共查询到20条相似文献,搜索用时 15 毫秒
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N Howard-Jones 《BMJ (Clinical research ed.)》1984,288(6414):379-381
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W H Frackelton 《Plastic and reconstructive surgery》1977,60(3):496-498
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Münch R 《Microbes and infection / Institut Pasteur》2003,5(1):69-74
This article traces the origins of bacteriological research, with particular attention to the role of Robert Koch, and his postulates, on infectious agents. By chronologically following Koch's work on anthrax, germ photography and tuberculosis, it shows how the visual representation of germs transformed laboratory research in medical science. 相似文献
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Koch is dead 总被引:1,自引:0,他引:1
R P Hanson 《Journal of wildlife diseases》1988,24(2):193-200
Although the foundation of Koch's postulates, that "if an agent is the cause of disease in one individual it should be capable of causing disease in a second individual," is basically sound, the ritual that has evolved into present day experimental studies has obscured almost completely what occurs in natural processes outside the laboratory. Through a series of examples, it is emphasized that just bringing the host and the parasite together is not enough, but that the circumstances under which this is done is equally important. These circumstances include: the prior history of the host; the host's behavioral patterns, environmental conditioning, and disease history; the circumstances of exposure; and the environmental factors related to the host and the parasite. Of equal importance is the individual variation (genetic, physiologic, immunologic, etc.) of the host and the individual variation (strains, immunogenicity, pathogenicity, virulence, etc.) of the parasite. Because the rigor of the present day "scientific method" demands clearcut and reproducible results and investigations require predictable performance of the parasite in an evenly maintained host that is in a highly constrained environment, we should not wonder why we cannot produce the events of nature. If we are going to understand diseases of wildlife, we must consider the genetic heterogenicity of the host and parasite population, and recognize the complexity of the environment in which both exist. Koch's postulates, in the narrow sense, will help us to identify parasitisms but will not provide us with an understanding of information about diseases in wildlife; the real significance of these parasitisms to the health of the individual and to the size of the population.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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Noboru Sugiyama Hideo Shimahara Tetsuo Andoh Motoko Takemoto 《Bioscience, biotechnology, and biochemistry》2013,77(1):9-17
A crude enzyme preparation hydrolyzing konjac mannan was extracted from germinating konjac tubers, and purified by chromatography with DEAE-cellulose and alkali-swollen cellulose, and by gel-filtration on Sephadex G-100. The purified enzyme preparation showed optimal activity at pH 4.7, optimum temperature at 40°C. It was considerably stable at pH’s between 4.0 and 8.0, but inactivated rapidly by temperaters above 50°C. Hydrolysis of the mannan by this enzyme proceeded by typical random mechanism, and the rate was in agreement with an empirical equation, p=0.43 E0.77 to0.5. As the Km and Vmax values for mannan, 7.14×10-2(%)and 23.8×10-3 (ΔOD500nm) were obtained, respectively. 相似文献
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A. C. Ronse Z. A. Popper J. C. Preston M. F. Watson 《Plant Systematics and Evolution》2010,287(1-2):1-17
European representatives of Apium sensu lato (Apiaceae), and Apium prostratum and Naufraga balearica, were studied with morphological, fruit anatomical, and palynological methods. Morphometric data were compared with phylogenetic results from previous molecular studies. This confirms that most of the European Apium species belong to a separate group corresponding to the previously named genus Helosciadium. All these species had previously been formally named as Helosciadium species, except for the new combination Helosciadium bermejoi, which is formally described here. Molecular studies place Apium prostratum and Naufraga balearica close to Apium graveolens, the type species of Apium. Our morphometric results show similarities of Naufraga with H. bermejoi, but fruit anatomy distinguishes it both from Helosciadium and from A. graveolens/prostratum. The placement of Cyclospermum leptophyllum in a separate genus is confirmed. Diagnostic keys to the genera and Helosciadium species, and an annotated checklist are given. 相似文献
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鹅观草属的地理分布 总被引:16,自引:2,他引:16
鹅观草属是禾本科小麦族中的最大的属,现知全世界有4组,20系,126种,分布于北半球的温带和寒带,中国有4组,18系,79种,主要分布于西北,西南,华北和东北,是鹅观草属植物种类最为集中的区域,尤其高原东北部的唐古特地区又是我国鹅观草属分布相对密集之地,有3组,12系,30种,而且其间不同等级,不同演化水平的类群均有分布,该地可能就是该属的现代分布中心,同时,唐古特地区多汇聚有鹅观草属不同等级的原始类群和与原始类群有很缘的短柄草属植物,其中最原始的大柄鹅观草特产于该区,而该区缺乏的是高级的大颖组类群,故推测唐古特地区可能又是该属的起源地,起源时间大约在青藏高原明显增高,气候转凉的晚第三纪初的中新世,鹅观草属起源后,在中国境内地质活动比较剧烈的地区得到了进一步的发展和分化,但只有少数适应性较强的类群大概以3条路径扩展到国外,并向东到在北美的巴芬岛,向西延伸到大西洋滨岸,向北进入寒冻的北极地区。 相似文献
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