Does Prison Crowding Predict Higher Rates of Substance Use Related Parole Violations? A Recurrent Events Multi-Level Survival Analysis

Objective

This administrative data-linkage cohort study examines the association between prison crowding and the rate of post-release parole violations in a random sample of prisoners released with parole conditions in California, for an observation period of two years (January 2003 through December 2004).

Background

Crowding overextends prison resources needed to adequately protect inmates and provide drug rehabilitation services. Violence and lack of access to treatment are known risk factors for drug use and substance use disorders. These and other psychosocial effects of crowding may lead to higher rates of recidivism in California parolees.

Methods

Rates of parole violation for parolees exposed to high and medium levels of prison crowding were compared to parolees with low prison crowding exposure. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using a Cox model for recurrent events. Our dataset included 13070 parolees in California, combining individual level parolee data with aggregate level crowding data for multilevel analysis.

Results

Comparing parolees exposed to high crowding with those exposed to low crowding, the effect sizes from greatest to least were absconding violations (HR 3.56 95% CI: 3.05–4.17), drug violations (HR 2.44 95% CI: 2.00–2.98), non-violent violations (HR 2.14 95% CI: 1.73–2.64), violent and serious violations (HR 1.88 95% CI: 1.45–2.43), and technical violations (HR 1.86 95% CI: 1.37–2.53).

Conclusions

Prison crowding predicted higher rates of parole violations after release from prison. The effect was magnitude-dependent and particularly strong for drug charges. Further research into whether adverse prison experiences, such as crowding, are associated with recidivism and drug use in particular may be warranted.     

Reconstructing relationships among mortality, status, and gender at the Medieval Gilbertine Priory of St. Andrew, Fishergate, York

The varied relationships among status, gender, and mortality are complex, historically produced phenomena that shape people's lives and deaths in socially meaningful ways. Paleodemographic analysis coupled with acute sensitivity to site-specific context has the potential to move us toward a greater understanding of these experiences in the past. After considering the potential effects of migration and fertility on the age-at-death profiles of adult individuals interred at the Gilbertine Priory of St. Andrew, Fishergate, York (n = 200), it is asserted that these profiles primarily reveal expected and unexpected relationships among status, gender, and mortality in this Medieval context. Collectively, the long lives of religious-status males compared to other composite and gendered status groups suggest that they experienced a relatively comfortable existence despite periodic complaints of destitution. The postulated demographic advantage of high-status males did not materialize in the analysis, and a reevaluation of the skeletal evidence indicates that nearly 20% of these individuals died violently. Unexpectedly, moderate-status females shared a mortality profile similar to that of religious-status males and retained a demographic advantage over all other secular status groups. In contrast to the experiences of moderate-status females, low-status females had, on average, the shortest lives at St. Andrew's. This pattern is intimately linked to their restriction from crucial social and economic resources, and provides further evidence of their marginalization in York's wage-labor economy. Overall, these relationships suggest that traditional, highly stratified and gendered notions of Medieval status and mortality are not adequate for understanding the intricacies of everyday life and death at St. Andrew's.     

Internal brooding favours pre-metamorphic chimerism in a non-colonial cnidarian, the sea anemone Urticina felina

The concept of intraorganismal genetic heterogeneity resulting from allogeneic fusion (i.e. chimerism) has almost exclusively been explored in modular organisms that have the capacity to reproduce asexually, such as colonial ascidians and corals. Apart from medical conditions in mammals, the natural development of chimeras across ontogenetic stages has not been investigated in any unitary organism incapable of asexual propagation. Furthermore, chimerism was mainly studied among gregarious settlers to show that clustering of genetically similar individuals upon settlement promotes the occurrence of multi-chimeras exhibiting greater fitness. The possible occurrence of chimeric embryos and larvae prior to settlement has not received any attention. Here we document for the first time the presence of natural chimeras in brooded embryos and larvae of a unitary cnidarian, the sea anemone Urticina felina. Rates of visible bi- and multi-chimerism of up to 3.13 per cent were measured in the broods of 16 females. Apart from these sectorial chimeras, monitored fusion events also yielded homogeneous chimeric entities (mega-larvae) suggesting that the actual rates of natural chimerism in U. felina are greater than predicted by visual assessment. In support of this assumption, the broods of certain individuals comprised a dominant proportion (to 90%) of inexplicably large embryos and larvae (relative to oocyte size). Findings of fusion and chimerism in a unitary organism add a novel dimension to the framework within which the mechanisms and evolutionary significance of genetic heterogeneity in animal taxa can be explored.     

