共查询到20条相似文献,搜索用时 31 毫秒
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Kim E Haworth Surendra Kotecha Timothy J Mohun Branko V Latinkic 《BMC developmental biology》2008,8(1):74
Background
GATA factors 4/5/6 have been implicated in the development of the heart and endodermal derivatives in vertebrates. Work in zebrafish has indicated that GATA5 is required for normal development earlier than GATA4/6. However, the GATA5 knockout mouse has no apparent embryonic phenotype, thereby questioning the importance of the gene for vertebrate development. 相似文献2.
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Ramegowda S Kumar A Savitha MR Krishnamurthy B Doddaiah N Ramachandra NB 《Indian journal of human genetics》2007,13(1):30-32
BACKGROUND:
The most common type of congenital heart disease is the cardiac septal defects, which has reported to be caused by a missense mutation (G296S) in exon 3 of the GATA4 gene.AIMS:
The present study was undertaken to find out whether GATA4 gene is the prime cause of the septal defects in Mysore population.MATERIALS AND METHODS:
GATA4 gene analyses were undertaken on 21 confirmed CHD cases by PCR and DNA sequencing.RESULTS AND CONCLUSION:
Analysis of this particular mutation in 21 septal defect patients revealed that none of the patients had the mutation, indicating that this mutation is population specific or septal defect in Mysore population is caused due to mutations in other regions of the GATA4 gene. 相似文献6.
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Raffaella Di Lisi Anne Picard Simonetta Ausoni Stefano Schiaffino 《BMC molecular biology》2007,8(1):78
Background
We reported previously that the cardiac troponin I (cTnI) promoter drives cardiac-specific expression of reporter genes in cardiac muscle cells and in transgenic mice, and that disruption of GATA elements inactivates the cTnI promoter in cultured cardiomyocytes. We have now examined the role of cTnI promoter GATA elements in skeletal muscle cells. 相似文献11.
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Background
Proteins of the tetraspanin family contain four transmembrane domains (TM1-4) linked by two extracellular loops and a short intracellular loop, and have short intracellular N- and C-termini. While structure and function analysis of the larger extracellular loop has been performed, the organization and role of transmembrane domains have not been systematically assessed. 相似文献20.
Sylvie Elsen Georgios Efthymiou Panagiotis Peteinatos George Diallinas Panayotis Kyritsis Jean-Marc Moulis 《BMC microbiology》2010,10(1):271