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《Molecular cell》2023,83(13):2206-2221.e11
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Lee HK Seo IA Seo E Seo SY Lee HJ Park HT 《Biochemical and biophysical research communications》2007,362(4):1057-1062
Netrin and its receptors, DCC (Deleted in Colorectal Cancer) and Unc5, are proposed to be involved in the axon guidance and neuroglial migration during development. However, accumulating evidence implies that they may also participate in the cell survival and apoptosis. Here, we show that netrin-1 induces proliferation of Schwann cells. Unc5b is the sole receptor expressed in RT4 schwannoma cells and adult primary Schwann cells, and netrin-1 and Unc5b are found to be expressed in the injured sciatic nerve. It was also found that the netrin-1-induced Schwann cell proliferation was blocked by the specific inhibition of Unc5b expression with RNAi. These data suggest that netrin-1 could be an endogenous trophic factor for Schwann cells in the injured peripheral nerves. 相似文献
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Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta 总被引：2，自引：0，他引：2
Tan L Peng H Osaki M Choy BK Auron PE Sandell LJ Goldring MB 《The Journal of biological chemistry》2003,278(20):17688-17700
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Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4 总被引：4，自引：0，他引：4
Chang CC Lin DY Fang HI Chen RH Shih HM 《The Journal of biological chemistry》2005,280(11):10164-10173
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Lu P Hankel IL Hostager BS Swartzendruber JA Friedman AD Brenton JL Rothman PB Colgan JD 《The Journal of biological chemistry》2011,286(20):18311-18319