共查询到20条相似文献,搜索用时 15 毫秒
1.
Chronic administration of cycloheximide to young rats from 15-th to 30-th postnatal day before daily 3-hour seances of their contacts, disturbed the formation of animals intraspecies aggressivity. In adults it was manifested by hyperaggressivity and by changes of proportions of different reactions in the integral act of aggressive behaviour. By their character these disturbances were close to those observed in the young rats completely deprived of social contacts in this period of ontogenesis. 相似文献
2.
T. V. Karelina R. A. Grigorian 《Journal of Evolutionary Biochemistry and Physiology》2010,46(3):259-266
Functional relationship between wave form of complex spike (CS) and depression time of simple spike (SS) in discharge of cerebellar
Purkinje cells was studied after their activation with afferent climbing fiber at different terms of postnatal ontogenesis
in norm and after treatment with harmaline. The experiments were carried out on three age groups of Wistar rats: rat pups
(2 weeks), the adult (4–6 months), and the old animals (22–26 months). It was established that the SS duration in norm was
approximately equal in rat pups, adult, and old animals, whereas it markedly decreased form the young to the old animals during
the SS depression in the Purkinje cell discharge. Frequency of small action potential (lAP) and their number in the Purkinje
cell discharge were approximately equal in young rat pups and adult animals, while in old animals these parameters were higher,
on average, by 30%. After administration of harmaline, all CS parameters in rat pups and old animals increased in parallel
with the depression time elongation. In adult rats, harmaline did not produce statistically significant changes of the mean
values of CS parameters, but an increase of the simple spike depression time was observed. The obtained results allow concluding
that the SS wave form and the simple spike depression time in norm are functionally coupled and change with age. The effect
of harmaline on the CS wave forms as well as on interrelation of the CS duration and the CS depression time in the Purkinje
cell discharge was more pronounced at the early and the late stages of Wistar rat postnatal ontogenesis. 相似文献
3.
V K Syrtsov 《Arkhiv anatomii, gistologii i émbriologii》1979,76(4):20-25
The synthesis of acid glycoproteins in the glands of the respiratory pathway has been studied radioautographically by means of sodium sulfate in the cat ontogenesis. 35S-sulfate incorporation into the fetal gland has been stated to increase by the time of delivery. After birth and in young kittens, 35S-sulfate incorporation into the gland decreases. Acid glycoproteins are intensively synthesized by the tracheal and bronchial gland in young and adult animals. In old animals this process is lowered. The synthesis of acid glycoproteins by the tracheal and bronchial glands in ontogenesis changes both quantitatively and qualitatively. 相似文献
4.
By means of electron microscopical morphometry and populational analysis it has been stated that hydrocortisone acetate, injected subcutaneously twice a week in dose 5 mg/kg of the body mass, produces decrease in number of intensively collagen-producing fibroblasts and increase in the part of fibroblasts and destroying cells in population of fibroblasts only in young (2-week-old) animals. The dose 10 mg/kg produces similar changes both in young and in mature (2-month-old) animals. In the young animals given hydrocortisone in dose 5 mg/kg of the body mass, the mean summational area and extension of the granular endoplasmic reticulum membranes in the fibroblast section diminishes, the summational area of the mitochondrial section decreases in the section of one cell, and the derm with less thickness, in comparison with the derm of intact animals, is formed, while in mature animals, given hydrocortisone in a small dose, all the parameters mentioned do not significantly differ from the control. Hydrocortisone in dose 20 mg/kg decreases all quantitative parameters of dermal fibroblasts both in young and mature animals. The data of the correlative analysis give evidence on the presence of a strong positive connection between inhibition of the synthetic apparatus of fibroblast development under hydrocortisone effect and decrease of the derm thickness, forming during the postnatal period of ontogenesis. 相似文献
5.
A. D. Nozdrachev P. M. Masliukov 《Journal of Evolutionary Biochemistry and Physiology》2003,39(2):249-256
The paper considers the problem of peculiarities of maturation of the stellate ganglion nerve elements in mammals of different species. This process differs in precocious and altricial animals. It has been shown that in spite of some individual peculiarities, the neurons, fibers, and conducting pathways in altricial animals are not, on the whole, completely formed morphologically and functionally. In the course of postnatal ontogenesis, not only an increase of cell sizes and development of dendrite tree, but also reorganization of nerve connections with target organ occur. The postnatal ontogenesis is also accompanied by an increase of the excitation transmission rate along the fibers and by their myelination. The asymmetry of the right and left stellate ganglia (SG) by their sizes and functional peculiarities, which exists in adult animals appears as soon as at early stages of postnatal development. The neural elements of precocious animals are changed to a lesser extent in postnatal ontogenesis and are, in many aspects, similar to those of adult organisms as early as at birth. 相似文献
6.
