Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

1. Download : Download high-res image (333KB)
2. Download : Download full-size image

     

A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth

1. Download : Download high-res image (220KB)
2. Download : Download full-size image

     

Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

1. Download : Download high-res image (175KB)
2. Download : Download full-size image

     

Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring

1. Download : Download high-res image (157KB)
2. Download : Download full-size image

     

HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

1. Download : Download high-res image (234KB)
2. Download : Download full-size image

     

CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency

1. Download : Download high-res image (223KB)
2. Download : Download full-size image

     

Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

1. Download : Download high-res image (123KB)
2. Download : Download full-size image

     

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study

1. Download : Download high-res image (136KB)
2. Download : Download full-size image

     

SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt

1. Download : Download high-res image (171KB)
2. Download : Download full-size image

     

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases

1. Download : Download high-res image (148KB)
2. Download : Download full-size image

     

3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males

1. Download : Download high-res image (323KB)
2. Download : Download full-size image

     

Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization

1. Download : Download high-res image (203KB)
2. Download : Download full-size image

     

Structural insights into adhesion GPCR ADGRL3 activation and Gq,Gs, Gi,and G12 coupling

1. Download : Download high-res image (233KB)
2. Download : Download full-size image

     

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins

1. Download : Download high-res image (270KB)
2. Download : Download full-size image

     

E6AP AZUL interaction with UBQLN1/2 in cells,condensates, and an AlphaFold-NMR integrated structure

1. Download : Download high-res image (246KB)
2. Download : Download full-size image

     

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

1. Download : Download high-res image (153KB)
2. Download : Download full-size image

     

Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs

1. Download : Download high-res image (141KB)
2. Download : Download full-size image

     

Shank3 Binds to and Stabilizes the Active Form of Rap1 and HRas GTPases via Its NTD-ANK Tandem with Distinct Mechanisms

1. Download : Download high-res image (176KB)
2. Download : Download full-size image

     

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

1. Download : Download high-res image (176KB)
2. Download : Download full-size image

     

Translation stress and collided ribosomes are co-activators of cGAS

1. Download : Download high-res image (200KB)
2. Download : Download full-size image