Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

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TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages

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Structural snapshots of R-loop formation by a type I-C CRISPR Cascade

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TIGER: Single-step in vivo genome editing in a non-traditional rodent

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Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8+ T cells

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A reference human induced pluripotent stem cell line for large-scale collaborative studies

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A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression

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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

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Structure of the type V-C CRISPR-Cas effector enzyme

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Deletion mapping of regulatory elements for GATA3 in T cells reveals a distal enhancer involved in allergic diseases

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Viral recombination systems limit CRISPR-Cas targeting through the generation of escape mutations

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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

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Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex

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Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons

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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

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Distribution and phasing of sequence motifs that facilitate CRISPR adaptation

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Biomarker-responsive engineered probiotic diagnoses,records, and ameliorates inflammatory bowel disease in mice

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High-Efficiency,Selection-free Gene Repair in Airway Stem Cells from Cystic Fibrosis Patients Rescues CFTR Function in Differentiated Epithelia

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Cleavage of viral DNA by restriction endonucleases stimulates the type II CRISPR-Cas immune response

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Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL

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