Dermatoglyphic analysis in bipolar affective disorder and schizophrenia--"continuum of psychosis" hypothesis corroborated?

Dermatoglyphic features are thought to be indicators of events in the early embryonal stages. They might also be associated with the developmental disorders of the central nervous system (CNS) including schizophrenia. Dermatoglyphic features of 92 male patients with bipolar affective disorder (BPAD) (unipolar depression and schizoaffective psychosis were excluded from the study) were compared with those of 195 males with schizophrenia (SCH) and both with those of 200 male controls (control group-CG). DSM-III-R criteria were used for the diagnostic evaluation. Quantitative analysis showed only one statistically significant difference between BPAD and SCH patients groups, regarding the c-d ridge count of the left hand. The canonical discriminant analysis did not permit correct classification (only 59.23% of cases were correctly classified) between BPAD and SCH. Numerous quantitative dermatoglyphic features of both BPAD and SCH differed significantly from those of the control subjects. Finger ridge counts as well as palmar ridge counts were markedly lower in BPAD and SCH as compared to the controls. These findings are not in contradiction with the hypothesis claiming that psychoses are a set of diverse expressions (due also to noninherited factors) of a single underlying entity.     

Quantitative dermatoglyphic asymmetry: a comparative study between schizophrenic patients and control groups of West Bengal, India

Quantitative Fluctuating (FA) and Directional asymmetry (DA) of dermatoglyphics on digito-palmar complex were analyzed in a group of 111 patients (males: 61, females: 50) with schizophrenia (SZ), and compared to an ethnically matched phenotypically healthy control (males: 60, females: 60) through MANOVA, ANOVA and canonical Discriminant analyses. With few exceptions, asymmetries are higher among patients, and this is more prominent in FA than DA. Statistically significant differences were observed between patient and control groups, especially in males. In both sexes, FA of combined dermatoglyphic traits (e.g. total finger ridge count, total palmar pattern ridge count) are found to be a strong discriminator between the two groups with a correct classification of over 83% probability.     

Comparative analysis of dermatoglyphic traits in Hungarian and Gypsy populations

We examined dermatoglyphic prints of children in 11 Hungarian and 5 Gypsy population samples (collected from 1,998 children). We compared Hungarian and Gypsy populations based on 22 finger and 24 palmar traits. In univariate comparisons the two ethnic groups differed significantly in half of the studied variables (9 finger and 14 palmar traits). We used several types of multivariate analyses of the studied traits to separate the population samples. Homogeneity analysis and discriminant analysis proved to be the most appropriate method to distinguish the populations, whereas a principal components analysis was less adequate. Multivariate analyses were conducted separately for both finger and palmar traits. Although the differences between the populations were more pronounced for palmar traits, in our study Hungarian and Gypsy populations showed the best separation when finger and palmar traits were combined for analysis, except in the principal components analysis. As expected, the Hungarian and Gypsy populations separated definitely in most statistical analyses; the main reason for this is the different origins of the two ethnic groups. The existence of the difference also shows that admixture between Hungarians and Gypsies has been small despite their living beside one another for several centuries.     

The dermatoglyphics of American Negroes

Digital and palmar dermatoglyphics of 184 male and 224 female normal American Negroes were evaluated for digital patterns, digital ridge counts, palmar patterns, palmar main line terminations, accessory triradii and palmar creases. All subjects were seven year olds examined and found free of chronic or other genetic diseases. The results were presented for the left and right hand for the most part comparable to those of the African and other American Negro groups reported earlier. The distributions of the various dermatoglyphic features among the Negroes taken as a group were compared to those of the other racial groups and their differences were discussed.     

