A Novel Robot System Integrating Biological and Mechanical Intelligence Based on Dissociated Neural Network-Controlled Closed-Loop Environment

We propose the architecture of a novel robot system merging biological and artificial intelligence based on a neural controller connected to an external agent. We initially built a framework that connected the dissociated neural network to a mobile robot system to implement a realistic vehicle. The mobile robot system characterized by a camera and two-wheeled robot was designed to execute the target-searching task. We modified a software architecture and developed a home-made stimulation generator to build a bi-directional connection between the biological and the artificial components via simple binomial coding/decoding schemes. In this paper, we utilized a specific hierarchical dissociated neural network for the first time as the neural controller. Based on our work, neural cultures were successfully employed to control an artificial agent resulting in high performance. Surprisingly, under the tetanus stimulus training, the robot performed better and better with the increasement of training cycle because of the short-term plasticity of neural network (a kind of reinforced learning). Comparing to the work previously reported, we adopted an effective experimental proposal (i.e. increasing the training cycle) to make sure of the occurrence of the short-term plasticity, and preliminarily demonstrated that the improvement of the robot’s performance could be caused independently by the plasticity development of dissociated neural network. This new framework may provide some possible solutions for the learning abilities of intelligent robots by the engineering application of the plasticity processing of neural networks, also for the development of theoretical inspiration for the next generation neuro-prostheses on the basis of the bi-directional exchange of information within the hierarchical neural networks.     

Volume signalling in real and robot nervous systems

Summary This paper presents recent work in computational modelling of diffusing gaseous neuromodulators in biological nervous systems. A variety of interesting and significant properties of such four dimensional neural signalling systems are demonstrated. It is shown that the morphology of the neuromodulator source plays a highly significant role in the diffusion patterns observed. The paper goes on to describe work in adaptive autonomous systems directly inspired by this: an exploration of the use of virtual diffusing modulators in robot nervous systems built from non-standard artificial neural networks. These virtual chemicals act over space and time modulating a variety of node and connection properties in the networks. A wide variety of rich dynamics are possible in such systems; in the work described here, evolutionary robotics techniques have been used to harness the dynamics to produce autonomous behaviour in mobile robots. Detailed comparative analyses of evolutionary searches, and search spaces, for robot controllers with and without the virtual gases are introduced. The virtual diffusing modulators are found to provide significant advantages.     

Piezoelectrically Actuated Biomimetic Self-Contained Quadruped Bounding Robot

This paper presents the development of a mesoscale self-contained quadruped mobile robot that employs two pieces ofpiezocomposite actuators for the bounding locomotion.The design of the robot leg is inspired by legged insects and animals,and the biomimetic concept is implemented in the robot in a simplified form,such that each leg of the robot has only one degreeof freedom.The lack of degree of freedom is compensated by a slope of the robot frame relative to the horizontal plane.For theimplementation of the self-contained mobile robot,a small power supply circuit is designed and installed on the robot.Experimentalresults show that the robot can locomote at about 50 mm·s^-1with the circuit on board,which can be considered as asignificant step toward the goal of building an autonomous legged robot actuated by piezoelectric actuators.     

A knowledge-based system for the strategic control level of robots in flexible manufacturing cells

The strategic control level synthesis for robots is related to a hierarchical robot control problem. The main control problem at the strategic control level is to select the model and algorithm to be used by the lower control level to execute the given robot task. Usually there are several lower control level models and algorithms that can be used by the robot control system for every robot task. Strategic control level synthesis depends on the particular robot system application. In a typical application, when the robot system is used in a flexible manufacturing system for manipulating various part types, the robot tasks executed by the robot system depend on the manufacturing processes in the system. If the robot system is applied in another flexible manufacturing system, dedicated to other manufacturing processes, another set of robot tasks might be needed to perform the necessary operations. Therefore, the quantity and the kind of knowledge required in the system for the strategic control level differ from one application to another. Such a fact creates the appropriate conditions for employing some artificial intelligence techniques. This article describes a knowledge-based system approach to the strategic control level synthesis problem.     

