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Zhou B Liu Y Kahn M Ann DK Han A Wang H Nguyen C Flodby P Zhong Q Krishnaveni MS Liebler JM Minoo P Crandall ED Borok Z 《The Journal of biological chemistry》2012,287(10):7026-7038
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Interaction and functional cooperation between the LIM protein FHL2, CBP/p300, and beta-catenin 总被引:1,自引:0,他引:1
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Labalette C Renard CA Neuveut C Buendia MA Wei Y 《Molecular and cellular biology》2004,24(24):10689-10702
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Guo S Cichy SB He X Yang Q Ragland M Ghosh AK Johnson PF Unterman TG 《The Journal of biological chemistry》2001,276(11):8516-8523
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WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in β-catenin turnover, but its effect on nuclear proteins is unknown. We report an interaction between WTX and p53, derived from the unexpected observation of WTX, p53, and E1B 55K colocalization within the characteristic cytoplasmic body of adenovirus-transformed kidney cells. In other cells without adenovirus expression, the C-terminal domain of WTX binds to the DNA-binding domain of p53, enhances its binding to CBP, and increases CBP/p300-mediated acetylation of p53 at Lys 373/382. WTX knockdown accelerates CBP/p300 protein turnover and attenuates this modification of p53. In p53-reconstitution experiments, cell-cycle arrest, apoptosis, and p53 target-gene expression are suppressed by depletion of WTX. Together, these results suggest that WTX modulates p53 function, in part through regulation of its activator CBP/p300. 相似文献
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