Life Course Perspectives on Women's Autonomy and Health Outcomes

Gender inequality leads to negative demographic consequences in many societies. Patterns of household formation and inheritance strongly influence these consequences. Peasant societies of preindustrial northern Europe emphasized the conjugal bond, while intergenerational bonds were weak. The reverse is true in contemporary northern India. As a result, greater potential exists there for marginalizing women. The convergence of low autonomy due to youth as well as gender means that women's autonomy is at its lowest point during the peak of childbearing years. This has considerable implications for demographic and health outcomes in terms of poorer child survival, slower fertility decline, and poorer reproductive health.     

Gender,Violence and HIV: Women's Survival in the Streets

In this article I propose that genderinequality promotes – directly or indirectly –vulnerability to HIV as a consequence of amultidimensional violence (structural, symbolicand physical) experienced by injection drugusing (IDU) women in The Mission District (SanFrancisco). Given the female subordinated positionstipulated by the street ideology, I analyzehow drug dependence afforded by precariousstrategies of subsistence places IDU womenunder multiple dangers and threats. In thissetting, unequal gender relations are part of acomplex system of transactions in the streeteconomy and a way to reduce or increase theeveryday violence. Facing multiple dangers andrisks, some women adopt a subordinatedposition, some try to negotiate the conditionsof the exchanges and the others resist theexploitation. Finally, everyday violence under conditions ofgender inequality and scarcity of resourcesimposes a logic defined by the challenge ofsurvival under the threat of immediate dangers,which transform HIV into a secondary risk.     

Canadian Medical Student Interest in General Practice and the Specialties

The interest of 1900 Canadian medical students in the various fields of medical practice was measured by a questionnaire. The students were asked to rank the various fields in order of their interest in them. It was found that general practice, internal medicine and surgery were the fields which consistently captured most interest among the students. Few students ranked dermatology, administration, teaching and research in the first three ranks.Striking differences in the interest preferences of male and female students were demonstrated, with the women ranking pediatrics and psychiatry higher than the men. Significantly more men, however, expressed a prime interest in surgery.Interest in general practice increases with the senior years in medical school, but it was shown that this increase is associated with marital status and with the number of children rather than with the year of training alone.Interest in the fields of medical practice varied between medical schools, with general practice ranking highest at British Columbia and relatively low at McGill and Manitoba. Significant differences between the students of the schools were displayed in the case of neurology, obstetrics, pediatrics and psychiatry.     

Evidence That Personal Genome Testing Enhances Student Learning in a Course on Genomics and Personalized Medicine

An emerging debate in academic medical centers is not about the need for providing trainees with fundamental education on genomics, but rather the most effective educational models that should be deployed. At Stanford School of Medicine, a novel hands-on genomics course was developed in 2010 that provided students the option to undergo personal genome testing as part of the course curriculum. We hypothesized that use of personal genome testing in the classroom would enhance the learning experience of students. No data currently exist on how such methods impact student learning; thus, we surveyed students before and after the course to determine its impact. We analyzed responses using paired statistics from the 31 medical and graduate students who completed both pre-course and post-course surveys. Participants were stratified by those who did (N = 23) or did not (N = 8) undergo personal genome testing. In reflecting on the experience, 83% of students who underwent testing stated that they were pleased with their decision compared to 12.5% of students who decided against testing (P = 0.00058). Seventy percent of those who underwent personal genome testing self-reported a better understanding of human genetics on the basis of having undergone testing. Further, students who underwent personal genome testing demonstrated an average 31% increase in pre- to post-course scores on knowledge questions (P = 3.5×10⁻⁶); this was significantly higher (P = 0.003) than students who did not undergo testing, who showed a non-significant improvement. Undergoing personal genome testing and using personal genotype data in the classroom enhanced students'' self-reported and assessed knowledge of genomics, and did not appear to cause significant anxiety. At least for self-selected students, the incorporation of personal genome testing can be an effective educational tool to teach important concepts of clinical genomic testing.     

