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1.
Neuronal firing activity pattern in the sensorimotor complex and conditioned reflexes produced by blockade of noradrenergic and serotoninergic input to the parafascicular complex (CM-PF) were investigated during chronic experiments on cats in which lever-pressing reflex had previously been set up. Micro-injection of obsidan, a beta-adrenergic blocker and lysergide, a serotonin blocker, were found to produce intensification and inhibition, respectively, of neuronal spontaneous firing activity in the sensorimotor cortex, with both blockers having a similar (inhibitory) effect on neuronal response induced by conditioned acoustic stimuli. Blockade of monoaminergic inputs to the CM-PF temporarily suppressed execution of the conditioned reflex and the non-conditioned reflex of lever-pressing (for 30–60 min). The study concludes that the pattern of effect produced by the monoaminergic system on the sensorimotor cortex is largely determined by indirect as well as direct agents and that such effects are mediated by neurons belonging to the CM-PF complex of the thalamic nuclei.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 22, No. 3, pp. 327–336, May–June, 1990. 相似文献
2.
Neuronal firing response in the sensorimotor cortex to tactile (non-conditioned) and acoustic (conditioned) stimuli was investigated in trained cats before and after iontophoretic application of serotonin and lysergide. Three functionally distinct groups of neurons were identified from the response produced by presenting tactile and acoustic stimuli. Applying serotonin was found to facilitate preliminary and residual spike response induced by tactile stimulation; it also facilitates and modulates response in many cortical neurons to conditioned stimuli. Facilitation takes the form of reduced latency of response and increased numbers of spikes in response to conditioned stimulus presentation, especially at the initial phase of response to sound and immediately after the onset of conditioned reflex motion. Additional neurons formerly unresponsive to acoustic stimuli joined in the reaction under the effects of serotonin. Changed response patterns often evolve following minor fluctuations in background activity level. It is suggested that facilitation of response following iontophoretic serotonin application in the neocortex is associated with activation of excitatory serotonin receptors (S2). The lysergide-induced increase in background and evoked activity noted during experimentation can apparently be put down to blockade of inhibitory serotonon (S1B) receptors.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 22, No. 3, pp. 337–347, May–June, 1990. 相似文献
3.
Spike response was investigated in 104 neurons of the nucleus reticularis thalami (R) and adjoining thalamic nuclei to acoustic, tactile, and visual stimuli during chronic experiments on cats. Of the test neurons, 29% responded to acoustic stimulation and 11% showed no preference in relation to different acoustic stimuli. Minimum latencies of response to sounds measured 12–37 msec in excitatory and 18–27 msec in inhibitory cells. Duration of excitation produced by acoustic stimuli reached 50–250 msec; inhibition lasted 27–190 msec. Most cells belonging to this nucleus were excited by different stimuli; the proportion of inhibitory neurons did not exceed 4–10%.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 21, No. 4, pp. 451–461, July–August, 1989. 相似文献
4.
Neuronal activity was investigated in different thalamic nuclei and the striopallidal complex in parkinsonian patients with long-term implantation of intracerebral electrodes in the structures concerned for diagnostic and therapeutic purposes. Directionally selective neurons were found with consistent response to presentation of visual stimuli oriented at the same angle in a variety of (spatial) head positions differing by 90°.Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 21, No. 1, pp. 93–101, January–February, 1989. 相似文献
5.
Effects of electrical stimulation of the medullary raphe nuclei on respiratory movement in rats 总被引:1,自引:0,他引:1
Ying Cao Yutaka Fujito Kiyoji Matsuyama Mamoru Aoki 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》2006,192(5):507-505
The present study was undertaken to examine the effects of electrical stimulation of the medullary raphe nuclei on respiration in rats anesthetized with ketamine and xylazine. Train pulse stimuli (100 Hz, 10–30 μA) were applied in the regions of the caudal raphe nuclei: the raphe magnus (RM), raphe pallidus (RP) and raphe obscurus (RO). Stimulation of the RM depressed inspiratory movements measured by means of an abdominal pneumograph, whereas stimulation of the RP augmented inspiratory movements. It was revealed that stimulation of the RO induced either inhibitory or facilitatory effects on respiratory movements depending on the stimulation sites. These findings confirm and extend previous studies concerning the effects of raphe stimulation on respiratory activity in cats. The present results demonstrate that in rats the caudal raphe nuclei are involved in respiratory control.An erratum to this article can be found at 相似文献
6.
