共查询到20条相似文献,搜索用时 15 毫秒
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The SGN comparative map viewer 总被引:1,自引:0,他引:1
Mueller LA Mills AA Skwarecki B Buels RM Menda N Tanksley SD 《Bioinformatics (Oxford, England)》2008,24(3):422-423
Motivation: With the rapid accumulation of genetic data fora multitude of different species, the availability of intuitivecomparative genomic tools becomes an important requirement forthe research community. Here we describe a web-based comparativeviewer for mapping data, including genetic, physical and cytologicalmaps, that is part of the SGN website (http://sgn.cornell.edu/)but that can also be installed and adapted for other websites.In addition to viewing and comparing different maps stored inthe SGN database, the viewer allows users to upload their ownmaps and compare them to other maps in the system. The vieweris implemented in object oriented Perl, with a simple extensibleinterface to write data adapters for other relational databaseschemas and flat file formats. Contact: lam87{at}cornell.edu
Associate Editor: Alex Bateman 相似文献
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Carver T Thomson N Bleasby A Berriman M Parkhill J 《Bioinformatics (Oxford, England)》2009,25(1):119-120
Summary: DNAPlotter is an interactive Java application for generatingcircular and linear representations of genomes. Making use ofthe Artemis libraries to provide a user-friendly method of loadingin sequence files (EMBL, GenBank, GFF) as well as data fromrelational databases, it filters features of interest to displayon separate user-definable tracks. It can be used to producepublication quality images for papers or web pages. Availability: DNAPlotter is freely available (under a GPL licence)for download (for MacOSX, UNIX and Windows) at the WellcomeTrust Sanger Institute web sites: http://www.sanger.ac.uk/Software/Artemis/circular/ Contact: artemis{at}sanger.ac.uk
Associate Editor: John Quackenbush 相似文献
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Summary: FAMHAP is an established software for haplotype associationanalysis of nuclear families. We have released a major updatethat comprises various new features for case-control data. Furthermore,weprovide an additional program runFamhap that allows usersto start the same method repeatedly for varying sets of geneticmarkers. In addition, a platform-independent graphical userinterface (GUI) was developed to simplify the usage of bothFAMHAP and runFamhap. The runFamhap program greatly facilitatesthe application of FAMHAP to genome-wide association studies(GWAS) and supports flexible genome-wide haplotype analysis.As an example, we describe application to HapMap data. Availability: The software is available at http://famhap.meb.uni-bonn.de Contact: herold{at}imbie.meb.uni-bonn.de; becker{at}imbie.meb.uni-bonn.de Supplementary information: Supplementary data are availableat Bioinformatics online.
Associate Editor: Alex Bateman 相似文献
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GENOME: a rapid coalescent-based whole genome simulator 总被引:1,自引:0,他引:1
Summary: GENOME proposes a rapid coalescent-based approach tosimulate whole genome data. In addition to features of standardcoalescent simulators, the program allows for recombinationrates to vary along the genome and for flexible population histories.Within small regions, we have evaluated samples simulated byGENOME to verify that GENOME provides the expected LD patternsand frequency spectra. The program can be used to study thesampling properties of any statistic for a whole genome study. Availability: The program and C++ source code are availableonline at http://www.sph.umich.edu/csg/liang/genome/ Contact: lianglim{at}umich.edu Supplementary information: Supplementary data are availableat Bioinformatics online.
