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1.
Ota T Degani A Zubiate B Wolf A Choset H Schwartzman D Zenati MA 《Innovations (Philadelphia, Pa.)》2006,1(6):335-340
OBJECTIVE: Minimally invasive epicardial atrial ablation to cure atrial fibrillation through the use of a percutaneous subxiphoid approach currently has a lack of dedicated technology for intrapericardial navigation around the beating heart. We have developed a novel articulated robotic medical probe and performed preliminary experiments in a porcine preparation. METHODS: In five large, healthy pigs, the teleoperated robotic system was introduced inside the pericardial space through a percutaneous subxiphoid approach. Secondary visualization of the left atrium and left atrial appendage was achieved with the use of a 5-mm scope inserted through a left thoracic port. The operator actively controlled the path of the robot by using a master manipulator. The catheter, with an irrigated radiofrequency tip, was guided through the working port of the robot to achieve epicardial ablation of the left atrium. RESULTS: Access to the pericardial space and progression around the left atrium was successful in all cases, with no interference with the beating heart such as a fatal arrhythmia, unexpected bleeding, and hypotension. Epicardial ablation was successfully performed in all five cases. No adverse hemodynamic or electrophysiological events were noted during the trials. When the animals were killed, there was no visually detected injury on the surrounding mediastinal structures caused by ablation. Transmural ablation was confirmed by histopathology of the left atrium. CONCLUSIONS: We have developed a dedicated articulated robotic medical probe and successfully performed epicardial left atrial radiofrequency ablation. Based on the feedback from these preliminary experiments, the radius of curvature and proper visualization of the device are being improved in the next generation prototype. 相似文献
2.
We describe two cases in which a biventricular implantable cardioverter defibrillator for cardiac resynchronization therapy had to be placed on the right side due to unsuitability of the left subclavian vein. Endocardial implantation of a left ventricular lead through the coronary sinus was previously attempted but was unsuccessful. Implantation of the epicardial left ventricular pacing lead was performed through video-assisted thoracic surgery on the left side. The connector end of the left ventricular pacing lead was tunnelized through the anterior mediastinum into the right pleural space. The right-sided pocket was then opened. A tunnel was created from the pocket to the thoracic wall, and the pleural space was entered over the second rib. The lead was retrieved from the right pleural space and connected with the Cardiac resynchronization therapy-device (CRT-D). Both procedures and postoperative periods were uneventful. Intrathoracic left-to-right tunneling of an epicardial left ventricular lead by video-assisted thoracic surgery is feasible and safe. It provides an alternative to subcutaneous tunneling. 相似文献
3.
ABSTRACT: INTRODUCTION: Local aneurysms after surgical repair of coarctation of the aorta occur mainly in patients surgically treated by Dacron patch plasty during adulthood. The management of these patients is always problematic, with frequent complications and increased mortality rates. Percutaneous stent-graft implantation avoids the need for surgical reintervention. CASE PRESENTATION: We report a case involving the hybrid treatment by stent-graft implantation and transposition of the left subclavian artery to the left common carotid artery of an aneurysmal dilatation of the thoracic aorta that occurred in a 64-year-old Caucasian man, operated on almost 40 years earlier with a Dacron patch plasty for aortic coarctation. Our patient presented to our facility for evaluation with back pain and shortness of breath after minimal physical effort. A physical examination revealed stony dullness to percussion of the left posterior thorax, with no other abnormalities. The results of chest radiography, followed by contrast-enhanced computed tomography and aortography, led to a diagnosis of giant aortic thoracic aneurysm. Successful treatment of the aneurysm was achieved by percutaneous stent-graft implantation combined with transposition of the left subclavian artery to the left common carotid artery. His post-procedural recovery was uneventful. Three months after the procedure, computed tomography showed complete thrombosis of the excluded aneurysm, without any clinical signs of left lower limb ischemia or new onset neurological abnormalities. CONCLUSIONS: Our patient's case illustrates the clinical outcomes of surgical interventions for aortic coarctation. However, the very late appearance of a local aneurysm is rather unusual. Management of such cases is always difficult. The decision-making should be multidisciplinary. A hybrid approach was considered the best solution for our patient. 相似文献
4.
Antoine Pironet Pierre C. Dauby Sabine Paeme Sarah Kosta J. Geoffrey Chase Thomas Desaive 《PloS one》2013,8(6)
During a full cardiac cycle, the left atrium successively behaves as a reservoir, a conduit and a pump. This complex behavior makes it unrealistic to apply the time-varying elastance theory to characterize the left atrium, first, because this theory has known limitations, and second, because it is still uncertain whether the load independence hypothesis holds. In this study, we aim to bypass this uncertainty by relying on another kind of mathematical model of the cardiac chambers. In the present work, we describe both the left atrium and the left ventricle with a multi-scale model. The multi-scale property of this model comes from the fact that pressure inside a cardiac chamber is derived from a model of the sarcomere behavior. Macroscopic model parameters are identified from reference dog hemodynamic data. The multi-scale model of the cardiovascular system including the left atrium is then simulated to show that the physiological roles of the left atrium are correctly reproduced. This include a biphasic pressure wave and an eight-shaped pressure-volume loop. We also test the validity of our model in non basal conditions by reproducing a preload reduction experiment by inferior vena cava occlusion with the model. We compute the variation of eight indices before and after this experiment and obtain the same variation as experimentally observed for seven out of the eight indices. In summary, the multi-scale mathematical model presented in this work is able to correctly account for the three roles of the left atrium and also exhibits a realistic left atrial pressure-volume loop. Furthermore, the model has been previously presented and validated for the left ventricle. This makes it a proper alternative to the time-varying elastance theory if the focus is set on precisely representing the left atrial and left ventricular behaviors. 相似文献
5.
