Early side effects of intrathoracic BCG therapy in patients with stage I squamous cell carcinoma,adenocarcinoma, or large cell lung cancer

Summary Data are presented on 179 stage I lung cancer patients subjected to resection operations and then given adjuvant intrapleural BCG and subsequent isoniazid (INH) therapy and on 167 control patients given intrapleural saline and placebo pills in a two-arm randomized double-blind study. The predominant immediate response to BCG/INH therapy was hyperpyrexia, which was found to be more pronounced in patients with larger induration in pretreatment PPD skin tests. Subsequently, chemical hepatitis (6 cases after BCG/INH versus 1 case after saline/placebo), peripheral neuropathy (3 versus 1), dermatitis/hives (5 versus 2), pleural thickening (4 versus 0), and persistent fever (10 versus 0) were noted. Analysis of laboratory changes measured at 18 weeks following randomization revealed that patients with BCG/INH lost 1.1 kg in weight and 0.30 g/dl in hemoglobin concentration on average, whereas control patients gained 1.2 kg and 0.33 g/dl, respectively. Modest rises in SGOT and alkaline phosphatase were apparent at 6 weeks after instillation of BCG compared with controls, but these differences were no longer statistically signifikant after 18 weeks. These side effects notwhithstanding, the BCG/INH therapy was well tolerated.Members of the Lung Cancer Study Group include R. T. Eagan*, R. E. Lee, W. S. Payne, R. E. Ritts, and L. Weiland from the Mayo Clinic, Rochester; C. F. Mountain*, H. T. Barkley, O. H. Frazier, K. Hermes, E. Hersh, and M. Valdivieso from M.D. Anderson Hospital, Houston; L. D. Hill*, M. D. Hafermann, and E. Morgan from The Mason Clinic, Seattle; P. W. Wright* and K.-E. Hellstrom from the Hutchinson Cancer Center, Seattle; C. Bagley, L. P. Johnson, H. Kellogg, and R. D. Pinkham from the Swedish Medical Center, Seattle; T. D. Ivey from University Hospital, Seattle; S. Hammar from Virginia Mason Hospital, Seattle; W. Nelems from St. Paul's Hospital, Vancouver; R. Feld*, D. Bergsagel, T. C. Brown, J. Curtis, C. Keen, J. F. Pringle, I. Quirt, and L. Yeoh from The Princess Margaret Hospital, Toronto; M. Blackstein and M. Goldberg from Mount Sinai Hospital, Toronto; F. G. Pearson*, D. W. Chamberlain, J. Cooper, W. Evans, and T. Todd from Toronto General Hospital, Toronto; M. Baker and R. Ginsberg from Toronto Western Hospital, Toronto; R. I. Mitchell from Wellesley Hospital, Toronto; E. C. Holmes*, W. F. Coulson, K. P. Ramming, and T. H. Weisenburger from the University of California, Los Angeles; Z. Petrovich from Wadsworth Veterans Hospital, Los Angeles; R. K. Oldham*, J. T. Forbes, F. A. Greco, D. L. Page, R. Prager, R. L. Richardson, and S. L. Stroup from Vanderbilt University, Nashville; J. M. Lukeman* and S. M. Sajjad from the Pathology Reference Center of M.D. Anderson Hospital, Houston; P. Grifone, A. Lebeck, and T. Voss from the Operations Office, Silver Spring, Maryland; M. Gail, W. McGuire, J. Allegra, and L. Rubinstein from the National Cancer Institute, Bethesda, Maryland; and L. Eirich, W. Heineman, and J. Beach from Information Management Services, Bethesda, Maryland. Asterisks designate principal investigators.     

