细胞工程

861355 用抗原偶合的微球体标记细胞[专,英]/Parks,D.R.…∥US Patent US 4510244.Pub.09.04.85.Appl.US 421668,fil-ed 22.09.82[译自CBA,1985,(6),1829]本专利介绍一种选择性分离能产生针对     

细胞工程

871486 针对血管紧张素转换酶的单克隆抗体及其制备和使用方法[专,英]/Aoerbach.R.//US Patent US 4582790.Pub.15.04.86.APPI.US 466477,filed 15.02.83[译自CBA,2986,(7),2534] 此单克隆抗体的交叉种特异性是经过改进的,用于测定血管紧张素转换酶。     

基因工程

871434新的载体和控制干扰素表达的方法[专,英]/Crowl,R.M,/US Patent US4582800.Pub.15.04.86.Appl.US 397388,filed 12.07.82[译自CBA,1956,(7),2477] 改良的表达载体包括噬菌体λ的Pl启动子和操纵基因、带碱基序列ATG的真核DNA及人免疫干扰素的基因,和一个结合有启动子下游和真核DNA上游的连接位点的杂种核糖体。     

疫苗

871756 酶-去污剂提取的马链球菌疫苗的制备和应用[专,英]/Brown,K.K.…//USPatent US 45s279s.Pub.15。04.s6.Appl。US 674449,filed 23.11。84[译自CBA,1986,(7),2670] 马链球菌的酶-去污剂提取物含有致免疫的类M蛋白质,可用作马的免疫疫苗。     

抗生素

871772 诺卡氏菌ATCC 39043发酵产生的红霉素D和醋[专,英}/Celmer,W .D.…//US Patent US 4552796。Pub。15.04。86。Appl.US 600612,filed 16。04。84[译自CBA,1986,·(7),2669] 诺卡氏菌(Norcardia)ATCC 39043在液体培养基中发酵,产生抗生素混合物,包括红霉素D及其3＇,4＇二一O乙酞基,3＇-O-乙酸基-4＇-O一priopionyl及4＇-O-乙酸基酯。     

其它药剂

861695 通过转氨基作用生产L-氨基酸[专,英]/Rozzell,J.D.∥European Patent A-PPl.EP 0135846.Pub.03.04.85.Appl.US528730,filed 01.09.83[译自CBA,1985,     

抗生素

861678 吸水链霉菌的一个新菌株通过发酵法生产抗生素[专,英]/Hanada,M.…∥U-S Patent US 4504580,Pub.12.03.85.A-     

基因工程

861302 外源蛋白的稳定和质粒在蛋白稳定中的应用[专,英]/Shub,D.A.…∥Euro-pean Patent Appl EP 013304 Pub.13.08.25.Appl.US 518226,filed 01.08.83[译自CBA,1985,(4),1050]     

疫苗

861668 产生免疫应答,防止疟疾感染的方法和材料[专,英]/Ristic,M.…∥Europ-ean Patent Appl EP 0136215 Pub 03.04.85.Appl.US 524919,filed 19.08.83     

食品上的应用

861734 连续发酵法[专,英]/Cheryan,M.…∥PCT Patent Appl.WO 85/01064.Pub.14.03.85.Appl.US 526427,filed25.08.83[译自CBA,1985,(6),2958]本专利的内容包括对牛乳或乳清产物以及副产物进行连续发酵,通过发酵可从其中     

淋巴因子和干扰素

861694 微生物表达白细胞介素Ⅱ[专,英]/Souza,L.M.…∥European Patent Ap-pl.EP 0136489.Pub.10.04.85.Appl.US521967,filed 10.08.83[译自CBA,1985,(6),2005]此专利述及DNA序列的制造,这些序列含有一些结构基因,它们编码具有白细胞介     

疫苗

<正> 854956 含流感 HA 基因的牛痘病毒重组体[专,英]/US-Dept.Health-Human-Serv./US 6555-811:28.11.83-US-555811(05.06.84)28.11.83 as 555811.84-219196/35     