Bone mineral density in patients with breast cancer in the perimenopausal period

Dual-energy X-ray absorptiometry was used to examine 54 patients with breast cancer. A clinical comparison group comprised 50 healthy women. All the examinees were aged 45 to 55 years. Bone mineral density was measured in the lumbar spine, proximal femur, and ultradistal antibrachium. The X-ray densitometric values of bone tissues in perimenopausal women with breast cancer were not found to be abnormal, which led to the conclusion that there were no significant bone metabolic disturbances. Along with this it was established that the women at this age had considerably reduced bone mineral density in the epimetaphyseal (ultradistal) forearm with evolving osteopenia. In this connection, it is expedient to identify an ultradistal portion of the antibrachium as an object of X-ray densitometric examination for the early diagnosis of impaired bone mineralization in women in the 45-to-55-year-old age group.     

Bone marrow microenvironment: The guardian of leukemia stem cells

Bone marrow microenvironment(BMM) is the main sanctuary of leukemic stem cells(LSCs) and protects these cells against conventional therapies. However, it may open up an opportunity to target LSCs by breaking the close connection between LSCs and the BMM. The elimination of LSCs is of high importance, since they follow cancer stem cell theory as a part of this population. Based on cancer stem cell theory, a cell with stem cell-like features stands at the apex of the hierarchy and produces a heterogeneous population and governs the disease.Secretion of cytokines, chemokines, and extracellular vesicles, whether through autocrine or paracrine mechanisms by activation of downstream signaling pathways in LSCs, favors their persistence and makes the BMM less hospitable for normal stem cells. While all details about the interactions of the BMM and LSCs remain to be elucidated, some clinical trials have been designed to limit these reciprocal interactions to cure leukemia more effectively. In this review, we focus on chronic myeloid leukemia and acute myeloid leukemia LSCs and their milieu in the bone marrow, how to segregate them from the normal compartment, and finally the possible ways to eliminate these cells.     

In Good Company? Perception of Movement Synchrony of a Non-Anthropomorphic Robot

Recent technological developments like cheap sensors and the decreasing costs of computational power have brought the possibility of robotic home companions within reach. In order to be accepted it is vital for these robots to be able to participate meaningfully in social interactions with their users and to make them feel comfortable during these interactions. In this study we investigated how people respond to a situation where a companion robot is watching its user. Specifically, we tested the effect of robotic behaviours that are synchronised with the actions of a human. We evaluated the effects of these behaviours on the robot’s likeability and perceived intelligence using an online video survey. The robot used was Care-O-bot3, a non-anthropomorphic robot with a limited range of expressive motions. We found that even minimal, positively synchronised movements during an object-oriented task were interpreted by participants as engagement and created a positive disposition towards the robot. However, even negatively synchronised movements of the robot led to more positive perceptions of the robot, as compared to a robot that does not move at all. The results emphasise a) the powerful role that robot movements in general can have on participants’ perception of the robot, and b) that synchronisation of body movements can be a powerful means to enhance the positive attitude towards a non-anthropomorphic robot.     

Bone metabolism: a note on the significance of mouse models

This minireview briefly surveys the complexity of regulations governing the bone metabolism. The impact of clinical studies devoted to osteoporosis is briefly summarized and the emphasis is put on the significance of experimental mouse models based on an extensive use of genetically modified animals. Despite possible arising drawbacks, the studies in mice are of prime importance for expanding our knowledge on bone metabolism. With respect to human physiology and medicine, one should be always aware of possible limitations as the experimental results may not be, or may be only to some extent, transposed to humans. If applicable to humans, results obtained in mice provide new clues for assessing unforeseen treatment strategies for patients. A recent publication representing in our opinion the important breakthrough in the field of bone metabolism in mice is commented in detail. It provides an evidence that skeleton is endocrine organ that affects energy metabolism and osteocalcin, a protein specifically synthesized and secreted by osteoblasts, is a hormone involved. If confirmed by other groups and applicable to humans, this study provides the awaited connection of long duration between bone disorders on one hand and obesity and diabetes on the other.     