Frpm artificial individuals to global patterns

Artificial Life is a model of biological systems that describes lives archived by computer simulation, chemical substrates or any other non-biological substrates. Artificial Life simulation adopts a bottom-up approach in which behavior of lower-level entities (e.g. molecules, cells and individuals) is all that is programed; global patterns (e.g. evolutionary patterns observed at the level of the population and the community) can emerge as a result of interaction among lower-level entities. Artificial Life simulations will be used not only to test ecological and evolutionary hypotheses explaining real organisms but also to show the validity of general theories, processes and concepts such as natural selection, theories of complexity, hierarchical relations and self-organization.     

Overview of acute and chronic stress responses

The psychobiological concept of stress built up over the years since the 1930s. The understanding of the neurobiological mechanisms involved has progressed remarkably during the past years. This article provides an overview of the recent data opposing acute and chronic stress. The former is an adaptative response of the organism to cope with the fluctuations of the environment and thereby is essential for survival. By contrast, chronic stress is deleterious and leads to various disease states in vulnerable individuals. Its adverse effects on the brain and the body result from a dysregulation of the stress system with various origins and mechanisms which we will discuss in this review.     

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC Working Paper No. 15/7. Reproductive consequences of alcohol abuse: males and females compared and contrasted

The adverse effects of ethyl alcohol on the hypothalamic pituitary gonadal axes of men and women are discussed with particular attention being given to effects of alcohol upon reproduction. Data obtained from acute and chronic alcohol exposure studies are presented. The putative pathophysiologic mechanisms responsible for disturbed reproductive performances in alcohol abusing individuals are discussed where sufficient data are available.     

Genetic analysis of isometric growth control mechanisms in the zebrafish caudal Fin

The body and fins of the zebrafish grow rapidly as juveniles and slower as they reach maturation. Throughout their lives, the fins grow isometrically with respect to the body. Growth of individual fin rays is achieved by the distal addition of bony segments. We have investigated the genetic control of mechanisms that initiate new segments or control size of newly initiated segments. We find that both segment initiation and segment length are regulated during fin growth in wild-type fish. We examined the growth properties of lof and sof fin length mutants for effects on the number and length of fin ray segments. Fins of lof mutants continue to grow rapidly even after wild-type fin growth slows, resulting in positive allometric growth and additional fin ray segments. We suggest that lof mutants bypass mechanisms that limit segment initiation. Isometric growth is retained in sof mutants, resulting in shorter fins one-half the length of wild-type fins. The primary defect in sof mutants is that fin ray segments are shorter than wild-type segments, although segment number is also diminished. Double mutants for sof;lof reveal that segment length and segment number are controlled in different pathways. Our findings suggest that the lof gene product regulates segment initiation and the sof gene product regulates segment length.     

Alteration of hepatic lipidperoxide levels during cataract formation caused by glucocorticoids in developing chick embryos

The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time of 20 hr and reached approximately 8-fold of control at 48 hr after the treatment. These studies indicate that the peroxidation of lipid in tissues should be considered in elucidating mechanisms of action or adverse effects of glucocorticoids.     

