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1.
Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types of cell divisions differ in terms of the stem cells'' flexibility to expand when needed. On the contrary, the implications of symmetric and asymmetric divisions for mutation accumulation are still poorly understood. In this paper we study a stochastic model of a renewing tissue, and address the optimization problem of tissue architecture in the context of mutant production. Specifically, we study the process of tumor suppressor gene inactivation which usually takes place as a consequence of two “hits”, and which is one of the most common patterns in carcinogenesis. We compare and contrast symmetric and asymmetric (and mixed) stem cell divisions, and focus on the rate at which double-hit mutants are generated. It turns out that symmetrically-dividing cells generate such mutants at a rate which is significantly lower than that of asymmetrically-dividing cells. This result holds whether single-hit (intermediate) mutants are disadvantageous, neutral, or advantageous. It is also independent on whether the carcinogenic double-hit mutants are produced only among the stem cells or also among more specialized cells. We argue that symmetric stem cell divisions in mammals could be an adaptation which helps delay the onset of cancers. We further investigate the question of the optimal fraction of stem cells in the tissue, and quantify the contribution of non-stem cells in mutant production. Our work provides a hypothesis to explain the observation that in mammalian cells, symmetric patterns of stem cell division seem to be very common. 相似文献
2.
Lewis MA 《Journal of mathematical biology》2000,41(5):430-454
Despite the recognized importance of stochastic factors, models for ecological invasions are almost exclusively formulated
using deterministic equations [29]. Stochastic factors relevant to invasions can be either extrinsic (quantities such as temperature
or habitat quality which vary randomly in time and space and are external to the population itself) or intrinsic (arising
from a finite population of individuals each reproducing, dying, and interacting with other individuals in a probabilistic
manner). It has been long conjectured [27] that intrinsic stochastic factors associated with interacting individuals can slow
the spread of a population or disease, even in a uniform environment. While this conjecture has been borne out by numerical
simulations, we are not aware of a thorough analytical investigation.
In this paper we analyze the effect of intrinsic stochastic factors when individuals interact locally over small neighborhoods.
We formulate a set of equations describing the dynamics of spatial moments of the population. Although the full equations
cannot be expressed in closed form, a mixture of a moment closure and comparison methods can be used to derive upper and lower
bounds for the expected density of individuals. Analysis of the upper solution gives a bound on the rate of spread of the
stochastic invasion process which lies strictly below the rate of spread for the deterministic model. The slow spread is most
evident when invaders occur in widely spaced high density foci. In this case spatial correlations between individuals mean
that density dependent effects are significant even when expected population densities are low. Finally, we propose a heuristic
formula for estimating the true rate of spread for the full nonlinear stochastic process based on a scaling argument for moments.
Received: 19 October 1998 / Revised version: 1 September 1999 / Published online: 4 October 2000 相似文献
3.
In this work we explore the temporal dynamics of spatial heterogeneity during the process of tumorigenesis from healthy tissue. We utilize a spatial stochastic model of mutation accumulation and clonal expansion in a structured tissue to describe this process. Under a two-step tumorigenesis model, we first derive estimates of a non-spatial measure of diversity: Simpson’s Index, which is the probability that two individuals sampled at random from the population are identical, in the premalignant population. We next analyze two new measures of spatial population heterogeneity. In particular we study the typical length scale of genetic heterogeneity during the carcinogenesis process and estimate the extent of a surrounding premalignant clone given a clinical observation of a premalignant point biopsy. This evolutionary framework contributes to a growing literature focused on developing a better understanding of the spatial population dynamics of cancer initiation and progression. 相似文献
4.
5.
We study the transient dynamics, following a spatially-extended perturbation of models describing populations residing in
advective media such as streams and rivers. Our analyses emphasize metrics that are independent of initial perturbations—resilience,
reactivity, and the amplification envelope—and relate them to component spatial wavelengths of the perturbation using spatial
Fourier transforms of the state variables. This approach offers a powerful way of understanding the influence of spatial scale
on the initial dynamics of a population following a spatially variable environmental perturbation, an important property in
determining the ecological implications of transient dynamics in advective systems. We find that asymptotically stable systems
may exhibit transient amplification of perturbations (i.e., have positive reactivity) for some spatial wavelengths and not
others. Furthermore, the degree and duration of amplification varies strongly with spatial wavelength. For two single-population
models, there is a relationship between transient dynamics and the response length that characterizes the steady state response
to spatial perturbations: a long response length implies that peak amplification of perturbations is small and occurs fast.