Intrapleural and intravenous Corynebacterium parvum in patients with resected stage I and II non-small cell carcinoma of the lung

Summary A prospective randomized trial compared the administration of intrapleural plus intravenous Corynebacterium parvum (C. parvum) versus placebo in patients with resected Stage I and Stage II non-small cell bronchogenic carcinoma. Treatment consisted of 7 mg C. parvum injected into the pleural space and 7 mg C. parvum intravenously once between days 6 and 12 postoperatively and 7 mg intravenously every 3rd month during the 1st year. Intrapleural administration of 35 cc of saline served as the placebo and the flush after intrapleural C. parvum.Of the 303 patients entered into this study, 286 were evaluable, with an average follow-up time of 3.5 years. More complications, especially fever, were observed in patients receiving C. parvum. A fever greater than 38 °C was observed in 9% of the patients assigned to placebo and 76% of the patients assigned to C. parvum. There was no significant difference between the treatments with respect to disease-free interval or survival.M. Kaufmann, J. Stjernswärd**, A. Zimmermann (Ludwig Institute for Cancer Research, Bern Branch); K. Stanley**, M. Isley, M. Zelen (Frontier Science & Tech. Research Foundation, Brookline, MA, USA); C. Mouritzen, P. Paulsen, U. Henriques (Dept. of Thoracic and Cardiovascular Surgery and Institute of Pathology, Kommunehospital, Aarhus, Denmark); N. Konietzko, W. Maassen, W. Hartung, W. Wierich (Ruhrland Clinic, Essen-Heidhausen, and Pathology Institute, Ruhr-University, Bochum, FRG); P. Oehl (Innere Klinik und Poliklinik Tumorforschung, Essen, FRG); J. Vogt-Moykopf, H. Toomes, W. Hofmann (Rohrbach Hospital, Clinic for Thoracic Medicine and Pathology Institute, Heidelberg, FRG); F. Krause, R. Rios, R. Spanel (Klinik Löwenstein, Löwenstein, and Pathology Institute, Ulm, FRG); J. Orel, B. Hrabar, D. Ferluga, T. Rott (University Medical Center, Thoracic Surgery and Pathology, Ljubljana, Yugoslavia); H. A. Rostad, J. R. Vale, P. Lexow (Rikshospital, Oslo, Norway); S. Hagen, S. Birkeland (Ulleval Hospital, Oslo, Norway); T. Harbitz, R. Nissen-Meyer (Aker Hospital, Oslo, Norway); E. Aspevik, H. Engedal, A. Mykin (Haukeland Hospital, Bergen, Norway); V. O. Björk, L. Rodriguez, K. Böök, J. Willems (Karolinska Sjukhuset, Thoracic Surgical Clinic and Pathology Department, Stockholm, Sweden); E. Grädel, J. Hasse, P. Dalquen (Kantonsspital, Dept of Surgery, Div. of Cardiac & Thoracic Surgery & Pathology Institute, Basel, Switzerland); L. Eckmann, K. Hänni, K. Zimmermann (Tiefenauspital Surg. Clinic, Univ. of Bern, Switzerland); B. Nachbur, H. U. Würsten, H. Cottier, A. Zimmermann (Inselspital Dept. of Thoracic and Cardiovascular Surg. and Pathology Institute, Bern, Switzerland); W. Maurer, M. Kaufmann (Bürgerspital, Surgical Department, Solothurn, Switzerland); H. Denck, E. Zwintz, St. Wuketich (Krankenhaus der Stadt Wien-Lainz, I. Chir. Dept., and Path. Inst., Vienna, Austria); N. Pridun, H. Hackl (Pulmonologisches Zentrum der Stadt Wien, and Path. Inst., Vienna, Austria); E. Moritz, W. Schlick, H. Holzner (II. Chir. University Clinic and Path. Inst., Vienna, Austria); K. Karrer (Institute for Cancer Research, Vienna, Austria); R. G. Crispen (ITR-Biomedical Research, University of Illinois, Chicago, USA); D. S. Freestone, R. Bomford, M. T. Scott, T. Priestman, L. Toy (The Wellcome Research Laboratories, Beckenham, England)** Present address: Cancer Unit, World Health Organization, Geneva, Switzerland Offprint requests to: K. Stanley, Ludwig Institute for Cancer Research, Inselspital, CH-3010 Bern, SwitzerlandLudwig Lung Cancer Study Group:     

