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1.
Abstract

The goal of identifying hazardous chemicals registered under the Registration, Evaluation, Authorization and restriction of CHemicals (REACH) Regulation and taking appropriate risk management measures relies on robust data registrations. However, the current procedures for European chemical manufacturers and importers to evaluate data under REACH neither support systematic evaluations of data nor transparently communicate these assessments. The aim of this study was to explore how using a data evaluation method with predefined criteria for reliability and establishing principles for assigning reliability categories could contribute to more structured and transparent evaluations under REACH. In total, 20 peer-reviewed studies for 15 substances registered under REACH were selected for an in-depth evaluation of reliability with the SciRAP tool. The results show that using a method for study evaluation, with clear criteria for assessing reliability and assigning studies to reliability categories, contributes to more structured and transparent reliability evaluations. Consequently, it is recommended to implement a method for evaluating data under REACH with predefined criteria and fields for documenting and justifying the assessments to increase consistency of data evaluations and transparency.  相似文献   

2.
The National Pollutant Release Inventory (NPRI) provides pollutant release and transfer data from point sources to various media in the Canadian environment. While the inventory serves as Canada's community right-to-know program, the growing number of listed substances and reporting facilities makes it exceedingly difficult for the public to discern which substances are of greatest concern in their respective communities. A chemical's impact is best characterized when its environmental release data are combined with its toxicity and environmental fate properties. Presently, the NPRI does not provide a synthesis of this critical information and there is a need to provide more context with NPRI data to increase its usability. To help deliver this context, a relative risk ranking was compiled for a subset of NPRI substances using a modified Chemical Hazard and Evaluation Management Strategies (CHEMS-1) model. The model combines toxicity, chemical fate properties, and NPRI release data to yield a risk score for each substance. The resulting risk scores are ranked accordingly to provide a priority ranking of the substances. In addition to contextualizing the NPRI release data with hazard information, the ranking can also help set priorities for future risk assessment and evaluation by the Canadian government and scientific community. Limitations included the reliance on modelled data and default values to fill data gaps and uncertain reliability in reported NPRI data. In spite of its limitations, the CHEMS-1 model is a useful tool for prioritizing NPRI substances.  相似文献   

3.
In recent years veterinary medicinal products (VMPs) have been recognized as emerging contaminants, giving rise to concerns regarding their environmental impact. Due to the high number of utilized VMPs, it is necessary to develop tools (indicators) for ranking these compounds according to their environmental risk relevance. These indicators can be useful, for example, for setting up monitoring programmes, and more in general for risk management purposes. In this paper we propose a new scoring system method (RANKVET) that enables ranking the risk of VMPs for aquatic and terrestrial organisms. The procedure is fully based on the information required by the EU Directives and Regulations for marketing authorization of VMPs and Veterinary International Conference on Harmonization (VICH) guidelines. According to the latter, if the environmental risk assessment of a VMP indicates an unacceptable risk to the environment, i.e., the risk quotient (RQ) consisting of the ratio of Predicted Environmental Concentration (PEC) to Predicted No Effect Concentration (PNEC) is ≥1, then mitigation measures should be proposed by the applicant in order to reduce the risk to an acceptable level. If a risk mitigation measure does not fulfil the criteria mentioned above then the outcome of the risk assessment is that a serious risk for the environment exists. In accordance with Directive 2001/82/EC (as amended) this risk has to be weighed against the favourable aspects of a marketing authorization. The prioritization scheme is based on a quantitative approach and consist of different phases. First, for each VMP, PECs are calculated using simple exposure models and worst case assumptions. PNECs are calculated for non-target organisms representative of the considered ecosystems (soil or surface water). Then numerical scores are given to the calculated PEC/PNEC ratio. Finally, the obtained score is multiplied with a further score which is based on the relevance of the metabolic rate in animals. RANKVET can be applied for surface water and soil systems and for different farming methods (intensive or pasture) and treated species. As an example of its potential use we applied RANKVET to 48 VMPs largely utilized in Italy.  相似文献   

