechnology, 10.1002/jctb.5771, 94 , 1, (256-264), (2018). Wiley Online Library
- Yannick Lerat, M. L. Cornish, Alan T. Critchley, Stéphane La Barre, Stephen S. Bates, Applications of Algal Biomass in Global Food and Feed Markets: From Traditional Usage to the Potential for Functional Products, Blue Biotechnology, 10.1002/9783527801718, (143-189), (2018). Wiley Online Library
- Gabriele Andressa Zatelli, Ana Cláudia Philippus, Miriam Falkenberg, An overview of odoriferous marine seaweeds of the Dictyopteris genus: insights into their chemical diversity, biological potential and ecological roles, Revista Brasileira de Farmacognosia, 10.1016/j.bjp.2018.01.005, 28 , 2, (243-260), (2018). Crossref
- Cyr Abel Maranguy Ogandaga, Yeon Ju Na, Sang-Rae Lee, Young Sik Kim, Han Gil Choi, Ki Wan Nam, Wart-like spot formation on the fronds of Chondrus ocellatus (Gigartinales) by a brown alga, Mikrosyphar zosterae (Ectocarpales) in Korea, Journal of Applied Phycology, 10.1007/s10811-016-1028-8, 29 , 5, (2539-2546), (2017). Crossref
- Fook Yee Chye, Birdie Scott Padam, Seah Young Ng, Innovation and Sustainable Utilization of Seaweeds as Health Foods, Sustainability Challenges in the Agrofood Sector, 10.1002/9781119072737, (390-434), (2017). Wiley Online Library
- Gaurav Rajauria, Lynn Cornish, Francesco Ometto, Flower E. Msuya, Raffaella Villa, Identification and selection of algae for food, feed, and fuel applications, Seaweed Sustainability, 10.1016/B978-0-12-418697-2.00012-X, (315-345), (2015). Crossref
- Jatinder Sangha, Owen Wally, Arjun Banskota, Roumiana Stefanova, Jeff Hafting, Alan Critchley, Balakrishnan Prithiviraj, A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans, Marine Drugs, 10.3390/md13106407, 13 , 10, (6407-6424), (2015). Crossref
- Jung-Ae Kim, Fatih Karadeniz, Byul-Nim Ahn, Myeong Sook Kwon, Ok-Ju Mun, Mihyang Kim, Sang-Hyeon Lee, Ki Hwan Yu, Yuck Yong Kim, Chang-Suk Kong, Sargassum sp. Attenuates Oxidative Stress and Suppresses Lipid Accumulation in vitro, Journal of Life Science, 10.5352/JLS.2014.24.3.274, 24 , 3, (274-283), (2014). Crossref
- Georgia M. Hart, Tamara Ticktin, Dovi Kelman, Anthony D. Wright, Nicole Tabandera, Contemporary Gathering Practice and Antioxidant Benefit of Wild Seaweeds in Hawai’i, Economic Botany, 10.1007/s12231-014-9258-7, 68 , 1, (30-43), (2014). Crossref
- Zahid Manzoor, Vivek Bhakta Mathema, Doobyeong Chae, Eun-Sook Yoo, Hee-Kyoung Kang, Jin-Won Hyun, Nam Ho Lee, Mi-Hee Ko, Young-Sang Koh, Extracts of the seaweed Sargassum macrocarpum inhibit the CpG-induced inflammatory response by attenuating the NF-κB pathway, Food Science and Biotechnology, 10.1007/s10068-014-0041-4, 23 , 1, (293-297), (2013). Crossref
- Jatinder Singh Sangha, Di Fan, Arjun H. Banskota, Roumiana Stefanova, Wajahatullah Khan, Jeff Hafting, James Craigie, Alan T. Critchley, Balakrishnan Prithiviraj, Bioactive components of the edible strain of red alga, Chondrus crispus, enhance oxidative stress tolerance in Caenorhabditis elegans, Journal of Functional Foods, 10.1016/j.jff.2013.04.001, 5 , 3, (1180-1190), (2013). Crossref
- Areum Daseul Kim, Mei Jing Piao, Yu Jae Hyun, Hee Kyoung Kang, In Soo Suh, Nam Ho Lee, Jin Won Hyun, Photo-protective properties of Lomentaria hakodatensis yendo against ultraviolet B radiation-induced keratinocyte damage, Biotechnology and Bioprocess Engineering, 10.1007/s12257-012-0336-3, 17 , 6, (1223-1231), (2013). Crossref