Clarke E 《Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences》2006,37(1):136-150
In A Darwinian left Peter Singer aims to reconcile Darwinian theory with left wing politics, using evolutionary game theory and in particular a model proposed by Robert Axelrod, which shows that cooperation can be an evolutionarily successful strategy. In this paper I will show that whilst Axelrod's model can give support to a kind of left wing politics, it is not the kind that Singer himself envisages. In fact, it is shown that there are insurmountable problems for the idea of increasing Axelrodian cooperation within a welfare state. My surprising conclusion will be that a Darwinian left worthy of the name would be anarchistic. 相似文献
6.
A fifth-month fetus and a newborn with amniogenic band anomalies were examined at autopsy. Both specimens were obtained from women who had undergone oophorectomy during early pregnancy. The dead male fetus was aborted spontaneously, and had a micrognathia, a right club foot, and a constriction ring on the left lower leg. The left fingers 2, 3, and 4 were attached to the placenta by a fibrous string. No internal anomaly was noted. In the other case, a male newborn was delivered at the 39th week of gestation and had an agenesis of the calvarium, a cleft lip with palate, an amputation of the right toe, and constriction rings on right fingers 3 and 4 and left finger 3. The placenta was attached to the left temporooccipital region of the head by a fibrous string. Also present was an atrial septum defect and a horseshoe kidney. Possible etiology is discussed in relation to the "amniogenic bands" hypotheses. 相似文献
7.
Ulphani JS Arora R Cain JH Villuendas R Shen S Gordon D Inderyas F Harvey LA Morris A Goldberger JJ Kadish AH 《American journal of physiology. Heart and circulatory physiology》2007,293(3):H1629-H1635
The objective of the study was to investigate the morphology, distribution, and electrophysiological profile of the autonomic fibers that innervate the ligament of Marshall (LOM). Gross anatomical dissections were performed in 10 dogs. Sections of the left vagus nerve, left stellate ganglion, and the LOM were immunostained to identify adrenergic and cholinergic nerves. Hearts were also stained for acetylcholinesterase to identify epicardial cholinergic nerves. In vivo electrophysiological studies were performed in another 10 dogs before and after LOM ablation. The anatomical examination revealed that the LOM is innervated by a branch of the left vagus. Immunohistochemistry confirmed that these nerve bundles are predominantly cholinergic (cholinergic-to-adrenergic ratio of 12.6 +/- 3.9:1). Cholinergic nerves originating in the LOM were found to innervate surrounding left atrial structures, including the pulmonary veins, left atrial appendage, coronary sinus, and posterior left atrial fat pad. Ablation of the LOM significantly attenuated effective refractory period shortening at distant sites, such as pulmonary veins and left atrial appendage, in response to vagal stimulation (vagal-induced ERP decrease in the left atrium: baseline vs. postablation = 17 vs. 4%; P = 0.0056). In conclusion, the LOM contains a predominance of cholinergic nerve fibers. Cholinergic fibers arising from the LOM innervate surrounding structures and contribute to the electrophysiological profile of the left atrium. These findings may provide a basis for the role of the LOM in the genesis and maintenance of atrial fibrillation. 相似文献
8.
LOEWENSTEIN WR 《The Journal of general physiology》1958,41(4):847-856
A period of supernormal excitability is left by a propagated impulse in a Pacinian corpuscle. The increase in excitability is found 6 to 10 msec. after an impulse occurs in the corpuscle. Supernormality is produced by either mechanically elicited dromic impulses, or by electrically excited antidromic impulses. Generator potentials do not cause supernormality. Local potentials discharged spontaneously by the corpuscle, and which fall on the supernormal trail left by an antidromic impulse, become enhanced in amplitude, an eventually are turned into propagated dromic potentials. The supernormal period is interpreted as caused by a negative after-potential left at the first intracorpuscular node of Ranvier which outlasts both the recovery time of the firing level and that of the generator potential during the corpuscle's relative refractory period. 相似文献
9.