N. V. Kolot 《Cell and Tissue Biology》2017,11(5):363-370
At present, little is known of what happens to bone-marrow cells under caloric restriction or periodic starvation. The aim of the study was to investigate the influence of periodic starvation on the proliferative potential and cell morphology of the heterogeneous bone-marrow pool of young and old rats. Periodic starvation reduced the number of bone-marrow cells independently of the animal age, but did not affect cell viability and morphology. In young rats, periodic starvation increased the proportion of differentiated cells in the bone-marrow population; in old animals, it increased the number of undifferentiated blasts and blood-cell precursors. Bone-marrow cell cultivation was accompanied with reduced cell heterogeneity. Periodic starvation increased proliferative potential of bone-marrow cells from old rats. This suggests that periodic starvation at late stages of ontogenesis has an antiaging effect on bone-marrow cells in vivo and in vitro. 相似文献
7.
A I Radostina 《Ontogenez》1986,17(5):508-515
The effects of hydrocortisone and acetate deoxycorticosterone on the composition of the fibroblast population and the changes in their ultrastructure during the derma development in ontogenesis were studied using the electron morphometry. Hydrocortisone was shown to decrease in the derma of young animals the number of fibroblasts, which actively produce collagen, and to increase the number of fibrocytes and degenerating cells. Hydrocortisone reduced both in young and adult animals the total extent of the rough endoplasmic reticulum membranes, the total area of the rough endoplasmic reticulum and Golgi complex cisternae at the fibroblast section, as well as the area of the cytoplasm. The introduction of acetate deoxycorticosterone increased insignificantly the number of fiblroblasts, which actively produce collagen, in the derma of 2 month old animals. Under its influence the ultrastructure of the fibroblasts changed reliably only at the later stages of ontogenesis. Both the corticosteroids changed the bulk ratios of various organelles in the fibroblast's cytoplasm. 相似文献
8.
Study of peculiarities of formation of preference in use of one of forepaws at learning of the manipulatory food-procuring skill has been carried out at different stages of early ontogenesis of white rats. It was established that as early as at the 3-week age the rat pups were already able to learn getting food from a narrow test-tube; however, no expressed preference in using one of the extremities was revealed. After repeated testing of adult rats at the age of 4 months the number of ambidexters was significantly higher than in the control animal group. At learning of the 30-day old rat pups of this manipulatory skill, in the majority of the rat pups, no significant lateralization also was found in using the forepaw. At repeated testing of adult rats the amount of ambidexters did not differ from that in the control group of animals. The obtained results indicate the existence of critical periods in formation of lateral preference in performance of the manipulatory food-procuring skill. There also was shown effect of learning in early ontogenesis of the capability for lateralization of this skill in the adult state in rats. 相似文献
9.
I Syrovy 《General physiology and biophysics》1988,7(3):243-251
Studies were conducted to analyze the effect of the thyroid hormone on ventricular myosin during ontogenesis of mice, rats and rabbits. Hypothyroidism was induced in mice and rats by administering propylthiouracyl in drinking water. Rabbits were made hyperthyroid by chronic administration of thyroxine. The change in the thyroid state of rats and rabbits influenced young and adult animals differently depending on whether V1 or V3 was the major ventricular isomyosin form present. Measurements of Ca2+-ATPase activity of myosins from young and old control animals and from animals with changed thyroid state showed that hypothyroidism in rats is associated with a greater decrease of myosin ATPase in young rats which contain V1 isomyosin only, when compared with old rats which contain a preponderance of V3 isomyosin and less of the V1 form. In rabbits, ATPase activity of ventricular myosin was more elevated after thyroxine administration in adult rabbits, which contain V3 isomyosin only, than in young rabbits in which myosin consists of V1 and V3 isomyosins. Ventricular myosins of young and adult mice did not differ in their ATPase activity and the treatment of mice with propylthiouracyl had only slight effect on myosin ATPase. It can be concluded based on these results that the hypothesis concerning hypothyroidism inducing transformation of V1 into V3 isomyosin does not hold generally. 相似文献
10.