Impact of Visual Context on Public Perceptions of Non-Human Primate Performers

Prior research has shown that the use of apes, specifically chimpanzees, as performers in the media negatively impacts public attitudes of their conservation status and desirability as a pet, yet it is unclear whether these findings generalize to other non-human primates (specifically non-ape species). We evaluated the impact of viewing an image of a monkey or prosimian in an anthropomorphic or naturalistic setting, either in contact with or in the absence of a human. Viewing the primate in an anthropomorphic setting while in contact with a person significantly increased their desirability as a pet, which also correlated with increased likelihood of believing the animal was not endangered. The majority of viewers felt that the primates in all tested images were “nervous.” When shown in contact with a human, viewers felt they were “sad” and “scared”, while also being less “funny.” Our findings highlight the potential broader implications of the use of non-human primate performers by the entertainment industry.     

The Effect of Calf Gender on Milk Production in Seasonal Calving Cows and Its Impact on Genetic Evaluations

Gender of the calf whose birth initiates lactation could influence whole lactation milk yield of the dam due to hormonal influences on mammary gland development, or through calf gender effects on gestation length. Fetal gender could influence late lactation yields because cows become pregnant at peak lactation. The effects of calf gender sequences in parities 1–3 were assessed by separately fitting animal models to datasets from New Zealand comprising 274 000 Holstein Friesian and 85 000 Jersey cows, decreasing to 12 000 and 4 000 cows by parity 3. The lactation initiated by the birth of a female rather than a male calf was associated with a 0.33–1.1% (p≤0.05) higher milk yield. Female calf gender had carryover effects associated with higher milk yield in second lactations for Holstein Friesians (0.24%; p = 0.01) and third lactations for Jerseys (1.1%; p = 0.01). Cows giving birth to bull calves have 2 day longer gestations, which reduces lactation length in seasonal calving herds. Adding a covariate for lactation length to the animal model eroded some of these calf gender effects, such that calving a female led to higher milk yield only for second lactation Holstein Friesians (1.6%; p = 0.002). The interval centering method generates lower estimates of whole lactation yield when Wood’s lactation curves are shifted to the right by 2 days for male calves and this explained the higher yield in female calves when differences in lactation length were considered. Correlations of estimated breeding values between models including or excluding calf gender sequence were 1.00 for bulls or cows. Calf gender primarily influences milk yield through increased gestation length of male calves, and bias associated with the interval centering method used to estimate whole lactation milk yields. Including information on calf gender is unlikely to have an effect on selection response in New Zealand dairy cattle.     

The Possible Role of Resource Requirements and Academic Career-Choice Risk on Gender Differences in Publication Rate and Impact

Many studies demonstrate that there is still a significant gender bias, especially at higher career levels, in many areas including science, technology, engineering, and mathematics (STEM). We investigated field-dependent, gender-specific effects of the selective pressures individuals experience as they pursue a career in academia within seven STEM disciplines. We built a unique database that comprises 437,787 publications authored by 4,292 faculty members at top United States research universities. Our analyses reveal that gender differences in publication rate and impact are discipline-specific. Our results also support two hypotheses. First, the widely-reported lower publication rates of female faculty are correlated with the amount of research resources typically needed in the discipline considered, and thus may be explained by the lower level of institutional support historically received by females. Second, in disciplines where pursuing an academic position incurs greater career risk, female faculty tend to have a greater fraction of higher impact publications than males. Our findings have significant, field-specific, policy implications for achieving diversity at the faculty level within the STEM disciplines.     

Affective Computing and the Impact of Gender and Age

Affective computing aims at the detection of users’ mental states, in particular, emotions and dispositions during human-computer interactions. Detection can be achieved by measuring multimodal signals, namely, speech, facial expressions and/or psychobiology. Over the past years, one major approach was to identify the best features for each signal using different classification methods. Although this is of high priority, other subject-specific variables should not be neglected. In our study, we analyzed the effect of gender, age, personality and gender roles on the extracted psychobiological features (derived from skin conductance level, facial electromyography and heart rate variability) as well as the influence on the classification results. In an experimental human-computer interaction, five different affective states with picture material from the International Affective Picture System and ULM pictures were induced. A total of 127 subjects participated in the study. Among all potentially influencing variables (gender has been reported to be influential), age was the only variable that correlated significantly with psychobiological responses. In summary, the conducted classification processes resulted in 20% classification accuracy differences according to age and gender, especially when comparing the neutral condition with four other affective states. We suggest taking age and gender specifically into account for future studies in affective computing, as these may lead to an improvement of emotion recognition accuracy.     

