Structure of the carbazole alkaloid isomurrayazoline from Murraya koenigii

The structure of a new hexacyclic carbazole alkaloid from Murraya koenigii has been shown to be 9a,10,11,12,13,13a-hexahydro-5,9,9,12-tetramethyl-1     

Glycozolidol,an antibacterial carbazole alkaloid from Glycosmis pentaphylla

Glycozolidol, a new carbazole alkaloid, has been isolated from the roots of Glycosmis pentaphylla. Its structure has been established as 6-hydroxy-2-methoxy-3-methylcarbazole on the basis of physical and chemical evidence. The compound has been found to be active at some Gram-positive and Gram-negative bacteria.     

Heptazolicine,a carbazole alkaloid from Clausena heptaphylla

A new carbazole alkaloid designated as heptazolicine has been isolated from the roots of Clausena heptaphylla. On the basis of spectral and chemical evidence it has been identified as [2,2-dimethyl-3,4-dihydropyrano-(5, 6-a)]-3-formyl-8-hydroxy-carbazole.     

四数九里香中的咔唑类生物碱成分及其细胞毒活性研究

为阐明民族药四数九里香Murraya tetramera Huang的药效物质基础,本研究使用色谱分离技术从其醇提取物中分离纯化得7个咔唑类生物碱和1个甾体类化合物,运用波谱方法鉴定为β-谷甾醇(1)、1-甲基-3-丙酰基咔唑(2)、1-甲氧基-3-乙基咔唑(3)、1-甲氧基-3-甲酰基咔唑(4)、1-甲氧基-3-甲基咔唑(5)、1-羧基甲酯-3-甲基咔唑(6)、1-羧基甲酯-3-乙基咔唑(7)、mananimbine(8)。除了化合物1,其他化合物为首次从该植物中分离得到;化合物2～5、7对SMMC-7721的IC50分别为40. 93±0. 66、46. 03±2. 05、114. 21±5. 67、15. 79±0. 99、185. 1±0. 44。结果表明化合物2～5、7对SMMC-7721显现很好的细胞毒活性。     

Glycozolinine,a carbazole derivative from Glycosmis pentaphilla

A new carbazole derivative, glycozolinine, was isolated from the seeds of Glycosmis pentaphylla. From physical and chemical evidence its structure is 6-hydroxy-3-methylcarbazole.     

A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity

A benzoisofuranone derivative, 3xi-(1xi-hydroxyethyl)-7-hydroxy-1-isobenzofuranone, and a dimeric carbazole alkaloid, 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole), along with six known carbazole alkaloids and three known steroids were isolated from the stem bark of Murraya koenigii. The structures of these compounds were established unambiguously by UV, IR, MS and a series of 1D and 2D NMR analyses. The minimum inhibitory concentrations (MIC) of these compounds were found to be in the range 3.13-100 microg/ml.     

Mukonal,a probable biogenetic intermediate of pyranocarbazole alkaloids from murraya koenigii

Mukonal, a carbazole alkaloid has been isolated from Murraya koenigii. The structure of the compound has been established as 2-hydroxy-3-formyl carbazole based on physical (UV, IR, ¹H NMR, ¹³C NMR and mass spectrometry) and chemical transformations.     

Glycarpine,a new alkaloid from Glycosmis cyanocarpa

Glycarpine, a new furoquinolone alkaloid and evolitrine have been isolated from Glycosmis cyanocarpa.     

In vitro antidiabetic,antioxidant, antimicrobial,and cytotoxic activity of Murraya koenigii leaf extract intercedes ZnO nanoparticles

Nanotechnology is an emerging field with tremendous potential and usage of medicinal plants and green preparation of nanoparticles (NPs) is one of the widely explored areas. These have been shown to be effective against different biological activities such as diabetes mellitus, cancer, antioxidant, antimicrobial, etc. The current studies focus on the green synthesis of zinc NPs (ZnO NPs) from aqueous leaf extract of Murraya koenigii (MK). The synthesized Murraya koeingii zinc oxide NPs (MK ZnO NPs) were characterized using UV–visible spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy-dispersive spectrum (EDS) and cyclic voltammetry (CV). The synthesized MK ZnO NPs were evaluated for their in vitro antidiabetic, antioxidant, antimicrobial, and cytotoxic activity. They demonstrated significant antidiabetic and cytotoxic activity, as well as moderate free-radical scavenging and antibacterial activity.     

