共查询到20条相似文献,搜索用时 15 毫秒
1.
Svenja Allhorn Carsten Böing Andrea A Koch Rainer Kimmig Isabella Gashaw 《Reproductive biology and endocrinology : RB&E》2008,6(1):40
Background
Toll-like receptors (TLRs) play an essential role in the innate immune system by initiating and directing immune response to pathogens. TLRs are expressed in the human endometrium and their regulation might be crucial for the pathogenesis of endometrial diseases. 相似文献2.
Iannis E Adamopoulos Cheng-chi Chao Richard Geissler Drake Laface Wendy Blumenschein Yoichiro Iwakura Terrill McClanahan Edward P Bowman 《Arthritis research & therapy》2010,12(1):R29
Introduction
The interaction between the immune and skeletal systems is evidenced by the bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we describe a new mechanism by which the immune cytokine IL-17A directly affects osteoclastogenesis. 相似文献3.
Background
a decline in immune and endocrine function occurs with aging. The main purpose of this study was to investigate the impact of long-term endurance training on the immune and endocrine system of elderly men. The possible interaction between these systems was also analysed. 相似文献4.
Johanna B Drott Oleg Alexeyev Patrik Bergström Fredrik Elgh Jan Olsson 《BMC microbiology》2010,10(1):126
Background
The immune stimulating bacterium Propionibacterium acnes is a frequent colonizer of benign and malignant prostate tissue. To understand the pathogenesis of the earliest phase of this infection, we examined the P. acnes triggered immune response in cultivated prostate epithelial cells. 相似文献5.
Linda May Anita HJ van den Biggelaar David van Bodegom Hans J Meij Anton JM de Craen Joseph Amankwa Marijke Fr?lich Maris Kuningas Rudi GJ Westendorp 《Immunity & ageing : I & A》2009,6(1):7
Background-
The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic inflammatory diseases at older age. Despite indications that environmental conditions can influence the senescence process of the adaptive immune system, it is not known whether the same holds true for the innate immune system. Therefore we studied whether age-related innate immune responses are similar or differ between populations living under very diverse environmental conditions. 相似文献6.
Background
Despite several reports on age-related phenotypic changes of the immune system's cells, studies that use a multipoint age comparison between the specific and innate immune cell populations of prototypical Th1- and Th2-type polarized mouse strains are still lacking. 相似文献7.
Akihiro Sakai Jiahuai Han Andrew CB Cato Shizuo Akira Jian-Dong Li 《BMC molecular biology》2004,5(1):2-16
Background
Despite the importance of glucocorticoids in suppressing immune and inflammatory responses, their role in enhancing host immune and defense response against invading bacteria is poorly understood. Toll-like receptor 2 (TLR2) has recently gained importance as one of the major host defense receptors. The increased expression of TLR2 in response to bacteria-induced cytokines has been thought to be crucial for the accelerated immune response and resensitization of epithelial cells to invading pathogens. 相似文献8.
Background
The hypothesis of immunosurveillance suggests that new neoplasms arise very frequently, but most are destroyed almost at their inception by an immune response. Its correctness has been debated for many years. 相似文献9.
Introduction
The objective was to study immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity. 相似文献10.
Martinez M Ono N Planutiene M Planutis K Nelson EL Holcombe RF 《Cancer cell international》2012,12(1):2
Background
Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. 相似文献11.
Aneta Kasza Paulina Wyrzykowska Irena Horwacik Piotr Tymoszuk Danuta Mizgalska Karren Palmer Hanna Rokita Andrew D Sharrocks Jolanta Jura 《BMC molecular biology》2010,11(1):14
Background
MCPIP is a novel CCCH zinc finger protein described as an RNase engaged in the regulation of immune responses. The regulation of expression of the gene coding for MCPIP - ZC3H12A is poorly explored. 相似文献12.
Peng Wang Alexander A Morgan Qing Zhang Alessandro Sette Bjoern Peters 《BMC bioinformatics》2007,8(1):269
Background
The Immune Epitope Database contains information on immune epitopes curated manually from the scientific literature. Like similar projects in other knowledge domains, significant effort is spent on identifying which articles are relevant for this purpose. 相似文献13.
Background
Stromal derived factor (SDF-1), an alpha chemokine, is a widely known chemoattractant in the immune system. A growing body of evidence now suggests multiple regulatory roles for SDF-1 in the developing nervous system. 相似文献14.
Background
Transplant rejection has been considered to occur primarily because donor antigens are not present during the development of the recipient's immune system to induce tolerance. Thus, transplantation prior to recipient immune system development (pre-immunocompetence transplants) should induce natural tolerance to the donor. Surprisingly, tolerance was often not the outcome in such 'natural tolerance models'. We explored the ability of natural tolerance to prevent immune responses to alloantigens, and the reasons for the disparate outcomes of pre-immunocompetence transplants. 相似文献15.
Background
This study aimed at investigating a potential effect caused by coccidia on the immune response to vaccine- and very virulent infectious bursal disase virus (vvIBDV) in SPF chickens. 相似文献16.
Sergey Kozhenkov Mayya Sedova Yulia Dubinina Amarnath Gupta Animesh Ray Julia Ponomarenko Michael Baitaluk 《BMC systems biology》2011,5(1):7
Background
Understanding of immune response mechanisms of pathogen-infected host requires multi-scale analysis of genome-wide data. Data integration methods have proved useful to the study of biological processes in model organisms, but their systematic application to the study of host immune system response to a pathogen and human disease is still in the initial stage. 相似文献17.
Daniela Karasova Alena Sebkova Hana Havlickova Frantisek Sisak Jiri Volf Martin Faldyna Petra Ondrackova Vladimir Kummer Ivan Rychlik 《BMC microbiology》2010,10(1):75
Background
In this study we were interested in the colonisation and early immune response of Balb/C mice to infection with Salmonella Enteritidis and isogenic pathogenicity island free mutants. 相似文献18.
Tomasz Lipniacki Krzysztof Puszynski Pawel Paszek Allan R Brasier Marek Kimmel 《BMC bioinformatics》2007,8(1):376
Background
The NF-κB regulatory network controls innate immune response by transducing variety of pathogen-derived and cytokine stimuli into well defined single-cell gene regulatory events. 相似文献19.
Nathalie D van Burgel Peter Kraiczy Tim J Schuijt Peter F Zipfel Alje P van Dam 《BMC microbiology》2010,10(1):43
Background
B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways. One important immune escape mechanism for evading complement activation is the binding of complement regulators Factor H (CFH) or Factor H-like protein1 (FHL-1) to Complement Regulator-Acquiring Surface Proteins (CRASPs). 相似文献20.
Faheem Mitha Timothy A Lucas Feng Feng Thomas B Kepler Cliburn Chan 《Source code for biology and medicine》2008,3(1):6