4.
Environmental risk analysts need to draw from a clear typology of uncertainties when qualifying risk estimates and/or significance statements about risk. However, categorizations of uncertainty within existing typologies are largely overlapping, contradictory, and subjective, and many typologies are not designed with environmental risk assessments (ERAs) in mind. In an attempt to rectify these issues, this research provides a new categorization of uncertainties based, for the first time, on the appraisal of a large subset of ERAs, namely 171 peer-reviewed environmental weight-of-evidence assessments. Using this dataset, a defensible typology consisting of seven types of uncertainty (data, language, system, extrapolation, variability, model, and decision) and 20 related sub-types is developed. Relationships between uncertainties and the techniques used to manage them are also identified and statistically evaluated. A highly preferred uncertainty management option is to take no action when faced with uncertainty, although where techniques are applied they are commensurate with the uncertainty in question. Key observations are applied in the form of guidance for dealing with uncertainty, demonstrated through ERAs of genetically modified higher plants in the European Union. The presented typology and accompanying guidance will have positive implications for the identification, prioritization, and management of uncertainty during risk characterization.  相似文献   

5.
Long-term preservation of habitats has become a cornerstone of modern conservation policies. As resources allocated to conservation actions are often limited, developing relevant prioritizing methods is necessary. Although many studies have been published on species prioritization, habitats have been the subject of less research. This study aims to develop a simple prioritization method suitable for habitats and appropriate to any typology. We analyzed literature to select criteria that would be the most accurate to rank habitats. Our final method consists in calculating a score based on four criteria: legal obligation, territorial responsibility, conservation condition and an extra criterion designed to fit local interests and objectives. The method is applied on habitats listed in Annex I of the Habitats Directive (92/43/EEC) on the territory of RESEDA-Flore, a network of stakeholders involved in the conservation of Mediterranean flora. Results highlight that dune habitats show the highest conservation values, while rocky habitats and caves obtain relatively low scores. At the top of the ranking, Mediterranean temporary ponds (3170), Dunes with Pinus pinea and/or Pinus pinaster forests (2270) and Coastal dunes with Juniperus spp. (2250) appear to be a high priority. These results can be used to design and implement habitat conservation strategies in the French Mediterranean.  相似文献   

6.
Species face many threats, including accelerated climate change, sea level rise, and conversion and degradation of habitat from human land uses. Vulnerability assessments and prioritization protocols have been proposed to assess these threats, often in combination with information such as species rarity; ecological, evolutionary or economic value; and likelihood of success. Nevertheless, few vulnerability assessments or prioritization protocols simultaneously account for multiple threats or conservation values. We applied a novel vulnerability assessment tool, the Standardized Index of Vulnerability and Value, to assess the conservation priority of 300 species of plants and animals in Florida given projections of climate change, human land-use patterns, and sea level rise by the year 2100. We account for multiple sources of uncertainty and prioritize species under five different systems of value, ranging from a primary emphasis on vulnerability to threats to an emphasis on metrics of conservation value such as phylogenetic distinctiveness. Our results reveal remarkable consistency in the prioritization of species across different conservation value systems. Species of high priority include the Miami blue butterfly (Cyclargus thomasi bethunebakeri), Key tree cactus (Pilosocereus robinii), Florida duskywing butterfly (Ephyriades brunnea floridensis), and Key deer (Odocoileus virginianus clavium). We also identify sources of uncertainty and the types of life history information consistently missing across taxonomic groups. This study characterizes the vulnerabilities to major threats of a broad swath of Florida’s biodiversity and provides a system for prioritizing conservation efforts that is quantitative, flexible, and free from hidden value judgments.  相似文献   

7.
Species prioritization for conservation is primarily based on extinction risk assessments but less on sociocultural factors that influence conservation effectiveness. Here, we prioritized mammals for conservation according to their need for conservation attention, the feasibility of their conservation, and their potential to be used as flagship species in a rural community in northeast Brazil. We assessed species occurrence and ethnobiology through interviews, camera trapping, and active searches, and developed a prioritization scheme that accounts for species’ threat level (conservation status and local hunting pressure), cultural importance, and popularity. We found Tolypeutes tricinctus as the overall top-priority species because of its Endangered status and high popularity, which makes its conservation needed and feasible, and this species a potential conservation flagship. Panthera onca was the highest priority regarding the need for conservation attention due to its Critically Endangered status but the least feasible to conserve as it was the most unpopular species. Mazama gouazoubira was the most hunted and popular species. Despite not being threatened, it may also be prioritized for conservation, given its high hunting pressure and popularity, thereby constituting a possible local flagship species. Our results show that priority species for conservation can be reliably identified based on measures of need for conservation attention and expected conservation feasibility in local scales using rapid assessments. Accounting for ethnobiology in species prioritization for conservation allows a better understanding of the needs, opportunities, and obstacles for their conservation, consequently leading to better resource-allocation decisions in different socio-economic scenarios.  相似文献   