Books

Book reviews in this article:
C ommunication and B ehavior of W hales . R. Payne (ed.).
S trandings : W ays T o S ave W hales . F. D. r obson .
O rders and F amilies of R ecent M ammals of T he W orld . S. Anderson and J. Knox Jones, Jr. (eds.).
S oviet -A merican C ooperative R esearch on M arine M ammals . V olume l—P innipeds . F. H. Fay and G. A. Fedoseev (eds.).
P athobiology of M arine M ammal D iseases . E. B. Howard (ed.).
S eals of T he W orld . (Second Edition.) J. E. Ring. British Museum and Cornell University Press.
T he G ray W hale : E schrichtius R obustus . M. L. Jones, S. L. Swartt and S. Leatherwood.
T he S ierra C lub H andbook of W hales and D olphins . S. Leatherwood and R. R. Reeves.     

REVIEWS

Book review in this article
Botanical Latin . By W. T. S tearn .
Laboratory Manual of Tropical Mycology and Elementary Bacteriology . By A. T hompson and G loria L im .
Agriculture in the Tropics . By C. C. W ebster and P. N. W ilson .
Bananas . By N. W. S immonds .
Rice . By D. H. G rist .
Tea . By T. E den .
Lowson's Botany . By E. W. S imon , K. J. D ormer and J. N. H artshorne .
Annual Review of Plant Physiology , Vol. 16. Ed. by L. M achlis and W. K. B riggs .
Ultrastructural Plant Cytology . By A. F rey -W yssling and K. M ühlethaler .
Drawings of British Platits . Part XXII, Scrophulariaceae (1). By S tella R oss
Molecules and Cells .By D. A. C oult . The Principles of Modern Biology. Ed. by D. A. C oult .
The Growth of Cereals and Grasses . Ed. by F. L. M ilthorpe and J. D. I vins .
Origins of Metidelism . By R. C. O lby .
Fungal Genetics . By J. R. S. F incham and P. R. D ay . Botanical Monographs, Vol. 4, ed. by W. O. J ames .
Genetik der Pilze . by K. E sser and R. K uenen .
Microbial and Molecular Genetics . By J. R. S. F incham . Modern Biology Series, ed. by J. E. W ebb .
Index Kewensis Plantarum Phanerogamarum, Supplementum XIII . Compiled at the Herbarium of the Royal Botanic Gardens, Kew, under the direction of Sir G eorge T aylor .
A Flora of Northeastern Minnesota . By O lga L akela .
Stephen Hales, D.D., F.R.S. An Eighteenth Century Biography . By A. E. C lark -K ennedy .     

BUCHBESPRECHUNGEN

Book reviewed in this article:
E rben , H. K.: Die Entwicklung der Lebewesen. Spielregeln der Evolution. R einboth , R. (Ed.): Intersexuality in the Animal Kingdom.
The Sea Urchin Embryo. Biochemistry and Morphogenesis. Hrsg. von G. C zihak unter Mitwirkung von R. P eter . Vorwort von J. B rachet .
The Blood of Sheep. Composition and Function. Ed. by M. H. B lunt . With contributions by M. H. B lunt , R. I. C ox , C. C. C urtain , J. D. D argie , K. A. F erguson , P. H. H olmes , T. H. J. H uisman , W. M. F. L eat , D. B. L indsay , W. V. M acfarlane , E. W. M oodie and E. M. T ucker .
S tephan , H.: Allocortex. Handbuch der mikroskopischen Anatomie des Menschen. Begründet von W. v. M öllendorf , fortgeführt von W. B argmann . Bd. 4, Teil 9.     