Neuronal response to single stimuli applied to the thalamic dorsolateral and posterolateral nuclei (DLN and PLN resepctively) was investigated in the parietal association cortex. Primary IPSP following DLN and PLN stimulation was noted in 62.5% and 79.6% of instances respectively. Latencies of EPSP and IPSP when stimulating the two nuclei were longer for the DLN. The amplitude of EPSP evoked by stimulating association nuclei rose and declined smoothly, while that of IPSP showed a fast rise and a more steady decline. The EPSP appearing during the evolution of IPSP were of higher amplitude than control level of resting potential. Both amplitude and duration of IPSP induced in a single unit by stimulating different association nuclei were extremely similar, thus confirming the involvement in this operation of the same inhibitory cortical interneurons. Duration of IPSP was shorter than that of inhibitory background spike activity. It is postulated that the discrepancy in duration can largely be ascribed to properties of the neurons themselves.State University, Odessa. Translated from Neirofiziologiya, Vol. 23, No. 5, pp. 529–536, September–October, 1991. 相似文献
7.
Endogenously secreted or injected corticosterone (CORT) rapidly suppresses courtship clasping in male roughskin newts (Taricha granulosa) by an action on a specific neuronal membrane receptor. Previous studies, using immobilized newts, showed that CORT administration rapidly depresses excitability of reticulospinal neurons and attenuates medullary neuronal responsiveness to clasp-triggering sensory stimuli. The present study used freely moving newts to examine clasping responses and concurrently record sensorimotor properties of 67 antidromically identified reticulospinal and other medullary reticular neurons before and after CORT injection. Before CORT, reticulospinal neurons fired in close association with onset and offset of clasps elicited by cloacal pressure. Reticulospinal neurons also showed firing correlates of nonclasping motor events, especially locomotion. Neuronal activity was typically reduced during clasping and elevated during locomotion. Medullary neurons that were not antidromically invaded (unidentified neurons) usually showed sensorimotor properties that resembled those of reticulospinal neurons. Intraperitoneal CORT (but not vehicle) reduced the probability and quality of hindlimb clasping in response to cloacal pressure, especially within 5–25 min of injection. Simultaneously, responses of reticulospinal and unidentified neurons to cloacal pressure and occurrence of clasping-related activity were attenuated or eliminated. CORT effects were relatively selective, altering clasping-related neuronal activity more strongly than activity associated with nonclasping motor events. The properties of CORT effects indicate that the hormone impairs clasping by depressing processing of clasp-triggering afferent activity and by disrupting the medullary control of clasping normally mediated by reticulospinal neurons. The rapid onset of these CORT effects implicates a neuronal membrane receptor rather than genomic action of the steroid. 相似文献
8.
L. É. Zinyuk 《Neurophysiology》1984,16(2):166-172
Unit activity in cortical areas 24 and 32 was studied during conditioned placing reflex formation in cats. Neuronal responses in the limbic cortex of trained animals correlated with acoustic stimulation, the motor response, and also with the presentation of food reinforcement. In untrained animals 16% of neurons responded to acoustic stimulation. After training the number of neurons responding to sound in area 32 increased to 51.3%. Of the total number of neurons, 34.6% responded by initial excitation and 26.7% by inhibition of spike activity. The latent period of these responses was about 50 msec and their duration up to 200 msec. Similar but weaker responses were observed in area 24. Short-latency activation responses to conditioned and differential stimulation were similar in character. It is suggested that after training processes taking place in the limbic cortex may contribute to better perception of both conditioned and differential acoustic stimuli, irrespective of their functional significance.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 16, No. 2, pp. 201–208, March–April, 1984. 相似文献
9.
P I Pakhotin O S Vinogradova 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1984,34(2):303-310
Neuronal activity of n. AV (n = 75) and n. AD (n = 55) of the thalamus was recorded extracellularly in unanaesthetized chronic rabbits after complete transection of the mammillo -thalamic tract (MTT). Elimination of this powerful afferent system produced a surprisingly small effect upon spontaneous and evoked neuronal activity. All types of responses were preserved in both nuclei, though some increase of multimodal diffuse tonic responses and decrease of more specialized phasic and complex on-effects occurred in n. AV. In both nuclei short-latency responses (less than 14 ms) to auditory stimuli disappeared. The number of units with dynamic transformations of responses during repeated stimuli application (gradual emergence and shaping of responses, as well as their habituation) decreased 2-3-fold in both nuclei. The impulse activity travelling in MTT seems to be not critical for limbic nuclei sensory reactivity but significant for plasticity of the responses. 相似文献
10.
