Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

1. Download : Download high-res image (174KB)
2. Download : Download full-size image

     

Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited

1. Download : Download high-res image (251KB)
2. Download : Download full-size image

     

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions

1. Download : Download high-res image (227KB)
2. Download : Download full-size image

     

ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

1. Download : Download high-res image (125KB)
2. Download : Download full-size image

     

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

1. Download : Download high-res image (152KB)
2. Download : Download full-size image

     

A replication fork determinant for the establishment of sister chromatid cohesion

1. Download : Download high-res image (224KB)
2. Download : Download full-size image

     

Molecular basis for the reversible ADP-ribosylation of guanosine bases

1. Download : Download high-res image (118KB)
2. Download : Download full-size image

     

Dynamic stem cell selection safeguards the genomic integrity of the epidermis

1. Download : Download high-res image (230KB)
2. Download : Download full-size image

     

Ligation of newly replicated DNA controls the timing of DNA mismatch repair

1. Download : Download high-res image (133KB)
2. Download : Download full-size image

     

Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes

1. Download : Download high-res image (207KB)
2. Download : Download full-size image

     

Proteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication

1. Download : Download high-res image (137KB)
2. Download : Download full-size image

     

Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

1. Download : Download high-res image (183KB)
2. Download : Download full-size image

     

Genome oligopaint via local denaturation fluorescence in situ hybridization

1. Download : Download high-res image (95KB)
2. Download : Download full-size image

     

Genetic admixture and language shift in the medieval Volga-Oka interfluve

1. Download : Download high-res image (161KB)
2. Download : Download full-size image

     

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century

1. Download : Download high-res image (150KB)
2. Download : Download full-size image

     

Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

1. Download : Download high-res image (90KB)
2. Download : Download full-size image

     

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

1. Download : Download high-res image (149KB)
2. Download : Download full-size image

     

Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

1. Download : Download high-res image (136KB)
2. Download : Download full-size image

     

A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility

1. Download : Download high-res image (200KB)
2. Download : Download full-size image

     

Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase

1. Download : Download high-res image (323KB)
2. Download : Download full-size image