This relationship holds less generally in a specialist consumer-resource model, likely due to the model’s tendency for flow-induced
instabilities at an alternative characteristic spatial scale. 相似文献
6.
Simple temporal models that ignore the spatial nature of interactions and track only changes in mean quantities, such as global
densities, are typically used under the unrealistic assumption that individuals are well mixed. These so-called mean-field
models are often considered overly simplified, given the ample evidence for distributed interactions and spatial heterogeneity
over broad ranges of scales. Here, we present one reason why such simple population models may work even when mass-action
assumptions do not hold: spatial structure is present but it relates to global densities in a special way. With an individual-based
predator–prey model that is spatial and stochastic, and whose mean-field counterpart is the classic Lotka–Volterra model,
we show that the global densities and densities of pairs (or spatial covariances) establish a bi-power law at the stationary state and also in their transient approach to this state. This relationship implies that the dynamics of
global densities can be written simply as a function of those densities alone without invoking pairs (or higher order moments).
The exponents of the bi-power law for the predation rate exhibit a remarkable robustness to changes in model parameters. Evidence
is presented for a connection of our findings to the existence of a critical phase transition in the dynamics of the spatial
system. We discuss the application of similar modified mean-field equations to other ecological systems for which similar
transitions have been described, both in models and empirical data. 相似文献
7.
Jenni Nordn Philip J. Harrison Louise Mair Juha Siitonen Anders Lundstrm Oskar Kindvall Tord Snll 《Ecology and evolution》2020,10(6):3079-3089
Understanding spatiotemporal population trends and their drivers is a key aim in population ecology. We further need to be able to predict how the dynamics and sizes of populations are affected in the long term by changing landscapes and climate. However, predictions of future population trends are sensitive to a range of modeling assumptions. Deadwood‐dependent fungi are an excellent system for testing the performance of different predictive models of sessile species as these species have different rarity and spatial population dynamics, the populations are structured at different spatial scales, and they utilize distinct substrates. We tested how the projected large‐scale occupancies of species with differing landscape‐scale occupancies are affected over the coming century by different modeling assumptions. We compared projections based on occupancy models against colonization–extinction models, conducting the modeling at alternative spatial scales and using fine‐ or coarse‐resolution deadwood data. We also tested effects of key explanatory variables on species occurrence and colonization–extinction dynamics. The hierarchical Bayesian models applied were fitted to an extensive repeated survey of deadwood and fungi at 174 patches. We projected higher occurrence probabilities and more positive trends using the occupancy models compared to the colonization–extinction models, with greater difference for the species with lower occupancy, colonization rate, and colonization:extinction ratio than for the species with higher estimates of these statistics. The magnitude of future increase in occupancy depended strongly on the spatial modeling scale and resource resolution. We encourage using colonization–extinction models over occupancy models, modeling the process at the finest resource‐unit resolution that is utilizable by the species, and conducting projections for the same spatial scale and resource resolution at which the model fitting is conducted. Further, the models applied should include key variables driving the metapopulation dynamics, such as the availability of suitable resource units, habitat quality, and spatial connectivity. 相似文献
8.
Emma E. Goldberg Heather J. Lynch Michael G. Neubert William F. Fagan 《Theoretical Ecology》2010,3(3):137-152
The dendritic structure of a river network creates directional dispersal and a hierarchical arrangement of habitats. These
two features have important consequences for the ecological dynamics of species living within the network. We apply matrix
population models to a stage-structured population in a network of habitat patches connected in a dendritic arrangement. By
considering a range of life histories and dispersal patterns, both constant in time and seasonal, we illustrate how spatial
structure, directional dispersal, survival, and reproduction interact to determine population growth rate and distribution.
We investigate the sensitivity of the asymptotic growth rate to the demographic parameters of the model, the system size,
and the connections between the patches. Although some general patterns emerge, we find that a species’ modes of reproduction
and dispersal are quite important in its response to changes in its life history parameters or in the spatial structure. The
framework we use here can be customized to incorporate a wide range of demographic and dispersal scenarios. 相似文献
9.