Evaluation of hand asymmetry in relation to hand preference

We evaluated the asymmetric hand measurements in right- and left-handed individuals. 343 men and 290 women aged 18-42 years (22.11 +/- 2.07) participated in the study. There were no statistically significant differences when right-left differences in hand length, third finger length, palmar length, and the digit index value were evaluated according to hand preference and sex. Statistically significant differences were found for right-left differences in hand width, hand-shape index, and the palmar length/width according to hand preference. The strong left-handers, weak left-handers, and ambidextrous individuals in the study group all exhibited asymmetry favoring the left and were considered together. Similarly, the strong and weak right-handers exhibited asymmetry favoring the right hand and were considered together. The difference between these two groups was significant. When the data were evaluated according to sex, significant differences were found between the subgroups. In particular, right-left differences in the hand-shape index and palmar length/width values of the strong left-handers, weak left-handers, and ambidextrous individuals were found to be statistically significant according to sex; in contrast, the strong and weak right-handers showed no significant differences according to sex. These results suggest a relation of hand asymmetry to hand preference in a Turkish population.     

Sexual dimorphism in the Chuvashian population of Russia in two types of dermatoglyphic traits: principal component analysis

With the aim of determining sexual dimorphism in the component structures among the Chuvashian population of Russia, finger and palmar dermatoglyphics of 547 individuals (293 males, 254 females) were analyzed. The sex differences in two categories of dermatoglyphic traits (22 quantitative traits and 38 asymmetry and diversity traits) are reflected differently and contradictory with other ethnic groups. However, a common feature of the factor 1 "digital pattern size factor" (finger ridge counts from the first category of traits) indicate its degree of universality when compared with other populations, which suggests that the variability of finger ridge counts is determined by the same genes that control the pattern types. The factors "intra-individual finger diversity factor", and "bi-lateral asymmetry factor" extracted from the second category of dermatoglyphic traits are also similar in both sexes. However, these components are hardly described in the literature. The nature of variation of these components (from two categories of dermatoglyphic traits) appears with a good similarity between sexes, which suggests their common biological validity of the underlying component structures of the finger and palmar dermatoglyphic characters.     

Neuropathological similarities and differences between schizophrenia and bipolar disorder: a flow cytometric postmortem brain study

Recent studies suggest that schizophrenia (SCH) and bipolar disorder (BPD) may share a similar etiopathology. However, their precise neuropathological natures have rarely been characterized in a comprehensive and quantitative fashion. We have recently developed a rapid, quantitative cell-counting method for frozen unfixed postmortem brains using a flow cytometer. In the present study, we not only counted stained nuclei, but also measured their sizes in the gray matter of frontopolar cortices (FPCs) and inferior temporal cortices (ITCs) from patients with SCH or BPD, as well as in that from normal controls. In terms of NeuN(+) neuronal nuclei size, particularly in the reduced densities of small NeuN(+) nuclei, we found abnormal distributions present in the ITC gray matter of both patient groups. These same abnormalities were also found in the FPCs of SCH patients, whereas in the FPCs of BPD patients, a reduction in oligodendrocyte lineage (olig2(+)) cells was much more common. Surprisingly, in the SCH FPC, normal left-greater-than-right asymmetry in neural nuclei densities was almost completely reversed. In the BPD FPC, this asymmetry, though not obvious, differed significantly from that in the SCH FPC. These findings indicate that while similar neuropathological abnormalities are shared by patients with SCH or BPD, differences also exist, mainly in the FPC, which may at least partially explain the differences observed in many aspects in these disorders.     

Associations between dermatoglyphic variation, topography, and climate in Kenya

Correlations between a number of dermatoglyphic finger and palmar taxonomic traits relating to 57 male and 53 female Kenyan populations, and altitude and mean annual rainfall are significant, not only in terms of the full range of samples, but also when samples are divided into independent smaller groups. These results are discussed and contrasted with those of other studies which have found no relationships between dermatoglyphic variation and climate in sub-Saharan Africa.     