Studies have been made of the effect of ACTH fragment 4-7 on learning in rats in early postnatal ontogenesis, as well as of the possibility of preservation of early learning during administration of this peptide to adult animals. It was shown that conditioned reaction of active avoidance practically cannot be formed in normal 13-15-day animals; however, administration of ACTH 4-7 increases the number of animals exhibiting adequate reactions. Weak effect of ACTH 4-7 in 12-15-day animals, in older ones (20-24 days) is changed by a significant stimulating effect. 相似文献
11.
V. N. Molodtsov E. V. Senchenkov E. D. Bazhanova 《Journal of Evolutionary Biochemistry and Physiology》2006,42(3):354-360
Despite a great many works dealing with apoptosis, the occurrence of this process at later stages of ontogenesis still is far from clear. The goal of the present study was to elucidate role of insulin and antiapoptotic protein Bcl-2 in initiation of apoptosis and preservation of functional status of hypothalamic neurosecretory cells of mice in aging. Neurosecretory cells of aged mice were shown to be eliminated intensively via apoptosis; however, functional activity (synthesis of vasopressin) of remaining cells is comparable with that in young animals. Hypothalamic neurosecretory cells were revealed to synthesize insulin, but its content in neurons of old animals decreases in correlation with initiation of apoptosis. It was shown that protein Bcl-2 in neurons of aged mice did not prevent initiation of apoptosis. It was also established that α-interferon had no apoptosis-protective effect to hypothalamic neurons in aging and suppressed synthesis of vasopressin, insulin, and Bcl-2 in cells of young and old mice. 相似文献
12.
The intensity of sarcoplasmic and myofibrillar protein synthesis in skeletal muscle homogenates of the cattle aged from 45 to 360 days is 3.5 and 3.8 times reduced, respectively, and remains at the same level in the old beef cattle aged 540 days. Exogenous insulin and thyroxin increases the sarcoplasmic and myofibrillar protein synthesis in skeletal muscle homogenates of animal at certain stages of postnatal ontogenesis. The catepsin and neutral protease activities are 2.0 and 1.7 times as low in the skeletal muscle of the cattle aged from 45 to 360 days while in the subsequent period they change slightly. Exogenous insulin decreases the catepsin protease activities but does not change the neutral protease activities in the skeletal muscle of animal at the most stages of postnatal ontogenesis. Exogenous thyroxin increases the catepsin and neutral protease activities in skeletal muscle of animals at the some stages of postnatal ontogenesis. 相似文献
13.
Sphingomyelin metabolism in liver cell nuclei of rats of various age has been studied. It was found that the level of sphingomyelin hydrolysis in cell nuclei is the highest in young animals, showing a decrease in 24-month-old animals. The age-specific fluctuations in the activity of phospholipase C may be one of possible reasons for sphingomyelinase activity changes in liver nuclei during ontogenesis. It has been shown that thyroid hormones and diacylglycerols control the sphingomyelinase activity in rat liver cells. 相似文献
14.
Toth E Gersner R Wilf-Yarkoni A Raizel H Dar DE Richter-Levin G Levit O Zangen A 《Journal of neurochemistry》2008,107(2):522-532
Exposure to chronic mild stress (CMS) is known to induce anhedonia in adult animals, and is associated with induction of depression in humans. However, the behavioral effects of CMS in young animals have not yet been characterized, and little is known about the long-term neurochemical effects of CMS in either young or adult animals. Here, we found that CMS induces anhedonia in adult but not in young animals, as measured by a set of behavioral paradigms. Furthermore, while CMS decreased neurogenesis and levels of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult animals, it increased these parameters in young animals. We also found that CMS altered alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor GluR1 subunit levels in the hippocampus and the nucleus accumbens of adult, but not young animals. Finally, no significant differences were observed between the effects of CMS on circadian corticosterone levels in the different age groups. The substantially different neurochemical effects chronic stress exerts in young and adult animals may explain the behavioral resilience to such stress young animals possess. 相似文献
15.