8.
Disease gene prioritization aims to suggest potential implications of genes in disease susceptibility. Often accomplished in a guilt-by-association scheme, promising candidates are sorted according to their relatedness to known disease genes. Network-based methods have been successfully exploiting this concept by capturing the interaction of genes or proteins into a score. Nonetheless, most current approaches yield at least some of the following limitations: (1) networks comprise only curated physical interactions leading to poor genome coverage and density, and bias toward a particular source; (2) scores focus on adjacencies (direct links) or the most direct paths (shortest paths) within a constrained neighborhood around the disease genes, ignoring potentially informative indirect paths; (3) global clustering is widely applied to partition the network in an unsupervised manner, attributing little importance to prior knowledge; (4) confidence weights and their contribution to edge differentiation and ranking reliability are often disregarded. We hypothesize that network-based prioritization related to local clustering on graphs and considering full topology of weighted gene association networks integrating heterogeneous sources should overcome the above challenges. We term such a strategy Interactogeneous. We conducted cross-validation tests to assess the impact of network sources, alternative path inclusion and confidence weights on the prioritization of putative genes for 29 diseases. Heat diffusion ranking proved the best prioritization method overall, increasing the gap to neighborhood and shortest paths scores mostly on single source networks. Heterogeneous associations consistently delivered superior performance over single source data across the majority of methods. Results on the contribution of confidence weights were inconclusive. Finally, the best Interactogeneous strategy, heat diffusion ranking and associations from the STRING database, was used to prioritize genes for Parkinson’s disease. This method effectively recovered known genes and uncovered interesting candidates which could be linked to pathogenic mechanisms of the disease.  相似文献   

9.
1. A number of parallel initiatives in South Africa have been addressing the prioritization and management of invasive alien plant species, the prioritization of rivers for the conservation of biodiversity, and broad‐scale planning for water resource management. This paper has combined aspects of these approaches to develop a composite index of prioritization of quaternary catchments for alien plant control purposes. 2. We calculated, for each quaternary catchment, a simple composite index that combined estimates of (i) the number of invasive alien plant species present; (ii) the potential number of invasive alien plant species that would be present if they occupied the full range as determined by climatic envelope models; (iii) the degree of habitat loss in rivers; and (iv) the degree of water stress. Each of the four components contributed between one and four to the combined index, which had a range of values between four and 16. 3. We used a geographic information system to map the distribution of priority catchments for invasive alien plant control. Of the 1911 quaternary catchments in South Africa and Lesotho, just over one‐third (650) were in the highest priority category with an index of 13 or more. A relatively small proportion (273, or 14%) of the catchments had the maximum scores of 15 or 16. 4. The approach identified priority areas that have not currently been identified as such, and should provide decision makers with an objective and transparent method with which to prioritize areas for the control of invasive alien plants. We anticipate debate about the way in which components of the index are calculated, and the weight given to the different components, and that this will lead to the transparent evolution of the index. Improvements would also come about through the addition of a more comprehensive list of species, and through the addition of further components.  相似文献   

10.
Large amounts of veterinary medicines are widely used as therapeutic drugs and feed additives (growth promoters) in China, the environmental presence of which possibly poses challenges to the environment and human health. Therefore, it is important to list the veterinary medicines that are considered to be of relatively high priority in China for environmental management. In this study, a three-stage prioritization scheme was applied to veterinary medicines in China. In Stage I, exposure assessment was conducted based on usage amounts and the possibility of entering the environment. In Stage II, the ecotoxicity and human health effects of compounds having a high potential to enter the environment were assessed. In Stage III, considering both the results of Stages I and II, veterinary medicines were assigned into four priority classifications. Using the approach, 38 compounds were assigned to “H,” 7 compounds to “M,” 2 compounds to “L,” and 22 compounds to “VL.” Among the top-ranked compounds, antibiotics, endoparasiticides, and aquacultural medicines accounted for 57.9%, 28.9%, and 10.5%, respectively. Insecticides used widely in China's aquaculture need to be taken into account due to their high priority rank. This is the first study on the prioritization of veterinary pharmaceuticals in China.  相似文献   