The findings in a cadaver demonstrated: (a) an aberrant retroesophageal right subclavian artery (RRSA); (b) a thoracic duct (Th.d.) terminating at the junction of the right internal jugular and subclavian veins ('venous angle'), and (c) a left vertebral artery (LVA) of aortic origin. The origin of the RRSA from the aortic arch was distal and medial to the left subclavian artery and it reached the upper extremity by crossing posterior to the esophagus. The Th.d. ran a normal retroesophageal course in the mediastinum, until it was intercepted by the anomalous subclavian artery. At this level the Th.d. was deflected towards the right and, accompanied by the anomalous artery, reached the right venous angle. The LVA arose from the aortic arch between the left common carotid and the left subclavian arteries, and ascended to the transverse foramen of C6. The practical importance of associations in general is discussed, and the special diagnostic and surgical significance of the RRSA and Th.d. is stressed. 相似文献
10.
The right uterine horn of alpacas causes luteolysis in the right ovary, whereas the left horn causes luteolysis in both ovaries. Female reproductive tracts were studied in 32 adult llamas, 12 adult alpacas, and 21 mid-gestation female fetuses to determine if there is a dichotomy in the vascular anatomy between the 2 sides. Adult tracts were studied by either injection of colored latex into the veins and arteries followed by tissue clearing or by injection of colored fluids during transillumination. Fetal uteri were studied by transillumination. The angioarchitecture of the ovarian vascular pedicle was similar to that reported for ewes. There was no vessel comparable to the middle uterine artery, which is the largest uterine artery in the other farm species. A striking difference from the uterine vascular of other farm species was the presence of a major branch of the right uterine artery that crossed the cranial intercornual area to supply much of the left uterine horn. A corresponding major vein originated from the left horn, crossed the mid-line, and terminated as a branch of the right uterine vein. Thus, the vascular anatomy indicated that much venous blood from the left horn drained to the right side. This was confirmed by injection of colored fluid into a small venous branch at the tip of the left horn. The prominent cross-over vessels were observed in the fetal uteri, and the diameter of the left uterine fetal horn (6.7 +/- 0.6 mm) was greater (P < 0.001) than the diameter of the right horn (5.8 +/- 0.5 mm). The presence of a large cross-over vein traversing from the left horn to the right side is compatible with the hypothesis that the left horn can exert luteolytic control over the corpus luteum in the right ovary through a veno-arterial pathway. The area of veno-arterial transfer of the luteolysin from a vein containing blood from the left horn into an artery supplying the right ovary was not defined in this study. However, the results provide an anatomical basis for functional testing of the cross-over hypothesis and defining the area of venoarterial transfer in camelids. 相似文献
11.
Unilateral (left eye) optic nerve hypoplasia was detected in a six-month-old male Beagle dog. Vision testing indicated that the left eye had poor vision and testing the pupillary light reflex showed the left eye to have an absence of the afferent pathway of the reflex but it had a normal efferent pathway. Ophthalmoscopy revealed a small-sized optic disc, winding retinal artery and dilated retinal vasculature in the left globe. Electroretinography showed no abnormal findings even in the left globe. Histopathologically, the left optic nerve was markedly hypoplastic and was composed of sparse neural elements and a moderate amount of connective and glial tissues. In the retina of the left globe, the nerve fibre layer and the ganglion cell layer were reduced in thickness, although a small number of ganglion cells were still present. There were no abnormal findings detected in the right globe and the right optic nerve. The brain appeared normal macroscopically. 相似文献
12.
目的观察大鼠左肾静脉不同程度狭窄所致左肾病变,为实验研究左肾静脉受压综合征肾组织淤血性损伤提供合适的动物模型。方法采用左肾静脉不全结扎的方法建立大鼠左肾静脉狭窄模型。将大鼠分为4组,假手术组和左肾静脉狭窄1.0mm模型组、0.7mm模型组、0.5mm模型组。术后7周处死动物。肾组织行病理学检查。肾皮质匀浆检测丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性。结果病理学检查见1.0mm模型组未见明显病变,0.7mm和0.5mm模型组肾小球系膜区增生,小管、间质细胞浸润和纤维化形成,0.5mm模型组病变程度较重。各模型组左肾皮质丙二醛含量均显著增高,超氧化物歧化酶活性均显著降低,变化幅度随狭窄程度的增大而增大。结论大鼠左肾静脉狭窄程度为0.7mm时,各项观察指标与胡桃夹综合征(NCS)患者的临床实际情况最接近,而1.0mm和0.5mm相对偏轻和偏重,0.7mm模型组可以作为大鼠左肾静脉狭窄致左肾淤血实验研究的合适模型。 相似文献
13.
目的建立胎羊单侧输尿管梗阻的动物模型,探讨其病理、影像学特点。方法取12只单胎妊娠75-85 d的健康山羊,采用宫内手术的方法造成胎羊左侧输尿管不完全梗阻。对羔羊进行影像、病理学研究。结果12只孕羊中有3只流产;有9只孕羊顺产羔羊。超声检查:梗阻后的第3周内胎羊左肾显著增大、积水及实质变薄。放射学检查:羔羊左肾积水并且功能受损害。病理学检查:左肾肾小球数目减少,肾小管扩张明显,未见肾发育不良。结论对山羊单胎妊娠中期胎羊进行宫内手术建立胎羊单侧输尿管梗阻的动物模型是可行的,该模型能很好地模拟肾盂输尿管连接部梗阻所致的胎儿肾积水。 相似文献
14.