- Min‐Jung Seo, Hyeon‐Son Choi, Ok‐Hwan Lee, Boo‐Yong Lee, Grateloupia lanceolata (Okamura) Kawaguchi, the Edible Red Seaweed, Inhibits Lipid Accumulation and Reactive Oxygen Species Production During Differentiation in 3T3‐L1 Cells, Phytotherapy Research, 10.1002/ptr.4765, 27 , 5, (655-663), (2012). Wiley Online Library
- Mi‐Seon Woo, Hyeon‐Son Choi, Ok‐Hwan Lee, Boo‐Yong Lee, The Edible red Alga, Gracilaria verrucosa, Inhibits Lipid Accumulation and ROS Production, but Improves Glucose Uptake in 3T3‐L1 Cells, Phytotherapy Research, 10.1002/ptr.4813, 27 , 7, (1102-1105), (2012). Wiley Online Library
- Young-Jun Lee, Bo-Ra Yoon, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee, Effect of Sargassum micracanthum extract on Lipid Accumulation and Reactive Oxygen Species (ROS) Production during Differentiation of 3T3-L1 Preadipocytes, Korean Journal of Food Preservation, 10.11002/kjfp.2012.19.3.455, 19 , 3, (455-461), (2012). Crossref
- Mei Piao, Yu Hyun, Suk Cho, Hee Kang, Eun Yoo, Young Koh, Nam Lee, Mi Ko, Jin Hyun, An Ethanol Extract Derived from Bonnemaisonia hamifera Scavenges Ultraviolet B (UVB) Radiation-Induced Reactive Oxygen Species and Attenuates UVB-Induced Cell Damage in Human Keratinocytes, Marine Drugs, 10.3390/md10122826, 10 , 12, (2826-2845), (2012). Crossref
Volume 47 , Issue 3 June 2011 Pages 548-556 相似文献
3.
The reaction of N-demethylation plays an important role in the degradation of some alkaloids in a number of organisms. This review presents
how our understanding of the N-demethylation of nicotine in plants has been improved through studies in cell cultures of Nicotiana plumbaginifolia and N. glutinosa using a variety of isotopic techniques. The overall aim is to understand how metabolism recycles the alkaloid skeleton, both
in terms of the metabolic route(s) exploited and the reaction mechanisms of the enzymes involved. The former has been approached
using high-resolution 2-dimensional NMR and GC-MS methods; the latter by determining kinetic isotope effects and modelling
the potential reaction steps. It appears that the mechanism for nicotine demethylation in plants is similar to but has significant
differences from that described for mammals and Pseudomonas bacteria. These differences are discussed.
相似文献
5.
1. |
We examined microspectrophotometrically the retinas of 3 species of stomatopods in the superfamily Gonodactyloidea, all of which live in environments that are reduced both in the intensity and spectral range of natural illumination. Species examined were Odontodactylus brevirostris, O. scyllarus, and Hemisquilla ensigera.
| 2. |
All 3 species had the typical gonodactyloid diversity of visual pigments, with 8 different photopigments residing in the 4 tiered rows of the midband and 2 additional types in the untiered classes of photoreceptors in the midband and peripheral retina. The spectral range covered by the max values of the visual pigments of each species was similar to that of other gonodactyloid and lysiosquilloid species.
| 3. |
Apparent retinal adaptations in species of Odontodactylus for vision in dimly lit, spectrally narrow photic environments were seen primarily as specializations of the intrarhabdomal filters. These were of reduced diversity, and had reduced absorption at long wavelengths compared to the filters of other gonodactyloid stomatopods. Retinas of H. ensigera lacked both proximal classes of intrarhabdomal filter, and had the smallest total range of visual pigment max yet observed in mantis shrimps. These modifications decrease the spectral range and number of types of narrow-band spectral classes of phooreceptors, while increasing their sensitivity.