Book Reviews

Book reviewed in this article:
Behaviour of Teleost Fishes, 2nd edn. Edited by T.J. P itcher
The IUCN Review of the Southern Okavango Integrated Water Development Project by T. S cudder , R.E. M anley , R.W. C olev , R.K. D avis , J. G reen , G.W. H oward , S.W. L awry , D. M artz , P.P. R ogers , A.R.D. T aylor , S.D. T urner , G.F. W hite and E.P. W right     

Reviews

Plant Lectins. By A. P ustzai .
Techniques for the Rapid Detection of Plant Pathogens . Ed. by J. M. D uncan and L. T orrance .
Ecological Genetics and Air Pollution. Ed. by G. R. T aylor , Jr., L. F. P itelka and M. T. C legg .
Arctic Ecosystems in a Changing Climate. Ed. By F. S. C hapin III, R. L. J efferies , J. F. R eynolds , G. R. S haver , J. S voboda and E. W. C hu .     

Book reviews

Book reviewed in this article:
P arasitology in F ocus : F acts and T rends (1988). Edited by H. Mehlman.
C olour A tlas for the D iagnosis of B acterial P athogens in A nimals (1988). Edited by W. Bisping & G. Amtsberg.
R ole of G ut F lora in T oxicity and C ancer (1988). By I.R. Rowland.
A naerobes T oday (1988). Edited by J.M. Hardie & S.P. Bordello.
T he R elease of G enetically -E ngineered M icro -O rganisms (1988). Edited by M. Sussman, C.H. Collins, F.A. Skinner & D.E. Stewart-Tull.
M icrobial T echnology in the D eveloping W orld (1988). Edited by E.J. Dasilva, Y.R. Dommergues, E.J. Nyns & C. Ratledge.
M icrobial L ipids Volume 1 (1988). Edited by C. Ratledge & S.G. Wilkinson.     

Reviews

General Microbiology . By R. Y. S tanier , M. D oudoroff and E. A. A delberg
Looking at Chromosomes . By J ohn M c L elish and B rian S noad
Drawings of British plants . Part X. Saxifragaceae, Crassulaceae. By S tella R oss -C raig
Marine Algae of the Northeastern Coast of North America . By W illiam R andolph T aylor
'Die Fagus- Abies- und Piceagurtelarten in der Kontaktzone der Tannen- und Fichtenwälder der Schweiz .' By A. S axer
Protoplasmatologia Handbuch der Protoplasmaforschung . By M. E rrhra
Bericht über das Geobotanische Forschungsinstitut Rübel in Zürich für das Jahr 1956 . Edited by E. RÜ bel and W. LÜ udi
An Atlas of Airborne Pollen Grains . By H. A. H yde and K. F. A dams
Flora of the British Isles , Illustrations. I Pteridophyta to Papilionaceae. Drawn by S ybil J. R oles . By A. R. C lapham , T. G. T utin and E. F. W arburg
Advances in Genetics , vol. IX. Edited by M. D emerec
Protoplasmatologia. Handbuch der Protoplamaforschung (L. V. Heilhrunn and F. Weber, editors), vol. 1, 2. Biocolloids and their Interactions . By H. L. B ooij and H. G. B ungenberg de J ong
Annual Review of Plant Physiology , vol. 9. Edited by A. S. C rafts , L. M achlis and J. G. T orrey     

Books

Books reviewed in this article:
B aker . K. 1993. Identification Guide to European Non-passerines.
B arnard . C., G ilbert , F. & M c G regor
B askett , T.S., S ayre . M.W., T omlinson , R.E. & M irarchi .
B ezzel . E. 1993. Kompendium der Vögel Mitteleuropas.
B right , M. 1993. The Private Life of Birds.
C ook , M. 1992. The Birds of Moray and Nairn.
D avison . G.W.H. 1992. Birds of Mount Kinabalu. Borneo.
E rritzoe . J. 1993. The Buds of CITES and How to Identify Them.
F arner , D.S., K ing , J.R. & P arkes , K.C.
G ibbons , D.W., R eid , J.B. & C hapman . R.A. (eds). 1993. The New Atlas of Breeding Birds in Britain and Ireland.
H illman , J.C.
H uxley . E.
J ackson . C.E. 1993. Great Bird Paintings of the World.
J ohnsgard . P.A. 1993. Cormorants, Darters and Pelicans of the World.
M adge . S. & B urn , H. 1994. Crows and Jays. A Guide to the Crows, Jays and Magpies of the World.
N icolai . B. (ed.).
P ower , D.M. (ed.).
P riklonskiy . S.G. (ed.).
R alph . R. 1993. William MacGillivray.
R obinson , D. & C hapman , A.
S harp . P.J. 1993. Avian Endocrinology.
S mith , K.W., D fe , C.W., F earnside . J.D., F letcher , E.W. & S mith , R.N.
S olomon . D. & W illiams , J.
S ørensen , S., B loch . D. & L angvad . S.
Z immerman , J.L.     