Grip pattern and finger coordination differences between pianists and non-pianists

The aim of this study was to assess differences of grip pattern and finger coordination in pianists and non-pianists, using hand tasks that were unrelated to pianistic practice. Eleven pianists with more than 10 years of intensive practice were compared to 14 non-pianists. Both groups performed four tasks with their right hand: (1) gross grip at fast velocity; (2) gross grip at slow velocity; (3) hook grip at fast velocity; and (4) hook grip at slow velocity. The three-dimensional coordinates were reconstructed using a kinematic analysis system, and the flexion and extension angles of the metacarpophalangeal joints were calculated. The phase diagrams were qualitatively and quantitatively appraised in order to identify differences between the groups. Principal component analysis was used to assess differences between pianists and non-pianists in terms of the reproducibility and regularity of palmar grip cycles. Coefficients of correlation between the joint angles were used to analyze finger coordination during the tasks. The pianists showed better reproducibility and regularity in the palmar grip pattern, as well as finger movements that were more coordinated when performing different hand tasks.     

Dermatoglyphic variation and weight and length at birth

Relationships between dermatoglyphic variables, including finger ridge counts and finger, palmar, and plantar pattern intensities, and weight and length at birth, were tested in a sample of 184 boys and 202 girls from Warsaw schools. No convincing evidence for such relationships has been obtained from the results of correlations and one-way analysis of variance, although there are indications that some palmar traits may be related to length at birth in females. The data agree with the common belief that birth weight and birth length are mainly determined by influences operating in later stages of pregnancy, that is, after the 20th gestational week.     

Qualitative dermatoglyphic traits as measures of population distance

Thirteen Iranian populations of diverse origin have been analyzed for qualitative dermatoglyphic features utilizing bilateral finger and palmar prints of 3,158 individuals. Bimanual differences were significant for some of the features examined, whereas sex differences were frequently nonsignificant. Interpopulational variation displayed significant heterogeneity for all of the features studied. Distance analysis and constructed dendrograms provided separation between populations in agreement with known ethnohistoric records for hypothenar triradii, and for palmar and finger patterns, but not for the terminations of the D-Line.     

Normal values for total hand length, palm length and middle finger length in Malaysian newborns from 34-42 weeks of gestation.

Early identification of a syndrome at birth is of paramount importance for genetic counselling and possible prevention. Often malformation of the hands and fingers are cardinal manifestations of recognizable syndromes. As there are no published standards for hand and finger size for Malay newborn infants, this study was undertaken to establish normal values for hand, middle finger and palmar lengths, and their indices. A cross-sectional study was done on 509 consecutive newborn Malay babies between 34 and 42 weeks of gestation. Measurements were made on the right hand according to the recommended guidelines of Bergsma & Feingold (1975). The mean values for the measurements did not differ significantly between boys and girls, or change with gestation. For the whole group the mean value for total hand length was 64.4 +/- 3.42 mm, middle finger length 37.1 +/- 2.91 mm, palmar length 27.4 +/- 2.15 mm, finger index 0.425 +/- 0.03 and palmar index 0.58 +/- 0.03. A comparison with published measurements for newborns of different racial origin shows significant differences for the total hand length, middle finger length and palm length from Indian and Jewish infants, but not from Japanese infants. The indices were similar in Malay, Indian, Jewish and Japanese newborn infants.     

Correlation of urinary inflammatory and oxidative stress markers in very low birth weight infants with subsequent development of bronchopulmonary dysplasia