Associate Editor: Martin Bishop 相似文献
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Summary: We present In silico Biochemical Reaction Network Analysis(IBRENA), a software package which facilitates multiple functionsincluding cellular reaction network simulation and sensitivityanalysis (both forward and adjoint methods), coupled with principalcomponent analysis, singular-value decomposition and model reduction.The software features a graphical user interface that aids simulationand plotting of in silico results. While the primary focus isto aid formulation, testing and reduction of theoretical biochemicalreaction networks, the program can also be used for analysisof high-throughput genomic and proteomic data. Availability: The software package, manual and examples areavailable at http://www.eng.buffalo.edu/~neel/ibrena Contact: neel{at}eng.buffalo.edu
Associate Editor: Limsoon Wong 相似文献
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Summary: Taverna is an application that eases the integrationof tools and databases for life science research by the constructionof workflows. The Taverna Interaction Service extends the functionalityof Taverna by defining human interaction within a workflow andacting as a mediation layer between the automated workflow engineand one or more users. Availability: Taverna, the Interaction Service plug-in and webapplication are available as open source and can be downloadedfrom http://taverna.sourceforge.net/ Contact: taverna-users{at}lists.sourceforge.net
Associate Editor: John Quackenbush 相似文献
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Summary: BLISS 2.0 is a web-based application for identifyingconserved regulatory modules in distantly related orthologoussequences. Unlike existing approaches, it performs the cross-genomecomparison at the binding site level. Experimental results onsimulated and real world data indicate that BLISS 2.0 can identifyconserved regulatory modules from sequences with little overallsimilarity at the DNA sequence level. Availability: http://www.blisstool.org/ Contact: leizhou{at}ufl.edu
Associate Editor: Olga Troyanskaya 相似文献
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Summary: BicOverlapper is a tool to visualize biclusters fromgene-expression matrices in a way that helps to compare biclusteringmethods, to unravel trends and to highlight relevant genes andconditions. A visual approach can complement biological andstatistical analysis and reduce the time spent by specialistsinterpreting the results of biclustering algorithms. The techniqueis based on a force-directed graph where biclusters are representedas flexible overlapped groups of genes and conditions. Availability: The BicOverlapper software and supplementary materialare available at http://vis.usal.es/bicoverlapper Contact: rodri{at}usal.es
Associate Editor: John Quackenbush
The first two authors should be reported as joint first authors. 相似文献
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Summary: Automated analysis of flow cytometry (FCM) data isessential for it to become successful as a high throughput technology.We believe that the principles of Trellis graphics can be adaptedto provide useful visualizations that can aid such automation.In this article, we describe the R/Bioconductor package flowVizthat implements such visualizations. Availability: flowViz is available as an R package from theBioconductor project: http://bioconductor.org Contact: dsarkar{at}fhcrc.org
Associate Editor: Olga Troyanskaya 相似文献
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Westbrook J Ito N Nakamura H Henrick K Berman HM 《Bioinformatics (Oxford, England)》2005,21(7):988-992
Summary: The Protein Data Bank (PDB) has recently released versionsof the PDB Exchange dictionary and the PDB archival data filesin XML format collectively named PDBML. The automated generationof these XML files is driven by the data dictionary infrastructurein use at the PDB. The correspondences between the PDB dictionaryand the XML schema metadata are described as well as the XMLrepresentations of PDB dictionaries and data files. Availability: The current software translated XML schema fileis located at http://deposit.pdb.org/pdbML/pdbx-v1.000.xsd,and on the PDB mmCIF resource page at http://deposit.pdb.org/mmcif/.PDBML files are stored on the PDB beta ftp site at ftp://beta.rcsb.org/pub/pdb/uniformity/data/XML Contact: jwest{at}rcsb.rutgers.edu 相似文献
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Mayampurath AM Jaitly N Purvine SO Monroe ME Auberry KJ Adkins JN Smith RD 《Bioinformatics (Oxford, England)》2008,24(7):1021-1023
Summary: DeconMSn accurately determines the monoisotopic massand charge state of parent ions from high-resolution tandemmass spectrometry data, offering significant improvement forLTQ_FT and LTQ_Orbitrap instruments over the commercially deliveredThermo Fisher Scientific's extract_msn tool. Optimal parention mass tolerance values can be determined using accurate massinformation, thus improving peptide identifications for high-massmeasurement accuracy experiments. For low-resolution data fromLCQ and LTQ instruments, DeconMSn incorporates a support-vector-machine-basedcharge detection algorithm that identifies the most likely chargeof a parent species through peak characteristics of its fragmentationpattern. Availability: http://ncrr.pnl.gov/software/ or http://www.proteomicsresource.org/ Contact: rds{at}pnl.gov Supplementary information: PowerPoint presentation/Poster onhttp://ncrr.pnl.gov/software/.
Associate Editor: Alfonso Valencia 相似文献
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Waegele Brigitte; Dunger-Kaltenbach Irmtraud; Fobo Gisela; Montrone Corinna; Mewes H.-Werner; Ruepp Andreas 《Bioinformatics (Oxford, England)》2009,25(1):141-143
Summary: Cross-mapping of gene and protein identifiers betweendifferent databases is a tedious and time-consuming task. Toovercome this, we developed CRONOS, a cross-reference serverthat contains entries from five mammalian organisms presentedby major gene and protein information resources. Sequence similarityanalysis of the mapped entries shows that the cross-referencesare highly accurate. In total, up to 18 different identifiertypes can be used for identification of cross-references. Thequality of the mapping could be improved substantially by exclusionof ambiguous gene and protein names which were manually validated.Organism-specific lists of ambiguous terms, which are valuablefor a variety of bioinformatics applications like text miningare available for download. Availability: CRONOS is freely available to non-commercial usersat http://mips.gsf.de/genre/proj/cronos/index.html, web servicesare available at http://mips.gsf.de/CronosWSService/CronosWS?wsdl. Contact: brigitte.waegele{at}helmholtz-muenchen.de Supplementary information: Supplementary data are availableat Bioinformatics online. The online Supplementary Materialcontains all figures and tables referenced by this article.
