三维标测环肺静脉前庭隔离术后肺静脉狭窄的相关因素

目的：探讨房颤射频消融术后肺静脉狭窄的相关因素,为其预防提供依据。方法：收集113例射频消融房颤患者的临床资料,记录射频术中消融时间、阻抗和温度;术后6个月64层CT左房-肺静脉重建随访,统计肺静脉狭窄的发生率;多元Logistic回归分析肺静脉狭窄的相关因素。结果：依据肺静脉数量计算的肺静脉狭窄率为3．4％,按照患者数量计算的肺静脉狭窄率为7．7％。多元Logistic回归分析,初始50例手术较其后病例的OR为2．167,95％CI=I．038-9．857,P=0．046,消融时间在总消融时间均数之上的患者比在均数之下者OR为2．856,95％CI=1．352-6．043,P=0．021。结论：初始50例手术和消融时间长是房颤射频消融术后肺静脉狭窄的相关因素。     

三维标测环肺静脉前庭隔离术后肺静脉狭窄的相关因素

目的:探讨房颤射频消融术后肺静脉狭窄的相关因素,为其预防提供依据。方法:收集113例射频消融房颤患者的临床资料,记录射频术中消融时间、阻抗和温度;术后6个月64层CT左房-肺静脉重建随访,统计肺静脉狭窄的发生率;多元Logistic回归分析肺静脉狭窄的相关因素。结果:依据肺静脉数量计算的肺静脉狭窄率为3.4%,按照患者数量计算的肺静脉狭窄率为7.7%。多元Logistic回归分析,初始50例手术较其后病例的OR为2.167,95%CI=1.038~9.857,P=0.046,消融时间在总消融时间均数之上的患者比在均数之下者OR为2.856,95%CI=1.352~6.043,P=0.021。结论:初始50例手术和消融时间长是房颤射频消融术后肺静脉狭窄的相关因素。     

肺静脉口弧形指数与房颤消融术后复发的关系

目的:探讨肺静脉口弧形指数与心房颤动(房颤)导管消融术后复发的关系。方法:选取2008年2月至2011年3月在我院接受导管消融术的房颤患者120例,所有患者于术前3日内利用多排CT行左心房及肺静脉造影,并进行图像的三维重建。测量每条肺静脉前后径及上下径,并计算弧形指数(肺静脉前后径/肺静脉上下径)以描述肺静脉口形态。行射频消融治疗的房颤病人全部达消融终点,术后随访超过3个月,根据患者房性快速性心律失常(房颤、房扑或房速)的发生情况,将其分为治愈组和复发组,进行统计分析。结果:由弧形指数分析,四支肺静脉开口形态存在统计学差异(P0.05);房颤消融术后,53例病人复发。房颤消融术后复发患者的LIPV弧形指数与治愈者不同,差异有显著性(P0.05);两组患者的左上肺静脉(Left Superior Pulmonary Vein,LSPV),右上肺静脉(Right Superior Pulmonary Vein,RSPV),右肺下静脉(Right Inferior Pulmonary Vein,RIPV),的弧形指数比较差异不明显(P0.05)。结论:左下肺静脉形态的不一致性与房颤导管消融术复发有关。     

Relationship between a Common Variant in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans

Dramatic shifts in the Western diet have led to a marked increase in the dietary intake of the n-6 polyunsaturated fatty acid (PUFA), linoleic acid (LA). Dietary LA can then be converted to arachidonic acid (ARA) utilizing three enzymatic steps. Two of these steps are encoded for by the fatty acid desaturase (FADS) cluster (chromosome 11, 11q12.2-q13) and certain genetic variants within the cluster are highly associated with ARA levels. However, no study to date has examined whether these variants further influence pro-inflammatory, cyclooxygenase and lipoxygenase eicosanoid products. This study examined the impact of a highly influential FADS SNP, rs174537 on leukotriene, HETE, prostaglandin, and thromboxane biosynthesis in stimulated whole blood. Thirty subjects were genotyped at rs174537 (GG, n = 11; GT, n = 13; TT, n = 6), a panel of fatty acids from whole serum was analyzed, and precursor-to-product PUFA ratios were calculated as a marker of the capacity of tissues (particularly the liver) to synthesize long chain PUFAs. Eicosanoids produced by stimulated human blood were measured by LC-MS/MS. We observed an association between rs174537 and the ratio of ARA/LA, leukotriene B₄, and 5-HETE but no effect on levels of cyclooxygenase products. Our results suggest that variation at rs174537 not only impacts the synthesis of ARA but the overall capacity of whole blood to synthesize 5-lipoxygenase products; these genotype-related changes in eicosanoid levels could have important implications in a variety of inflammatory diseases.     

Variation in the Fatty‐Acid Content in Seeds of Various Black,Red, and White Currant Varieties

Currant seeds, a by‐product of juice production, are recognized as a valuable source of oil rich in polyunsaturated fatty acids. We have evaluated 28 currant varieties for their oil content and fatty‐acid composition. The oil content in the seeds ranged from 18.2–27.7%, and no statistical difference between varieties of different fruit color were recorded. Furthermore, the estimated oil yields in the field production ranged from 26.4–212.4 kg/ha. The GC and GC/MS chemical profiles of the seed oils extracted from all examined varieties were common for currants. Linoleic acid (LA) was the major component, with contents ranging from 32.7–46.9% of total fatty acids, followed by α‐linolenic acid (ALA; 2.9–32.0 %), oleic acid (OA; 9.8–19.9%), γ‐linolenic acid (GLA; 3.3–18.5%), palmitic acid (PA; 4.4–8.1%), stearidonic acid (SDA; 2.2–4.7%), and stearic acid (SA; 1.2–2.4%). Quantitative differences in the fatty‐acid profiles between varieties of different fruit color were observed. Blackcurrant varieties showed significantly higher contents of LA, GLA, and PA than red and white currant varieties, whereas significantly higher amounts of ALA and OL were detected in the red and white varieties. Cluster analysis based on the chemical oil profiles joined the blackcurrants in one group, while most of the red and white cultivars joined in a second group at the same linkage distance.