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1.
To clarify the changes of mineral levels in different tissues of riboflavin-deficient rats, Wistar rats were separated into
three groups. One group was fed a diet ad libitum that was deficient in riboflavin. The other two were fed either the complete
diet that was weight-matched to the riboflavin-deficient group or fed a complete diet ad libitum. In riboflavin-deficient
rats, the hemoglobin concentration and riboflavin contents of blood, liver, and kidney were significantly decreased, compared
with weight-matched and ad libitum-fed controls. The mineral concentrations of tissues are summarized as follows: The iron
(Fe) concentration in the heart, liver, and spleen was decreased in the riboflavin-deficient group compared with the other
groups. Calcium (Ca) and magnesium (Mg) concentrations in tibia were decreased in the riboflavin-deficient group compared
with the other two groups. Copper (Cu) concentration was increased in the heart and liver when the riboflavin-deficient group
was compared with the other groups. Zinc (Zn) concentration was increased in tibia when the riboflavin-deficient group was
compared with the other groups. 相似文献
2.
U. Carpentieri J. Myers C. W. Daeschner M. E. Haggard 《Biological trace element research》1988,16(2):165-176
The effects of simultaneous changes of calcium, magnesium, iron, copper, and zinc concentrations were evaluated in normal
human T and B lymphocytes, cultured in cation-depleted media. Optimal concentrations for thymidine incorporation (TI) in both
cell populations were Fe and Zn 15 μM and Cu 5 μM; for t cells Ca 2 mM and Mg 4 mM; for B cells Ca 4 mM and Mg 6 mM. TI decreased with increasing molarity of cations and the decrease was particularly apparent with Cu. Minimal amounts of
Ca and Mg (0.5 mM) were necessary for growth, even in presence of optimal concentrations of Fe, Cu, and Zn. Fe and Cu showed synergistic stimulatory
effects at low concentrations and synergistic inhibitory effects at high concentrations. Antagonism between Fe and Zn, Cu
and Zn, and Ca and Zn was also demonstrated. CD4/CD8 increased with PHA stimulation in presence of Zn, and decreased with
ConA stimulation in presence of Zn or Fe. The results demonstrate: (1) the relationship and interdependence of Fe, Cu, and
Zn concentrations in modulating the growth of normal lymphocytes; (2) the stimulatory effects of Fe on B cells and Zn on CD8
positive cells; (3) the inhibitory effect of Cu at concentrations lower than those of Fe and Zn; (4) the requirement of Ca
and Mg in certain concentration and ratio for the action of the other cations; and (5) the Ca and Mg requirement for the growth
of B cells higher than T cells. 相似文献
3.
Hair zinc and copper: Relationship to hair type and serum concentrations in children and adolescents
The zinc and copper serum and hair concentrations of 691 3-18-y-old girls and boys previously determined as a part of the
Multicentre Study of Atherosclerosis Precursors in Finnish Children and Adolescents were further analyzed in order to find
a possible association between these two zinc and copper indices. The influence of hair color and the diameter of individual
hair strands on hair concentrations were studied by the analysis of covariance. Hair color and serum zinc concentrations were
found to be associated with hair zinc concentrations in boys. Such an association was not found for zinc and copper concentrations
in girls. Hair vs serum concentrations in different age and hair color groups did not show however, a significant relationship
either in copper or in zinc concentrations. The subjects with very low or high serum zinc or copper concentrations did not
usually have extreme hair concentrations and vice versa. However, there were some subjects with low or high serum concentrations
associated with low or high hair concentrations. 相似文献
4.
Hair zinc and copper in chronic alcoholics 总被引:1,自引:0,他引:1
González-Reimers E Alemán-Valls MR Barroso-Guerrero F Santolaria-Fernández F López-Lirola A García-Valdecasas CE Jarque-López A Rodríguez-Gaspar M 《Biological trace element research》2002,85(3):269-275
Chronic alcoholics frequently show associated malnutrition. Both ethanol and malnutrition exert profound changes on zinc and
copper metabolism. In this study, we found higher hair zinc and copper values in 43 male alcoholics than in 39 controls. Hair
copper was significantly related to the amount of ethanol consumed, whereas hair zinc was higher in consumers of distilled
beverages. No relation was observed between hair zinc and copper and nutritional status, kind of diet consumed, style of life,
and liver cirrhosis. Consequently, hair zinc and copper levels are related only with alcohol intake. 相似文献
5.
