共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
An alternative to standard approaches to uncover biologically meaningful structures in micro array data is to treat the data as a blind source separation (BSS) problem. BSS attempts to separate a mixture of signals into their different sources and refers to the problem of recovering signals from several observed linear mixtures. In the context of micro array data, "sources" may correspond to specific cellular responses or to co-regulated genes. 相似文献2.
Lope A Flórez Katrin Gunka Rafael Polanía Stefan Tholen Jörg Stülke 《BMC systems biology》2011,5(1):5
Background
Several computational methods exist to suggest rational genetic interventions that improve the productivity of industrial strains. Nonetheless, these methods are less effective to predict possible genetic responses of the strain after the intervention. This problem requires a better understanding of potential alternative metabolic and regulatory pathways able to counteract the targeted intervention. 相似文献3.
Background
The ability to monitor the change in expression patterns over time, and to observe the emergence of coherent temporal responses using gene expression time series, obtained from microarray experiments, is critical to advance our understanding of complex biological processes. In this context, biclustering algorithms have been recognized as an important tool for the discovery of local expression patterns, which are crucial to unravel potential regulatory mechanisms. Although most formulations of the biclustering problem are NP-hard, when working with time series expression data the interesting biclusters can be restricted to those with contiguous columns. This restriction leads to a tractable problem and enables the design of efficient biclustering algorithms able to identify all maximal contiguous column coherent biclusters. 相似文献4.
Esterina Fazio Pietro Medica Vincenzo Aronica Loredana Grasso Adriana Ferlazzo 《Acta veterinaria Scandinavica》2008,50(1):6
Background
Since transport evokes physiological adjustments that include endocrine responses, the objective of this study was to examine the responses of circulating β-endorphin, adrenocorticotrophic hormone (ACTH) and cortisol levels to transport stress in stallions. 相似文献5.
Christopher Burton Hans Knoop Nikola Popovic Michael Sharpe Gijs Bleijenberg 《BioPsychoSocial medicine》2009,3(1):1-9
Objective
We examined developmental aspects of the emotional awareness of adolescents by evaluating their responses to a self-reported questionnaire based on the Toronto Alexithymia Scale-20 (TAS-20). 相似文献6.
Darren?G?Woodside David?K?Wooten T?Kent?Teague Yuko?J?Miyamoto Eva?G?Caudell Taturo?Udagawa Bernard?F?Andruss Bradley?W?McIntyre
Background
Rho family GTPase regulation of the actin cytoskeleton governs a variety of cell responses. In this report, we have analyzed the role of the GTPase Rho in maintenance of the T lymphocyte actin cytoskeleton. 相似文献7.
8.
Aneta Kasza Paulina Wyrzykowska Irena Horwacik Piotr Tymoszuk Danuta Mizgalska Karren Palmer Hanna Rokita Andrew D Sharrocks Jolanta Jura 《BMC molecular biology》2010,11(1):14
Background
MCPIP is a novel CCCH zinc finger protein described as an RNase engaged in the regulation of immune responses. The regulation of expression of the gene coding for MCPIP - ZC3H12A is poorly explored. 相似文献9.
Sheran HW Law Rudolf SS Wu Patrick KS Ng Richard MK Yu Richard YC Kong 《BMC molecular biology》2006,7(1):15-13
Background
Hypoxia-inducible factors (HIFs) are involved in adaptive and survival responses to hypoxic stress in mammals. In fish, very little is known about the functions of HIFs. 相似文献10.
Robert Urbanczik 《BMC bioinformatics》2006,7(1):129-4
Background
Despite recent algorithmic and conceptual progress, the stoichiometric network analysis of large metabolic models remains a computationally challenging problem. 相似文献11.
Thomas J Lee Yannick Pouliot Valerie Wagner Priyanka Gupta David WJ Stringer-Calvert Jessica D Tenenbaum Peter D Karp 《BMC bioinformatics》2006,7(1):170-14
Background
This article addresses the problem of interoperation of heterogeneous bioinformatics databases. 相似文献12.
Franziska Hufsky Léon Kuchenbecker Katharina Jahn Jens Stoye Sebastian Böcker 《BMC bioinformatics》2011,12(1):106
Background
The center string (or closest string) problem is a classic computer science problem with important applications in computational biology. Given k input strings and a distance threshold d, we search for a string within Hamming distance at most d to each input string. This problem is NP complete. 相似文献13.
Robert R Edwards Ajay D Wasan Clifton O Bingham III Joan Bathon Jennifer A Haythornthwaite Michael T Smith Gayle G Page 《Arthritis research & therapy》2009,11(3):R61-9
Introduction
Maladaptive physiological responses to stress appear to play a role in chronic inflammatory diseases such as rheumatoid arthritis (RA). However, relatively little stress research in RA patients has involved the study of pain, the most commonly reported and most impairing stressor in RA. In the present study, we compared psychophysical and physiological responses to standardized noxious stimulation in 19 RA patients and 21 healthy controls. 相似文献14.
Background
Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. Few studies have examined the nociception and stress hormone responses after consumption of soy isoflavones. 相似文献15.
Mariana Conte Silvia de Simone Susan J Simmons Carlos L Ballaré Ann E Stapleton 《BMC plant biology》2010,10(1):112
Background
Understanding of the genetic architecture of plant UV-B responses allows extensive targeted testing of candidate genes or regions, along with combinations of those genes, for placement in metabolic or signal transduction pathways. 相似文献16.
17.
Background
An important goal of whole-genome studies concerned with single nucleotide polymorphisms (SNPs) is the identification of SNPs associated with a covariate of interest such as the case-control status or the type of cancer. Since these studies often comprise the genotypes of hundreds of thousands of SNPs, methods are required that can cope with the corresponding multiple testing problem. For the analysis of gene expression data, approaches such as the empirical Bayes analysis of microarrays have been developed particularly for the detection of genes associated with the response. However, the empirical Bayes analysis of microarrays has only been suggested for binary responses when considering expression values, i.e. continuous predictors. 相似文献18.
Hana Bandouchova Miroslav Pohanka Kristina Vlckova Veronika Damkova Lucie Peckova Jana Sedlackova Frantisek Treml Frantisek Vitula Jiri Pikula 《Acta veterinaria Scandinavica》2011,53(1):2
Background
The aim of the present study was to investigate biochemical and oxidative stress responses to experimental F. tularensis infection in European brown hares, an important source of human tularemia infections. 相似文献19.
Background
The pro-apoptotic protein CC3/TIP30 has an unusual cellular function as an inhibitor of nucleocytoplasmic transport. This function is likely to be activated under conditions of stress. A number of studies support the notion that CC3 acts as a tumor and metastasis suppressor in various types of cancer. The yeast homolog of CC3 is likely to be involved in responses to DNA damage. Here we examined the potential role of CC3 in regulation of cellular responses to genotoxic stress. 相似文献20.