Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1

1. Download : Download high-res image (196KB)
2. Download : Download full-size image

     

A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

1. Download : Download high-res image (196KB)
2. Download : Download full-size image

     

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

1. Download : Download high-res image (267KB)
2. Download : Download full-size image

     

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia

1. Download : Download high-res image (228KB)
2. Download : Download full-size image

     

Phosphorylation at Ser65 modulates ubiquitin conformational dynamics

1. Download : Download high-res image (75KB)
2. Download : Download full-size image

     

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

1. Download : Download high-res image (201KB)
2. Download : Download full-size image

     

Orphan quality control shapes network dynamics and gene expression

1. Download : Download high-res image (124KB)
2. Download : Download full-size image

     

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

1. Download : Download high-res image (192KB)
2. Download : Download full-size image

     

An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure

1. Download : Download high-res image (229KB)
2. Download : Download full-size image

     

A Cycle of Ubiquitination Regulates Adaptor Function of the Nedd4-Family Ubiquitin Ligase Rsp5

1. Download : Download high-res image (104KB)
2. Download : Download full-size image

     

K63-linked ubiquitin chains are a global signal for endocytosis and contribute to selective autophagy in plants

1. Download : Download high-res image (171KB)
2. Download : Download full-size image

     

APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain

1. Download : Download high-res image (284KB)
2. Download : Download full-size image

     

TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity

1. Download : Download high-res image (212KB)
2. Download : Download full-size image

     

Cryo-EM Reveals Unanchored M1-Ubiquitin Chain Binding at hRpn11 of the 26S Proteasome

1. Download : Download high-res image (343KB)
2. Download : Download full-size image

     

Molecular mechanism for activation of the 26S proteasome by ZFAND5

1. Download : Download high-res image (207KB)
2. Download : Download full-size image

     

Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection

1. Download : Download high-res image (188KB)
2. Download : Download full-size image

     

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

1. Download : Download high-res image (271KB)
2. Download : Download full-size image

     

Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1

1. Download : Download high-res image (246KB)
2. Download : Download full-size image

     

Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion

1. Download : Download high-res image (174KB)
2. Download : Download full-size image

     

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

1. Download : Download high-res image (229KB)
2. Download : Download full-size image