11.
Recent growth in the wind energy industry has increased concerns about its impacts on wildlife populations. Direct impacts of wind energy include bird and bat collisions with turbines whereas indirect impacts include changes in wildlife habitat and behavior. Although many species may withstand these effects, species that are long-lived with low rates of reproduction, have specialized habitat preferences, or are attracted to turbines may be more prone to declines in population abundance. We developed a prioritization system to identify the avian species most likely to experience population declines from wind facilities based on their current conservation status and their expected risk from turbines. We developed 3 metrics of turbine risk that incorporate data on collision fatalities at wind facilities, population size, life history, species’ distributions relative to turbine locations, number of suitable habitat types, and species’ conservation status. We calculated at least 1 measure of turbine risk for 428 avian species that breed in the United States. We then simulated 100,000 random sets of cutoff criteria (i.e., the metric values used to assign species to different priority categories) for each turbine risk metric and for conservation status. For each set of criteria, we assigned each species a priority score and calculated the average priority score across all sets of criteria. Our prioritization system highlights both species that could potentially experience population decline caused by wind energy and species at low risk of population decline. For instance, several birds of prey, such as the long-eared owl, ferruginous hawk, Swainson’s hawk, and golden eagle, were at relatively high risk of population decline across a wide variety of cutoff values, whereas many passerines were at relatively low risk of decline. This prioritization system is a first step that will help researchers, conservationists, managers, and industry target future study and management activity.  相似文献   

12.
This article is the preamble to a set of articles describing initial results from an on-going European Commission funded, 5th Framework project called OMNIITOX, Operational Models aNd Information tools for Industrial applications of eco/TOXicological impact assessments. The different parts of this case study-driven project are briefly presented and put in relation to the aims of contributing to an operational life cycle-impact assessment (LCIA) model for impacts of toxicants. The present situation has been characterised by methodological difficulties, both regarding choice of the characterisation model(s) and limited input data on chemical properties, which often has resulted in the omission of toxicants from the LCIA, or at best focus on well characterised chemicals. The project addresses both problems and integrates models, as well as data, in an information system- the OMNIITOX IS. There is also a need for clarification of the relations between the (environmental) risk assessments of toxicants and LCIA, in addition to investigating the feasibility of introducing LCA into European chemicals legislation, tasks that also were addressed in the project. Keywords: Case studies; characterisation factor; chemicals; environmental risk assessment; hazard assessment; information system; life cycle impact assessment (LCIA); potentially toxic substances; regulation; risk assessment; risk ranking  相似文献   

13.
Selected biological control agents and conventional pesticides were used to critically review the applicability of a newly developed Risk Indicator (RI) system. Five basic components are proposed for the calculation of the overall environmental risk score: persistence of the active ingredient, dispersal potential, range of non-target organisms that are affected, and direct and indirect effects on the ecosystem. Several risk measurement systems were reviewed; risk categories in the proposed system were modified from a model developed for classical biocontrol agents. Additionally, one new category was included, to assess the risks to vertebrate non-target species. Besides a detailed discussion of the new RI model, the suitability of the model was demonstrated by calculating the risk scores for 17 selected products. It became obvious that the environmental risk score varied greatly within the assessed chemical products, and also within the group of biological products. The use pattern greatly influenced the estimated environmental risk posed by any given product. The overall environmental risk score varied between a very low risk score of 24 (Coniothyrium minitans, soil application) and a near maximum risk score of 4275 (high risk reference DDT, foliar spray). The proposed model can be used to communicate environmental risk and to design lower risk integrated pest management strategies. It is suggested that the proposed RI system may serve to define low risk and reduced risk pesticides. Yet, it remains debatable whether the RI will be useful in determining acceptability of data waivers for regulatory purposes.  相似文献   

14.

Background

Zoonoses account for over half of all communicable diseases causing illness in humans. As there are limited resources available for the control and prevention of zoonotic diseases, a framework for their prioritization is necessary to ensure resources are directed into those of highest importance. Although zoonotic outbreaks are a significant burden of disease in North America, the systematic prioritization of zoonoses in this region has not been previously evaluated.

Methodology/Principal Findings

This study describes the novel use of a well-established quantitative method, conjoint analysis (CA), to identify the relative importance of 21 key characteristics of zoonotic diseases that can be used for their prioritization in Canada and the US. Relative importance weights from the CA were used to develop a point-scoring system to derive a recommended list of zoonoses for prioritization in Canada and the US. Over 1,500 participants from the general public were recruited to complete the online survey (761 from Canada and 778 from the US). Hierarchical Bayes models were fitted to the survey data to derive CA-weighted scores. Scores were applied to 62 zoonotic diseases of public health importance in Canada and the US to rank diseases in order of priority.