Selenium, iron, copper, and zinc levels and copper-to-zinc ratios in serum of patients at different stages of viral hepatic diseases 总被引:12,自引:0,他引:12
Viral hepatic diseases, especially those induced by the hepatitis B virus, can progress into more serious pathological outcomes
and eventually to hepatocellular carcinoma. A growing body of evidence indicates that many trace elements play important roles
in a number of carcinogenic processes that proceed through various mechanisms. To examine the status of trace elements during
the development of hepatic carcinoma, we determined the selenium, iron, copper, and zinc levels and copper-to-zinc ratios
in the serum of patients at different stages of viral hepatic disease. We observed significant changes in the selenium, iron
copper, and zinc levels in the serum of patients having hepatocellular carcinoma, relative to those of healthy controls (p<0.05). The mean serum copper level in patients with hepatocellular carcinoma was significantly higher than that of the control
group. In contrast, the mean selenium, iron, and zinc levels in patients having hepatocellular carcinoma were significantly
lower than those of the control group. In addition, the mean zinc level in the serum of patients with hepatic cirrhosis was
significantly lower than that of the control group (p<0.05). Moreover, we found markedly elevated Cu: Zn ratios (p<0.05) in patients having hepatic cirrhosis or hepatocellular carcinoma. Our findings imply that the levels of some trace
elements, such as selenium, iron, copper, and zinc, and Cu:Zn ratios, might serve as biomarkers for the increased severity
of viral hepatic damage. 相似文献
6.
Po Lau Leung Han Ming Huang Da Ze Sun MeI Guang Zhu 《Biological trace element research》1999,69(3):269-282
In this investigation, the concentration levels of hair elements of calcium, iron, and zinc were measured in pregnant women
from Tianjin metropolis, China. The subjects were 93 cases of pregnant women who had been suffering from calcium, iron, or
zinc deficiency judged by blood tests at the mid-term of the second trimester or early in the third trimester. Of these 93
cases, 82 subjects had their hair element levels measured when the blood tests were conducted. Then, they were supplied with
mineral element nutrients of gluconic acidic zinc (noted as Zn-nutrient), gluconic acidic calcium (Ca-nutrient), or/and ferrous
sulfate (Fe-nutrient) which were correspondent to the deficient element(s) for more than 2 mo before 84 subjects returned
to hospital for further diagnoses and had their hair element levels measured for the second time. Finally, in the third trimester
or nearparturient phase, 13 subjects had their hair element levels measured again. Except for the deficiencies of calcium,
iron, or/and zinc, these subjects were all healthy without symptoms of any diseases.
The concentrations of hair Ca, Fe, and Zn were measured by X-ray fluorescence (XRF) spectrometry. These concentrations of
the three hair elements measured at three different times were statistically analyzed. From the analyses, it was clear that
hair concentrations of Ca, Fe, and Zn could reflect the effects of supplementation. Also, the mutual resistant effects among
Ca-, Fe-, and Zn-nutrients were revealed. However, by appropriate combination, the mutual resistant effects could be depressed
and mutual promotional effects might be enhanced. Finally, it could be concluded that mineral element deficiencies might be
convalesced by adequate compensations of mineral element nutrients. 相似文献
7.
Aydin Ece Bekir Sami Uyamik Akin IŞcan Pelin Ertan M. Ramazan Yiğitolu 《Biological trace element research》1997,59(1-3):31-39
In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged
1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children
with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL)
(p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum
copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels
were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum
zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment
should be initiated with zinc. 相似文献
8.
The purpose of this study was to investigate changes in serum concentration of copper, zinc, and calcium in sheep naturally
infested with lice (Bovicola caprae, Linognathus africanus, Linognatus ovillus, and Linognattus pedalis). Twenty sheep naturally infested with lice and 20 healthy sheep were used as subjects. Blood samples were collected from
the sheep before and 8 and 15 d after treatment with Avermectin, a veterinary antiparasitic drug. The samples were analyzed
for their serum copper, zinc, and calcium concentrations by atomic absorption spectrometry. The concentrations of these elements
in the infested animals were lower than in the healthy controls, mainly because the general condition of the affected sheep
was poor. When the infested animals were treated with an ectoparasitic drug, the serum levels of the studied elements rose
to normal ranges while the health of the animals improved. 相似文献
9.