R K Danilov 《Arkhiv anatomii, gistologii i émbriologii》1982,83(10):71-78
By means of electron microscopic radioautography of RNA and DNA synthesis, morphometry of satellite cells, transmissive electron microscopy applying photometric scanning of the image, a successive development and maturation of myosatellites has been studied in ontogenesis of hens, rats and the man. The initial muscle cells for simplasts are promyoblasts. At the stage of myotubes and young muscle fibres, structural and functional heterogeneity of the satellite cells in the myotubes takes place. It is possible to distinguish satellite promyoblasts (the cells which are at the state of proliferative rest, interact with simplasts, intensively synthesize RNA, temporarily do not fuse with simplasts but have certain metabolic connection with them). Subsequently, promyocytes form myosatellitocytes of the I type, they are constantly found in small amount in the muscle fibre composition during the whole course of the animal's ontogenesis. According to the morphological classification, promyoblasts and promyocytes belong to myosatellitocytes of the II type. When studying myosatellitogenesis in the animals, no other sources of cell production have been found. 相似文献
16.
R M Kurabekova G D Mataradze V B Rozen 《Biulleten' eksperimental'no? biologii i meditsiny》1991,111(2):186-188
The role of sex steroids in the programming of the level of serum corticosteroid binding globulin (CBG) of male and female rats has been studied at different stages of ontogenesis. It was shown that castration of adult males lead to the increase of the level of CBG, but not to the elimination of sex differences. Gonadectomy of males up to 28th day of postnatal life results in complete feminization of the CBG content in these animals at the age of 10-12 weeks. The castration after 35th day of life does not prevent the formation of the male phenotype of CBG content. The results of administration of testosterone-propionate (TP) to castrated males at different periods of ontogenesis suggests that the sensitivity to irreversible negative action of androgens appears after 28th day of life and disappears after the puberty. It was concluded that short period of ontogenesis from 29th to 35th days of life is critical for the realization of the irreversible masculinization of CBG level upon the influence of androgens in the physiological conditions. It was found that injections of both synthetic estrogens diethylstilbestrol or TP in the sensitive period of ontogenesis lead to the expression of male phenotype of CBG level in a similar fashion. 相似文献
17.
Dynamics of changes in glucocorticoid (hydrocortisone and corticosterone) levels was studied in the ontogenesis of freshwater crawfish Astacus Leptodactylus Esch. It was shown that steroid concentrations increase during the embryogenesis period. Decrease in the glucocorticoid levels during postembryonic development is most probably related to the stabilization of young fish growth and the attainment of hormone levels typical for adult individuals. The correlation ofglucocorticoid levels with physiological-biochemical changes at different stages of ontogenesis indicates that these steroids play an essential role in the regulation of freshwater crawfish vital functions. 相似文献
18.
The dynamics on the formation of different types of mechno- and chemosensitive papillae in the rat tongue has been studied during different periods of postnatal ontogenesis by means of scanning electron microsopy. Asynchronous maturation of these papillae has been demonstrated, they perform certain functions during the early postnatal ontogenesis and reach their functional maturity by the age of 3 weeks when animals go over from suckling to solid food. 相似文献
19.
N I Flerova P K Smirnov I A Sytinski? 《Zhurnal evoliutsionno? biokhimii i fiziologii》1981,17(3):298-301
The activity of gamma-glutamyl transferase (GGTF, EC 2.3.2.2) has been investigated in different brain structures (hemispheres, cerebellum, hippocamp, brain stem) of newborn, 3-8-, 15-, 21-30-day and adult rats and piping hare. In both animals, the activity of this enzyme in all the structures investigated increases during ontogenesis. Interspecific differences were found in the increase of the enzymic activity in different brain structures during ontogenesis as well as in the level of the activity in different structures in mature animals. 相似文献
20.
As demonstrates estimation of myosin ATPase and SDG activity, the guinea pig is already born with differentiated muscle fibers (MF), and the first histochemical differences between them take place in the uterine 10 days before birth. Tonic oxidative fibers of the first type, arranging hexagonally, develop especially quickly at early stages of postnatal ontogenesis. Their relative contents up to the end of the observations (185 days) do not change, and area of their transversal section increases but slightly in comparison to the phasic fibers. The main age changes of the muscle tissue are connected with formation and rearrangement of the phasic fibers. The most intensive reconstructions of the phasic fibers coincide with the period of game activity and sex maturation. In mixed muscles the part of the glycolytic fibers increase during the postnatal ontogenesis. In the process of ontogenesis the soleus muscle fully consists of oxidative fibers. The definitive level of the MF development is established after the guinea pigs have reached their sex maturation. Comparing the results of the given investigation with the previous data on development of MF in rats, it is possible to conclude that term and premature animals have various rates in development of the muscle system, however, main stages of myogenesis coincide, though they are connected with various phases of ontogenesis. 相似文献