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Chromatin structure of the HLA-DR alpha gene in different functional states of major histocompatibility complex class II gene expression. 总被引:4,自引:2,他引:2
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We utilized DNase I hypersensitivity mapping to study chromatin structure within the HLA-DR alpha gene. We found a single DNase I-hypersensitive site coinciding with the HLA-DR alpha gene promoter in all cells studied. Moreover, in cells that constitutively express HLA-DR, two additional DNase I-hypersensitive sites were observed. These lie within the first intron of the HLA-DR alpha gene and encompass DNA sequences that share homologies with regulatory loci of the immunoglobulin and immune response genes, as well as with core enhancer consensus sequences. 相似文献
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Interleukin-8 gene expression in human bronchial epithelial cells 总被引:28,自引:0,他引:28
H Nakamura K Yoshimura H A Jaffe R G Crystal 《The Journal of biological chemistry》1991,266(29):19611-19617
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Liver cells contain constitutive DNase I-hypersensitive sites at the xenobiotic response elements 1 and 2 (XRE1 and -2) of the rat cytochrome P-450IA1 gene and a constitutive, nuclear XRE-binding factor that is distinct from the dioxin receptor.
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J Hapgood S Cuthill P S?derkvist A Wilhelmsson I Pongratz R H Tukey E F Johnson J A Gustafsson L Poellinger 《Molecular and cellular biology》1991,11(9):4314-4323
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D B Jump 《The Journal of biological chemistry》1989,264(8):4698-4703
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