Neuronal response in the caudate nucleus to presentation of a wide variety of visual and other sensory stimuli was investigated in waking cats. Pronounced discrepancies in background activity of unknown origin as well as differing neuronal activity level were noted in adjacent sections of the nucleus. Of the neurons from which readings of response to sensory stimulation could be made, some reacted to presentation of exclusively visual and others to tactile stimuli; a third group responded to a combination of visual and somatic stimulation only. Response could only be produced in cells of all types by a high level of activity in the animal. Visual stimuli attracting the animal's interest proved to be the most effective form of stimulation. Ipsi- and contralateral sides of the animal's body were both represented in the caudate nucleus of each hemisphere. Neuronal response in the caudate nucleus may be compared with that produced by application of similar stimuli in cells belonging to different cortical areas.Institute for Research on Information Transmission, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 22, No. 1, pp. 3–10, January–February, 1990. 相似文献
11.
P R Laming T H Bullock M C McClune 《Comparative biochemistry and physiology. A, Comparative physiology》1991,100(1):81-93
1. Changes in EEG power spectrum of carp to a priming non-acoustic stimulus followed by acoustic clicks were compared to those due to acoustic clicks delivered alone. Recordings were made from the telencephalon, midbrain and medulla. Acoustic evoked potentials (AEPs) to the clicks were also recorded. 2. EEG power changes to non-acoustic stimuli occurred over the whole 1-40 Hz frequency range and were regionally specific and consistent. 3. The changes in the EEG midfrequency 12-24 Hz power spectrum to non-acoustic stimuli were significantly correlated with changes in the AEP to subsequent clicks. An elevated medullary AEP amplitude and reduced duration were correlated with increased medullary EEG power and increased midbrain AEP duration. 4. Telencephalic EEG power changes were inversely related to changes in medullary and midbrain AEP amplitude. 相似文献
12.
Selectivity in the response of human cerebral neurons to visual stimuli at different angles of alignment 总被引:1,自引:0,他引:1
The neuronal activity of different nuclei of the thalamus and striopallidar complex was investigated in Parkinsonian patients with intracerebral electrodes chronically implanted in these structures for diagnostic and therapeutic purposes. Neuronal populations were discovered responding differently to the presentation of stimuli identical in all but angle of presentation, some of which responded solely to a single orientation and might therefore be thought of as displaying directional sensitivity. It is suggested that when motor and visual information converge within the above systems, a matching process takes place, together with an interaction relating to stability of visual perception.Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad; Institute of Information and Automotive Sciences, Academy of Sciences of the USSR, Leningrad. Translated from Neirofizologiya, Vol. 19, No. 1, pp. 3–11, January–February, 1987. 相似文献
13.
L. N. Shapoval L. S. Pobegailo L. G. Stepanenko O. V. Dmytrenko V. A. Bouryi V. F. Sagach 《Neurophysiology》2011,43(4):299-308
Physical inactivity can be considered one of the major risk factors related to cardiovascular diseases. There are reasons
to believe that the positive effect of exercise training is, to a large extent, mediated by modulation of the nervous control
of the circulation system. In our previous studies, we showed that modulation of mitochondrial permeability transition in
medullary cardiovascular neurons significantly contributes to the hemodynamic reactions in both the norm and a number of pathological
states. In this study, we examined in acute experiments on urethane-anesthetized rats the hemodynamic effects mediated by
either modulation of mitochondrial permeability transition in medullary neurons, or activation of neuronal NO synthase (NOS-1)
in these neuronal populations after preliminary moderate exercise training (everyday swimming sessions of increased duration
carried out for four weeks). It was shown that, after exercise training had been completed, the effects of injections of an
inductor of mitochondrial permeability transition pore (MPTP) opening, phenylarsine oxide (PAO, 0.5 to 1.5 nmol), into populations
of cardiovascular neurons in the medullary autonomic nuclei (nucl. tractus solitarius and paramedian and lateral reticular nuclei) were less expressed, as compared with those in control (untrained) animals.