Kucukatay V Turgut S Kocamaz E Emmungil G Bor-Kucukatay M Turgut G Akca H Bagci H 《Biological trace element research》2006,114(1-3):185-195
Sulfite is a potentially toxic molecule that might enter the body via ingestion, inhalation, or injection. For cellular detoxification,
mammalians rely on sulfite oxidase to convert sulfite to sulfate. The purpose of this research was to determine the effect
of sulfite on zinc, iron, and copper levels in rat liver and kidney tissues. Forty normal and sulfite oxidase-deficient male
albino rats were divided into four groups that included untreated controls (group C), a sulfite-supplemented group that received
70 mg sodium metabisulfite per kilogram per day (group S), a sulfite oxidase-deficient group (group D), and a sulfite oxidase-deficient
group that was also given 70 mg sodium metabisulfite per kilogram per day (group DS). The iron and zinc levels in the liver
and kidney in groups S and DS were not affected by sulfite treatment compared to their respective controls (groups C and D).
Sulfite exposure led to an increase of kidney copper content in the S group when compared to untreated controls. The kidney
copper levels were significantly increased in the unexposed deficient rats, but it was not different than that of the deficient
rats that were given oral sulfite treatment. These results suggest that kidney copper levels might be affected by exogenous
or endogenous sulfite.
An erratum to this article is available at . 相似文献
10.
Plasma essential trace elements, selenium, copper, zinc, and iron concentrations and the levels of immunoregulatory cytokines,
interleukin-1β (IL-1β), interleukin-2 receptor (IL-2r), IL-6, IL-8, and tumor necrosis factor-α (TNF-α) were evaluated in patients with cutaneous leishmaniasis (CL) to investigate a possible role of these cytokines on selenium,
zinc, copper, and iron homeostasis in CL patients. Plasma albumin levels were measured as an index of nutritional status.
Plasma selenium, zinc, and iron concentrations, and IL-2r levels were significantly lower, and copper concentrations and IL-1β, IL-8, IL-6 and TNF-α levels were significantly higher in patients with CL than those of healthy controls. There was no significant difference
in plasma albumin levels between two groups. There were positive important correlations between plasma selenium and IL-2r,
copper and IL-6, and copper and IL-1β, and negative correlations between selenium and IL-8, iron and TNF-α, and zinc and IL-1β contents in patients with CL. Our results showed that plasma trace element contents change in patients with CL. These changes
may not be a result of a specific deficiency from dietary inadequacies or imbalances, but, probably, a result of a part of
the defense strategies of an organism that is regulated by immunoregulatory cytokines. 相似文献
11.
A number of essential trace elements play a major role in various metabolic pathways. Selenium (Se), manganese (Mn), copper
(Cu), zinc (Zn), and iron (Fe) are essential trace elements that have been studied in many diseases, including autoimmune,
neurological, and psychiatric disorders. However, the findings of previous research on the status of trace elements in patients
with schizophrenia have been controversial. We studied these elements in patients with a DSM-IV diagnosis of schizophrenia
and compared them with sex- and age-matched healthy controls. Plasma Cu concentrations were significantly higher (p<0.01) and Mn and Fe concentrations were lower (p<0.05 and p<0.05, respectively) in schizophrenic patients than in controls. Se and Zn concentrations and protein levels did not differ
between patients and healthy controls. These observations suggest that alterations in essential trace elements Mn, Cu, and
Fe may play a role in the pathogenesis of schizophrenia. However, findings from trace element levels in schizophrenia show
a variety of results that are difficult to interpret. 相似文献
12.
Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading 总被引:1,自引:0,他引:1
Katrina J. Allen Nicole E. Buck Daphne M. Y. Cheah Sophie Gazeas Prithi Bhathal Julian F. B. Mercer 《Biometals》2006,19(5):555-564
The toxic milk (tx) mouse is a rodent model for Wilson disease, an inherited disorder of copper overload. Here we assessed the effect of copper
accumulation in the tx mouse on zinc and iron metabolism. Copper, zinc and iron concentrations were determined in the liver, kidney, spleen and
brain of control and copper-loaded animals by atomic absorption spectroscopy. Copper concentration increased dramatically
in the liver, and was also significantly higher in the spleen, kidney and brain of control tx mice in the first few months of life compared with normal DL mice. Hepatic zinc was increased with age in the tx mouse, but zinc concentrations in the other organs were normal. Liver and kidney iron concentrations were significantly lower
at birth in tx mice, but increased quickly to be comparable with control mice by 2 months of age. Iron concentration in the spleen was significantly
higher in tx mice, but was lower in 5 day old tx pups. Copper-loading studies showed that normal DL mice ingesting 300 mg/l copper in their diet for 3 months maintained normal
liver, kidney and brain copper, zinc and iron levels. Copper-loading of tx mice did not increase the already high liver copper concentrations, but spleen and brain copper concentrations were increased.
