共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
Silencer region of a chalcone synthase promoter contains multiple binding sites for a factor,SBF-1, closely related to GT-1 总被引:14,自引:0,他引:14
Michael A. Lawton Susan M. Dean Michel Dron Jan M. Kooter Karsten M. Kragh Maria J. Harrison Lloyd Yu Lisa Tanguay Richard A. Dixon Christopher J. Lamb 《Plant molecular biology》1991,16(2):235-249
8.
9.
10.
11.
12.
DREAM is a critical transcriptional repressor for pain modulation. 总被引:19,自引:0,他引:19
Hai-Ying M Cheng Graham M Pitcher Steven R Laviolette Ian Q Whishaw Kit I Tong Lisa K Kockeritz Teiji Wada Nicholas A Joza Michael Crackower Jason Goncalves Ildiko Sarosi James R Woodgett Antonio J Oliveira-dos-Santos Mitsuhiko Ikura Derek van der Kooy Michael W Salter Josef M Penninger 《Cell》2002,108(1):31-43
13.
14.
15.
16.
The presentation by antigen-presenting cells of immunodominant peptide segments in association with major histocompatibility complex (MHC) encoded proteins is fundamental to the efficacy of a specific immune response. One approach used to identify immunodominant segments within proteins has involved the development of predictive algorithms which utilize amino acid sequence data to identify structural characteristics or motifs associated with in vivo antigenicity. The parallel-computing technique termed ‘neural networking’ has recently been shown to be remarkably efficient at addressing the problem of pattern recognition and can be applied to predict protein secondary structure attributes directly from amino acid sequence data. In order to examine the potential of a neural network to generalize peptide structural feature related to binding within class II MHC-encoded proteins, we have trained a neural network to determine whether or not any given amino acid of a protein is part of a peptide segment capable of binding to HLA-DR1. We report that a neural network trained on a data base consisting of peptide segments known to bind to HLA-DR1 is able to generalize features relating to HLA-DR1-binding capacity (r = 0.17 and p = 0.0001). 相似文献
17.
Wu H Kao SC Barrientos T Baldwin SH Olson EN Crabtree GR Zhou B Chang CP 《The Journal of biological chemistry》2007,282(42):30673-30679
18.
19.