共查询到20条相似文献,搜索用时 46 毫秒
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L A Bondarenko 《Biulleten' eksperimental'no? biologii i meditsiny》1985,100(8):137-139
Pineal function was studied in Wistar pubertal male rats in summer and winter. It was demonstrated that the pineal weight is inversely related to the day length, increasing in winter and reducing in summer. In winter pineal serotonin is actively metabolized via N-acetylation and subsequent ortho-methylation to form N-acetyl serotonin and melatonin as well as via oxidative deamination followed by ortho-methylation to form 5-hydroxyindolacetic and 5-methoxyindolacetic acids. In summer serotonin metabolism in the pinealocytes changes to direct ortho-methylation of serotonin to form 5-methoxytryptamine. The decreased level of N-acetyltransferase limits the formation of melatonin in the pineal gland in summer. 相似文献
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In intact Wistar pubertal male rats held on LD 8:16 (winter) and 16:8 (summer) pineal melatonin (M) production and other pineal indoles content serotonin (S), 5-methoxytriptamine (5-MT), N-acetylserotonin (N-aS), 5-hydroxyindoleacetic acid (5-HIAA) and 5-methoxyindoleacetic acid (5-MIAA) were investigated in basic conditions and after 10-days T4 administration. The results suggest, that intact control in winter comparing with summer demonstrates high M, N-aS, 5-HIAA and 5-MIAA level, but low 5-MT concentrations, S level was not changed. T4 administration in winter produced a pronounced augmentation of all parameters (excluding serotonin), in summer M production not only increased, but appears to be dependent on the active metabolism of his precursors (S, 5-MT, N-aS). The experimental data favour more profound comprehension to the mechanisms of pineal activity regulation. 相似文献
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Augusto Foà Roland Brandstätter Cristiano Bertolucci 《Chronobiology international》2013,30(1-2):317-327
Previous studies have shown that the amplitude of daily melatonin production in cultured ruin lizard pineal organs explanted in the summer is significantly higher than that from organs explanted in the winter. To test whether seasonal photoperiodic changes are decoded autonomously by the pineal gland, pineals explanted in summer were cultured in vitro and exposed to changes between winter and summer photoperiods. The changes in photoperiod duration did not affect the daily profiles of in vitro melatonin production. The discrepancy between the present in vitro results and those from lizards exposed to winter or summer photoperiods before pineal explantation supports the view that circadian information entering the pineal gland via its innervation is involved in determining seasonal changes of melatonin production in ruin lizards. We further examined whether a central component of the circadian system of ruin lizards, specifically the retinae of the lateral eyes, expresses similar seasonal changes in function as does the pineal gland. We did not find any difference between summer and autumn‐winter in the effectiveness of either bilateral retinalectomy or optic nerve lesion—at the level of the optic chiasm—in altering circadian locomotor behavior in constant conditions. Both surgical procedures mostly induced a shortening of the free‐running period of the locomotor rhythm of similar magnitude in all seasons. Thus, the retinae do not appear to participate in the seasonal reorganization of the circadian system in ruin lizards. 相似文献
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effective pharmacological procedures are described which markedly increase activity of serotonin N-acetyltransferase (NAT), the key regulatory enzyme in melatonin biosynthesis, during the daytime (in light) and counteract suppressive effects of light on NAI activity at night in the hen retina and pineal gland. Of the tested compounds, and their combinations, the most effective were: “aminophylline + spiroperidol + alpha-methyl-p-tyrosine” for the retina, and “aminophylline + yohimbine (+ alpha-methyl-p-tyrosine)” for the pineal gland. The results give strong support to the concept that the dopaminergic (C2-receptor) and noradrenergic (alpha2-adrenergic receptor) mechanisms control NAT activity, and melatonin synthesis, in the hen retina and pineal gland, respectively. 相似文献
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M. Zeman E. Gwinner 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1993,172(3):333-338
A distinct daily rhythm of melatonin production was found in the pineal gland of both precocial Japanese quail (Coturnix coturnix japonica) and altricial European starling (Sturnus vulgaris) during the first day of postembryonic life. Rhythmic melatonin production was reflected in a rhythmic profile in the general circulation. Significant day-night differences in melatonin content were also observed in the eyes of Japanese quail.The amplitude of the rhythm in the quail pineal gland increased steadily during the first two weeks of postem-bryonic life. A transient increase in maximum melatonin concentration was observed at the end of the first week of life in the plasma but not in the pineal gland of quail suggesting that a metabolizing pathway or a changed ocular contribution may influence the melatonin profile in the circulation and its availability to other tissues. There was no delay in the postembryonic development of melatonin rhythmicity in the altricial starling in comparison with the precocial quail. The amplitude of the plasma melatonin rhythm did not increase over the first week of life in starlings as it did in quail and the only significant increase was found between 6- and 17-day old starlings.In general, the development of the rhythm resulted from an increase of dark-time values. The day-time concentrations were low in all age groups of both species. A one-hour light pulse suppressed the high dark-time melatonin concentrations in 1-, 7- and 14-day old Japanese quail as well as in 7- and 14-day old European starlings. The manner in which the rhythm develops suggests that the circadian pacemaker(s) as well as the mechanisms of photoreception and entrainment are developed in hatchlings of both species in spite of their otherwise different developmental strategies. 相似文献
