共查询到20条相似文献,搜索用时 31 毫秒
1.
Nikki Charles Tatsuya Ozawa Massimo Squatrito Anne-Marie Bleau Cameron W. Brennan Dolores Hambardzumyan Eric C. Holland 《Cell Stem Cell》2010,6(2):141-152
Highlights? Perivascular niche nitric oxide activates Notch in PDGF-induced gliomas ? Notch signaling drives tumor stem-like characteristics and reduces survival ? Loss of eNOS activity decreases tumor stem-like characteristics ? Suppressing eNOS activity prolongs survival in glioma-bearing mice 相似文献
2.
3.
Haoran Tang Ang Li Jing Bi Douwe M. Veltman Tobias Zech Heather J. Spence Xinzi Yu Paul Timpson Robert H. Insall Margaret C. Frame Laura M. Machesky 《Current biology : CB》2013,23(2):107-117
Highlights? Arp2/3 complex drives epithelial cell invasion in the absence of WRC ? Loss of WRC promotes N-WASP-dependent invasion and degradative focal adhesions ? Loss of WRC promotes FAK activation and enhances anchorage-independent growth ? WRC suppresses cell transformation and tumor formation 相似文献
4.
Felix Willmund Marta del Alamo Sebastian Pechmann Taotao Chen Véronique Albanèse Eric B. Dammer Junmin Peng Judith Frydman 《Cell》2013,152(1-2):196-209
Highlights? Yeast Hsp70 SSB binds cotranslationally to a defined set of nascent polypeptides ? SSB shows specificity for substrates highly challenged in cotranslational folding ? The heterodimeric cochaperone RAC modulates cotranslational SSB specificity ? Loss of SSB function leads to widespread misfolding and aggregation 相似文献
5.
6.
Celine Delaloy Lei Liu Jin-A Lee Hua Su Fanxia Shen Guo-Yuan Yang William L. Young Kathy N. Ivey Fen-Biao Gao 《Cell Stem Cell》2010,6(4):323-335
Highlights? miR-9 is expressed in hESC-derived early hNPCs and their progeny ? Loss of miR-9 inhibits early hNPC proliferation and delays maturation ? miR-9 knockdown promotes hNPC migration in vitro and in vivo ? Stathmin is a target of miR-9 and mediates its effects in early hNPCs 相似文献
7.
Li A Ma Y Yu X Mort RL Lindsay CR Stevenson D Strathdee D Insall RH Chernoff J Snapper SB Jackson IJ Larue L Sansom OJ Machesky LM 《Developmental cell》2011,21(4):722-734
Highlights? Rac1 and the Scar/WAVE complex drive pseudopod-based motility of melanoblasts ? Rac1-depleted melanoblasts move using unique actin-based stubs and not blebs ? Rac1 controls pseudopod frequency but is dispensable for pseudopod formation ? Loss of Rac1 delays melanoblast cell-cycle progression and cytokinesis 相似文献
8.
Brandon Faubert Gino Boily Said Izreig Takla Griss Bozena Samborska Zhifeng Dong Fanny Dupuy Christopher Chambers Benjamin J. Fuerth Benoit Viollet Orval A. Mamer Daina Avizonis Ralph J. DeBerardinis Peter M. Siegel Russell G. Jones 《Cell metabolism》2013,17(1):113-124
Highlights? Loss of AMPKα1 cooperates with the Myc oncogene to accelerate lymphomagenesis ? AMPKα dysfunction enhances aerobic glycolysis (Warburg effect) ? Inhibiting HIF-1α reverses the metabolic effects of AMPKα loss ? HIF-1α mediates the growth advantage of tumors with reduced AMPK signaling 相似文献
9.
Highlights? mVam2 mediates endocytic transport from late endosomes to lysosomes ? mVam2 is essential for assembly of large apical vacuoles in visceral endoderm ? Loss of mVam2 results in hyperactivation of BMP signaling ? The mVam2-dependent BMP attenuation contributes to patterning in gastrulation 相似文献
10.
Hana Antonicka Florin Sasarman Tamiko Nishimura Vincent Paupe Eric A. Shoubridge 《Cell metabolism》2013,17(3):386-398
Highlights? GRSF1 (G-rich sequence binding factor 1) is a mitochondrial RNA-binding protein ? GRSF1 localizes to granules containing newly synthesized RNA in close proximity to mitochondrial nucleoids ? GRSF1 specifically binds one mRNA and two long noncoding RNAs transcribed from contiguous genes on the light strand of mtDNA ? Loss of GRSF1 leads to misloading of RNAs onto the mitochondrial ribosome and a specific translation defect 相似文献
11.
Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis 总被引:1,自引:0,他引:1
Highlights? A metabolic behavior revealing a key homeostatic role for the invertebrate intestine ? Enteric neurons couple reproductive state with intestinal physiology ? An insulinergic brain-gut neuronal circuit adjusts feeding to nutritional conditions ? A vasopressin-like system of central neurons is essential for water homeostasis 相似文献
12.