Halyna R Shcherbata 《EMBO reports》2022,23(5)
The Invasion of Ukraine prompts us to support our Ukranian colleagues but also to keep open communication with the Russian scientists who oppose the war. In the eyes of the civilized world, Russia has already lost the war: politically, it is becoming ever more isolated; economically as the sanctions take an enormous toll; militarily as the losses of the Russian army mount. In contrast, the courage of Ukrainian people fighting for their independence has united the Western world that is providing enormous support for those Ukrainians who fight the Russian invasion and those who have fled their war‐torn country. Once this war is over, Ukraine will have to heal the wounds of war, reunite families, restore its economy, reestablish infrastructure, and rebuild science and education. Russia will have to restore its dignity and overcome its self‐inflicted isolation.Europe’s unity in condemning Russia’s war of aggression and showing its solidarity with Ukraine has been impressive. This includes not the least welcoming and accommodating millions of refugees. We, the scientific community in Europe, have a moral obligation to help Ukrainian students and colleagues by providing safe space to study and to continue their research. First, European research organizations and funding agencies should develop strategies to support them in the years to come. Second, efforts by EMBO, research funders, universities, and research institutions to support Ukrainian students and scientists are necessary. As a first priority, dedicated and unbureaucratic short‐term scholarship and grant programs are required to accommodate Ukrainian scientists; such programs have been already initiated by many organizations, for example, by EMBO, Volkswagen Stiftung, Max Planck Society, and the ERC among others. These help Ukrainian scientists to stay connected to research and become integrated into the European research landscape. In the long‐term and after the war, this aid should be complemented by funding for research centers of excellence in Ukraine, to which scientists could then return.Even though the priority must be to help Ukrainians, we must also think of students and colleagues in Russia who oppose the war and are affected by the sanctions. As the Iron Curtain closes again, we have to think differently about our ongoing and future collaborations. Although freezing most, if not all, research collaborations with official Russian organizations is justified, it would be a mistake to extend these sanctions to all scientists and students. There is already an exodus of Russian and Belarusian scholars, which will only accelerate in the next months and years, and accepting scientists who ask for political asylum will be beneficial for Europe.The fraction of Russian society in open opposition to the war is, unfortunately, smaller than that officially in support of it. At the beginning of the war, a number of Russian scientists published an open letter on the internet, in which they condemn this war (https://t‐invariant.org/2022/02/we‐are‐against‐war/). They clearly state that "The responsibility for unleashing a new war in Europe lies entirely with Russia. There is no rational justification for this war”, and “demand an immediate halt to all military operations directed against Ukraine". At the same time, other prominent Russian science and education officials signed the “Statement of the Russian Union of University Rectors (Provosts)”, which expressed unwavering support for Russia, its president and its Army and their goal to “to achieve demilitarization and denazification of Ukraine and thus to defend ourselves from the ever‐growing military threat” (https://www.rsr‐online.ru/news/2022‐god/obrashchenie‐rossiyskogo‐soyuza‐rektorov1/).Inevitably, Russian scientists must decide themselves how to live and continue their scientific work under the increasingly tight surveillance of the Kremlin regime. History is repeating itself. Not long ago, during the Cold War, Soviet scientists were largely isolated from the international research community and worked in government‐controlled research. In some fields, no one knew what they were working on or where. However, even in those dark times, courageous individuals such as Andrei Sakharov spoke out against the regime and tried to educate the next generation about the importance of free will. Many Soviet geneticists had been arrested under Stalin’s regime of terror and as a result of Lysenkoism and were executed or sent to the Gulag or had to emigrate, such as Nikolaj Timofeev‐Resovskij, one of the great geneticists of his time and an opponent of communism. As a result of sending dissident scientists to Siberia, great educational institutions were created in the region, which trained many famous scientists. History tells us that it is impossible to kill free will and the search for truth.The Russian invasion of Ukraine is a major humanitarian tragedy and a tragedy for science at many levels. Our hope is that the European science community, policymakers, and funders will be prepared to continue and expand support for our colleagues from Ukraine and eventually help to rebuild the bridges with Russian science that have been torn down.This commentary has been endorsed and signed by the EMBO Young Investigators and former Young Investigators listed below. All signatories are current and former EMBO Young Investigators and endorse the statements in this article.