Respiratory motor activity: influence of neuromodulators and implications for sleep disordered breathing

Sleep, especially rapid-eye-movement sleep, causes fundamental modifications of respiratory muscle activity and control mechanisms, modifications that can predispose individuals to sleep-related breathing disorders. One of the most common of these disorders is obstructive sleep apnea (OSA) that affects approximately 4% of adults. OSA is caused by repeated episodes of pharyngeal airway obstruction that can occur hundreds of times per night, leading to recurrent asphyxia, arousals from sleep, daytime sleepiness, and adverse cardiovascular and cerebrovascular consequences. OSA is caused by the effects of sleep on pharyngeal muscle tone in individuals with already narrow upper airways. Moreover, since OSA occurs only in sleep, this disorder by definition is a state-dependent process ultimately caused by the influence of sleep neural mechanisms on the activity of pharyngeal motoneurons. This review synthesizes recent findings relating to control of pharyngeal muscle activity across sleep-wake states, with special emphasis on the influence of neuromodulators acting at the hypoglossal motor nucleus that inervates the genioglossus muscle of the tongue. The results of such basic physiological studies may be relevant to identifying and developing new pharmacological strategies to augment pharyngeal muscle activity in sleep, especially rapid-eye-movement sleep, as potential treatments for OSA.     

Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance

Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of genetics, spurring much research into the transmission of underlying epigenetic mechanisms. Epigenetic mechanisms play important roles in the development of an organism and are responsive to environmental exposures. To date, rodent studies have demonstrated that acquired epigenetic marks, particularly DNA methylation, that are inherited following parental EDC exposure can escape embryonic epigenome reprogramming. The acquired epimutations can lead to subsequent adult-onset diseases. Increasing studies have reported inter-individual variations that occur with epigenetic inheritance. Factors that underlie differences among individuals could reveal previously unidentified mechanisms of epigenetic transmission. In this review, we give an overview of DNA methylation and posttranslational histone modification as the potential mechanisms for disease transmission, and define the requirements for multi- and transgenerational epigenetic inheritance. We subsequently evaluate rodent studies investigating how acquired changes in epigenetic marks especially DNA methylation across multiple generations can vary among individuals following parental EDC exposure. We also discuss potential sources of inter-individual variations and the challenges in identifying these variations. We conclude our review discussing the challenges in applying rodent generational studies to humans.

     

Toxicities induced in cultured cells exposed to zearalenone: Apoptosis or mutagenesis?

Zearalenone (ZEN) is a fusarotoxin produced mainly by Fusarium graminearum in temperate and warm countries. ZEN has several adverse effects on humans and animals. It has a strong estrogenic activity associated with hyperestrogenism and leads to several physiological alterations in the reproductive tract. Even though the mutagenic and genotoxic proprieties of ZEN have been described recently, its molecular mechanisms of action are not completely understood. The aim of this study was to determine the involvement of other possible mechanisms in ZEN-induced toxicities. Each of the following toxicities, cytotoxicity, cell cycle perturbation, genotoxicity, and mutagenicity, was monitored in Vero cells exposed to ZEN. Our results showed that ZEN-reduced cell viability correlated to cell cycle perturbation-induced DNA fragmentation, resulting in DNA-laddering patterns on agar gel electrophoresis. This observation is consistent with apoptosis, which was confirmed by induction of apoptotic bodies. Moreover, ZEN induced in a concentration-dependant manner the formation of micronuclei and chromosome aberrations. This apparent contradiction between the apoptotic and mutagenic effects of ZEN can be explained by the modification of normal cellular regulation inducing apoptotic or antiapoptotic factors resulting from a lack of or an incorrect DNA-reparation in relation to cell exposure to the toxin.     

