Ventral striatum: a critical look at models of learning and evaluation

Extensive evidence implicates the ventral striatum in multiple distinct facets of action selection. Early work established a role in modulating ongoing behavior, as engaged by the energizing and directing influences of motivationally relevant cues and the willingness to expend effort in order to obtain reward. More recently, reinforcement learning models have suggested the notion of ventral striatum primarily as an evaluation step during learning, which serves as a critic to update a separate actor. Recent computational and experimental work may provide a resolution to the differences between these two theories through a careful parsing of behavior and the instrinsic heterogeneity that characterizes this complex structure.     

Microbial consortia: a critical look at microalgae co-cultures for enhanced biomanufacturing

Monocultures have been the preferred production route in the bio-industry, where contamination has been a major bottleneck. In nature, microorganisms usually exist as part of organized communities and consortia, gaining benefits from co-habitation, keeping invaders at bay. There is increasing interest in the use of co-cultures to tackle contamination issues, and simultaneously increase productivity and product diversity. The feasibility of extending the natural phenomenon of co-habitation to the biomanufacturing industry in the form of co-cultures requires careful and systematic consideration of several aspects. This article will critically examine and review current work on microbial co-cultures, with the intent of examining the concept and proposing a design pipeline that can be developed in a biomanufacturing context.     

Monitoring rocky-shore communities: a critical look at spatial and temporal variation

Increasingly programmes are being set up to monitor rocky-shore communities in order to provide baseline data which will indicate changes resulting from subsequent pollution. However, these efforts are complicated by several factors. Firstly, there are overall changes in the composition of communities both within and between years. Secondly, there is variation within certain communities due to a mosaic distribution of components, the mosaic format changing continuously with a cycle of several years. This paper reports on studies of a medium-exposed rocky shore in the Isle of Man (U. K.). It describes patterns of spatial and temporal variation, and looks at certain implications for monitoring programmes: (a) the frequency of sampling, and the duration of the sampling programme, in the light of seasonal and long-term variation; (b) the efficiency, in terms of the minimisation of variability, of sampling the same area by different strategies — belt transects, small random quadrats, single large quadrat; (c) the effect of the distribution patterns of some commoner species on the variation between samples.     

Dreams and revelations: A critical look at Kelsey.

After a seven-century lull in Christian scholarship about dreams, the mid-Twentieth Century saw the beginning of a growing effort to convince Christians dreams are a significant means of communication with God. This essay summarizes and criticizes Morton Kelsey's central argument concerning the Christian significance of dreams in his God, dreams, and revelation (1991). Kelsey's is a thoughtful version of the argument common to his colleagues. As such, it displays both the strengths and the weaknesses of the general position. It correctly reminds Christians of dreams' significance in their past. But if Kelsey means to offer a fully supported logical argument, that argument is not clear and even the most sympathetic restatement of it leaves it unsound. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Specialist registration: a critical look at the proposals of the Merrison report.

In the general euphoria over the many views in the Merrison Report that the profession welcomed too little attention has been paid to what has been said about specialist registration. The report contains several basic confusions and a serious misunderstanding of the nature of specialist medical training and practice. It makes several cardinal errors in thinking that some notorious problems related to NHS staffing are also related to a lack of an effective specialist register, and it shows how the creation of such a register would largely destroy the authority of the colleges and faculties. Nowhere in the report is there any convincing argument to show that specialist registration would confer advantages sufficient to outweigh the disadvantages. To let specialist registration in the UK slip in on the irrelevant coat tails of EEC requirements would be a grave dereliction of the long-term interests of medical practice and patient care. The General Medical Council is holding a conference in which this topic is to be discussed on 24 February 1976 and it is still not too late for the profession to think again on this topic.     

A new look at the critical community size for childhood infections

Quasi-stationarity and time to extinction are studied for the classic endemic model. Attention is restricted to the transition region in parameter space where the quasi-stationary distribution is non-normal. A new approximation of the marginal distribution of infected individuals in quasi-stationarity is presented. It leads to a simple explicit expression for an approximation of the critical community size in terms of model parameters.     