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6.
In recent years, some marine microbes have been used to degrade diesel oil. However, the exact mechanisms underlying the biodegradation are still poorly understood. In this study, a hypothermophilous marine strain, which can degrade diesel oil in cold seawater was isolated from Antarctic floe-ice and identified and named as Rhodococcus sp. LH. To clarify the biodegradation mechanisms, a gas chromatography-mass spectrometry (GC-MS)-based metabolomics strategy was performed to determine the diesel biodegradation process-associated intracellular biochemical changes in Rhodococcus sp. LH cells. With the aid of partial least squares-discriminant analysis (PLS-DA), 17 differential metabolites with variable importance in the projection (VIP) value greater than 1 were identified. Results indicated that the biodegradation of diesel oil by Rhodococcus sp. LH was affected by many different factors. Rhodococcus sp. LH could degrade diesel oil through terminal or sub-terminal oxidation reactions, and might also possess the ability to degrade aromatic hydrocarbons. In addition, some surfactants, especially fatty acids, which were secreted by Rhodococcus into medium could also assist the strain in dispersing and absorbing diesel oil. Lack of nitrogen in the seawater would lead to nitrogen starvation, thereby restraining the amino acid circulation in Rhodococcus sp. LH. Moreover, nitrogen starvation could also promote the conversation of relative excess carbon source to storage materials, such as 1-monolinoleoylglycerol. These results would provide a comprehensive understanding about the complex mechanisms of diesel oil biodegradation by Rhodococcus sp. LH at the systematic level. 相似文献
7.
Background Gram-positive bacteria of the genus Rhodococcus have shown an extraordinary capacity for metabolizing recalcitrant organic compounds. One hindrance to the full exploitation
of Rhodococcus is the dearth of genetic tools available for strain manipulation. To address this issue, we sought to develop a plasmid-based
system for genetic manipulation of a variety of Rhodococcus strains. 相似文献
8.
1. |
Interspecific diversity in the visual pigments of stomatopod crustaceans was characterized using microspectrophotometry. We examined the 10 visual pigments in main rhabdoms in retinas of 3 species of each of two genera of stomatopod crustaceans of the superfamily Gonodactyloidea, Gonodactylus (G. oerstedii, G. aloha, and G. curacaoensis) and Odontodactylus (O. scyllarus, O. brevirostris, and O. havanensis). Species were selected to provide a matched diversity of habitats.
| 2. |
In each genus, visual pigments varied in max in several regions of the retina, as revealed by analysis of variance. The variation within closely related species of the same genus implies that visual pigments can evolve rapidly in stomatopods.
| 3. |
In photoreceptors of the peripheral retina, which are devoted to spatial vision, visual pigment max decreased as the depth range of the various species increased, a typical pattern for marine animals. In contrast, visual pigment max in photoreceptors of retinal regions devoted to polarization vision (midband Rows 5 and 6) is not obviously correlated with the spectral environment, implying that polarization information may be confined to particular spectral ranges. Visual pigments of the tiered rows of the midband, which are committed to spectral analysis, span a larger spectral range in shallow-water than deepwater species.
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9.
Risk management in the hospital, which is one of the referentiels of the ANAES accreditation manual, may be considered on two levels. Firstly, risk management may be approached globally, in the same way as it is tackled in the accreditation process. Secondly, risk management may be more definite. A specific risk chosen in accordance with the priorities of a particular plan may be dealt with individually. In this respect, the tranfusion process allows the risk management method to be tested and developed. RésuméLa gestion des risques est mise en œuvre dans le cadre d'un projet d'établissement. Elle représente l'un des référentiels du manuel d'accréditation de l'ANAES. Le dispositif de gestion des risques peut être envisagé selon deux niveaux. Le premier concerne l'approche globale du risque, telle qu'elle a été expérimentée, conformément au référentiel d'accréditation. Le second, dans l'objectif d'une approche globale, consiste à gérer un risque spécifique choisi selon les priorités, les besoins, ou encore dans le cadre d'une planification. À cet égard, le processus transfusionnel permet l'expérimentation et le développement d'une culture du risque transposable. © 1999 Elsevier, Paris PDF (940 K)
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