Open in a separate window 相似文献
Igor Adameyko | Karolinska Institut, Stockholm, Sweden |
Bungo Akiyoshi | University of Oxford, United Kingdom |
Leila Akkari | Netherlands Cancer Institute, Amsterdam, Netherlands |
Panagiotis Alexiou | Masaryk University, Brno, Czech Republic |
Hilary Ashe | Faculty of Life Sciences, University of Manchester, United Kingdom |
Michalis Averof | Institut de Génomique Fonctionnelle de Lyon (IGFL), France |
Katarzyna Bandyra | University of Warsaw, Poland |
Cyril Barinka | Institute of Biotechnology AS CR, Prague, Czech Republic |
Frédéric Berger | Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna, Austria |
Vitezslav Bryja | Institute of Experimental Biology, Masaryk University, Brno, Czech Republic |
Janusz Bujnicki | International Institute of Molecular and Cell Biology, Warsaw, Poland |
Björn Burmann | University Gothenburg, Sweden |
Andrew Carter | MRC Laboratory of Molecular Biology, Cambridge, United Kingdom |
Pedro Carvalho | Sir William Dunn School of Pathology University of Oxford, United Kingdom |
Ayse Koca Caydasi | Koç University, Istanbul, Turkey |
Hsu‐Wen Chao | Medical University, Taipei, Taiwan |
Jeffrey Chao | Friedrich Miescher Institute, Basel, Switzerland |
Alan Cheung | University of Bristol, United Kingdom |
Tim Clausen | Research Institute for Molecular Pathology (IMP), Vienna, Austria |
Maria Luisa Cochella | The Johns Hopkins University School of Medicine, USA |
Francisco Cubillos | Santiago de Chile, University, Chile |
Uri Ben‐David | Tel Aviv University, Tel Aviv, Israel |
Sebastian Deindl | Uppsala University, Sweden |
Pierre‐Marc Delaux | Laboratoire de Recherche en Sciences Végétales, Castanet‐Tolosan, France |
Christophe Dessimoz | University, Lausanne, Switzerland |
Maria Dominguez | Institute of Neuroscience, CSIC ‐ University Miguel Hernandez, Alicante, Spain |
Anne Donaldson | Institute of Medical Sciences, University of Aberdeen, United Kingdom |
Peter Draber | BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic |
Xiaoqi Feng | John Innes Centre, Norwich, United Kingdom |
Luisa Figueiredo | Institute of Molecular Medicine, Lisbon, Portugal |
Reto Gassmann | Institute for Molecular and Cell Biology, Porto, Portugal |
Kinga Kamieniarz‐Gdula | Adam Mickiewicz University in Poznań, Poland |
Roger Geiger | Institute for Research in Biomedicine, Bellinzona, Switzerland |
Niko Geldner | University of Lausanne, Switzerland |
Holger Gerhardt | Max Delbrück Center for Molecular Medicine, Berlin, Germany |
Daniel Wolfram Gerlich | Institute of Molecular Biotechnology (IMBA), Vienna, Austria |
Jesus Gil | MRC Clinical Sciences Centre, Imperial College London, United Kingdom |
Sebastian Glatt | Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland |
Edgar Gomes | Institute of Molecular Medicine, Lisbon, Portugal |
Pierre Gönczy | Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
Maria Gorna | University of Warsaw, Poland |
Mina Gouti | Max‐Delbrück‐Centrum, Berlin, Germany |
Jerome Gros | Institut Pasteur, Paris, France |
Anja Groth | Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark |
Annika Guse | Centre for Organismal Studies, Heidelberg, Germany |
Ricardo Henriques | Instituto Gulbenkian de Ciência, Oeiras, Portugal |
Eva Hoffmann | Center for Chromosome Stability, University of Copenhagen, Denmark |
Thorsten Hoppe | CECAD at the Institute for Genetics, University of Cologne, Germany |
Yen‐Ping Hsueh | Academia Sinica, Taipei, Taiwan |
Pablo Huertas | Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Seville, Spain |
Matteo Iannacone | IRCCS San Raffaele Scientific Institute, Milan, Italy |
Alvaro Rada‐Iglesias | Institue of Biomedicine and Biotechnology of Cantabria (IBBTEC) University of Cantabria, Santander, Spain |
Axel Innis | Institut Européen de Chimie et Biologie (IECB), Pessac, France |
Nicola Iovino | MPI für Immunbiologie und Epigenetik, Freiburg, Germany |
Carsten Janke | Institut Curie, France |
Ralf Jansen | Interfaculty Institute for Biochemistry, Eberhard‐Karls‐University Tübingen, Germany |
Sebastian Jessberger | HiFo / Brain Research Institute, University of Zurich, Switzerland |
Martin Jinek | University of Zurich, Switzerland |
Simon Bekker‐Jensen | University, Copenhagen, Denmark |
Nicole Joller | University of Zurich, Switzerland |
Luca Jovine | Department of Biosciences and Nutrition & Center for Biosciences, Karolinska Institutet, Stockholm, Sweden |
Jan Philipp Junker | Max‐Delbrück‐Centrum, Berlin, Germany |
Anna Karnkowska | University, Warsaw, Poland |
Zuzana Keckesova | Institute of Organic Chemistry and Biochemistry AS CR, Prague, Czech Republic |
René Ketting | Institute of Molecular Biology (IMB), Mainz, Germany |
Bruno Klaholz | Institute of Genetics and Molecular and Cellular Biology (IGBMC), University of Strasbourg, Illkirch, France |
