A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

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An in vitro system to silence mitochondrial gene expression

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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan

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The human mitochondrial genome contains a second light strand promoter

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Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

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A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ribosome profiling

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Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons

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The Plant Mitochondrial TAT Pathway Is Essential for Complex III Biogenesis

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Structure and Function of an Elongation Factor P Subfamily in Actinobacteria

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Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes

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Mosaic dysfunction of mitophagy in mitochondrial muscle disease

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Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer

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Increased fidelity of protein synthesis extends lifespan

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A mitochondrial iron-responsive pathway regulated by DELE1

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Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice

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Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex

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SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

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Lipocalin-2 induces mitochondrial dysfunction in renal tubular cells via mTOR pathway activation

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HIGD2A is Required for Assembly of the COX3 Module of Human Mitochondrial Complex IV

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Highlights

• •Quantitative proteomics reveals HIGD2A is required for assembly of the COX3 module.
• •Pulse-SILAC demonstrates that HIGD2A is involved in COX3 biogenesis.
• •Supercomplexes in HIGD2A knockout cells are depleted of COX3.
• •HIGD2A is the first assembly factor identified for the COX3 module of Complex IV.