Human operator dynamics in manual tracking systems with auditory input

Response characteristics of human operators in manual pursuit tracking with auditory input are investigated. The human operator hears in his left ear a sound whose frequency varies in proportion to an external random signal. At the same time, he hears in his right ear another sound whose frequency varies in proportion to the angle of a control lever of a potentiometer. The operator controls the angle of the lever so that the frequencies of the sounds in both ears remain as close as possible. The dynamics of the human operator is studied by assuming a manmachine system whose input is the external signal and whose output is the voltage of the potentiometer. A learning identification method proposed by one of the authors is used to calculate the weighting function of the man-machine system, which is displayed on a CRT screen in real time. During the tracking task, the skin potential activity (SPA) is measured as an index of arousal of the operator.     

Hemispheric asymmetry of movement

Studies in brain-damaged patients indicate that the left hemisphere in right-handers is specialized for controlling cognitive-motor tasks in both arms. Recent functional imaging data support this conclusion, with the finding that ipsilateral, as well as contralateral, movements activate the left, but not the right, motor cortex or associated areas of either hemisphere. Future studies must aspire to identify the mechanisms for this asymmetry.     

The auditory sensory epithelium: the instrument of sound perception

The auditory sensory epithelium is the specialized region of the cochlear epithelium that transduces sound. It is composed of a highly ordered, repeated array of mechanosensory hair cells and nonsensory supporting cells that run along the length of the cochlea. On the apical surface of the hair cells is a specialized structure called the hair bundle that deflects in response to sound vibration, resulting in depolarization of the hair cell and neurotransmitter release. Formation of the auditory sensory epithelium during embryogenesis involves strict control of both cell proliferation and cell patterning. Misregulation of these events can lead to congenital hearing loss, and damage to the auditory sensory epithelium during adult life can lead to adult-onset deafness. This paper reviews recent data on the formation of the auditory sensory epithelium during embryogenesis, the identification of components of the sound transduction apparatus, and advances in the treatment of hearing impairment.     

The evolution of fidelity in sensory systems

We investigate the effect that noise has on the evolution of measurement strategies and competition in populations of organisms with sensory systems of differing fidelities. We address two questions motivated by experimental and theoretical work on sensory systems in noisy environments: (1) How complex must a sensory system be in order to face the need to develop adaptive measurement strategies that change depending on the noise level? (2) Does the principle of competitive exclusion for sensory systems force one population to win out over all others? We find that the answer to the first question is that even very simple sensory systems will need to change measurement strategies depending on the amount of noise in the environment. Interestingly, the answer to the second question is that, in general, at most two populations with different fidelity sensory systems may co-exist within a single environment.     

The sensory and motor roles of auditory hair cells

Cochlear hair cells respond with phenomenal speed and sensitivity to sound vibrations that cause submicron deflections of their hair bundle. Outer hair cells are not only detectors, but also generate force to augment auditory sensitivity and frequency selectivity. Two mechanisms of force production have been proposed: contractions of the cell body or active motion of the hair bundle. Here, we describe recently identified proteins involved in the sensory and motor functions of auditory hair cells and present evidence for each force generator. Both motor mechanisms are probably needed to provide the high sensitivity and frequency discrimination of the mammalian cochlea.     

Functional differentiation of sensory cells in the avian auditory periphery

Summary Mammals and birds have independently developed different populations of sensory cells grouped across the width of their auditory papillae. Although in mammals there is clear evidence for disparate functions for the two hair-cell populations, the different anatomical pattern in birds has made comparisons difficult. In two species of birds, we have used single-fibre staining techniques to trace physiologically-characterized primary auditory nerve fibres to their peripheral synapses. As in mammals, acoustically-active afferent fibres of these birds innervate exclusively the neurally-lying group of hair cells in a 11 relationship, suggesting important parallels in the functional organization of the auditory papillae in these two vertebrate classes. In addition, we found a strong trend of the threshold to acoustic stimuli at the characteristic frequency across the width of the avian papilla.Abbreviations IHC inner hair cell(s) - OHC outer hair cell(s) - SHC short hair cell(s) - THC tall hair cell(s)     

Induction of coordinated movement of Myxococcus xanthus cells.

Rhythmically advancing waves of cells, called ripples, arise spontaneously during the aggregation of Myxococcus xanthus into fruiting bodies. Extracts prepared by washing rippling cells contain a substance that will induce quiescent cells to ripple. Three lines of evidence indicate that murein (peptidoglycan) is the ripple-inducing substance in the extracts. First, ripple-inducing activity is associated with the cell envelope of sonically disrupted M. xanthus cells. Second, whole cells, cell extracts, or purified murein from a variety of different bacteria are capable of inducing ripples. In contrast, extracts prepared from Methanobacterium spp. which contain pseudomurein instead of typical bacterial murein fail to induce ripples. Third, four components of M. xanthus murein, N-acetylglucosamine, N-acetylmuramic acid, diaminopimelate, and D-alanine, are able to induce ripples. Ripples produced by aggregating cells have a wavelength of 45 micrometers and a maximum velocity of 2 micrometers/min. Both of the multigene systems that control gliding motility appear to be required for rippling, and all known mutations at the spoC locus eliminate both rippling and sporulation.     