MORPHOLOGY, PHYSIOLOGY AND GENETICS

A dolph , E. F. 1967. Ontogeny of volume regulation in embryonic extracellular fluids.
A nderson , K. S., R andall , E. J., M ain , A. J. & T onn , R. J. 1966. Netting at High Pines.
D avis , F. W. 1965. Robins and D.D.T.
G ans , C. & B ock , W. J. 1965. The functional significance of muscle architecture—a theoretical analysis.
G rant , P. R. 1966. Retarded or arrested cranial development in a Mexican passerine, Myiopagis viridicata (Vieillot)
H udson , G. E., P arker , R. A., V an den B erge , J. & L anzillotti , P. J. 1966. A numerical analysis of the modifications of the appendicular muscles in various genera of gallinaceous birds.
KING, J. R. Adipose tissue composition in experimentally induced fat deposition in the 1967.
P eiponen , V. A. & B osley , A. 1964. Torpidity in a captive Nightjar ( Caprimulgus europaeus L.).
P owell , J. R. & B urke , J. D. 1966. Avian blood oxygen capacity.
R ijke , A. M. 1967. The water repellency and feather structure of cormorants, Phalacrocoracidae.
S iegfried , W. R. 1966. Growth, plumage development and moult in the Crowned Guineafowl Numida meleagris coronata Gurney.
S laden , W. J. L., B oyd , J. C. & P ederson , J. M. 1966. Biotelemetry studies on Penguin body temperatures.
S now , D. W. & S now , B. K. 1963. Meights and wing-lengths of some Trinidad birds.
Z wckel , F. C. 1966. Sex and age ratios and weights of Caprrcaillie from the 1965–66 shooting season in Scotland.     

Books

Book reviews in this article:
A ntarcitc E cology . R. M. Laws (ed.).
S eals O f T he W orld . J. E. King.
R eproduction I n W hales , D olphins and P orpoises . W. F. Perrin, R. L. Brownell, Jr., and D. P. DeMaster, eds.
E volution I n T he G alapagos I slands . R. J. Berry (ed.).
H istorical W haling R ecords . M. F. Tillman and G. P. Donovan (eds.).
D iving and A sphyxia , A C omparative S tudy O f A nimals and M an . R. Elsner and B. Gooden.     

REVIEWS

Atlas of Mapped Distributions of Dominance and Modern Pollen Percentages for Important Tree Taxa of Eastern North America . By P. A. D elcourt , H. R. D elcourt and T. W ebb III.
New Manual of Bryology. Volume 1. Edited by R. M. S chuster .
The Ecology and Physiology of the Fungal Mycelium. Edited by D. H. J ennings and A. D. M. R ayner .
Isotopes and Radiation in Agricultural Sciences. Edited by M. E. L'A nnunziata and J. O. L egg .
The Physiology of Flowering Plants : their growth and development . Third edition. By H. E. S treet and H. Ö pik .
Reconstructing Quaternary Environments. By J. J. L owe and M. J. C. W alker .
European Mires. Edited by P. M oore .
Compartments in Algal Cells and Their Interaction. (Proceedings in Life Sciences Series.) Edited by W. W iessner , D. G. R obinson and R. C. S tarr .
Chloroplast Metabolism. By B arry H alliwell .
Flooding and Plant Growth. Ed. by T. T. K ozlowski .
Mode of Action of Antifungal Agents. Ed. by A. P. J. T rinci and J. F. R yley .
Disease Resistance in Plants. By J. E. V anderplank .     