化工上的应用

870411微生物性多糖、制备它们的工艺、适宜的微生物及多糖的利用〔专,英〕/Voe-lskow,H.…/US PatentL〕5 4567140.Pub.28.01.86.appi.Ee 3224953,fij-ed 22 .04.82[译自CBA,1986,(4),1406〕     

基因工程

870001完整基因及其摘出和克隆的方法[专,英」/McCute han,T.F.…/EuropeanPatent Appl.Ep 0170146.Pub.05.02. 86.Appl.US 636261,filed 31.07.54〔译自CBA,1956,(4),1115] 本发明揭示功能齐全完整基因以及获得     

抗生素

880356 BBM一928的发酵过程〔专,英」/Ko-shiyama,H.…了US Patent US连631256Pub.23.12.86.Appl.US 539513,fil-ed 06.10.83〔译自CBA,1987,(4),1669〕 本专利涉及生产抗肿瘤抗生素BBM-928复合物的发酵过程。它包括将具各已知特」}生的放线菌(Aet‘nomad:ra)G455一101株培育于含可吸收氮源和碳原的水溶液中,在水下充气条件下培育至产生BBM一928复合物,并使溶液具实质性抗肿瘤活性。(戴顺志)一89一880357抗生素A一4696因子G〔专,英〕/He-rshberger,C.L.…了US Patent US4637981.Pub.20.01.87.Appl.US593015,filed 26.03.54…     

化工上的应用

861767 天冬氨酰苯丙氨酸烷基酯的制备方法[专,英]/Harada,T.…∥US PatentUS 4506011.Pub.19.03.85.Appl.JA 56-139247,filed 05.09.81[译自CBA,1985,(6),2047]本项专利报道了天冬氨酰苯丙氨酸烷基酯的制备方法。它是用选自一些微生物的细胞或细胞溶解产物的液体培养物,这些微生     

基因工程

872378带有重组表面蛋白的病毒〔专,英」/Dulbeeeo,R.//US Patent US 4593002.Pub.03.06.86.Appl.US338416,filed.11.01.82〔译自CBA,1986,(9),3352〕肽基因作为表面病毒蛋白的一个裸露片段,经遗传操作及其后的表达,可实行对病毒的修饰。     

Evolutionary Genomics of Weedy Rice in the USA

Red rice Is an Interfertlle, weedy form of cultivated rice （Oryza sativa L.） that competes aggressively with the crop In the southern US, reducing yields and contaminating harvests. No wild Oryza species occur In North America and the weed has been proposed to have evolved through multiple mechanisms, Including ＂de-domestication＂ of US crop cultlvars, accidental introduction of Asian weeds, and hybridization between US crops and Asian wild/weedy Oryza strains. The phenotype of US red rice ranges from ＂crop mimics＂, which share some domestication traits with the crop, to strains closely resembling Asian wild Oryza species. Assessments of genetic diversity have Indicated that many weed strains are closely related to Asian taxa （Including indica and aus rice varieties, which have never been cultivated In the US, and the Asian crop progenitor O. ruflpogon）, whereas others show genetic similarity to the tropical Japonica varieties cultivated In the southern US. Herein, we review what Is known about the evolutionary origins and genetic diversity of US red rice and describe an ongoing research project to further characterize the evolutionary genomlcs of this aggressive weed.     

超声刺激在红藻氨酸诱导的癫痫小鼠中呈现抗癫痫和海马神经保护作用

目的 研究超声刺激(ultrasound stimulation,US)在红藻氨酸(kainate,KA)诱导的小鼠癫痫模型中的抗癫痫作用.方法 将小鼠随机分为对照组(n=11)、KA组(n=12)和KA+US组(n=12).通过侧脑室注射KA建立小鼠癫痫模型,并给予US处理2周.通过视频监控记录US对KA诱发的小鼠癫...     

On Bioinformatic Resources

<正>A starting point of curating bioinformatic resources for the public is marked by the establishment of the US National Center for Biotechnology Information(NCBI)in 1988[1].One of its many purposes is certainly to echo the initiative of the Human Genome Project(HGP)––when two landmark reports were published at the same time:‘‘Mapping and Sequencing the Human Genome’’by the National Research Council[2]and‘‘Mapping Our Genes––The Genome Project:How Big,How Fast?’’by the US Congress[3].