Evaluation of Natural Products for Algicidal Properties

A procedure for the screening of antialgal substances has been described and evaluated with specific reference to microbial products. Data on the extracellular materials of 545 actinomycete and fungal isolates showed a wide distribution of agents having algicidal activities. Of these culture filtrates, 20.4% apparently had selective antagonistic effects against particular algal groups. A more comprehensive examination revealed that metabolic products from two actinomycete cultures exhibited properties that warrant further studies on their chemical and physiological characteristics.     

天然产物的生物转化

本文按反应类型综述了近五年来天然产物生物转化的研究进展,并对生物技术干预下的生物转化作了简要介绍.     

天然产物抗病毒活性成分的研究进展

按照化学成分结构类型的不同,将近五年来具有抗病毒活性的天然产物研究近况做一综述,旨为以天然产物为研究对象,大力开展开发抗病毒药物提供依据。     

Bioprospecting for Microbial Endophytes and Their Natural Products

Endophytic microorganisms are to be found in virtually every plant on earth. These organisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic. Because of what appears to be their contribution to the host plant, the endophytes may produce a plethora of substances of potential use to modern medicine, agriculture, and industry. Novel antibiotics, antimycotics, immunosuppressants, and anticancer compounds are only a few examples of what has been found after the isolation, culture, purification, and characterization of some choice endophytes in the recent past. The potential prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great.     

New Natural Products from Asphodelus albus MILL. Essential Oil

A detailed chemical analysis of the essential oil of Asphodelus albus roots performed in this work, in combination with a chemical synthesis approach – the synthesis of selected compounds and their detailed spectral analysis – has led to the identification of a series of new natural products, the esters of furan-3-ylmethanol: furan-3-ylmethyl 2-methylpropanoate, furan-3-ylmethyl butanoate, furan-3-ylmethyl 2-methylbutanoate, furan-3-ylmethyl 3-methylbutanoate, furan-3-ylmethyl pentanoate, furan-3-ylmethyl 4-methylpentanoate, and furan-3-ylmethyl hexanoate.     

Free Marine Natural Products Databases for Biotechnology and Bioengineering

Marine organisms and micro‐organisms are a source of natural compounds with unique chemical features. These chemical properties are useful for the discovery of new functions and applications of marine natural products (MNPs). To extensively exploit the potential implementations of MNPs, they are gathered in chemical databases that allow their study and screening for applications of biotechnological interest. However, the classification of MNPs is currently poor in generic chemical databases. The present availability of free‐access‐focused MNP databases is scarce and the molecular diversity of these databases is still very low when compared to the paid‐access ones. In this review paper, the current scenario of free‐access MNP databases is presented as well as the hindrances involved in their development, mainly compound dereplication. Examples and opportunities for using freely accessible MNP databases in several important areas of biotechnology are also assessed. The scope of this paper is, as well, to notify the latent potential of these information sources for the discovery and development of new MNPs in biotechnology, and push future efforts to develop a public domain MNP database freely available for the scientific community.     

塞克肽类(Sactipeptide)天然产物的研究进展

塞克肽是一类重要的核糖体肽天然产物,具有多种生物活性,它们的共同特征是存在由半胱氨酸巯基与受体氨基的α-碳原子连接的分子内硫醚键.本篇综述总结了近年来塞克肽的发现、活性、生物合成、作用机制等多方面的工作,详细讨论了由SAM自由基酶介导的硫醚键形成机制.     

天然多羟基化合物在酶催化下的选择性酯化

综述了近十几年来几种天然多羟基化合物包括皂草苷类、黄酮苷类、生物碱类、甾醇类、倍半萜(烯)化合物、熊果苷和槐糖脂在脂肪酶和枯草杆菌蛋白酶催化下的选择性酯化。     

天然产物的C-糖基化研究进展

自然界中的天然产物在其结构上存在各种修饰,C-糖基化为其中一种比较稀少的修饰方式.C-C糖苷键的形成由C-糖基转移酶负责催化.含C-糖基的化合物多数来自微生物,但高等植物也会有少量积累.综述了近些年来在天然产物C-糖基化方面的研究工作,并对其在药物开发方面的潜力进行了展望.     

国际香辛料产品加工标准化现状(二)

阐述了国际标准化组织（ISO）、欧盟、印度、法国和德国香辛料产品加工标准化现状、发展趋势及其特点。