State-dependent foraging rules for social animals in selfish herds

Many animals gain benefits from living in groups, such as a dilution in predation risk when they are closely aggregated (referred to as the 'selfish herd'). Game theory has been used to predict many properties of groups (such as the expected group size), but little is known about the proximate mechanisms by which animals achieve these predicted properties. We explore a possible proximate mechanism using a spatially explicit, individual-based model, where individuals can choose to rest or forage on the basis of a rule-of-thumb that is dependent upon both their energetic reserves and the presence and actions of neighbours. The resulting behaviour and energetic reserves of individuals, and the resulting group sizes, are shown to be affected both by the ability of the forager to detect conspecifics and areas of the environment suitable for foraging, and by the distribution of energy in the environment. The model also demonstrates that if animals are able to choose (based upon their energetic reserves) between selecting the best foraging sites available and moving towards their neighbours for safety, then this also has significant effects upon individuals and group sizes. The implications of the proposed rule-of-thumb are discussed.     

Rethinking phenotypic plasticity and its consequences for individuals,populations and species

Much research has been devoted to identify the conditions under which selection favours flexible individuals or genotypes that are able to modify their growth, development and behaviour in response to environmental cues, to unravel the mechanisms of plasticity and to explore its influence on patterns of diversity among individuals, populations and species. The consequences of developmental plasticity and phenotypic flexibility for the performance and ecological success of populations and species have attracted a comparatively limited but currently growing interest. Here, I re-emphasize that an increased understanding of the roles of plasticity in these contexts requires a ‘whole organism'' (rather than ‘single trait'') approach, taking into consideration that organisms are integrated complex phenotypes. I further argue that plasticity and genetic polymorphism should be analysed and discussed within a common framework. I summarize predictions from theory on how phenotypic variation stemming from developmental plasticity and phenotypic flexibility may affect different aspects of population-level performance. I argue that it is important to distinguish between effects associated with greater interindividual phenotypic variation resulting from plasticity, and effects mediated by variation among individuals in the capacity to express plasticity and flexibility as such. Finally, I claim that rigorous testing of predictions requires methods that allow for quantifying and comparing whole organism plasticity, as well as the ability to experimentally manipulate the level of and capacity for developmental plasticity and phenotypic flexibility independent of genetic variation.     

Dietary and pharmacological intervention to mitigate the cardiopulmonary effects of air pollution toxicity

BackgroundExposure to air pollution contributes importantly to excess morbidity and mortality. And while regulatory actions under the “Clean Air Act” have saved millions of lives by improving air quality, there are still millions of people in the U.S. who live in areas where particulate air pollution (PM) levels exceed the U.S. Environmental Protection Agency's National Ambient Air Quality Standards. Therefore, apart from such localities working to attain such standards the protection of the health of public and in particular those at high risk might benefit from interventional strategies that would ameliorate air pollution's adverse health effects. Because inflammation and oxidative stress appear to mediate the health effects of air pollution, one interventional approach to consider is the use of dietary supplementation or medication with anti-inflammatory or antioxidant properties to block the biological responses that initiate the pathophysiological process that culminates in adverse health effects.Scope of reviewThis article reviews the capability of dietary supplementation, such as antioxidant vitamins, polyunsaturated fatty acids, and medications as a strategy to mitigate air pollution-induced subclinical cardiopulmonary effects.Major conclusionsAntioxidant vitamins C and E protect the lungs against short-term ozone and PM exposure. Polyunsaturated fatty acids, such as fish oil and olive oil appear to offer protection against short-term air pollution-induced adverse cardiovascular responses.General significanceTaking dietary supplements or medications with antioxidant or anti-inflammatory properties has the potential to provide at least partial protection against air pollution-induced adverse health effects in those individuals who are known to be most susceptible, namely those with pre-existing respiratory and cardiovascular diseases. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu.     