Despite a significant elevation of copper in the brain of the copper-loaded tx mice no behavioural changes were observed. The livers of copper-loaded tx mice had a lower zinc concentration than control tx mice, whilst the kidney had double the concentration of iron suggesting that there was increased erythrocyte hemolysis in
the copper-loaded mutants. 相似文献
13.
Ciftci TU Ciftci B Yis O Guney Y Bilgihan A Ogretensoy M 《Biological trace element research》2003,95(1):65-71
The effectiveness and success of antituberculosis therapy is mainly measured by its ability to identify the organism in the
sputum. In certain cases, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness
of antituberculosis therapy. Copper (Cu), zinc (Zn), and selenium (Se) are the essential elements that play a crucial role
in the immune system. The serum levels of these elements vary in many diseases including tuberculosis. In this study, we investigate
whether the serum levels of Cu, Zn, and Se change during antituberculosis therapy. We have included 22 pulmonary tuberculosis
cases that were newly diagnosed with positive sputum and 18 healthy subjects. At the beginning and 2 mo after therapy, serum
levels of Cu, Zn, and Se were measured by atomic absorption spectrometry. Despite Se and Cu levels not being affected during
the treatment, we found that there was a significant increase in the levels of Zn and a decrease in the Cu/Zn ratio. Serum
Zn levels and the Cu/Zn ratio could be used as a valuable laboratory tool for the clinicians to assess response to therapy
or effectiveness of the ongoing antituberculosis therapy. 相似文献
14.
In recent years, a great number of studies have investigated the possible role of trace elements in the etiology and pathogenesis
of rheumatoid arthritis (RA) and osteoartritis (OA). We studied synovial fluid and plasma concentrations of selenium (Se),
zinc (Zn), copper (Cu), and iron (Fe) in patients with RA and OA and compared them with sex- and age-matched healthy subjects.
Plasma albumin levels were measured as an index of nutritional status. Plasma Se, Cu, and Zn concentrations were determined
by atomic absorption spectrophotometry and Fe concentrations were determined by the colorimetric method. Although plasma and
synovial fluid Se concentration were found to be significantly lower (p<0.05, and p<0.05, respectively), Cu concentrations were significantly higher in patients with RA than those of healthy subjects and OA
(p<0.05 and p<0.05, respectively). There were no significant differences in plasma and synovial fluid Zn concentrations and albumin levels
among three groups (p>0.05). On the other hand, synovial fluid Cu and Fe concentrations were significantly higher in patients with OA than those
of healthy subjects (p<0.05). There was a significantly positive correlation between synovial fluid Se−Cu values and Zn−Fe values in patients with
RA. Our results showed that synovial fluid and plasma trace element concentrations, excluding Zn, change in inflammatory RA,
but not in OA. These alterations in trace element concentrations in inflammatory Ra might be a result on the changes of the
immunoregulatory cytokines. 相似文献
15.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
16.
17.
To evaluate the species specificity of Cd accumulation and the relationship of Cd with other essential metals and metallothionein
(MT), the concentrations of Cd, Zn, Cu, and Fe in the liver and kidney and the MT concentrations in the soluble fractions
of the liver and kidney were determined in Cd-uncontaminated nonhuman primates (11 species, 26 individuals) kept in a zoo
and two wild-caught Japanese macaques. The compositions of metal-binding proteins in the soluble fractions were also investigated
by high-performance liquid chromatography (HPLC). The hepatic Cd concentration was 0.03–14.0 μg/g and the renal Cd concentration was 0.35–99.0 μg/g, both varying greatly and being higher in nonhuman primates, which were more closely related to man. The hepatic Zn concentration
was 24.0–176 μg/g and the renal Zn concentration was 13.5–138 μg/g, showing 7- to 10-fold differences, and a correlation (r=0.558, p<0.01) was found between renal Zn and renal Cd concentrations.