P. David Polly 《Palaeontology》2019,62(2):175-195
Evolution is a fundamentally population level process in which variation, drift and selection produce both temporal and spatial patterns of change. Statistical model fitting is now commonly used to estimate which kind of evolutionary process best explains patterns of change through time using models like Brownian motion, stabilizing selection (Ornstein–Uhlenbeck) and directional selection on traits measured from stratigraphic sequences or on phylogenetic trees. But these models assume that the traits possessed by a species are homogeneous. Spatial processes such as dispersal, gene flow and geographical range changes can produce patterns of trait evolution that do not fit the expectations of standard models, even when evolution at the local‐population level is governed by drift or a typical OU model of selection. The basic properties of population level processes (variation, drift, selection and population size) are reviewed and the relationship between their spatial and temporal dynamics is discussed. Typical evolutionary models used in palaeontology incorporate the temporal component of these dynamics, but not the spatial. Range expansions and contractions introduce rate variability into drift processes, range expansion under a drift model can drive directional change in trait evolution, and spatial selection gradients can create spatial variation in traits that can produce long‐term directional trends and punctuation events depending on the balance between selection strength, gene flow, extirpation probability and model of speciation. Using computational modelling that spatial processes can create evolutionary outcomes that depart from basic population‐level notions from these standard macroevolutionary models. 相似文献
10.
Cheryl J. Briggs Roger M. Nisbet William W. Murdoch 《Journal of mathematical biology》1999,38(4):317-345
Continuous-time, age structured, host–parasitoid models exhibit three types of cyclic dynamics: Lotka–Volterra-like consumer-resource
cycles, discrete generation cycles, and “delayed feedback cycles” that occur if the gain to the parasitoid population (defined
by the number of new female parasitoid offspring produced per host attacked) increases with the age of the host attacked.
The delayed feedback comes about in the following way: an increase in the instantaneous density of searching female parasitoids
increases the mortality rate on younger hosts, which reduces the density of future older and more productive hosts, and hence
reduces the future per head recruitment rate of searching female parasitoids. Delayed feedback cycles have previously been
found in studies that assume a step-function for the gain function. Here, we formulate a general host–parasitoid model with
an arbitrary gain function, and show that stable, delayed feedback cycles are a general phenomenon, occurring with a wide
range of gain functions, and strongest when the gain is an accelerating function of host age. We show by examples that locally
stable, delayed feedback cycles commonly occur with parameter values that also yield a single, locally stable equilibrium,
and hence their occurrence depends on initial conditions. A simplified model reveals that the mechanism responsible for the
delayed feedback cycles in our host–parasitoid models is similar to that producing cycles and initial-condition-dependent
dynamics in a single species model with age-dependent cannibalism.
Received: 24 October 1997 / Revised version: 13 June 1998 相似文献
11.
In this paper we propose a general framework for discrete time one-dimensional Markov population models which is based on
two fundamental premises in population dynamics. We show that this framework incorporates both earlier population models,
like the Ricker and Hassell models, and experimental observations concerning the structure of density dependence. The two
fundamental premises of population dynamics are sufficient to guarantee that the model will exhibit chaotic behaviour for
high values of the natural growth and the density-dependent feedback, and this observation is independent of the particular
structure of the model. We also study these models when the environment of the population varies stochastically and address
the question under what conditions we can find an invariant probability distribution for the population under consideration.
The sufficient conditions for this stochastic stability that we derive are of some interest, since studying certain statistical
characteristics of these stochastic population processes may only be possible if the process converges to such an invariant
distribution.
Received 15 May 1995; received in revised form 17 April 1996 相似文献
12.
Aim The study and prediction of species–environment relationships is currently mainly based on species distribution models. These purely correlative models neglect spatial population dynamics and assume that species distributions are in equilibrium with their environment. This causes biased estimates of species niches and handicaps forecasts of range dynamics under environmental change. Here we aim to develop an approach that statistically estimates process‐based models of range dynamics from data on species distributions and permits a more comprehensive quantification of forecast uncertainties. Innovation We present an approach for the statistical estimation of process‐based dynamic range models (DRMs) that integrate Hutchinson's niche concept with spatial population dynamics. In a hierarchical Bayesian framework the environmental response of demographic rates, local population dynamics and dispersal are estimated conditional upon each other while accounting for various sources of uncertainty. The method thus: (1) jointly infers species niches and spatiotemporal population dynamics from occurrence and abundance data, and (2) provides fully probabilistic forecasts of future range dynamics under environmental change. In a simulation study, we investigate the performance of DRMs for a variety of scenarios that differ in both ecological dynamics and the data used for model estimation. Main conclusions Our results demonstrate the importance of considering dynamic aspects in the collection and analysis of biodiversity data. In combination with informative data, the presented framework has the potential to markedly improve the quantification of ecological niches, the process‐based understanding of range dynamics and the forecasting of species responses to environmental change. It thereby strengthens links between biogeography, population biology and theoretical and applied ecology. 相似文献
13.
