共查询到20条相似文献,搜索用时 62 毫秒
1.
2.
3.
4.
5.
6.
7.
Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy 总被引:6,自引:0,他引:6
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Bacheler L Jeffrey S Hanna G D'Aquila R Wallace L Logue K Cordova B Hertogs K Larder B Buckery R Baker D Gallagher K Scarnati H Tritch R Rizzo C 《Journal of virology》2001,75(11):4999-5008
8.
9.
10.
El Hadri K Glorian M Monsempes C Dieudonné MN Pecquery R Giudicelli Y Andreani M Dugail I Fève B 《The Journal of biological chemistry》2004,279(15):15130-15141
11.
12.
Suppression of virus load by highly active antiretroviral therapy in rhesus macaques infected with a recombinant simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
North TW Van Rompay KK Higgins J Matthews TB Wadford DA Pedersen NC Schinazi RF 《Journal of virology》2005,79(12):7349-7354
13.
14.
15.
16.
17.
18.
19.
20.
Phairote Teeranaipong Sunee Sirivichayakul Suwanna Mekprasan Pirapon June Ohata Anchalee Avihingsanon Kiat Ruxrungtham Opass Putcharoen 《PloS one》2016,11(4)
IntroductionEtravirine(ETR) can be used for patients who have failed NNRTI-based regimen. In Thailand, ETR is approximately 45 times more expensive than rilpivirine(RPV). However, there are no data of RPV use in NNRTI failure. Therefore, we assessed the susceptibility and mutation patterns of first line NNRTI failure and the possibility of using RPV compared to ETV in patients who have failed efavirenz(EFV)- and nevirapine(NVP)-based regimens.MethodsClinical samples with confirmed virological failure from EFV- or NVP-based regimens were retrospectively analyzed. Resistance-associated mutations (RAMs) were interpreted by IAS-USA Drug Resistance Mutations. Susceptibility of ETR and RPV were interpreted by DUET, Monogram scoring system, and Stanford University HIV Drug Resistance Database.Results1,279 and 528 patients failed EFV- and NVP-based regimens, respectively. Y181C was the most common NVP-associated RAM (54.3% vs. 14.7%, p<0.01). K103N was the most common EFV-associated RAM (56.5% vs. 19.1%, P<0.01). The results from all three scoring systems were concordant. 165(11.1%) and 161(10.9%) patients who failed NVP-based regimen were susceptible to ETR and RPV, respectively (p = 0.85). 195 (32.2%) and 191 (31.6%) patients who failed EFV-based regimen, were susceptible to ETR and RPV, respectively (p = 0.79). The susceptibility of ETV and RPV in EFV failure was significantly higher than NVP failure (p<0.01).ConclusionThe mutation patterns for ETR and RPV were similar but 32% and 11% of patients who failed EFV and NVP -based regimen, respectivly were susceptible to RPV. This finding suggests that RPV can be used as the alternative antiretroviral agent in patients who have failed EFV-based regimen. 相似文献