共查询到20条相似文献,搜索用时 78 毫秒
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In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions 总被引:5,自引:0,他引:5
Miao F Gonzalo IG Lanting L Natarajan R 《The Journal of biological chemistry》2004,279(17):18091-18097
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Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. 总被引:14,自引:0,他引:14
H Wang R Cao L Xia H Erdjument-Bromage C Borchers P Tempst Y Zhang 《Molecular cell》2001,8(6):1207-1217
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Stadler F Kolb G Rubusch L Baker SP Jones EG Akbarian S 《Journal of neurochemistry》2005,94(2):324-336
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Heterochromatin is an epigenetically heritable and conserved feature of eukaryotic chromosomes with important roles in chromosome segregation, genome stability, and gene regulation. The formation of heterochromatin involves an ordered array of chromatin changes, including histone deacetylation, histone H3-lysine 9 methylation, and recruitment of histone binding proteins such as Swi6/HP1. Recent discoveries have uncovered a role for the RNA interference (RNAi) pathway in heterochromatin assembly in the fission yeast Schizosaccharomyces pombe and other eukaryotes. Purification of two RNAi complexes, RITS and RDRC, from fission yeast has provided further insight into the mechanism of RNAi-mediated heterochromatin assembly. These discoveries have given rise to a model in which small interfering RNA molecules act as specificity factors that initiate epigenetic chromatin modifications and double strand RNA synthesis at specific chromosome regions. 相似文献
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Guillermo Pablo Vicent Roser Zaurin A. Silvina Nacht Ang Li Jofre Font-Mateu Francois Le Dily Michiel Vermeulen Matthias Mann Miguel Beato 《PLoS genetics》2009,5(7)
Steroid hormones regulate gene expression by interaction of their receptors with hormone responsive elements (HREs) and recruitment of kinases, chromatin remodeling complexes, and coregulators to their target promoters. Here we show that in breast cancer cells the BAF, but not the closely related PBAF complex, is required for progesterone induction of several target genes including MMTV, where it catalyzes localized displacement of histones H2A and H2B and subsequent NF1 binding. PCAF is also needed for induction of progesterone target genes and acetylates histone H3 at K14, an epigenetic mark that interacts with the BAF subunits by anchoring the complex to chromatin. In the absence of PCAF, full loading of target promoters with hormone receptors and BAF is precluded, and induction is compromised. Thus, activation of hormone-responsive promoters requires cooperation of at least two chromatin remodeling activities, BAF and PCAF. 相似文献
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《Trends in biochemical sciences》2023,48(4):321-330
The concept of the histone code posits that histone modifications regulate gene functions once interpreted by epigenetic readers. A well-studied case is trimethylation of lysine 4 of histone H3 (H3K4me3), which is enriched at gene promoters. However, H3K4me3 marks are not needed for the expression of most genes, suggesting extra roles, such as influencing the 3D genome architecture. Here, we highlight an intriguing analogy between the H3K4me3-dependent induction of double-strand breaks in several recombination events and the impact of this same mark on DNA incisions for the repair of bulky lesions. We propose that Su(var)3–9, Enhancer-of-zeste and Trithorax (SET)-domain methyltransferases generate H3K4me3 to guide nucleases into chromatin spaces, the favorable accessibility of which ensures that DNA break intermediates are readily processed, thereby safeguarding genome stability. 相似文献
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