Alcaloïdes dihydrofuroquinoleiques de quelques rutaceae: Isolement,structure, proprietes biologiques

Six dihydrofuroquinoline quaternary bases have been isolated from Choisya ternata, Ptelea trifoliata and Ruta graveolens. Their structures have been determined by spectrometry and for some, the absolute configuration is reported. Some of the six isolated alkaloids have a prominent cytotoxic action on plant and animal tumor cells, and an inhibitory effect on Gram-positive bacteria.     

民族药四数九里香的化学成分及其细胞毒活性研究

为了阐明民族药四数九里香Murraya tetramera Huang的药效物质基础,课题组使用色谱技术从其醇提取物中分离得14个化合物;运用~1H NMR、¹³C NMR波谱方法和文献数据对比鉴定为正24烷酸(1)、9,13,17,21-tetramethyl-5-docosenoic acid(2)、3-O-β-D-吡喃葡萄糖基-山奈酚甙(3)、补骨脂素(4)、紫苏醛(5)、槲皮素(6)、methyl salicylate glucoside(7)、(9S,10R,11E,13R,15Z)-9,10,13-trihydroxyoctadeca-11,15-dienoic Acid(8)、2-isopropyl-5-methylphenol(9)、β-胡萝卜甘(10)、7-羟基香豆素(11)、七叶内酯(12)、β-谷甾醇醋酸酯(13)、山奈酚(14)。除了化合物4、6外,其他化合物为首次从该植物中分离得到。同时,研究各化合物对5株肿瘤细胞的体外生长抑制作用。与阳性对照组比较,结果表明:化合物3、4、5、6、7、8、10、11、12、13、14对白血病HL60显现良好的细胞毒活性;化合物1～14对肺腺癌A549的的细胞毒活性低于阳性对照组;化合物6、13、14对肝癌SMMC7721显现良好的细胞毒活性;化合物1、2、3、6、7、9、11、12对乳腺癌MCF7显现良好的细胞毒活性;化合物1～14对结肠癌SW480的细胞毒活性低于阳性对照组。     

Zanoxyline—a new alkaloid from stem bark of Zanthoxylum oxyphyllum

The EtOH extract of stem bark of Zanthoxylum oxyphyllum yielded rhetsinine and a new alkaloid 1-(4′methoxy benzyl)-6,7-dimethoxy N:N dimethyl 1,2,3,4 tetrahydroisoquinolinium hydroxide provisionally named zanoxyline.     

Murragleinin,a coumarin from Murraya gleinei leaves

A new trioxygenated C-8 prenylated coumarin, 5,6,7-trimethoxy-8-(2′,3′-dihydroxyisopentenyl)-coumarin and the laevorotatory form of mexoticin, sibiricin and phebalosin were isolated from the leaves of Murraya gleinei together with the coumarins meranzin hydrate, meranzin, murralongin, murrangatin and scopoletin, the flavone exoticin, the alkaloid skimianine and the sterol stigmasterol.     

Ravesilone,a quinolone alkaloid from Ravenia spectabilis

A new quinolone alkaloid designated ravesilone has been isolated from the leaves of Ravenia spectabilis. From spectral evidence the structure of the compound has been established as 3,4,5,6-tetrahydro-7-hydroxy-2,2,6-trimethyl-5-oxo-2H-pyrano[3,2-c]quinoline.     

Honatisine, a novel diterpenoid alkaloid, and six known alkaloids from Delphinium honanense and their cytotoxic activity

A novel diterpene alkaloid named honatisine (1) has been isolated from the whole plants of Delphinium honanense, along with six known alkaloids, siwanine E (2), isoatisine (3), atisine (4), delcorinine (5), uraphine (6), and nordhagenine A (7). Their structures were deduced on the basis of their spectral data. All of them were evaluated by a SRB assay for their cytotoxicity, and compound 1 showed a significant cytotoxic activity (IC(50) =3.16 μM) against the MCF-7 cell line.     

Glycolone,a quinolone alkaloid from Glycosmis pentaphylla

Glycolone, a quinolone alkaloid has been isolated from the leaves of Glycosmis pentaphylla. The structure of the compound has been established as 4,8-dimethoxy-3-(3-methyl but-2-enyl)-2-quinolone from physical and chemical evidences.