REVIEWS

Books reviewed in this article:
Thonner's Analytical Key to the Families of Flowering Plants. By R. G eesink , A. J. M. L eeuwenberg , C. E. R idsdale and J. F. V eldkamp
The Plant Cuticle. Ed. by D. F. C utler , K. L. A lvin and C. E. P rice
Introduction to Ecological Biochemistry . By J. B. H arborne
Vegetation Mitteleuropas mit den Alpen. By H einz E llenberg
Chloroplasts and Mitochondria. By M. T ribe and P. W hittaker
The Physiology and Biochemistry of Drought Resistance in Plants. Ed. by L. G. P aleg and D. A spinall     

REVIEWS

Book reviewed in this article:
Atlas of the British Flora . Edited by F. H. P erring and S. M. W althrs .
Handbuch der Pflanzenphysiologie: Encyclopedia of Plant Physiology . Vol. XIV: Growth and Growth Substances. Edited by W. R uhland .
Drawings of British Plants . Part XVII: Compositae (3). By S tella R oss -C raig .
Apical Meristems . By F. A. L. C lowes . Botanical Monographs, vol. 2. Edited by W. O. J ames .
Cellular Regulatory Mechanisms . Cold Spring Harbor Symposia on Quantitative Biology
Proceedings of the Summer School of Botany held June 2–15, 1960, at Darjeeling . Edited by P. M aheshwari , B. M. J ohri and I. K. V asil .
Exotic Forest Trees in the British Commonwealth . By R. J. S treets . Edited by Sir H arry C hampion .
A Flora of the Alaskan Arctic Slope . By I. L. W iggins and J. H. T homas
Grundzüge der Pflanzenanatomie . By B. H uber .
Taschenbuch der Botanik . By H. M iehe . Revised by W. M evius .
A Conspectus of Aphids as Vectors of Plant Viruses . By J. S. K ennedy , M. F. D ay and V. F. E astop .
Crop Adaptation and Distribution . By C arroll P. W ilsie .
Flora of Cultivated Plants of the U.S.S.R. Vol. XIII: Perennial Leguminous Plants: Medicago, Melilotus and Trigonella. Edited by E. N. S inskaya . Translated by N. L andau .
Der Federsee . Edited by W. Z immermann .
Carbohydrate Resources within the Perennial Plant . By C. A. P riestley .
Flora of the British Isles . By A. R. C lapham , T. G. T utin and E. F. W arburg .
Mineral Salts Absorption in Plants . By J. F. S utcliffe .
The Development of British Heathlands and their Soils . By G. W. D imbleby .
Annual Review of Plant Physiology , vol. 13. Edited by L. M achlis and W. R. B riggs .     

REVIEWS

Book reviewed in this article:
Excursion Flora of the British Isles , 2nd edn. By A. R. C lapham , T. G. T utin and E. F. W arburg .
Critical Supplement to the Atlas of the British Flora . Ed. by F. H. P erring assisted by P. D. S ell .
Drawings of British Plants . Part XXIV. Labiatae . By S tella R oss -C raig .
Britain's Green Mantle , 2nd edn. By the late A. G. T ansley . Revised by M. C. F. P roctor .
The Flora of Berkshire . By H. J. M. B owen .
Flora of Turkey and the East Aegean Islands . By P. H. D avis , assisted by J. C ullen and M. J. E. C oode .
Plants and Man on the Seychelles Coast . By J. D. S auer .
Key to the Families of Flowering Plants of the World . Revised and enlarged by J. H utchinson .
The Diversity of Green Flants . By P. R. B ell and C. L. F. W oodcock .
IBP Handbook No . 5: Handbook to the Conservation Section of the International Biological Programme . By E. M. N icholson .
Plants, Man and Life , 2nd edn. By E dgar A nderson .
Production and Mineral Cycling in Terrestrial Vegetation . By L. E. R odin and N. I. B azilevich . Translation by Scripta Technica Ltd (Ed. by G. E. F ogg ).
'Torrey Canyon' Pollution and Marine Life . A Report by the Plymouth Laboratory of the Marine Biological Association of the United Kingdom. Ed. by J. E. S mith .
Geobotanische Untersuchungen auf der Feddersen Wier de . By U. K örber -G rohne .
Cell Walls and Membranes . By H. J. R ogers and H. R. P erkins .
Wachstums regulatoren bei Pflanzen . Ed. by E. L ibbert and B. S teyer .
The Ecology of Soil Bacteria ( An International Symposium ). Ed. by T. R. G. G ray and D. P arkinson .
Genetics of Fungi . By K arl E sser and R udolf K uenen . Translated by E rich S teiner .
Plant Pathologist's Pocketbook . Compiled by The Commonwealth Mycological Institute.     