Modelling reproductive allocation of dusky salamanders using optimal control theory: Pros,cons and caveats

Summary Optimal control theory has been used to examine the evolution of life history characters in a variety of plant and animal species. In this paper, I examine control theoretic models of reproductive allocation in female dusky salamanders and consider some practical aspects of modelling, including the appropriateness of nonlinear formulations, methods for describing semelparous reproduction, and data needed to parameterize models. The model analysed includes state variables for somatic and reproductive tissue, energy intake and requirements for physiological maintenance, and iteroparous reproduction. It predicts that female salamanders should spend the first part of their lives growing. After reaching sexual maturity, females should either spend the remainder of their lives reproducing at the expense of decreasing body size, possibly resulting in death by starvation, or maintain approximately constant body size at the expense of low reproductive output. This lack of correspondence to the observed biology of dusky salamanders suggests that not all the appropriate biology has been described. In particular, inclusion of a storage variable may be necessary in future modelling efforts.     

Smaller, stiffer coronary bypass can moderate or reverse the adverse effects of wave reflections.

The question of whether the mechanical stiffness of a coronary bypass or that of a diseased coronary artery can have a significant effect on the hemodynamics in these vessels is addressed analytically, with emphasis on the effects of wave reflections. The analysis is based on a model of the vessels involved, and the results show the essential hemodynamic effects in each vessel. It is found that in the absence of a bypass graft, wave reflections resulting from a narrowing and stiffening of a diseased coronary artery have the effect of actually aiding the flow in the diseased vessel. In the presence of a bypass graft, however, the effects of wave reflections are reversed and become adverse to flow in both the bypass graft and the diseased coronary artery. A stiffer bypass moderates these effects and is therefore preferable to a more elastic bypass. The adverse effects also depend critically on the relative diameter of the bypass. Here the results indicate that a bypass of smaller diameter than that of the native coronary artery can moderate and even reverse the adverse effects of wave reflections resulting from the presence of the bypass.     

Value, obligation and the asymmetry question

Is there a prima facie obligation to produce additional individuals whose lives would be worth living? In his paper ‘Is it Good to Make Happy People?’, Stuart Rachels argues not only that there is, but, also, that precisely as much weight should be assigned to the quality of life that would be enjoyed by such potential persons, if they were to be actualized, as to the quality of life enjoyed by actually existing persons. In response, I shall argue, first, that Rachels’ view is exposed to very serious objections, and secondly, that his arguments in support of his position involve a crucial assumption, which cannot be sustained, concerning the relation between, on the one hand, propositions about good-making and bad-making properties, and, on the other, propositions about right-making and wrong-making ones. I shall then argue that there is a very plausible position concerning the conditions under which an action can be morally wrong which entails the following asymmetry: there is a prima facie obligation not to bring into existence individuals whose lives are not worth living, but there is no corresponding obligation to create additional individuals whose lives would be worth living.     

Current concepts in RET-related genetics, signaling and therapeutics

The receptor tyrosine kinase RET is expressed in cell lineages derived from the neural crest and has a key role in regulating cell proliferation, migration, differentiation and survival during embryogenesis. Germline and somatic mutations in RET that produce constitutively activated receptors cause the cancer syndrome multiple endocrine neoplasia type 2 and several endocrine and neural-crest-derived tumors, whereas mutations resulting in nonfunctional RET or lower expression of RET are found in individuals affected with Hirschsprung disease. This review focuses on the genetics and molecular mechanisms underlying the different inherited human neural-crest-related disorders in which RET dysfunction has a crucial role and discusses RET as a potential therapeutic target.     

Freedom,responsibility, and health.

Freedom and responsibility, how much of each and how they are balanced, have profound implications for our personal lives and for our work. The health of a population and its achievement in the workplace are enhanced when individuals have some freedom and some responsibility, but not too much of either, and when civil associations of individuals rather than individuals acting alone are the essential social units. The consistent association of social contacts with health and productivity provides strong support for the premise that intimate relationships are the focus around which people''s lives revolve. Membership of a "social network" may be merely conforming to a reigning social norm, and this could mean having to pay an important price in the loss of creativity associated with individualism. But social conformity should not prevent individuals from going their own way, and it should be possible to combine the luxury of individuality with an active life in civic affairs. Less than complete freedom may fall short of existential utopia, but it may be best for our health and wellbeing.