Justus Veerkamp Franziska Rudolph Zoltan Cseresnyes Florian Priller Cécile Otten Marc Renz Liliana Schaefer Salim Abdelilah-Seyfried 《Developmental cell》2013,24(6):660-667
Highlights? Cardiac laterality involves Nodal modulating an antimotogenic Bmp activity ? The Nodal target Hyaluronan synthase 2 unilaterally dampens Bmp signaling activity ? Nonmuscle myosin II is positively regulated by Bmp within cardiac tissue ? High levels of nonmuscle myosin II activity reduce cardiac cell motility 相似文献
13.
Florian MC Dörr K Niebel A Daria D Schrezenmeier H Rojewski M Filippi MD Hasenberg A Gunzer M Scharffetter-Kochanek K Zheng Y Geiger H 《Cell Stem Cell》2012,10(5):520-530
Highlights? Constitutively increasing Cdc42 activity causes aging of young HSCs ? Elevated Cdc42 activity correlates with a loss of cell polarity in aged HSCs ? Inhibition of Cdc42 activity rejuvenates aged LT-HSC function ? Cdc42 inhibition restores the level and spatial distribution of AcH4K16 相似文献
14.
Mark R. Morgan Hellyeh Hamidi Mark D. Bass Stacey Warwood Christoph Ballestrem Martin J. Humphries 《Developmental cell》2013,24(5):472-485
Highlights? c-Src phosphorylates syndecan-4 in response to extracellular stimuli ? Syndecan-4 phosphorylation and engagement regulate Arf6 activity ? Syndecan-4-mediated Arf6 activity regulates differential integrin recycling ? Syndecan-4-mediated integrin recycling controls FA dynamics and cell migration 相似文献
15.
Chunzhang Yang Kristin Huntoon Alexander Ksendzovsky Zhengping Zhuang Russell R. Lonser 《Cell reports》2013,3(1):52-59
Highlights? Loss of mutant pVHL in VHL-associated tumors is due to rapid degradation ? Mutant pVHL maintains its intrinsic function as an E3 ligase ? HDACIs stabilize mutant pVHL and ameliorate tumor growth in vivo ? HDACIs represent a targeted therapy for VHL-associated tumors 相似文献
16.
Tommy E. White Alberto Brandariz-Nuñez Jose Carlos Valle-Casuso Sarah Amie Laura Anh Nguyen Baek Kim Marina Tuzova Felipe Diaz-Griffero 《Cell host & microbe》2013,13(4):441-451
Highlights? SAMHD1 only exhibits antiviral activity when expressed in noncycling cells ? SAMHD1 is unphosphorylated in noncycling cells ? Reverse genetics revealed that phosphorylated SAMHD1 is repressive for restriction ? SAMHD1 phosphorylation regulates restriction, but not the cellular levels of dNTPs 相似文献
17.
Highlights? C. elegans DAF-2 insulin-like signaling negatively regulates HSF-1 activity ? DDL-1 and DDL-2 are negative regulators of HSF-1 ? Formation of a complex containing DDL-1/2 and HSF-1 inhibits HSF-1 activity ? DAF-2 signaling promotes DHIC formation by inhibiting DDL-1 phosphorylation 相似文献
18.
Ryan C. Wilson Meghan A. Jackson Janice D. Pata 《Structure (London, England : 1993)》2013,21(1):20-31
Highlights? Y-family polymerases differ in fidelity and translesion synthesis specificity ? Polymerase fidelity and specificity are controlled by the interdomain linker ? Three amino acids in the interdomain linker are sufficient to determine conformation ? Differences in polymerase conformation determine differences in polymerase activity 相似文献
19.
Bärbel Ulmer Cathrin Hagenlocher Silke Schmalholz Sabrina Kurz Axel Schweickert Ayelet Kohl Lee Roth Dalit Sela-Donenfeld Martin Blum 《Cell reports》2013,3(3):615-621
Highlights? Cnn2 is expressed in NCCs and required for their migration in frogs and chicks ? Cnn2 is inactivated by noncanonical Wnt signaling ? Loss of Cnn2 causes a switch from cortical actin to central stress fibers ? Cnn2 polarizes the actin cytoskeleton downstream of PCP 相似文献
20.
Yucai Wang Justin W. Leung Yingjun Jiang Megan G. Lowery Huong Do Karen M. Vasquez Junjie Chen Weidong Wang Lei Li 《Molecular cell》2013,49(5):997-1009
Highlights? FANCM and FAAP24 exhibit nonepistatic functions in cell survival upon DNA damage ? FAAP24 confers unique lesion specificity in DNA damage cell-cycle checkpoint ? FANCM translocase activity is involved in recombination-independent ICL repair 相似文献