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Arylalkylamine N-acetyltransferase (AA-NAT) is the rate-limiting enzyme of melatonin biosynthetic pathway. In vitro effects of 5-hydroxytryptophan (5-HTP) and indoleamines (serotonin, N-acetylserotonin and melatonin) were studied on AA-NAT activity in the pineal organ of the fish, C. gariepinus during different phases of its annual breeding cycle. Further, in vitro effects of leptin on AA-NAT activity in the pineal organ were studied in fed and fasted fishes during summer and winter seasons. Treatments with 5-HTP and indoleamines invariably stimulated pineal AA-NAT activity in a dose-dependent manner during all the phases. However, leptin increased AA-NAT activity in a dose-dependent manner only in the pineal organ of the fed fishes, but not of the fasted fishes irrespective of the seasons. 相似文献
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The biosynthesis of serotonin into melatonin was decreased in old (18-20-month) in comparison to young (4-5-month) male Wistar rats. 5-day morning injections to young and old rats with polypeptide pineal preparation (epithalamin) in a dose of 2.5 mg/kg of body weight induced the increase in the night peak of serotonin, N-acetylserotonin and melatonin in young and melatonin alone in old rats and did not influence 5-methoxytryptamine, 5-oxy- and 5-methoxyindoleacetic acids level. These data support suggestion of ultrashort loop between pineal peptides and indoles and that epithalamin increases the metabolism of serotonin into melatonin. 相似文献
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Bertolucci C Wagner G Foà A Gwinner E Brandstätter R 《Journal of biological rhythms》2003,18(1):63-70
The pineal gland and its major output signal melatonin have been demonstrated to play a central role in the seasonal organization of the ruin lizard Podarcis sicula. Seasonal variations in the amplitude of the nocturnal melatonin signal, with high values in spring as compared to low values in summer and autumn, have been found in vivo. The authors examined whether the pineal gland of the ruin lizard contains autonomous circadian oscillators controlling melatonin synthesis and whether previously described seasonal variations of in vivo melatonin production can also be found in isolated cultured pineal glands obtained from ruin lizards in summer and winter. In vitro melatonin release from isolated pineal glands of the ruin lizard persisted for 4 days in constant conditions. Cultured explanted pineal glands obtained from animals in winter and summer showed similar circadian rhythms of melatonin release, characterized by damping of the amplitude of the melatonin rhythm. Although different photoperiodic conditions were imposed on ruin lizards before explantation of pineal glands, the authors did not find any indication for corresponding differences in the duration of elevated melatonin in vitro. Differences were found in the amplitude of in vitro melatonin production in light/dark conditions and, to a lesser degree, in constant conditions. The presence of a circadian melatonin rhythm in vitro in winter, although such a rhythm is absent in vivo in winter, suggests that pineal melatonin production is influenced by an extrapineal oscillator in the intact animal that may either positively or negatively modulate melatonin production in summer and winter, respectively. 相似文献
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Martin Zatz 《Seminars in cell & developmental biology》1996,7(6):811-820
Chick pineal cells make melatonin rhythmically, even in culture. Light pulses have two effects on these cells: acute suppression of melatonin synthesis and phase shifts (entrainment) of the underlying pacemaker. The two effects use different mechanistic pathways: the first goes through cAMP, and the second goes through the clock. Both converge on serotonin N-acetyltransferase, whose gene has recently been cloned, with cAMP acting on mRNA levels, but primarily on, enzyme activity, and the clock acting primarily on mRNA levels. Aspects of calcium regulation, not yet well-understood, may impinge on both pathways. These cells also have a novel calcium channel and a novel photopigment. 相似文献
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The Djungarian hamster,Phodopus sungorus, shows a clear annual cycle in some thermogenic parameters such as nonshivering thermogenesis (NST) and cold resistance. These seasonal changes were found to be basically controlled by natural changes in photoperiod. Further support for this view was obtained by exposing the hamsters to artificial long and short photoperiods.Implantation of melatonin during fall and winter results in an increased thermogenic capacity in both short and long day hamsters comparable to that shown by values of control hamsters exposed to short photoperiods during winter. This thermotropic action of melatonin and of short photoperiod could be found only in fall and winter whereas during spring and summer, melatonin, like photoperiod, had no influence on thermogenic capacities. These results show that the actions of melatonin and photoperiod vary with the season and that they depend upon the photoperiodic history of the hamsters. Our results further indicate that the pineal gland with its hormone melatonin is involved in mediation of photoperiodic control of seasonal acclimatization. 相似文献