A critical look at some widely used estimators in mark-resighting experiments

1. For many species and circumstances, mark-resighting procedures constitute valid alternatives to capture-recapture methods. Indeed, resightings are generally cheaper to acquire than physically recapturing and rehandling the animals, especially when radiotelemetry or other tracking devices are available. 2. In order to estimate population abundance, the joint hypergeometric maximum likelihood estimator, the Minta-Mangel estimator and the Bowden estimator are implemented in noremark, software which has become very popular with biologists in the past decade. 3. In this paper, the basic assumptions regarding these widely applied procedures are delineated and discussed. A simulation study is performed in order to investigate the robustness of the estimators under failure of the assumptions. 4. Theoretical considerations and simulation results motivate the use of the Bowden estimator which, when marks are distributed quite evenly among groups, constitutes the sole reliable method, offering computational simplicity and robustness. On the other hand, if the marks are distributed unevenly, no mark-resighting procedure seems reliable. An application to a case study is considered.     

A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content.

Many studies have demonstrated that the sensory and motor systems are activated during conceptual processing. Such results have been interpreted as indicating that concepts, and important aspects of cognition more broadly, are embodied. That conclusion does not follow from the empirical evidence. The reason why is that the empirical evidence can equally be accommodated by a 'disembodied' view of conceptual representation that makes explicit assumptions about spreading activation between the conceptual and sensory and motor systems. At the same time, the strong form of the embodied cognition hypothesis is at variance with currently available neuropsychological evidence. We suggest a middle ground between the embodied and disembodied cognition hypotheses--grounding by interaction. This hypothesis combines the view that concepts are, at some level, 'abstract' and 'symbolic', with the idea that sensory and motor information may 'instantiate' online conceptual processing.     

Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation

Recently, investigation of new neurons in memory formation has focused on a specific function-pattern separation. However, it has been difficult to reconcile the form of separation tested in behavioral tasks with how it is conceptualized according to computational and electrophysiology perspectives. Here, we propose a memory resolution hypothesis that considers the unique information contributions of broadly tuned young neurons and highly specific mature neurons and describe how the fidelity of memories can relate to spatial and contextual discrimination. See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A?Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron.     

Carbon sequestration in tropical forests and water: a critical look at the basis for commonly used generalizations

Tree planting in the tropics is conducted for a number of reasons including carbon sequestration, but often competes with increasingly scarce water resources. The basics of forest and water relations are frequently said to be well understood but there is a pressing need to better understand and predict the hydrological effects of land‐use and climate change in the complex and dynamic landscapes of the tropics. This will remain elusive without the empirical data required to feed hydrological process models. It is argued that the current state of knowledge is confused by too broad a use of the terms ‘forest’ and ‘(af)forestation’, as well as by a bias towards using data generated mostly outside the tropics and for nondegraded soil conditions. Definitions of forest, afforestation and reforestation as used in the climate change community and their application by land and water managers need to be reconciled.     

Proteomics: a subcellular look at spermatozoa

Background  

Male-factor infertility presents a vexing problem for many reproductively active couples. Many studies have focused on abnormal sperm parameters. Recent advances in proteomic techniques, especially in mass spectrometry, have aided in the study of sperm and more specifically, sperm proteins. The aim of this study was to review the current literature on the various proteomic techniques, and their usefulness in diagnosing sperm dysfunction and potential applications in the clinical setting.     

CMA conference to look at role research plays when critical policy decisions are being made

Physician leaders will meet in Ottawa Feb. 28 and Mar. 1 for the CMA''s 9th Annual Leadership Conference to examine how evidence, research and data influence health policy. For information or to register contact CMA Meetings and Travel Department, 800 663-7336, ext. 2274; fax 613 731-8047.     

A critical look at the Treatise family-group classification of Conodonta: an exercise in eclecticism

The family-group classification of conodonts presented in the revised edition of the Treatise on Invertebrate Paleontology, Part W, Supplement 2, Conodonta, published in 1981, is shown to contain errors with regard to the International Code of Zoological Nomenclature. The classification lacks a concise philosophical and methodological foundation and exhibits very poor conceptualization of the taxa it recognizes. The classification is analyzed and discussed in terms of, among Linnkan taxonomists, generally accepted objectives and conventions with regard to the internal structure and phylogenetic message of a hierarchical natural classification. The obvious errors in terms of the ICZN are pointed out and corrected. As a demonstration of an alternative approach, a classification of the superfamilies Prioniodontacea, Hibbardellacea, and Icriodontacea is presented.