Conclusions/Significance

This was the first study to describe a systematic and quantitative approach to the prioritization of zoonoses in North America involving public participants. We found individuals with no prior knowledge or experience in prioritizing zoonoses were capable of producing meaningful results using CA as a novel quantitative approach to prioritization. More similarities than differences were observed between countries suggesting general agreement in disease prioritization between Canadians and Americans. We demonstrate CA as a potential tool for the prioritization of zoonoses; other prioritization exercises may also consider this approach.  相似文献   

15.
As large-scale re-sequencing of genomes reveals many protein mutations, especially in human cancer tissues, prediction of their likely functional impact becomes important practical goal. Here, we introduce a new functional impact score (FIS) for amino acid residue changes using evolutionary conservation patterns. The information in these patterns is derived from aligned families and sub-families of sequence homologs within and between species using combinatorial entropy formalism. The score performs well on a large set of human protein mutations in separating disease-associated variants (∼19 200), assumed to be strongly functional, from common polymorphisms (∼35 600), assumed to be weakly functional (area under the receiver operating characteristic curve of ∼0.86). In cancer, using recurrence, multiplicity and annotation for ∼10 000 mutations in the COSMIC database, the method does well in assigning higher scores to more likely functional mutations (‘drivers’). To guide experimental prioritization, we report a list of about 1000 top human cancer genes frequently mutated in one or more cancer types ranked by likely functional impact; and, an additional 1000 candidate cancer genes with rare but likely functional mutations. In addition, we estimate that at least 5% of cancer-relevant mutations involve switch of function, rather than simply loss or gain of function.  相似文献   

16.
To establish strategic priorities for the Public Health Agency of Sweden we prioritized pathogens according to their public health relevance in Sweden in order to guide resource allocation. We then compared the outcome to ongoing surveillance. We used a modified prioritization method developed at the Robert Koch Institute in Germany. In a Delphi process experts scored pathogens according to ten variables. We ranked the pathogens according to the total score and divided them into four priority groups. We then compared the priority groups to self-reported time spent on surveillance by epidemiologists and ongoing programmes for surveillance through mandatory and/or voluntary notifications and for surveillance of typing results. 106 pathogens were scored. The result of the prioritization process was similar to the outcome of the prioritization in Germany. Common pathogens such as calicivirus and Influenza virus as well as blood-borne pathogens such as human immunodeficiency virus, hepatitis B and C virus, gastro-intestinal infections such as Campylobacter and Salmonella and vector-borne pathogens such as Borrelia were all in the highest priority group. 63% of time spent by epidemiologists on surveillance was spent on pathogens in the highest priority group and all pathogens in the highest priority group, except for Borrelia and varicella-zoster virus, were under surveillance through notifications. Ten pathogens in the highest priority group (Borrelia, calicivirus, Campylobacter, Echinococcus multilocularis, hepatitis C virus, HIV, respiratory syncytial virus, SARS- and MERS coronavirus, tick-borne encephalitis virus and varicella-zoster virus) did not have any surveillance of typing results. We will evaluate the possibilities of surveillance for the pathogens in the highest priority group where we currently do not have any ongoing surveillance and evaluate the need of surveillance for the pathogens from the low priority group where there is ongoing surveillance in order to focus our work on the pathogens with the highest relevance.  相似文献   

17.
摘要 目的:探讨快速序贯器官功能衰竭评估(qSOFA)评分、血乳酸(Lac)及红细胞分布宽度(RDW)与急性上消化道出血(AUGIB)病情严重程度的关系及其预测患者预后的效能。方法:选取2017年6月~2022年6月我院收治的230例AUGIB患者为研究对象,根据病情严重程度分为低危组44例、中危组140例、高危组36例、极高危组10例,且根据其入院28 d内生存情况分为死亡组(n=31)和存活组(n=199)。收集AUGIB患者临床资料,检测血Lac、RDW水平并计算qSOFA评分。采用多因素Logistic回归分析AUGIB患者预后不良的影响因素,受试者工作特征(ROC)曲线分析qSOFA评分和血Lac、RDW对AUGIB患者预后不良的预测价值。结果:低危组、中危组、高危组、极高危组qSOFA评分和血Lac、RDW水平依次升高(P<0.05)。230例AUGIB患者入院28 d内死亡率为13.48%(31/230)。多因素Logistic回归分析显示,年龄增加、GBS评分≥6分及休克指数、qSOFA评分、血尿素氮、血Lac、RDW水平升高为AUGIB患者预后不良的独立危险因素(P<0.05)。ROC曲线分析显示,qSOFA评分、血Lac及RDW联合预测AUGIB患者预后不良的曲线下面积大于qSOFA评分、血Lac及RDW单独预测。结论:AUGIB患者qSOFA评分、血Lac及RDW水平升高与病情加重和预后不良密切相关,qSOFA评分、血Lac及RDW联合预测AUGIB患者预后不良的效能较高。  相似文献   

