共查询到20条相似文献,搜索用时 15 毫秒
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A "molecular energy" muscle model 总被引:2,自引:0,他引:2
C W McClare 《Journal of theoretical biology》1972,35(3):569-595
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R.A. Fisher's contributions to genetical statistics 总被引:1,自引:0,他引:1
E A Thompson 《Biometrics》1990,46(4):905-914
R. A. Fisher (1890-1962) was a professor of genetics, and many of his statistical innovations found expression in the development of methodology in statistical genetics. However, whereas his contributions in mathematical statistics are easily identified, in population genetics he shares his preeminence with Sewall Wright (1889-1988) and J. B. S. Haldane (1892-1965). This paper traces some of Fisher's major contributions to the foundations of statistical genetics, and his interactions with Wright and with Haldane which contributed to the development of the subject. With modern technology, both statistical methodology and genetic data are changing. Nonetheless much of Fisher's work remains relevant, and may even serve as a foundation for future research in the statistical analysis of DNA data. For Fisher's work reflects his view of the role of statistics in scientific inference, expressed in 1949: There is no wide or urgent demand for people who will define methods of proof in set theory in the name of improving mathematical statistics. There is a widespread and urgent demand for mathematicians who understand that branch of mathematics known as theoretical statistics, but who are capable also of recognising situations in the real world to which such mathematics is applicable. In recognising features of the real world to which his models and analyses should be applicable, Fisher laid a lasting foundation for statistical inference in genetic analyses. 相似文献
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The RNA conformational changes of B, A and C forms are reflected in the infrared absorption spectra in the region of 800 cm?1 to 900 cm?1 and allow one to investigate unoriented samples. The transition to the A form is characterized by the appearence of bands at about 870 cm?1 and at 813 cm?1 whereas the B and the C forms exhibit a band at 837 cm?1, these bands undoubtedly arise from phosphate diester stretching vibrations and yield information about backbone conformation. The presence of these infrared bands provides a criterion for testing the simultaneous presence of two coexisting forms of DNA. It represents a useful method for structural studies of nucleic acid complexes such as protein-DNA for which it is difficult to obtain orientation. 相似文献
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R. M. Anderson 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》1999,354(1384):689-690
Preface to The epidemiology of infectious diseases. A Theme edited by R. M. Anderson. 相似文献
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