Currently, bronchopulmonary dysplasia (BPD) occurs almost exclusively in pre-term infants. In addition to prematurity, other factors like oxygen toxicity and inflammation can contribute to the pathogenesis. This study aimed to compare urinary inflammatory and oxidative stress markers between the no/mild BPD group and moderate/severe BPD group and between BPD cases with significant early lung disease like respiratory distress syndrome (RDS) ('classic' BPD) and with minimal early lung disease ('atypical' BPD). A total of 60 patients who were a gestational age < 30 weeks or a birth weight < 1250 g were included. Urine samples were obtained on the 1(st), 3(rd) and 7(th) day of life and measured the levels of leukotriene E(4) (LTE(4)) and 8-hydroxydeoxyguanosine (8-OHdG). The 8-OHdG values on the 3(rd) day showed significant correlation to duration of mechanical ventilation. The 8-OHdG levels on the 7(th) day were the independent risk factor for developing moderate/severe BPD. In 'classic' BPD, the 8-OHdG values on the 3(rd) day were higher than those of 'atypical' BPD. In 'atypical' BPD, the LTE(4) values on the 7(th) day were higher than the values in 'classic' BPD. These results suggest that oxidative DNA damage could be the crucial mechanism in the pathogenesis of current BPD and the ongoing inflammatory process could be an important mechanism in 'atypical' BPD.     

Diversity of topological palmar patterns in Iranian populations

The bilateral palmar prints of 3,158 females and males from 13 Iranian populations of diverse origins were analyzed to see how well topological palmar pattern frequencies reflect population distances. The results showed bimanual variation among most of the populations studied. Sex variation showed significant differences among all of the populations studied. Distance analysis and constructed dendrograms showed separation between the populations studied. These distances were frequently in agreement with the known ethnohistoric background of the populations studied. The male data gave better results. It appears that topological palmar patterns are a better indicator of population distance than topological finger patterns.     

Quantitative palmar dermatoglyphics and the assessment of population affinities: data from marine fishermen of Puri, India

Variation in quantitative dermatoglyphics among three endogamous groups of marine fishermen of Puri Coast, India, is greater for the palmar variables than for the fingers. This is the case in both the sexes. The pattern of population affinities, however, differs for the males and females. In order to evaluate the importance of palmar variables in population studies, the results in males are compared with those of finger variables and anthropometrics. There is no significant heterogeneity between the groups for finger variables. Although significant intergroup variability is observed in the palmar and anthropometric traits, the two sets of results are not in the same direction. Palmar dermatoglyphic relationships reflect the caste affiliations, while the anthropometric are in line with geographic proximity.     

A reverse ulnar hypothenar flap for finger reconstruction

A reverse-flow island flap from the hypothenar eminence of the hand was applied in 11 patients to treat palmar skin defects, amputation injuries, or flexion contractures of the little finger. There were three female and eight male patients, and their ages at the time of surgery averaged 46 years. A 3 x 1.5 to 5 X 2 cm fasciocutaneous flap from the ulnar aspect of the hypothenar eminence, which was located over the abductor digiti minimi muscle, was designed and transferred in a retrograde fashion to cover the skin and soft-tissue defects of the little finger. The flap was based on the ulnar palmar digital artery of the little finger and in three patients was sensated by the dorsal branch of the ulnar nerve or by branches of the ulnar palmar digital nerve of the little finger. Follow-up periods averaged 42 months. The postoperative course was uneventful for all patients, and all of the flaps survived without complications. The donor site was closed primarily in all cases, and no patient complained of significant donor-site problems. Satisfactory sensory reinnervation was achieved in patients who underwent sensory flap transfer, as indicated by 5 mm of moving two-point discrimination. A reverse island flap from the hypothenar eminence is easily elevated, contains durable fasciocutaneous structures, and has a good color and texture match to the finger pulp. This flap is a good alternative for reconstruction of palmar skin and soft-tissue defects of the little finger.     

