Contents of Volume 24

Culture, Medicine, and Psychiatry -     

白介素24与肿瘤

IL-24的抑癌机制复杂,可通过调节p38MAPK、PKR、β-通路;干扰线粒体功能和增加ROS合成;抑制DNA的修复、β-联蛋白(β-catenin)、P13K、ERK1／2和JNK1／2信号瘤血管形成和肿瘤细胞侵袭转移的能力等途径抑制肿瘤细胞的生长,促进凋亡。用复制缺陷的腺病毒携带的IL-24(AdlL-24)现已进入Ⅰ、Ⅱ期临床实验．与三氧化二砷、放疗联合应用可增加疗效。     

Synthesis of 24-dehydrocholecalciferol

This paper describes the synthesis of 24-dehydrocholecalciferol from 5,7-cholestadiene-3β,25-diol 3-acetate.     

Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants

Feeding of chemically synthesized [27-13C]codisterol ([27-13C]2), [27-13C]24-epicodisterol ([27-13C]3), [23,24-2H2]codisterol ([23,24-2H2]2), and [26,27-2H6]24-methyldesmosterol ([26,27-2H6]8) to Oryza sativa cell cultures, followed by MS and NMR analysis of the biosynthesized dihydrobrassicasterol (9)/campesterol (10), revealed that both (24R)- and (24S)-epimers of 24-methyl-Delta25-cholesterol (2/3) were converted to 9 and 10 via the common intermediate 24-methyldesmosterol (8).