Jürgen Knoblich | Institute of Molecular Biotechnology (IMBA), Vienna, Austria |
Taco Kooij | Centre for Molecular Life Sciences, Nijmegen, Netherlands |
Romain Koszul | Institut Pasteur, Paris, France |
Claudine Kraft | Institute for Biochemistry and Molecular Biology, Universität Freiburg, Germany |
Alena Krejci | Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech Republic |
Lumir Krejci | National Centre for Biomolecular Research (NCBR), Masaryk University, Brno, Czech Republic |
Arnold Kristjuhan | Institute of Molecular and Cell Biology, University of Tartu, Estonia |
Yogesh Kulathu | MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee, United Kingdom |
Edmund Kunji | MRC Mitochondrial Biology Unit, Cambridge, United Kingdom |
Karim Labib | MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, United Kingdom |
Thomas Lecuit | Developmental Biology Institute of Marseilles ‐ Luminy (IBDML), France |
Gaëlle Legube | Center for Integrative Biology in Toulouse, Paul Sabatier University, France |
Suewei Lin | Academia Sinica, Taipei, Taiwan |
Ming‐Jung Liu | Academia Sinica, Taipei, Taiwan |
Malcolm Logan | Randall Division of Cell and Molecular Biophysics, King’s College London, United Kingdom |
Massimo Lopes | University of Zurich, Switzerland |
Jan Löwe | Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom |
Martijn Luijsterburg | University Medical Centre, Leiden, Netherlands |
Taija Makinen | Uppsala University, Sweden |
Sandrine Etienne‐Manneville | Institut Pasteur, Paris, France |
Miguel Manzanares | Spanish National Center for Cardiovascular Research (CNIC), Madrid, Spain |
Jean‐Christophe Marine | Center for Biology of Disease, Laboratory for Molecular Cancer Biology, VIB & KU Leuven, Belgium |
Sascha Martens | Max F. Perutz Laboratories, University of Vienna, Austria |
Elvira Mass | Universität Bonn, Germany |
Olivier Mathieu | Clermont Université, Aubière, France |
Ivan Matic | Max Planck Institute for Biology of Ageing, Cologne, Germany |
Joao Matos | Max Perutz Laboratories, Vienna, Austria |
Nicholas McGranahan | University College London, United Kingdom |
Hind Medyouf | Georg‐Speyer‐Haus, Frankfurt, Germany |
Patrick Meraldi | University of Geneva, Switzerland |
Marco Milán | ICREA & Institute for Research in Biomedicine (IRB), Barcelona, Spain |
Eric Miska | Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, United Kingdom |
Nuria Montserrat | Institut de Bioenginyeria de Catalunya (IBEC), Barcelona, Spain |
Nuno Barbosa‐Morais | Institute of Molecular Medicine, Lisbon, Portugal |
Antonin Morillon | Institut Curie, Paris, France |
Rafal Mostowy | Jagiellonian University, Krakow, Poland |
Patrick Müller | University of Konstanz, Konstanz, Germany |
Miratul Muqit | University of Dundee, United Kigdom |
Poul Nissen | Centre for Structural Biology, Aarhus University, Denmark |
Ellen Nollen | European Research Institute for the Biology of Ageing, University of Groningen, Netherlands |
Marcin Nowotny | International Institute of Molecular and Cell Biology, Warsaw, Poland |
John O''Neill | MRC Laboratory of Molecular Biology, Cambridge, United Kigdom |
Tamer Önder | Koc University School of Medicine, Istanbul, Turkey |
Elin Org | University of Tartu, Estonia |
Nurhan Özlü | Koç University, Istanbul, Turkey |
Bjørn Panyella Pedersen | Aarhus University, Denmark |
Vladimir Pena | London, The Institute of Cancer Research, United Kingdom |
Camilo Perez | Biozentrum, University of Basel, Switzerland |
Antoine Peters | Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland |
Clemens Plaschka | IMP, Vienna, Austria |
Pavel Plevka | CEITEC, Masaryk University, Brno, Czech Republic |
Hendrik Poeck | Technische Universität, München, , Germany |
Sophie Polo | Université Diderot (Paris 7), Paris, France |
Simona Polo | IFOM ‐ The FIRC Institute of Molecular Oncology, Milan, Italy |
Magdalini Polymenidou | University of Zurich, Switzerland |
Freddy Radtke | Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
Markus Ralser | Institute of Biochemistry Charité, Berlin, Germany & MRC National Institute for Medical Research, London, United Kingdom |
Jan Rehwinkel | John Radcliffe Hospital, Oxford, United Kingdom |
Maria Rescigno | European Institute of Oncology (IEO), Milan, Italy |
Katerina Rohlenova | Prague, Institute of Biotechnology, Czech Republic |
Guadalupe Sabio | Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain |
Ana Jesus Garcia Saez | University of Cologne, CECAD Research Center, Germany |
Iris Salecker | Institut de Biologie de l''Ecole Normale Supérieure (IBENS), Paris, France |
Peter Sarkies | University of Oxford, United Kingdom |
Frédéric Saudou | Grenoble Institute of Neuroscience, France |
Timothy Saunders | Centre for Mechanochemical Cell Biology, Interdisciplinary Biomedical Research Building, Warwick Medical School, Coventry, United Kingdom |