REVIEWS

The Chemical Activities of Bacteria. By E. F. G ale , B.A., Ph.D.
Heredity and Variation in Micro-organisms. Cold Spring Harbor Symposia on Quantitative Biology.
The Royal Botanical Expedition to New Spain. By H erbert W illiam R ickett .
The Living Plant. By I. V. N ewman .
Hormones and Horticulture. The use of special chemicals in the control of plant growth. By G eorge S. A very and E lizabeth B indloss J ohnson , with the collaboration of R uth M. A ddoms and B etty F. T homson .
Plant Physiology. By M eirion T homas .
The Genetics of Garden Plants. By M. B. C rane and W. J. C. L awrence , with a foreword by S ir D aniel H all .
Plant Viruses. By K enneth M. S mith , F.R.S.     

Reviews

Book reviewed in this article:
Plant Molecular Biology. Molecular Genetic Analysis of Plant Development and Metabolism. Ed. by G loria C oruzzi & P ere P uigdomégnech
Vacuum Methods in Electron Microscopy. By W. C. B igelow . Practical Methods in Electron Microscopy. Vol 15. Series Editor: Audrey M. G lauert .
The Fungi. By M ichael J. C arlile & S arah C. W atkinson .
Aspects of Tropical Mycology. Symposium of the British Mycological Society held at the University of Liverpool, April 1992. Edited by S. I saac , J. C. F rankland , R. W atling & A. J. S. W halley .
Belalong, A Tropical Rainforest. By T he E arl O f C ranbrook & D avid S. E dwards .
Ecology and Management of Invasive Riverside Plants. Ed. by L. C. D e W aal , L. E. C hild , P. M. W ade & J. H. B rock     

REVIEWS

Molds, Yeasts and Actinomycetes. By C. E. S kinner , C. W. E mmons and H. M. T suchiya
Probit Analysis: A Statistical Treatment of the Sigmoid Response Curve. By D. J. F inney . With a foreword by F. T attersfield
Leguminous Forage Plants. By D. H. R obinson
Cytologie Végétale et Cytologie Générale. Par P ierre D angeard
German-English Science Dictionary for Students in Chemistry, Physics, Biology, Agriculture and Related Sciences. By L. D e V ries     

REVIEWS

Book reviewed in this article:
A Course in Biology . By J. J. B aker and G. E. A llen .
Papers on Plant Systematics . By R. O rnduff .
Die Entstehung der Arten und hoheren Kategorien . By H. L amprecht .
Flora of Iraq , Vol. 9. Gramineae . By N. L. B or . (Ed. by C. C. T ownsend and E van G uest , with the collaboration of A li A l -R awi ).
Wild Elowers of North Carolina . By W illiam S. J ustice and C. R itchie B ell .
The Lichen Genera Cetrelia and Platismatia ( Parmeliaceae ). By W. L. C ulberson and C. F. C ulberson .
Essays on Form in Plants . By C. W. W ardlaw .
Crop Responses to Water at Different Stages of Growth . By P. J. S alter and J. E. G oode .
Protons, Electrons, Phosphorylation and Active Transport . By R. N. R obertson .
Encyclopedia of Plant Physiology, XVIII, Sexuality: Reproduction; Alternation of Generations . General editor, W. R uhland ; sub-editor for this volume, H. F. L inskens .
Annual Review of Plant Physiology , Vol. 19. 1968. By L. M achlis (Ed.).
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