The Impact of Gender Norms on Condom Use among HIV-Positive Adults in KwaZulu-Natal,South Africa

Critical to preventing the spread of HIV is promoting condom use among HIV-positive individuals. Previous studies suggest that gender norms (social and cultural constructions of the ways that women and men are expected to behave) may be an important determinant of condom use. However, the relationship has not been evaluated among HIV-positive women and men in South Africa. We examined gender norms and condom use at last sex among 550 partnerships reported by 530 sexually-active HIV-positive women (372) and men (158) who had sought care, but not yet initiated antiretroviral therapy in a high HIV-prevalence rural setting in KwaZulu-Natal, South Africa between January 2009 and March 2011. Participants enrolled in the cohort study completed a baseline questionnaire that detailed their socio-demographic characteristics, socio-economic circumstances, religion, HIV testing history and disclosure of HIV status, stigma, social capital, gender norms and self-efficacy. Gender norms did not statistically differ between women and men (p = 0.18). Overall, condoms were used at last sex in 58% of partnerships. Although participants disclosed their HIV status in 66% of the partnerships, 60% did not have knowledge of their partner’s HIV status. In multivariable logistic regression, run separately for each sex, women younger than 26 years with more equitable gender norms were significantly more likely to have used a condom at last sex than those of the same age group with inequitable gender norms (OR = 8.88, 95% CI 2.95–26.75); the association between condom use and gender norms among women aged 26+ years and men of all ages was not statistically significant. Strategies to address gender inequity should be integrated into positive prevention interventions, particularly for younger women, and supported by efforts at a societal level to decrease gender inequality.     

Student Perceptions of,and Attitudes toward,Bats in Barak Valley,Assam, India

Bats are commonly found all over the world and provide significant ecosystem services. These animals are facing serious threats due to various anthropogenic activities, including hunting. Additionally, bats are often not particularly well liked due to their non-aesthetic characteristics. A positive attitude to these animals is essential to protect them through appropriate conservation measures involving public intervention. Current high school students are the conservationists of the future, and the extent of support for bat conservation received from this and future generations is dependent upon their attitude toward these animals. It is therefore important to assess their perceptions of bats so that appropriate awareness programs can be devised, and negative attitudes (if any) rectified. The present study aimed to understand this aspect in order to provide inputs for shaping positive attitudes toward bat conservation. The study was undertaken in Barak Valley, Assam, India, where 65 bat colonies had already been recorded. A total of 3,059 high school students from 36 schools situated in their vicinity were questioned using a close-ended questionnaire to determine their perceptions. The responses received were divided among three categories: familiarity with bats, opinion on bats, and attitudes toward conservation, and were ranked on a scale of 10, based on selected aspects. Most students were awarded a score of four, indicating an average knowledge and opinion of bats. These findings suggest that awareness programs are urgently needed in schools to improve the general knowledge of and attitudes toward bats, and to inspire the next generation of bat conservationists.     

Evaluation Studies of The Nuffield A-Level Biology Trials 3. Student Characteristics and Achievement

An abstract of the project which won the title of “Young Biologist of the Year 1973” for Neil R. Beatson, Sixth Form, Clifton College, Bristol.     

The Impact of Study Size on Meta-analyses: Examination of Underpowered Studies in Cochrane Reviews

Background

Most meta-analyses include data from one or more small studies that, individually, do not have power to detect an intervention effect. The relative influence of adequately powered and underpowered studies in published meta-analyses has not previously been explored. We examine the distribution of power available in studies within meta-analyses published in Cochrane reviews, and investigate the impact of underpowered studies on meta-analysis results.