18.
大庆地区油田开发排水工程环境风险评价初探   总被引:2,自引:0,他引:2  
利用定性分析的方法,对大庆地区永乐油田永5转油站地区不同设计排水方案进行环境风险因素识别和危害环境预测,在此基础上,运用模糊综合评价法,建立相应的环境风险模糊指数,确定危害环境系数,最后得出环境风险模糊评价指数,表征各方案风险相对大小,提出针对优选方案环境风险管理的措施。  相似文献   

19.

Background

Antimicrobial resistance (AMR) of infectious agents is a growing concern for public health organizations. Given the complexity of this issue and how widespread the problem has become, resources are often insufficient to address all concerns, thus prioritization of AMR pathogens is essential for the optimal allocation of risk management attention. Since the epidemiology of AMR pathogens differs between countries, country-specific assessments are important for the determination of national priorities.

Objective

To develop a systematic and transparent approach to AMR risk prioritization in Canada.

Methods

Relevant AMR pathogens in Canada were selected through a transparent multi-step consensus process (n=32). Each pathogen was assessed using ten criteria: incidence, mortality, case-fatality, communicability, treatability, clinical impact, public/political attention, ten-year projection of incidence, economic impact, and preventability. For each pathogen, each criterion was assigned a numerical score of 0, 1, or 2, and multiplied by criteria-specific weighting determined through researcher consensus of importance. The scores for each AMR pathogen were summed and ranked by total score, where a higher score indicated greater importance. A sensitivity analysis was conducted to determine the effects of changing the criteria-specific weights.

Results

The AMR pathogen with the highest total weighted score was extended spectrum B-lactamase-producing (ESBL) Enterobacteriaceae (score=77). When grouped by percentile, ESBL Enterobacteriaceae, Clostridium difficile, carbapenem-resistant Enterobacteriaceae, and methicillin-resistant Staphylococcus aureus were in the 80-100th percentile.

Conclusion

This assessment provides useful information for prioritising public health strategies regarding AMR resistance at the national level in Canada. As the AMR environment and challenges change over time and space, this systematic and transparent approach can be adapted for use by other stakeholders domestically and internationally. Given the complexity of influences, resource availability and multiple stakeholders, regular consideration of AMR activities in the public health realm is essential for appropriate and responsible prioritisation of risk management that optimises the health and security of the population.  相似文献   

20.

Background

The wild relatives of crops represent a major source of valuable traits for crop improvement. These resources are threatened by habitat destruction, land use changes, and other factors, requiring their urgent collection and long-term availability for research and breeding from ex situ collections. We propose a method to identify gaps in ex situ collections (i.e. gap analysis) of crop wild relatives as a means to guide efficient and effective collecting activities.

Methodology/Principal Findings

The methodology prioritizes among taxa based on a combination of sampling, geographic, and environmental gaps. We apply the gap analysis methodology to wild taxa of the Phaseolus genepool. Of 85 taxa, 48 (56.5%) are assigned high priority for collecting due to lack of, or under-representation, in genebanks, 17 taxa are given medium priority for collecting, 15 low priority, and 5 species are assessed as adequately represented in ex situ collections. Gap “hotspots”, representing priority target areas for collecting, are concentrated in central Mexico, although the narrow endemic nature of a suite of priority species adds a number of specific additional regions to spatial collecting priorities.

Conclusions/Significance

Results of the gap analysis method mostly align very well with expert opinion of gaps in ex situ collections, with only a few exceptions. A more detailed prioritization of taxa and geographic areas for collection can be achieved by including in the analysis predictive threat factors, such as climate change or habitat destruction, or by adding additional prioritization filters, such as the degree of relatedness to cultivated species (i.e. ease of use in crop breeding). Furthermore, results for multiple crop genepools may be overlaid, which would allow a global analysis of gaps in ex situ collections of the world''s plant genetic resources.  相似文献   

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