Lateralization of hand skill in bipolar affective disorder

Diverse strands of evidence suggest that schizophrenia is associated with an excess of left and mixed handedness, reflecting anomalous cerebral lateralization. Genetic studies have indicated a degree of overlap between bipolar disorder (BPD) and schizophrenia. Nevertheless, pattern of handedness and degree of lateralization have not been explicitly tested in BPD. We measured handedness, footedness and relative manual dexterity in a sample of 47 families comprising BPD probands and their bipolar-spectrum and unaffected relatives (N = 240). The BPD I sample (N = 55) was significantly more lateralized on handedness, footedness and relative manual dexterity than their unaffected relatives (N = 66). They were also more lateralized than their relatives with other psychiatric diagnoses. No evidence of excess mixed handedness or footedness was observed in the BPD I sample. We raise the possibility that schizophrenia and BPD I differ in that disproportionate left-hemisphere dominance in BPD I is associated with right-hemisphere dysfunction leading to deficits in emotional regulation. Given our results, we hypothesized that degree of lateralization may be a phenotypic marker or endophenotype for BPD I. We therefore conducted a family-based genetic association analysis with this quantitative trait. Relative hand skill was significantly associated with a functional variant in the catechol-O-methyltransferase gene. We speculate that this polymorphism may influence brain lateralization.     

Study of arterial patterns of the hand in primates. Deep palmar arterial arches and their correlating arteries in Macaca fuscata

Study of the arterial patterns of the hand in Macaca fuscata, especially those of the deep palmar arterial arches and their correlating arteries, by three-dimensional arteriographic analysis revealed the following: (1) The deep palmar arterial arches are formed by the perforating branches of the 2nd dorsal metacarpal artery, and they are usually composed of two proximal arches (catella volaris proximalis and arcus volaris profundus) and one distal arch (catella volaris distalis). (2) In the 3rd and 4th metacarpal interosseous spaces, the intermetacarpal arteries arise from the catella volaris proximalis, and the arcus volaris profundus has palmar metacarpal arteries which descend along the palmar side of each metacarpal bone. (3) There is a definite regularity in the formation of the intermetacarpal arteries between the catella volaris proximalis and the catella volaris distalis and of the palmar metacarpal arteries between the arcus volaris profundus and the catella volaris distalis.     

Quantitative digital and palmar dermatoglyphics: Sexual dimorphism in the Chuvashian population of Russia

With the aim of determining sex dimorphism among the Chuvashian population of Russia, digital and palmar dermatoglyphics of 547 individuals (293 males, 254 females) were analyzed. The sex differences for PII, TRC, and AFRC are similar to Indian and Jewish populations. Correlation coefficients between individual finger ridge counts are a little lower than in Jews but are almost equal to Indian populations. The Mantel test of matrix correlation between sexes for 22 traits shows a very good similarity. However, sex differences of palmar traits display different levels when compared with other human populations. In light of this, our evidence indicates the possible role of environmental (prenatal) factors in the realization of dermatoglyphic sex differences. The development of palmar dermatoglyphics has had a relatively longer growth period compared with fingers [Cummins, H., 1929. The topographic history of the volar pads (walking pads, tast ballen) in the human embryo. Embryol. 20, 103-126]. The palmar dermatoglyphic pattern of affinities therefore corresponds better than fingers to the ethno historical background of the populations, ascertained by numerous studies.     

Qualitative dermatoglyphic traits in ovarian cancer patients: a case-control study

The authors investigated the correlation between the occurrence of certain qualitative dermatoglyphic traits and the susceptibility to ovarian cancer, using the case-control design. A sample of 168 diseased cases, treated at the University Department of Gynecologic Oncology in Zagreb, Croatia between 1996-1997 was compared to 200 healthy females, investigated at the Institute for Anthropological Research in Zagreb. The results showed significant differences between ovarian cancer cases and healthy controls regarding the frequency of arches on the fingers of both hands (10-11% vs. 4-5%, respectively, p < 0.05), and of characteristic patterns on the palms of right hand (33% vs. 54% in 3rd interdigital space (IS), p < 0.001; 39% vs. 47% in 4th IS, p < 0.05) and of the left hand (42% vs. 58% in 4th IS, p < 0.001; 24% vs. 34% in hypothenar, p < 0.01). Although probably neither very sensitive nor specific, these findings could still be used in addition to other diagnostic procedures, as a rough screening method in early detecting of ovarian cancer.