Methods and Findings

For 14,886 meta-analyses of binary outcomes from 1,991 Cochrane reviews, we calculated power per study within each meta-analysis. We defined adequate power as ≥50% power to detect a 30% relative risk reduction. In a subset of 1,107 meta-analyses including 5 or more studies with at least two adequately powered and at least one underpowered, results were compared with and without underpowered studies. In 10,492 (70%) of 14,886 meta-analyses, all included studies were underpowered; only 2,588 (17%) included at least two adequately powered studies. 34% of the meta-analyses themselves were adequately powered. The median of summary relative risks was 0.75 across all meta-analyses (inter-quartile range 0.55 to 0.89). In the subset examined, odds ratios in underpowered studies were 15% lower (95% CI 11% to 18%, P<0.0001) than in adequately powered studies, in meta-analyses of controlled pharmacological trials; and 12% lower (95% CI 7% to 17%, P<0.0001) in meta-analyses of controlled non-pharmacological trials. The standard error of the intervention effect increased by a median of 11% (inter-quartile range −1% to 35%) when underpowered studies were omitted; and between-study heterogeneity tended to decrease.

Conclusions

When at least two adequately powered studies are available in meta-analyses reported by Cochrane reviews, underpowered studies often contribute little information, and could be left out if a rapid review of the evidence is required. However, underpowered studies made up the entirety of the evidence in most Cochrane reviews.     

Mechanistic Studies on Thiaminase I : 1. The Stereochemical Course of the Reaction

Thiaminase I catalyzes the displacement of the thiazole moiety of thiamin by a wide variety of nucleophiles. In this paper, we demonstrate that this reaction proceeds with overall retention of stereochemistry.     

Perceptions and Measurements: The Assessment of Pasture States in a Semi-Arid Area of Namibia

How farmers perceive the state of their pastures is an important component of their management decisions and affects natural resources in arid and semi-arid regions. In an explorative study conducted in the Rehoboth farm area of central Namibia, we addressed the question whether the judgments of commercial farmers on pasture conditions are consistent with a botanical assessment of these pastures based on measurements. The perceptions were inferred from the comparative statements of farmers on the pasture quality of adjacent farm pairs. For the botanical assessment, biomass and plant species frequency counts of the same pastures were used. The results of the statistical analysis show a large agreement between perceived and measured pasture states of corresponding farm pairs, thus pasture quality dimensions perceived by the farmers agreed with the measured pasture quality variables. We also discuss the problems of designing more elaborate studies of this type.     

Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort

DNA methylation is an epigenetic mechanism that regulates gene expression and can be modified by one-carbon nutrients. The objective of this study was to investigate the impact of folic acid (FA) fortification of the US food supply on leukocyte global DNA methylation and the relationship between DNA methylation, red blood cell (RBC) folate, and other one-carbon biomarkers among postmenopausal women enrolled in the Women's Health Initiative Observational Study. We selected 408 women from the highest and lowest tertiles of RBC folate distribution matching on age and timing of the baseline blood draw, which spanned the pre- (1994–1995), peri- (1996–1997), or post-fortification (1998) periods. Global DNA methylation was assessed by liquid chromatography-tandem mass spectrometry and expressed as a percentage of total cytosine. We observed an interaction (P = 0.02) between fortification period and RBC folate in relation to DNA methylation. Women with higher (vs. lower) RBC folate had higher mean DNA methylation (5.12 vs. 4.99%; P = 0.05) in the pre-fortification period, but lower (4.95 vs. 5.16%; P = 0.03) DNA methylation in the post-fortification period. We also observed significant correlations between one-carbon biomarkers and DNA methylation in the pre-fortification period, but not in the peri- or post-fortification period. The correlation between plasma homocysteine and DNA methylation was reversed from an inverse relationship during the pre-fortification period to a positive relationship during the post-fortification period. Our data suggest that (1) during FA fortification, higher RBC folate status is associated with a reduction in leukocyte global DNA methylation among postmenopausal women and; (2) the relationship between one-carbon biomarkers and global DNA methylation is dependent on folate availability.