共查询到20条相似文献,搜索用时 31 毫秒
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J A Engelman X L Zhang B Razani R G Pestell M P Lisanti 《The Journal of biological chemistry》1999,274(45):32333-32341
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The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells 总被引:3,自引:0,他引:3
Tsai JC Liu L Guan J Aird WC 《American journal of physiology. Cell physiology》2000,279(5):C1414-C1424
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v-Fps-responsiveness in the Egr-1 promoter is mediated by serum response elements. 总被引:5,自引:0,他引:5
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K Alexandropoulos S A Qureshi M Rim V P Sukhatme D A Foster 《Nucleic acids research》1992,20(9):2355-2359
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Ruo-Pan Huang Lan Ngo Daryl Okamura Mark Tucker Eileen D. Adamson 《Journal of cellular biochemistry》1994,56(4):469-479
The early growth response gene, Egr-1, is up-regulated transiently by mitogens and many other simuli in all cells tested. Using NIH3T3 cells conditionally expressing v-sis from a metallothionein promoter, we show that the addition of Zn2+ stimulates the production of PDGF-B(v-sis) and elicits the expression of Egr-1 in a dose-dependent and time-regulated manner. The signal is likely independent of protein kinase C, but depends on tyrosine kinase and other kinase activities and is mediated by c-Ha-Ras since the presence of dominant-negative mutants of Ras and Raf abrogates the induction of Egr-1 expression by Zn2+. Transiently activated Ras expression in NIH3T3 cells also stimulates the transient expression of Egr-1, but cells that constitutively express Rass do not have elevated levels of Egr-1. Transient assays also demonstrated that Zn2+ or activated Ras expression stimulated the activity of a 950 bp Egr-1 promoter-reporter gene construct and this is abrogated in the presence of mutant Ras and Raf. The accumulated data show that Egr-1 gene expression is regulated by multiple mechanisms, as would be needed for putative role in Cell proliferation, in suppression of transformation and in differentiation. 相似文献
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