The data obtained suggest that exercise training can exert a protective action on functional activity of medullary neurons
due to the decreased sensitivity of MPTPs to their opening. Injections of an inhibitor of MPTP opening, melatonin (0.7 to
2.1 nmol), into populations of medullary neurons under study in trained rats induced a decrease in the systemic arterial pressure
(SAP), in contrast to untrained animals demonstrating mostly hypertensive responses following injections of melatonin into
the above nuclei. Injections of an activator of neuronal NO synthase (NOS-1), L-arginine, into the medullary nuclei of swimming-trained
rats resulted in more expressed hemodynamic shifts than in control animals, which suggests an increase in the activity of
neuronal NO synthase in medullary neurons of such animals. 相似文献
14.
Nelken I 《Current opinion in neurobiology》2004,14(4):474-480
Neuronal responses in auditory cortex show a fascinating mixture of characteristics that span the range from almost perfect copies of physical aspects of the stimuli to extremely complex context-dependent responses. Fast, highly stimulus-specific adaptation and slower plastic mechanisms work together to constantly adjust neuronal response properties to the statistics of the auditory scene. Evidence with converging implications suggests that the neuronal activity in primary auditory cortex represents sounds in terms of auditory objects rather than in terms of invariant acoustic features. 相似文献
15.
E. V. Sharova 《Human physiology》2005,31(3):245-254
Analysis of the character and systemic organization of cerebral reactions to external effects aids in adequate evaluation of functional and adaptive human capabilities in norm and pathology. Changes in the spatiotemporal organization of the EEG (according to visual and spectral coherence analyses, as well as localization of equivalent dipole sources of pathological EEG phenomena) and the electrooculogram in response to afferent stimuli at different stages of postcomatose recovery of mental activity were studied in 84 patients with severe brain injury in a prolonged postcomatose unconscious state. Both standard indifferent (a rhythmically flashing light and an acoustic tone) and functionally significant (a moving contrasting black-and-white strip, a red spot, the mother’s voice, music, etc.) afferent stimuli were used. Functionally different reactive changes in the EEG were detected even in deep inhibition of consciousness (a vegetative state). EEG reactions including a strengthening of pathological foci in the CNS with dominant features suggested a poor prognosis. In the absence of such foci, a positive activating effect on mental recovery was found for afferent stimulation, in particular, functionally significant stimulation. Selective sensitivity of the CNS to certain external stimuli was observed for certain unconscious states.__________Translated from Fiziologiya Cheloveka, Vol. 31, No. 3, 2005, pp. 5–15.Original Russian Text Copyright © 2005 by Sharova. 相似文献
16.
N P Shugalev 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1975,25(5):974-980
Changes of slow spindle electrical activity (12 to 14 cps) and evoked potentials in the cat caudate nuclei and the motor cortex were studied at different stages of elaboration of differentiation inhibition of a conditioned food-procuring reflex to acoustic stimuli. It has been shown that participation of the caudate nuclei in the inhibitory process begins at the stage of enhancement of food-procuring activity (second stage) and is apparently due to the animal's strong alimentary motivational excitation. At the third stage the inhibitory influence of caudate nuclei on the animal's motor activity in general, and the activity of the motor cortex in particular, develops to the full. 相似文献
17.
Toshiya Matsushima Masahiko Satou Kazuo Ueda 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1989,166(1):7-22
1. To elucidate the neural mechanisms that mediate visual responses of optic tectum (OT) to medullary and spinal motor systems, we analyzed medullary reticular neurons in paralyzed Japanese toads (Bufo japonicus). We examined their responses to electrical stimulation of OT, and stained some neurons intracellularly. Responses to stimulation of the glossopharyngeal nerve (IX) were also analyzed. 2. Extracellular single unit recording revealed excitatory responses of medullary neurons to OT and IX stimulation. Among 92 units encountered, 79 responded to OT stimuli, 10 to IX stimuli, and 3 to both. Some units responded to successive stimuli of short intervals with relatively stable lags. 3. Intracellular recording and staining experiments revealed morphologies of reticular neurons that received excitatory inputs from OT. Thirteen units were identified after complete reconstruction of somata and dendrites. Neurons in the nucleus reticularis medius received excitatory inputs from bilateral OT. They had wide dendrites in ventral, ventrolateral and lateral funiculi, and single axons descending in the ipsilateral ventral funiculus as far caudally as the cervical spinal cord. Some collaterals of these axons projected directly to the hypoglossal and spinal motor nuclei. Some neurons in other medullary nuclei (nuc. reticularis superior, pretrigeminal nucleus, nuc. reticularis inferior, and nuc. tractus spinalis nervi trigemini) also responded to the OT stimulation. 4. Activities in bilateral OT converge onto medullary reticular neurons, which may directly control medullary and spinal motor systems. 相似文献
18.