Systems analysis of density-dependent population processes in the azuki bean weevil,Callosobruchus chinensis 总被引:1,自引:0,他引:1
Masakazu Shimada 《Ecological Research》1989,4(2):145-156
Systems analysis of density-dependent population processes was conducted in an experimental population of the azuki bean weevil,Callosobruchus chinensis. Density-dependent population change was formulated for two separate processes; adult production of eggs and hatching of
the eggs outside the beans, and survival of the first instar larvae inside the beans and their emergence as new adults. The
formulation of each process was based on a common basic equation modified from the logistic-difference equation. Parametric
values were estimated from experimental data onC. chinensis in a laboratory population.
Simulations of the model showed good fits not only to observed population changes both outside and inside the beans, but also
to the observed reproduction curve reflecting the population change as a whole within one generation in an experimental population.
Furthermore, population dynamics from generation to generation were simulated from the model reproduction curve. The simulation
showed a slight dumped oscillation and converged to a carrying capacity, which fitted well with the experimental population
dynamics. 相似文献
14.
We examine a generalised SIR model for the infection dynamics of four competing disease strains. This model contains four
previously-studied models as special cases. The different strains interact indirectly by the mechanism of cross-immunity;
individuals in the host population may become immune to infection by a particular strain even if they have only been infected
with different but closely related strains. Several different models of cross-immunity are compared in the limit where the
death rate is much smaller than the rate of recovery from infection. In this limit an asymptotic analysis of the dynamics
of the models is possible, and we are able to compute the location and nature of the Takens–Bogdanov bifurcation associated
with the presence of oscillatory dynamics observed by previous authors.
Received: 5 December 2001 / Revised version: 5 May 2002 / Published online: 17 October 2002
Keywords or phrases: Infection – Pathogen – Epidemiology – Multiple strains – Cross-immunity – Oscillations – Dynamics – Bifurcations 相似文献
15.
Amodel of the population dynamics of birds in the river floodplain is developed with the purpose to organize monitoring of
the floodplain ecosystems, based on the principles of system dynamics formulated by Jay Forrester. We used the long-run observations
(1977–2000) made in spring and summer in the floodplain of the middle Ob in the Kolpashevskii raion of Tomsk oblast, which
helped to improve the model structure. The model is realized with the help of MATLAB 5.2.1 software. The modeling confirmed
the hypothesis that hydrological regime is a main factor determining the dynamics and structure of birds population in the
floodplain of the middle Ob. 相似文献
16.
Parvinen K 《Journal of mathematical biology》2002,45(2):106-124
Dispersal polymorphism and evolutionary branching of dispersal strategies has been found in several metapopulation models.
The mechanism behind those findings has been temporal variation caused by cyclic or chaotic local dynamics, or temporally
and spatially varying carrying capacities. We present a new mechanism: spatial heterogeneity in the sense of different patch
types with sufficient proportions, and temporal variation caused by catastrophes. The model where this occurs is a generalization
of the model by Gyllenberg and Metz (2001). Their model is a size-structured metapopulation model with infinitely many identical
patches. We present a generalized version of their metapopulation model allowing for different types of patches. In structured
population models, defining and computing fitness in polymorphic situations is, in general, difficult. We present an efficient
method, which can be applied also to other structured population or metapopulation models.
Received: 6 March 2001 / Revised version: 12 February 2002 / Published online: 17 July 2002 相似文献
17.