Orlando D. Schärer | IBS Center for Genomic Integrity, Ulsan, South Korea |
Arp Schnittger | Biozentrum Klein Flottbek, University of Hamburg, Germnay |
Frank Schnorrer | Aix Marseille University, CNRS, IBDM, Turing Centre for Living Systems, Marseille, France |
Maya Schuldiner | Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel |
Schraga Schwartz | Weizmann Institute of Science, Rehovot, Israel |
Martin Schwarzer | Institute of Microbiology, Academy of Sciences of the Czech Republic |
Claus Maria | Instituto de Medicina Molecular Faculdade de Medicina da Universidade de Lisboa, Portugal |
Hayley Sharpe | The Babraham Institute, United Kingdom |
Halyna Shcherbata | Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany |
Eric So | Department of Haematological Medicine, King''s College London, United Kingdom |
Victor Sourjik | Max Planck Institute for Terrestrial Microbiology, Marburg, Germany |
Anne Spang | Biozentrum, University of Basel, Switzerland |
Irina Stancheva | Institute of Cell Biology, University of Edinburgh, United Kingdom |
Bas van Steensel | Department of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, Netherlands |
Richard Stefl | CEITEC, Masaryk University, Brno, Czech Republic |
Yonatan Stelzer | Weizmann Institute of Science, Rehovot, Israel |
Julian Stingele | Ludwig‐Maximilians‐Universität, München, Germany |
Katja Sträßer | Institute for Biochemistry, University of Giessen, Germany |
Kvido Strisovsky | Institute of Organic Chemistry and Biochemistry ASCR, Prague, Czech Republic |
Joanna Sulkowska | University, Warsaw, Poland |
Grzegorz Sumara | Nencki Institute of Experimental Biology, Warsaw, Poland |
Karolina Szczepanowska | International Institute Molecular Mechanisms & Machines PAS, Warsaw, Poland |
Luca Tamagnone | Institute for Cancer Research and Treatment, University of Torino Medical School, Italy |
Meng How Tan | Singapore, Nanyang Technological University, Singapore |
Nicolas Tapon | Cancer Research UK London Research Institute, United Kingdom |
Nicholas M. I. Taylor | University, Copenhagen, Denmark |
Sven Van Teeffelen | Université de Montréal, Canada |
Maria Teresa Teixeira | Laboratory of Molecular and Cellular Biology of Eukaryotes, IBPC, Paris, France |
Aurelio Teleman | German Cancer Research Center (DKFZ), Heidelberg, Germany |
Pascal Therond | Institute Valrose Biology, University of Nice‐Sophia Antipolis, France |
Pavel Tolar | University College London, United Kingdom |
Isheng Jason Tsai | Academia Sinica, Taipei, Taiwan |
Helle Ulrich | Institute of Molecular Biology (IMB), Mainz, Germany |
Stepanka Vanacova | Central European Institute of Technology, Masaryk University, Brno, Czech Republic |
Henrique Veiga‐Fernandes | Champalimaud Center for the Unknown, Lisboa, Portugal |
Marc Veldhoen | Instituto de Medicina Molecular, Lisbon, Portugal |
Louis Vermeulen | Academic Medical Centre, Amsterdam, Netherlands |
Uwe Vinkemeier | University of Nottingham Medical School, United Kingdom |
Helen Walden | MRC Protein Phosphorylation & Ubiquitylation Unit, University of Dundee, United Kingdom |
Michal Wandel | Institute of Biochemistry and Biophysics, PAS, Warsaw, Poland |
Julie Welburn | Wellcome Trust Centre, Edinburgh, United Kingdom |
Ervin Welker | Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary |
Gerhard Wingender | Izmir Biomedicine and Genome Center, Dokuz Eylul University, Izmir, Turkey |
Thomas Wollert | Institute Pasteur, Membrane Biochemistry and Transport, Centre François Jacob, Paris, France |
Hyun Youk | University of Massachusetts Medical School, USA |
Christoph Zechner | MPI für molekulare Zellbiologie und Genetik, Dresden, Germany |
Philip Zegerman | Wellcome Trust / Cancer Research UK Gurdon Institute, University of Cambridge, United Kingdom |
Alena Ziková | Institute of Parasitology, Biology Centre AS CR, Ceske Budejovice, Czech Republic |
Piotr Ziolkowski | Adam Mickiewicz University, Poznan, Poland |
David Zwicker | MPI für Dynamik und Selbstorganisation, Göttingen, Germany |
15.
Implantation of resynchronization implantable cardioverter defibrillator was performed in a patient with persistent left superior vena cava. A dual coil defibrillation lead was inserted in the right ventricle apex via a small innominate vein. Left ventricular and atrial leads were implanted through persistent left superior vena cava. Left ventricular lead was easily implanted into the postero lateral vein. Pacing thresholds and sensing values were excellent and remained stable at 18 months follow-up.Presence of persistent left superior vena cava generally makes transvenous lead implantation difficult. However when a favorable coronary sinus anatomy is also present, it may facilitate left ventricular lead positioning in the coronary sinus branches. 相似文献
16.