Associate Editor: Martin Bishop 相似文献
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Webb-Robertson BJ Peterson ES Singhal M Klicker KR Oehmen CS Adkins JN Havre SL 《Bioinformatics (Oxford, England)》2007,23(13):1705-1707
Summary: The visual Platform for Proteomics Peptide and Proteindata exploration (PQuad) is a multi-resolution environment thatvisually integrates genomic and proteomic data for prokaryoticsystems, overlays categorical annotation and compares differentialexpression experiments. PQuad requires Java 1.5 and has beentested to run across different operating systems. Availability: http://ncrr.pnl.gov/software Contact: bobbie-jo.webb-robertson{at}pnl.gov
Associate Editor: Thomas Lengauer 相似文献
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A multivariate test of association 总被引:1,自引:0,他引:1
Summary: Although genetic association studies often test multiple,related phenotypes, few formal multivariate tests of associationare available. We describe a test of association that can beefficiently applied to large population-based designs. Availability: A C++ implementation can be obtained from theauthors. Contact: manuel.ferreira{at}qimr.edu.au Supplementary information: Supplementary figures are availableat Bioinformatics online.
Associate Editor: Alex Bateman 相似文献
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Summary: Three dimensional structures of proteins contain errorswhich often originate from limitations of the experimental techniquesemployed. Such errors frequently result in unfavorable atomicinteractions. Here we present a new web service, called InteractionViewer, for the visualization and correction of such errors.We show how the Interaction Viewer is used in combination withthe NQ-Flipper service to spot strained asparagine and glutaminerotamers and we emphasize the convenience of this service incorrecting such errors. Availability: The web service is integrated with the NQ-Flipperservice and accessible at http://flipper.services.came.sbg.ac.at Contact: sippl{at}came.sbg.ac.at
Associate Editor: Anna Tramontano 相似文献
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Derthick M 《Bioinformatics (Oxford, England)》2008,24(6):868-869
Summary: The Summary Tree Explorer (STE) is a Java applicationfor interactively exploring sets of phylogenetic trees usingtwo coupled representations: a node-and-link diagram and a textuallist of common clades. Selection, pruning, filtering or re-rootingin one representation is immediately reflected in the other.While summary trees are more effective at showing the relationshipamong clades, they can only show a consistent subset of thosethat appear in the textual list. Working with both representationsmitigates the disadvantages of having to choose just one. Availability: STE, along with several sample datasets, is availableat http://cityscape.inf.cs.cmu.edu/phylogeny/ Contact: mad{at}cs.cmu.edu
Associate Editor: Martin Bishop 相似文献
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Furusawa C Ono N Suzuki S Agata T Shimizu H Yomo T 《Bioinformatics (Oxford, England)》2009,25(1):36-41
Motivation: High-density DNA microarrays provide us with usefultools for analyzing DNA and RNA comprehensively. However, thebackground signal caused by the non-specific binding (NSB) betweenprobe and target makes it difficult to obtain accurate measurements.To remove the background signal, there is a set of backgroundprobes on Affymetrix Exon arrays to represent the amount ofnon-specific signals, and an accurate estimation of non-specificsignals using these background probes is desirable for improvementof microarray analyses. Results: We developed a thermodynamic model of NSB on shortnucleotide microarrays in which the NSBs are modeled by duplexformation of probes and multiple hypothetical targets. We fittedthe observed signal intensities of the background probes withthose expected by the model to obtain the model parameters.As a result, we found that the presented model can improve theaccuracy of prediction of non-specific signals in comparisonwith previously proposed methods. This result will provide auseful method to correct for the background signal in oligonucleotidemicroarray analysis. Availability: The software is implemented in the R languageand can be downloaded from our website (http://www-shimizu.ist.osaka-u.ac.jp/shimizu_lab/MSNS/). Contact: furusawa{at}ist.osaka-u.ac.jp Supplementary information: Supplementary data are availableat Bioinformatics online.
The authors wish it to be known that, in their opinion, thefirst two authors should be regarded as joint First Authors.
Associate Editor: Trey Ideker 相似文献