The structural organization of the snail sensory systems]

In the paper are reviewed the author's data on the structure of peripheral nervous system of the body wall, gravitational organs--statocysts, eyes, and organs of distant chemoreception--ommatophors, or posterior head tentacles, of the snails Helix vulgaris and Helix pomatia. Localization in the CNS of central parts of the main sensory systems is shown and some structural characteristics of them are described. The data on the organization of the procerebrum which takes part in processing of information from the receptors of the head tentacles are presented. By some morphological features the procerebrum may be considered as one of the highest associative centers of the snails. The data under consideration were obtained by means of silver impregnation by Golgi, retro- and anterograde infusion of CoCl2, horseradish peroxidase and Lucifer yellow into the nerves, as well as by means of a number of other classical histological techniques.     

The asymmetry of movement direction in freshwater shrimp (Gammarus oceanicus) in the open-field test

Behaviour of Gammarus oceanicus was studied in the open field test. For the whole except (n = 204) spatial-motor asymmetry was found. It was manifested in significantly greater number of movements clockwise (to the right) than counterclockwise (to the left). Animals with significant asymmetry dominated, forming 93.5% of the except. The asymmetry was characterized by distinct right-sided direction. Motor activity and spatial-motor asymmetry at repeated tests in the main weakened; the changes in "right" and "left" animals were manifested differently. The essential factor which disturbed the behaviour of the animals in the open field test (including the asymmetry of movement direction) proved to be a toxicant (oil pollution) action.     

Extending the HKB model of coordinated movement to oscillators with different eigenfrequencies

 We study the dynamics of a system of coupled nonlinear oscillators that has been used to model coordinated human movement behavior. In contrast to earlier work we examine the case where the two component oscillators have different eigenfrequencies. Problems related to the decomposition of a time series (from an experiment) into amplitude and phase are discussed. We show that oscillations at multiples of the main frequency of the oscillator system may occur in the phase and amplitude due to the choice of a coordinate system and how these oscillations can be eliminated. We derive an explicit equation for the dynamics of the relative phase of the oscillator system in phase space that enables a direct comparison between theory and experiment. Received: 30 December 1994/Accepted in revised form: 27 June 1995     

Extending the HKB model of coordinated movement to oscillators with different eigenfrequencies

We study the dynamics of a system of coupled nonlinear oscillators that has been used to model coordinated human movement behavior. In contrast to earlier work we examine the case where the two component oscillators have different eigenfrequencies. Problems related to the decomposition of a time series (from an experiment) into amplitude and phase are discussed. We show that oscillations at multiples of the main frequency of the oscillator system may occur in the phase and amplitude due to the choice of a coordinate system and how these oscillations can be eliminated. We derive an explicit equation for the dynamics of the relative phase of the oscillator system in phase space that enables a direct comparison between theory and experiment.     

Fast motility of isolated mammalian auditory sensory cells

Auditory sensory cells (hair cells) are responsible for sound transduction in the cochlea of the inner ear. In the presence of a longitudinal a.c. field isolated living outer hair cells showed reversible motile responses. They followed the stimulus up to at least 1 kHz. Control experiments in the presence of cytochalasin B, phalloidin and dinitrophenol excluded actomyosin as a molecular basis of the high frequency motility. The results suggest, that outer hair cells might amplify sound-induced oscillations in the inner ear and thus increase sensitivity and frequency selectivity of hearing.     

Characterizing asymmetry across the whole sit to stand movement in healthy participants

Sit-to-stand transfer (STS) is a common yet critical prerequisite for many daily tasks. Literature conducted on healthy STS often assume the body to behave symmetrically across the left and right side; yet only a few studies have been conducted to investigate this supposition. These studies have focused on a single numerical indicator such as peak joint moment (JM) values to describe symmetricity; however, STS is a dynamic and time dependent movement. This study addresses the validity of peak value analyses through the introduction of a time based peak-offset measure and proposes two time-dependent techniques to further characterize asymmetry and assesses their feasibility in ten (10) healthy male participants. JM and joint power (JP) over the whole STS movement was determined using motion capture and inverse dynamics. Using a paired one-tailed t-test differences were found in the time at which the left and right side reached peak values in all lower extremity joints (p<0.05) with exception of the hip JM. Using a measure of JM and JP straight-difference it was determined that the ankle joint displayed the largest number of JM and JP development strategies of all the lower extremity joints. Finally, through numerical integration of the JM and JP data with respect to time, it was found that the longer one side spends dominating the movement, the larger the excess angular impulse and work that can be expected from that side. The results suggest that when analyzing STS movements, one must be aware of the potential asymmetry present even in healthy movements. Furthermore, a simple peak JM or JP analysis may not fully describe the extent of these asymmetries.