Human-like Manipulation Planning for Articulated Manipulator

A new method based on human-likeness assessment and optimization concept to solve the problem of human-like manipulation planning for articulated robot is proposed in this paper.This method intrinsically formulates the problem as a constrained optimization problem in robot configuration space.The robot configuration space is divided into different subregions by human likeness assessment.A widely used strategy,Rapid Upper Limb Assessment (RULA) in applied ergonomics,is adopted here to evaluate the human likeness of robot configuration.A task compatibility measurement of the robot velocity transmission ratio along a specified direction is used as the target function for the optimization problem.Simple illustrative examples of this method applied to a two Degree of Freedom (DOF) planar robot that resembles the upper limb of a human are presented.Further applications to a humanoid industrial robot SDA10D are also presented.The reasonable planning results for these applications assert the effectiveness of our method.     

A Bio-Inspired Biped Water Running Robot Incorporating the Watt-I Planar Linkage Mechanism

In this paper, a biped water running robot is developed by mimicking the water-running pattern of basilisk lizards. The dynamic mechanism of the robot was studied based on Watt-I planar linkages, and the movement trajectory of the double bar Assur Group was deduced to simulate the water-running foot trajectories of the basilisk lizard. A Central Pattern Generator （CPG）-based fuzzy control method was proposed to control the robot for realizing balance control and gait adjustment. The effectiveness of the proposed control method was verified on the prototype of a water running robot （weight： 320 g）. When the biped robot is running on water, the average force generated by the propulsion mechanism is 1.3 N, and the robot body tilt angle is 5~. The experiment results show that the propulsion mechanism is effective in realizing the basilisk lizards-like water running patterns, and the CPG-based fuzzy control method is effective in keeping the balance of the robot.     

Robots with Display Screens: A Robot with a More Humanlike Face Display Is Perceived To Have More Mind and a Better Personality

It is important for robot designers to know how to make robots that interact effectively with humans. One key dimension is robot appearance and in particular how humanlike the robot should be. Uncanny Valley theory suggests that robots look uncanny when their appearance approaches, but is not absolutely, human. An underlying mechanism may be that appearance affects users’ perceptions of the robot’s personality and mind. This study aimed to investigate how robot facial appearance affected perceptions of the robot’s mind, personality and eeriness. A repeated measures experiment was conducted. 30 participants (14 females and 16 males, mean age 22.5 years) interacted with a Peoplebot healthcare robot under three conditions in a randomized order: the robot had either a humanlike face, silver face, or no-face on its display screen. Each time, the robot assisted the participant to take his/her blood pressure. Participants rated the robot’s mind, personality, and eeriness in each condition. The robot with the humanlike face display was most preferred, rated as having most mind, being most humanlike, alive, sociable and amiable. The robot with the silver face display was least preferred, rated most eerie, moderate in mind, humanlikeness and amiability. The robot with the no-face display was rated least sociable and amiable. There was no difference in blood pressure readings between the robots with different face displays. Higher ratings of eeriness were related to impressions of the robot with the humanlike face display being less amiable, less sociable and less trustworthy. These results suggest that the more humanlike a healthcare robot’s face display is, the more people attribute mind and positive personality characteristics to it. Eeriness was related to negative impressions of the robot’s personality. Designers should be aware that the face on a robot’s display screen can affect both the perceived mind and personality of the robot.     

Development of a Biomimetic Quadruped Robot

This paper presents the design and prototype of a small quadruped robot whose walking motion is realized by two piezocomposite actuators. In the design, biomimetic ideas are employed to obtain the agility of motions and sustainability of a heavy load. The design of the robot legs is inspired by the leg configuration of insects, two joints （hip and knee） of the leg enable two basic motions, lifting and stepping. The robot frame is designed to have a slope relative to the horizontal plane, which makes the robot move forward. In addition, the bounding locomotion of quadruped animals is implemented in the robot. Experiments show that the robot can carry an additional load of about 100 g and run with a fairly high velocity. The quadruped prototype can be an important step towards the goal of building an autonomous mobile robot actuated by piezocomposite actuators.     

