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X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency
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Wilson SJ Tsao EH Webb BL Ye H Dalton-Griffin L Tsantoulas C Gale CV Du MQ Whitehouse A Kellam P 《Journal of virology》2007,81(24):13578-13586
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Abada R Dreyfuss-Grossman T Herman-Bachinsky Y Geva H Masa SR Sarid R 《Journal of virology》2008,82(5):2230-2240
Kaposi's sarcoma-associated herpesvirus (KSHV), also referred to as human herpesvirus 8, is a potentially tumorigenic virus implicated in the etiology of Kaposi's sarcoma, primary effusion lymphoma, and some forms of multicentric Castleman's disease. The open reading frame 45 (ORF45) protein, encoded by the KSHV genome, is capable of inhibiting virus-dependent interferon induction and appears to be essential for both early and late stages of infection. In the present study, we show, both in yeast two-hybrid assays and in mammalian cells, that the ORF45 protein interacts with the cellular ubiquitin E3 ligase family designated seven in absentia homologue (SIAH). We provide evidence that SIAH-1 promotes the degradation of KSHV ORF45 through a RING domain-dependent mechanism and via the ubiquitin-proteasome system. Furthermore, our data indicate the involvement of SIAH-1 in the regulation of the expression of ORF45 in KSHV-infected cells. Since the availability of KSHV ORF45 is expected to influence the course of KSHV infection, our findings identify a novel biological role for SIAH proteins as modulators of virus infection. 相似文献
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Transcriptional downregulation of ORF50/Rta by methotrexate inhibits the switch of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 from latency to lytic replication
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Curreli F Cerimele F Muralidhar S Rosenthal LJ Cesarman E Friedman-Kien AE Flore O 《Journal of virology》2002,76(10):5208-5219
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ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection
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Sharma-Walia N Krishnan HH Naranatt PP Zeng L Smith MS Chandran B 《Journal of virology》2005,79(16):10308-10329