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Klonowski KD Williams KJ Marzo AL Lefrançois L 《Journal of immunology (Baltimore, Md. : 1950)》2006,177(7):4247-4251
Expression of IL-7Ralpha on a subset of Ag-specific effector CD8 T cells is believed to identify memory cell precursors. However, whether IL-7 regulates IL-7Ralpha expression in vivo and is responsible for selective survival of IL-7Ralpha(+) effector cells is unknown. Our results show that in the absence of IL-7, IL-7Ralpha expression was extinguished on the majority of CD8 T cells responding to virus infection, sustained on a subset of effector cells transitioning to memory, and expressed at high levels by memory cells. Additionally, an IL-7-deficient environment was capable of supporting bcl-2 up-regulation and memory cell development in response to virus infection. Thus, IL-7Ralpha regulation occurs independently of IL-7 in responding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7Ralpha interactions. 相似文献
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In the past year, additional experimental data have expanded our understanding of the molecular mechanisms that underlie nuclear receptor control of regulatory programs. It is increasingly clear -that steroid members (e.g. glucocorticoid and estrogen) and non-steroid members (e.g. retinoic acid, thyroid hormone, and vitamin D) of the nuclear receptor superfamily may utilize distinct strategies in achieving their complex control of gene regulation. 相似文献
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Raspè E Mautino G Duval C Fontaine C Duez H Barbier O Monte D Fruchart J Fruchart JC Staels B 《The Journal of biological chemistry》2002,277(51):49275-49281
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Liu C Xu D Sjöberg J Forsell P Björkholm M Claesson HE 《Experimental cell research》2004,297(1):61-67