A Bio-Inspired Hopping Kangaroo Robot with an Active Tail

Inspired by kangaroo＇s locomotion, we report on developing a kangaroo-style hopping robot. Unlike bipeds, quadrupeds, or hexapods which altemate the legs for forward locomotion, the kangaroo uses both legs synchronously and generates the forward locomotion by continuous hopping behavior, and the tail actively balances the unwanted angular momentum generated by the leg motion. In this work, we generate the Center of Mass （CoM） locomotion of the robot based on the reduced-order Rolling Spring Loaded Inverted Pendulum （R-SLIP） model, for matching the dynamic behavior of the empirical robot legs. In order to compensate the possible body pitch variation, the robot is equipped with an active tail for pitch variation compensation, emulating the balance mechanism of a kangaroo. The robot is empirically built, and various design issues and strategies are addressed. Finally, the experimental evaluation is executed to validate the performance of the kangaroo-style robot with hopping locomotion.     

Using insects to drive mobile robots — hybrid robots bridge the gap between biological and artificial systems

The use of mobile robots is an effective method of validating sensory–motor models of animals in a real environment. The well-identified insect sensory–motor systems have been the major targets for modeling. Furthermore, mobile robots implemented with such insect models attract engineers who aim to avail advantages from organisms. However, directly comparing the robots with real insects is still difficult, even if we successfully model the biological systems, because of the physical differences between them. We developed a hybrid robot to bridge the gap. This hybrid robot is an insect-controlled robot, in which a tethered male silkmoth (Bombyx mori) drives the robot in order to localize an odor source. This robot has the following three advantages: 1) from a biomimetic perspective, the robot enables us to evaluate the potential performance of future insect-mimetic robots; 2) from a biological perspective, the robot enables us to manipulate the closed-loop of an onboard insect for further understanding of its sensory–motor system; and 3) the robot enables comparison with insect models as a reference biological system. In this paper, we review the recent works regarding insect-controlled robots and discuss the significance for both engineering and biology.     

Parasitic Robot System for Waypoint Navigation of Turtle

In research on small mobile robots and biomimetic robots,locomotion ability remains a major issue despite many advances in technology.However,evolution has led to there being many real animals capable of excellent locomotion.This paper presents a "parasitic robot system" whereby locomotion abilities of an animal are applied to a robot task.We chose a turtle as our first host animal and designed a parasitic robot that can perform "operant conditioning".The parasitic robot,which is attached to the turtle,can induce object-tracking behavior of the turtle toward a Light Emitting Diode (LED) and positively reinforce the behavior through repeated stimulus-response interaction.After training sessions over five weeks,the robot could successfully control the direction of movement of the trained turtles in the waypoint navigation task.This hybrid animal-robot interaction system could provide an alternative solution to some of the limitations of conventional mobile robot systems in various fields,and could also act as a useful interaction system for the behavioral sciences.     

Haptic/Graphic Rehabilitation: Integrating a Robot into a Virtual Environment Library and Applying it to Stroke Therapy

Recent research that tests interactive devices for prolonged therapy practice has revealed new prospects for robotics combined with graphical and other forms of biofeedback. Previous human-robot interactive systems have required different software commands to be implemented for each robot leading to unnecessary developmental overhead time each time a new system becomes available. For example, when a haptic/graphic virtual reality environment has been coded for one specific robot to provide haptic feedback, that specific robot would not be able to be traded for another robot without recoding the program. However, recent efforts in the open source community have proposed a wrapper class approach that can elicit nearly identical responses regardless of the robot used. The result can lead researchers across the globe to perform similar experiments using shared code. Therefore modular "switching out"of one robot for another would not affect development time. In this paper, we outline the successful creation and implementation of a wrapper class for one robot into the open-source H3DAPI, which integrates the software commands most commonly used by all robots.     

