共查询到20条相似文献,搜索用时 15 毫秒
1.
CNV-seq, a new method to detect copy number variation using high-throughput sequencing 总被引:2,自引:0,他引:2
Background
DNA copy number variation (CNV) has been recognized as an important source of genetic variation. Array comparative genomic hybridization (aCGH) is commonly used for CNV detection, but the microarray platform has a number of inherent limitations. 相似文献2.
Elke M Lohmeier-Vogel David Kerk Mhairi Nimick Susan Wrobel Lori Vickerman Douglas G Muench Greg BG Moorhead 《BMC plant biology》2008,8(1):120
Background
Starch accumulation and degradation in chloroplasts is accomplished by a suite of over 30 enzymes. Recent work has emphasized the importance of multi-protein complexes amongst the metabolic enzymes, and the action of associated non-enzymatic regulatory proteins. Arabidopsis At5g39790 encodes a protein of unknown function whose sequence was previously demonstrated to contain a putative carbohydrate-binding domain. 相似文献3.
Whitelaw NC Chong S Morgan DK Nestor C Bruxner TJ Ashe A Lambley E Meehan R Whitelaw E 《Genome biology》2010,11(11):R111
Background
Inbred individuals reared in controlled environments display considerable variance in many complex traits but the underlying cause of this intangible variation has been an enigma. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. 相似文献4.
Francesco Fabbri Silvia Carloni Giovanni Brigliadori Wainer Zoli Rosa Lapalombella Marina Marini 《BMC cell biology》2006,7(1):1-14
Background
Pim-1, 2 and 3 are a group of enzymes related to the calcium calmodulin family of protein kinases. Over-expression of Pim-1 and Pim-2 in mice promotes the development of lymphomas, and up-regulation of Pim expression has been observed in several human cancers. 相似文献5.
Background
Integration of heterogeneous data types is a challenging problem, especially in biology, where the number of databases and data types increase rapidly. Amongst the problems that one has to face are integrity, consistency, redundancy, connectivity, expressiveness and updatability. 相似文献6.
David Tanne Noa Molshatzki Oleg Merzeliak Rakefet Tsabari Maya Toashi Yvonne Schwammenthal 《BMC neurology》2010,10(1):22
Background
In the setting of an acute stroke, anemia has the potential to worsen brain ischemia, however, the relationship between the entire range of hemoglobin to long-term outcome is not well understood. 相似文献7.
Background
Unlike a pedigree initiated with two inbred lines, a full-sib family derived from two outbred parents frequently has many different segregation types of markers whose linkage phases are not known prior to linkage analysis. 相似文献8.
Background
Chronic venous insufficiency is a serious disease for which there is no clearly successful surgical treatment. Availability of a proven prosthetic vein valve could provide such an option by reducing venous reflux while permitting normal antegrade flow. 相似文献9.
10.
Background
Whole-cell biocatalysis in organic solvents has been widely applied to industrial bioprocesses. In two-phase water-solvent processes, substrate conversion yields and volumetric productivities can be limited by the toxicity of solvents to host cells and by the low mass transfer rates of the substrates from the solvent phase to the whole-cell biocatalysts in water. 相似文献11.
Background
Large biological data sets, such as expression profiles, benefit from reduction of random noise. Principal component (PC) analysis has been used for this purpose, but it tends to remove small features as well as random noise. 相似文献12.
Takeshi Asano Shinya Koizumi Atsushi Takagi Takayuki Hatori Kentaroh Kuwabara Osamu Fujino Yoshitaka Fukunaga 《BMC neurology》2011,11(1):101
Background
Acute encephalopathy includes rapid deterioration and has a poor prognosis. Early intervention is essential to prevent progression of the disease and subsequent neurologic complications. However, in the acute period, true encephalopathy cannot easily be differentiated from febrile seizures, especially febrile seizures of the complex type. Thus, an early diagnostic marker has been sought in order to enable early intervention. The purpose of this study was to identify a novel marker candidate protein differentially expressed in the cerebrospinal fluid (CSF) of children with encephalopathy using proteomic analysis. 相似文献13.
Ignacio Rodriguez-Llorente Miguel A Caviedes Mohammed Dary Antonio J Palomares Francisco M Cánovas José M Peregrín-Alvarez 《BMC systems biology》2009,3(1):63-18
Background
Rhizobium-Legume symbiosis is an attractive biological process that has been studied for decades because of its importance in agriculture. However, this system has undergone extensive study and although many of the major factors underpinning the process have been discovered using traditional methods, much remains to be discovered. 相似文献14.
Background
SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts derived from them. 相似文献15.
Background
The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. 相似文献16.
Kellie J Archer Catherine I Dumur G Scott Taylor Michael D Chaplin Anthony Guiseppi-Elie Geraldine Grant Andrea Ferreira-Gonzalez Carleton T Garrett 《BMC bioinformatics》2007,8(1):447
Background
Recent research examining cross-platform correlation of gene expression intensities has yielded mixed results. In this study, we demonstrate use of a correction factor for estimating cross-platform correlations. 相似文献17.
Jiangqin Zhao Shixing Tang James Storhoff Sudhakar Marla Y Paul Bao Xue Wang Eric Y Wong Viswanath Ragupathy Zhiping Ye Indira K Hewlett 《BMC biotechnology》2010,10(1):74
Background
For more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe a rapid and simple gold nanoparticle (NP)-based genomic microarray assay for specific identification of avian influenza virus H5N1 and its discrimination from other major influenza A virus strains (H1N1, H3N2). 相似文献18.
Michael L Traub Anne Van Arsdale Lubna Pal Sangita Jindal Nanette Santoro 《Reproductive biology and endocrinology : RB&E》2009,7(1):33-7
Background
In-vitro fertilization (IVF) with blastocyst as opposed to cleavage stage embryos has been advocated to improve success rates. Limited information exists on which to predict which patients undergoing blastocyst embryo transfer (BET) will achieve pregnancy. This study's objective was to evaluate the predictive value of patient and cycle characteristics for clinical pregnancy following fresh BET. 相似文献19.
Jan B Howes Paul L de Souza Leanne West Li Jiu Huang Laurence G Howes 《BMC clinical pharmacology》2011,11(1):1
Background
Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer. 相似文献20.
Valeria Edefonti Francesca Bravi Katherine Turner Ettore Beghi Maria Paola Canevini Monica Ferraroni Ada Piazzini 《BMC neurology》2011,11(1):33