Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α

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RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

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Inhibition of talin-induced integrin activation by a double-hit stapled peptide

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise

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Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch

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Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy

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Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis

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Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM

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Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling

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Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism

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An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking

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Embryonic Stem Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK

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Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

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Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

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A general chemical principle for creating closure-stabilizing integrin inhibitors

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Flow-induced Reorganization of Laminin-integrin Networks Within the Endothelial Basement Membrane Uncovered by Proteomics

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Highlights

• •Proteomics uncovers the flow-induced remodeling of the endothelial basement membrane.
• •Flow alters the composition and localization of the laminin-integrin network.
• •Flow induces proteolytic processing of LAMA4, resulting in shedding of LG4–5 region.
• •TNFα- and flow-exposure induce a distinct proteomic signature with limited interplay.

     

A pair of readers of bivalent chromatin mediate formation of Polycomb-based “memory of cold” in plants

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