A neural network controller for the path tracking control of a hopping robot involving time delays

In this paper a hopping robot motion with offset mass is discussed. A mathematical model has been considered and an efficient single layered neural network has been developed to suit to the dynamics of the hopping robot, which ensures guaranteed tracking performance leading to the stability of the otherwise unstable system. The neural network takes advantage of the robot regressor dynamics that expresses the highly nonlinear robot dynamics in a linear form in terms of the known and unknown robot parameters. Time delays in the control mechanism play a vital role in the motion of hopping robots. The present work also enables us to estimate the maximum time delay admissible with out losing the guaranteed tracking performance. Further this neural network does not require offline training procedures. The salient features are highlighted by appropriate simulations.     

Research on the Kinematic Properties of a Sperm-Like Swimming Micro Robot

Nowadays, it has been one of the hottest topics for scientists to research the interventional micro robots operating in human lumen. In this paper, a novel sperm-like interventional swimming robot with single tail is presented. The kinematic models of the sperm-like helical swimming modes are built, and the motion principles are analyzed numerically. Positions and orientations are displayed graphically during the single-tail micro robot swims in liquid. Also, the displacements and the swimming velocities of the robot in x, y, z directions are plotted. It is shown that, when the single flexible tail screws in liquid environment, it generates both axial and radial propulsion forces, thus to cause the axial and the radial movements. In order to make the swimming micro robot more controllable, an improved sperm-like swimming intervention micro robot with four flexible tails is fabricated and characterized in pipes filled with silicone oil. Experimental results show that the sperm-like micro robot can swim efficiently. With different combinations of the tails' rotation directions, the robot can gain excellent controlled performance.     

Designing an assistive robot for older adults: The ROBADOM project

ObjectiveThe ROBADOM project was devoted to the design of a “robot butler”, capable of providing verbal and non-verbal interactions and feedbacks for assisting older adults at home. In this article we focused on the following issues: (1) study the social context for designing social robot; define the robot appearance and investigate the perceptions and attitudes of older adults towards an assistive robot; (2) examine the perception of the expressivity of the robot, the social signals showing the end-user engagement level and the role of agent embodiment during the interaction between older adults and a robot.MethodThe design of the studies involved both qualitative and experimental methods.Results & DiscussionSmall robots with some traits between human/animal and machine were appreciated by the participants. As regards services, cognitive stimulation, reminder and object localization were positively rated. Although the participants considered an assistive robot as useful, they were not yet ready to adopt it. The expressions of the robot were perceived differently in older and young adults. Thus, a robotic system dedicated to older adults should be tailored to the specific characteristics of this population. We also identified social signals as indicators of the user's engagement level during interaction. Finally, the issue of the added valued of a robotic system in comparison to a laptop was raised by our participants. Therefore, various issues (technological development, human-robot interaction, social context…) are to be explored before testing the impact of the robot at home.     

Simultaneous Optimization of Robot Structure and Control System Using Evolutionary Algorithm

The simultaneous optimization of a robot structure and control system to realize effective mobility in an outdoor environment is investigated. Recently, various wheeled mechanisms with passive and/or active linkages for outdoor environments have been developed and evaluated. We developed a mobile robot having six active wheels and passive linkage mechanisms, and experimentally verified its maneuverability in an indoor environment. However, there are various obstacles in outdoor environment and the travel ability of a robot thus depends on its mechanical structure and control system.We proposed a method of simultaneously optimizing mobile robot structure and control system using an evolutionary algorithm. Here, a gene expresses the parameters of the structure and control system. A simulated mobile robot and controller are based on these parameters and the behavior of the mobile robot is evaluated for three typical obstacles. From the evaluation results, new genes are created and evaluated repeatedly. The evaluation items are travel distance, travel time, energy consumption, control accuracy, and attitude of the robot.Effective outdoor travel is achieved around the 80th generation, after which, other parameters are optimized until the 300th generation. The optimized gene is able to pass through the three obstacles with low energy consumption, accurate control, and stable attitude.