XIIIth INTERNATIONAL COURSE ON CHRONOPHARMACOLOGY Ruprecht-Karls-Universität Heidelberg Summer School 2012: 30 July – 4 August

Daily rhythmicity in the locomotor activity of laboratory animals has been studied in great detail for many decades, but the daily pattern of locomotor activity has not received as much attention in humans. We collected waist-worn accelerometer data from more than 2000 individuals from five countries differing in socioeconomic development and conducted a detailed analysis of human locomotor activity. Body mass index (BMI) was computed from height and weight. Individual activity records lasting 7 days were subjected to cosinor analysis to determine the parameters of the daily activity rhythm: mesor (mean level), amplitude (half the range of excursion), acrophase (time of the peak) and robustness (rhythm strength). The activity records of all individual participants exhibited statistically significant 24-h rhythmicity, with activity increasing noticeably a few hours after sunrise and dropping off around the time of sunset, with a peak at 1:42?pm on average. The acrophase of the daily rhythm was comparable in men and women in each country but varied by as much as 3?h from country to country. Quantification of the socioeconomic stages of the five countries yielded suggestive evidence that more developed countries have more obese residents, who are less active, and who are active later in the day than residents from less developed countries. These results provide a detailed characterization of the daily activity pattern of individual human beings and reveal similarities and differences among people from five countries differing in socioeconomic development.     

What’s new for ESC Congress 2013? (Amsterdam 30 August – 4 September 2013)

The innovative Spotlight of the Congress is “The heart interacting with systemic organs”. For our patients, the interaction of cardiac conditions with other organs is fundamentally important to outcome, to safety and to clinical management. Related specialty areas have much to learn from each other and the ESC Congress 2013 will attract specialists from other organ systems to help understand disease mechanisms and improve the management of our patients.     

Zur transspezifischen Variabilität der NAD-Malatdehydrogenase (E.C.: 1.1.1.37) der Primaten

Zusammenfassung Die NAD-Malatdehydrogenase der Primaten zeigt eine genetisch determinierte Variabilität. Bei der Untersuchung von 425 subhumanen Primaten konnten vier Varianten nachgewiesen werden; ihre Verteilung wurde ermittelt.

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Transspecific variability of NDA-malate dehydrogenase in primates

Summary The NAD-Malate dehydrogenase in the erythrocytes of Primates show a transspecific variability. Four variants were found to be present in subhuman Primates; their distribution in 425 individuals was estimated.

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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.