A 5-year-old cheetah suffered a complete prolapse of the left uterine horn after the birth of her second litter. Two attempts to reduce the prolapse transvaginally failed. The animal was hospitalized 13 days after the prolapse first occurred, and an ovariohysterectomy was performed to resolve the prolapse. The prolapsed uterine horn had been mutilated: its tip, together with the ipsilateral ovary was absent. Laparotomy revealed no sign of recent or past hemorrhage or adhesions, or any signs of the left ovarian artery or left ovarian vein in the remnants of the left mesovarium. A large vein crossed the uterine body from the left uterine horn to join the right uterine vein, presumably serving as the only route of venous drainage for the prolapsed uterine horn. A possible cause for the prolapse is excessive mobility of the uterus due to prior rupture of its mesial support. The animal died 24 days after surgery due to chronic renal failure, as a result of severe renal amyloidosis. 相似文献
17.
A 46-year-old Brugada syndrome patient underwent insertion of a dual-chamber implantable cardioverter- defibrillator (ICD), revealing a left-sided superior vena cava (SVC), (figure 1), running, characteristically, left from the sternum and flowing into the great cardiac vein. Following this course, the atrial lead was placed in the right atrium (RA) (figure 2, arrow, note dorsal position). The ventricular lead was inserted through the connecting anonymous vein between left and right SVC (figure 1, double arrow), into the right SVC and right ventricle (RV). The presence of a left superior vena cava results from the persistence of the embryonic left anterior cardinal vein. This anomaly is present in approximately 0.5% of the general population and in 3 to 5% of persons with other congenital heart defects, as established by autopsy. 相似文献
18.
Extranodal non-Hodgkin's lymphoma (NHL) of the breast is a rare entity. It represents 0.04-1.1% of malignant tumors of the breast. 1.7-2.2% of extranodal lymphomas and 0.7% of all NHL. However, primary NHL (PNHL) is the most frequent hematopojetic tumor of the breast. CASE: A 23-year-old woman presented with a mass in the left breast for 3 months followed by enlarged left axillary lymph nodes. Mammography showed a diffuse increase in the density of the left breast. Other investigations were unremarkable. Both fine needle aspiration cytology (FNAC) and histopathology were diagnostic of NHL. Immunohistochemistry was confirmatory of NHL, diffuse large cell type, of B-cell lineage. CONCLUSION: Primary and secondary lymphomas of the breast, though rare, should be considered in the differential diagnosis of breast malignancies. PNHL of the breast is usually right sided, but this patient had left breast involvement. Diagnosis by FNAC was successful as the cytologic picture is similar to that of any other lymphoid or extranodal NHL. When histopathology and immunohistopathology are conclusive, FNAC, supplemented by immunocytochemistry, can be applied as a simple, reliable and cost-effective tool in the early diagnosis of breast lymphomas. 相似文献
19.
A labiogingival notch appearing on the enamel of maxillary central incisors seems to be a potential factor for compromised gingival and dental health. The objective of the survey was to describe the phenomenon and its prevalence in a random Israeli population. One thousand eight hundred eighty children with fully erupted permanent incisors were clinically examined. The appearance of the labiogingival notch on the enamel surface of the maxillary central incisors was determined. Two depth categories of the phenomenon were distinguished by probing. The possible differences in the prevalence of the labial notch appearance, between the sexes as well as between the right and left sides, were statistically evaluated. The prevalence between the right and left sides, were statistically evaluated. The prevalence of the labial notch on at least one incisor in the population examined was 6.5% (5.1% unilaterally and 1.4% bilaterally). No significant difference between the sexes regarding the appearance of this phenomenon was found. The shallow notch was similarly distributed between the right and left sides in both sexes. However, the deeper malformations appeared significantly more on the left side in boys (P less than 0.05) and in girls (P less than 0.01). The gingivae tended to follow the enamel contour; however, only in few cases was gingival inflammation or incipient caries diagnosed. It was concluded that the labio-gingival notch is not a rare phenomenon, and it should be given special attention to prevent possible damage to the dental and gingival tissues. 相似文献
20.
Matteo Anselmino Maria Cristina Marocco Marcella Jorfida Riccardo Massa 《Indian pacing and electrophysiology journal》2009,9(3):177-179
Transvenous endocardial pacing through classical implantation of a pace/sensing lead in the right ventricle is strictly contraindicated in patients with a mechanical tricuspid valve. Usually permanent pacing is achieved by an epimyocardial surgical approach. We hereby describe the implantation of a single site left ventricle pacing lead in the anterior interventricular vein in a 60 year-old woman with symptomatic bradycardia, permanent atrial fibrillation, and mechanical tricuspid valve. The described use of left ventricle pacing through a coronary vein lead, in a patient with favorable venous anatomy, provided (through a minimal invasive approach) effective with a low and stable threshold. 相似文献