19.
L. N. Shapoval O. V. Dmytrenko L. S. Pobegailo L. G. Stepanenko V. F. Sagach 《Neurophysiology》2007,39(3):201-212
In acute experiments on normotensive rats and those with genetically determined hypertension (urethane anesthesia), we studied
hemodynamic effects resulting from modulation of the activities of neuronal NO synthase (NOS-1), arginase II, and superoxide
dismutase, and also of the mitochondrial permeability in medullary cardiovascular neurons. Unilateral microinjections of either
a nitric oxide (NO) donor, sodium nitroprusside, or a substrate for endogenous NO synthesis, L-arginine, into the medullary
cardiovascular nuclei (nucl. tractus solitarius, NTS, nucl. ambiguous, AMB, paramedian nucleus, PMn, and lateral reticular nucleus LRN) were shown to induce hemodynamic responses with rather similar dynamics in both normotensive and spontaneously hypertensive
rats, although in the latter the reactions were more intense. Injections of an antagonist of NOS-1, NG nitro-L-arginine (L-NNA), into the medullary nuclei under study in spontaneously hypertensive rats resulted in shifts of
the systemic arterial pressure (SAP), which did not differ dramatically from those observed in normotensive animals. The data
obtained serve as the background for the suggestion that the functional activity of NOS-1 is not fundamentally impaired under
hypertension conditions, but, probably, the amount of the substrate for adequate synthesis of NO via the NO-synthase pathway
of metabolism of L-arginine is insufficient. Considering this, we examined the functional activity of arginase, an enzyme
that also, similarly to NOS, uses L-arginine for metabolic transformation. Injections of antagonists of arginase, norvaline
or α-difluoromethylornithine hydrochloride (DFMO), into populations of the medullary neurons under study induced similar shifts
of the SAP in normotensive and spontaneously hypertensive rats, and those responses did not differ significantly from the
effects of inhibition of the NOS-1 activity. Thus, both the above-mentioned enzymes are potentially active in normotensive
and spontaneously hypertensive rats; so, a possibility for their competition for L-arginine in certain situations does exist.
Modulation of the mitochondrial permeability in medullary cardiovascular neurons in normotensive and spontaneously hypertensive
rats induced significant hemodynamic effects. In particular, an increase in the mitochondrial permeability in the medullary
cardiovascular nuclei by injections of an inductor of mitochondrial permeability transition pore (mPTP) opening, phenylarsine
oxide (PAO), was accompanied by SAP drops in both normotensive and spontaneously hypertensive rats; the effects were dose-dependent
and, in some cases, irreversible. A decrease in the mitochondrial permeability in the neurons under study by injections of
an inhibitor of mPTP, melatonin, induced mostly hypertensive responses, although in some experiments we observed hypotensive
and two-phase responses.
Neirofiziologiya/Neurophysiology, Vol. 39, No. 3, pp. 232–244, May–June, 2007. 相似文献
20.
Neuronal response to single stimuli was investigated in a cortical slab isolated from immobilized cats before, during, and after onset of induced epileptic states. Neurons of the isolated cortical slab were found to generate EPSP and paroxysmal depolarizing shifts (PDS) in membrane potential (MP) during the development of generalized epileptoid activity; these occurred together with refractory periods. Duration of the latter corresponds with the PDS plateau and repolarizing shifts in MP. Single electrical stimuli induced gradual alteration in PDS as these shifts developed. Neurons still maintain their ability to generate PDS arising in response to presentation of single stimuli once ictal activity has ceased. Postsynaptic response is not thought to play a decisive role in the genesis of epileptoid activity. Nonspecific factors and especially alterations in the concentration of electrogenic ions apparently contribute to this phenomenon.I. I. Mechnikov State University, Odessa. Translated from Neirofiziologiya, Vol. 21, No. 2, pp. 198–204, March–April, 1989. 相似文献