Extrapolating ecological processes from small-scale experimental systems to scales of natural populations usually entails a considerable increase in spatial heterogeneity, which may affect process rates and, ultimately, population dynamics. We demonstrate how information on the heterogeneity of natural populations can be taken into account when scaling up laboratory-derived process functions, using the technique of moment approximation. We apply moment approximation to a benthic crustacean predator-prey system, where a laboratory-derived functional response is made spatial by including correction terms for the variance in prey density and the covariance between prey and predator densities observed in the field. We also show how moment approximation may be used to incorporate spatial information into a dynamic model of the system. While the nonspatial model predicts stable dynamics, its spatial equivalent also produces bounded fluctuations, in agreement with observed dynamics. A detailed analysis shows that predator-prey covariance, but not prey variance, destabilizes the dynamics. We conclude that second-order moment approximation may provide a useful technique for including spatial information in population models. The main advantage of the method is its conceptual value: by providing explicit estimates of variance and covariance effects, it offers the possibility of understanding how heterogeneity affects ecological processes. 相似文献
18.
We study a system of differential equations that models the population dynamics of an SIR vector transmitted disease with two pathogen strains. This model arose from our study of the population dynamics of dengue
fever. The dengue virus presents four serotypes each induces host immunity but only certain degree of cross-immunity to heterologous
serotypes. Our model has been constructed to study both the epidemiological trends of the disease and conditions that permit
coexistence in competing strains. Dengue is in the Americas an epidemic disease and our model reproduces this kind of dynamics.
We consider two viral strains and temporary cross-immunity. Our analysis shows the existence of an unstable endemic state
(‘saddle’ point) that produces a long transient behavior where both dengue serotypes cocirculate. Conditions for asymptotic
stability of equilibria are discussed supported by numerical simulations. We argue that the existence of competitive exclusion
in this system is product of the interplay between the host superinfection process and frequency-dependent (vector to host)
contact rates.
Received 4 December 1995; received in revised form 5 March 1996 相似文献
19.
Timothy H. Keitt Ottar N. Bjrnstad Philip M. Dixon Steve Citron‐Pousty 《Ecography》2002,25(5):616-625
Statistical models of environment-abundance relationships may be influenced by spatial autocorrelation in abundance, environmental variables, or both. Failure to account for spatial autocorrelation can lead to incorrect conclusions regarding both the absolute and relative importance of environmental variables as determinants of abundance. We consider several classes of statistical models that are appropriate for modeling environment-abundance relationships in the presence of spatial autocorrelation, and apply these to three case studies: 1) abundance of voles in relation to habitat characteristics; 2) a plant competition experiment; and 3) abundance of Orbatid mites along environmental gradients. We find that when spatial pattern is accounted for in the modeling process, conclusions about environmental control over abundance can change dramatically. We conclude with five lessons: 1) spatial models are easy to calculate with several of the most common statistical packages; 2) results from spatially-structured models may point to conclusions radically different from those suggested by a spatially independent model; 3) not all spatial autocorrelation in abundances results from spatial population dynamics; it may also result from abundance associations with environmental variables not included in the model; 4) the different spatial models do have different mechanistic interpretations in terms of ecological processes – thus ecological model selection should take primacy over statistical model selection; 5) the conclusions of the different spatial models are typically fairly similar – making any correction is more important than quibbling about which correction to make. 相似文献
20.
We examined gene models for two traits with and without antagonistic pleiotropy using a locus-based simulation model to investigate
the effects of different population sizes, heritabilities and economic weights, using index selection, and index selection
with optimum selection (OS), over 10 generations. Gene models included additive and dominance gene action, with equal and
varying initial allele frequencies with and without pleiotropy for a fixed level of resources (i.e. founder sizes each generation
of 40, 80 and 160 with progeny arrays that totaled 800 per generation). Pleiotropy (with an initial r
g of −0.5), reduced gain by ~8–10% when heritabilities for both traits were the same (0.2), relative to non-pleiotropic cases.
When traits had different heritabilities (i.e. 0.2 and 0.4), gains in the lower heritability trait were substantially lower,
especially with pleiotropy present. In general, OS with slightly larger population sizes could offset losses in gain, but
rarely overrode the large effects of different heritabilities or economic weights. Pleiotropy increased response variance
among traits, which was magnified when heritabilities were different. Identifying an appropriate weight on relatedness in
the OS process is important to manage coancestry expectations around the loss of alleles (or fixation of recessive alleles)
and to minimise response variance. The dynamics of selection intensity, drift, rate of coancestry build-up, response variance,
etc. are complex for multi-trait selection; however, a few economically viable strategies could reduce the adverse effects
of selecting against genetic correlations without drastically impairing gain. 相似文献