It was proved that in the liver, MT is more closely correlated with Zn (r=0.795, p<0.001) than with Cd (r=0.492, p<0.01) and that in the kidney MT is correlated with both Cd (r=0.784, p<0.001) and Zn (r=0.742, p<0.001). HPLC analysis of metals bound to MT-like protein in chimpanzees, de Brazza’s monkeys, and Bolivian squirrel monkeys
showed that more than 90% of Cd in both the liver and kidney, approx 40% of Zn in liver and 28–69% of Zn in kidney were bound
to MT-like protein. The higher percentage Zn was bound to high-molecular protein. 相似文献
18.
Abdurrahim Kocyigit Ozcan Erel Mehmet S. Gurel Senel Avci Necmeddim Aktepe 《Biological trace element research》1998,65(3):271-281
The aim of this study was to measure the alterations in serum selenium (Se), copper (Cu), zinc (Zn), and iron (Fe) concentrations
and their carrier proteins, ceruloplasmin (Cp), transferrin (Tf) albumin, and related antioxidant enzyme activities, erythrocyte
Cu-Zn Superoxide dismutase (Cu-Zn SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities in patients with cutaneous
leishmaniasis (CL). Erythrocyte Cu-Zn SOD activities, serum Cu concentrations, and Cp levels were found to be significantly
higher in the patients group than those of controls. However, GSH-Px and CAT activities and Se, Zn, Fe, and Tf levels were
lower in patients than in the control subjects. There were positive important correlation’s between Cu-Zn SOD and Cp, Cu-Zn
SOD and Cu, Cp and Cu, GSH-Px and Se, and Fe and CAT in the patients group. Our results showed that serum essential trace
elements Se, Zn, Cu, and Fe concentrations and their related enzymes Cu-Zn SOD, GSH-Px, and CAT activities change in CL patients.
The changes may be a part of defense strategies of organism and are induced by the hormonelike substances. 相似文献
19.
对单性结实的龟井温州蜜柑和自花授粉结实的鄂柑1号柑橘果实的铁、锰、锌和铜含量的年周期变化进行了测定。结果表明:(1)龟井子房的锌和铜含量在花前至花期居较高,花后趋下降,而鄂柑1号对应值在花期出现明显下降并居较低,花后却有一明显上升;两品种子房(幼果)的铁和锰含量变化却无明显差异,花后呈类似的下降趋势。(2)幼果阶段的果实铁、锰、锌和铜含量均居较高,在果实膨大初期(干旱期)均出现一明显下降,而在果实膨大中期却出现显著上升,之后又趋下降。本文还对果实发育中的微量元素含量动态及其与果实发育之间的关系进行了讨论。 相似文献
20.
A. M. Rofe J. C. Philcox D. R. Haynes M. W. Whitehouse P. Coyle 《Biological trace element research》1992,34(3):237-248
The early changes in hepatic metallothionein (MT) and plasma zinc (Zn), copper (Cu), and iron (Fe) were investigated during
the induction of adjuvant (AJ) arthritis in rats in conjunction with cyclosporin (CSA) treatment. Plasma Zn decreased after
AJ injection (60% of control values at 8 h), and this was associated with a 4.5-fold increase in hepatic MT at 8 h. Plasma
Zn was lowest at 16 h (40% of control), whereas hepatic MT concentrations increased to a maximum of 20-fold at 16 h. Changes
in plasma Fe paralleled those of Zn, whereas plasma Cu levels were increased. Plasma metal and hepatic MT concentrations returned
toward normal from d 1–7. At d 14, when marked paw swelling was apparent, hepatic MT and plasma Cu were again increased and
plasma Zn decreased.
Administration of CsA decreased MT induction in rats injected with AJ and also caused a marked recovery in plasma Zn and Fe
levels. These changes were small but significant even in the early stages (up to 24 h) after AJ injection and were followed
by a sustained improvement in all parameters, corresponding to the nonappearance of clinical arthropathy in CsA-treated rats.
TNF-α and IL-6 production by peritoneal macrophages isolated from AJ-injected rats was significantly decreased by CsA treatment
at d 7 and 14. The inhibition of hepatic MT induction during acute and chronic inflammation by cyclosporin emphasizes the
role of the immune system in altered metal homeostasis in inflammation. 相似文献